ライフサイエンスコーパス: conserved sequence

1 amino acids at position 201 in the otherwise conserved sequence.

2 hly variable blocks punctuated by regions of conserved sequence.

3 terminally adjacent to this phylogenetically conserved sequence.

4 and comparable breadth of responses against conserved sequences.

5 Fezf2-bound fragments were enriched for conserved sequences.

6 -gene reporter construct that includes these conserved sequences.

7 s across gene bodies, coinciding with highly conserved sequences.

8 verse group of agents displays six blocks of conserved sequences.

9 ough these repeats were nestled among highly conserved sequences.

10 logous mammalian introns contain many highly conserved sequences.

11 y of peptides of 7-10 amino acids flanked by conserved sequences.

12 ng partners of Sir2 is a key function of non-conserved sequences.

13 microRNAs in the same family or with highly conserved sequences.

14 ied three disordered loops in TP with highly conserved sequences.

15 egions in proteins are often flanked by very conserved sequences.

16 t they consist of clustered blocks of highly conserved sequences.

17 orter indicated that all four motifs and the conserved sequence 2 (CS2) element within the 3'-DB are

18 We also identified a highly conserved sequence 21 kilobase 5' of BP4 that we called

19 A-binding module, since it includes a poorly conserved sequence, a solvent-exposed and somewhat unsta

20 Many methods have been developed to identify conserved sequences across species; however, existing me

21 tified 964 copy number differences (CNDs) of conserved sequences across three primate species and exa

22 mammalian HEK293T cells, the 5' part of this conserved sequence acts at the nascent peptide level to

23 The only universally conserved sequence among all influenza A viral neuramini

24 hese two sites that was found to be a highly conserved sequence among alphaviruses and flaviviruses b

25 The conserved sequence and distinct secondary structures of

26 rmation, whereas regional centromeres lack a conserved sequence and instead are epigenetically inheri

27 omprehend the functional significance of the conserved sequence and structural elements in this novel

28 ng bioinformatics algorithms that search for conserved sequence and structural features located in in

29 Homologous protein families share highly conserved sequence and structure regions that are freque

30 ini-vRNAP recognizes promoters that comprise conserved sequences and a 3-base loop-5-base pair (bp) s

31 NA template-containing promoters composed of conserved sequences and a 3-base loop-5-base pair stem h

32 ns of L1- and L2-dsRNA/SsMBV1 share strictly conserved sequences and form stable stem-loop structures

33 e U2, U4, U5, and U6 snRNAs contain expected conserved sequences and have the ability to adopt second

34 egions, (2) rapid extraction and curation of conserved sequences, and (3) for bacteria, identifies un

35 ies reveal that all the five residues in the conserved sequence are required for binding to Nedd8.

36 mputational studies of UCEs and other highly conserved sequences are consistent with these functional

37 Interestingly, the conserved sequences are located within the regions ident

38 were able to bind hemin, suggesting that the conserved sequences are responsible for the hemin bindin

39 The dsDMRs contain evolutionarily conserved sequences, are associated with developmental g

40 x grass species made it possible to identify conserved sequences as short as 9 bp with false discover

41 that provides a single uninterrupted view of conserved sequences as they appear in a species of inter

42 ring membrane fusion may lie in part in this conserved sequence associated with the gp41 loop region.

43 orylating caspase-2 within an evolutionarily conserved sequence at Ser 340.

44 An evolutionarily conserved sequence at the 5' terminus of hantaviral geno

45 These results demonstrate that a conserved sequence at the C-terminus of a type I RIP med

46 the influenza A virus (IAV) genome contains conserved sequences at the 5'- and 3'-terminal ends, whi

47 wo different modes and provide evidence that conserved sequence B helps ensure release of APC from Ax

48 for new partners--20-amino-acid repeat 2 and conserved sequence B--in destruction complex action.

49 Conserved sequences between CFH and CFHR3 mean that the

50 The guanine (G)-tract of conserved sequence block 2 (CSB 2) in human mitochondria

51 Its location within conserved sequence block 3 (CSBIII), just upstream of th

52 Regions of 100% homology were found for Conserved Sequence Block I, Conserved Sequence Block III

53 The latter position is the 5'-nucleotide of conserved sequence block II and is critical to replicati

54 ositions 263 and 303; the latter is known as conserved sequence block II and is vital to DNA replicat

55 Since DNA base oxidation at conserved sequence block II should weaken the ability of

56 These mutations are found within conserved sequence block II, a critical regulatory eleme

57 y were found for Conserved Sequence Block I, Conserved Sequence Block III and the L-strand origin of

58 The conserved sequence block that includes rs55705857 is con

59 e analysis found one repetitive unit between conserved sequence blocks (CSB)-1 and CSB-2 for L. hubba

60 t within these genomic expanses, clusters of conserved sequence blocks (CSBs) are positioned once eve

61 evealed that they contain clusters of highly conserved sequence blocks (CSBs) made up of shorter shar

62 regulatory regions identified evolutionarily conserved sequence blocks (CSBs) with similarities to ne

63 putative feline gene orthologs, and 133,499 conserved sequence blocks (CSBs).

64 erfin-1 mRNA 3' UTR contains multiple highly conserved sequence blocks that either harbor and/or over

65 2 proteins enables additional distinguishing conserved sequence blocks within the helicase-like motor

66 There are two conserved sequence blocks within this intron, and the la

67 We identify a polymorphism within the conserved sequence box II region of the D-loop as a plau

68 is mediated by the X domain of P (XD) and a conserved sequence (Box-2) within the C-terminal domain

69 sms in this common subspace, genes of highly conserved sequences but significantly different cell-cyc

70 The conserved sequence C-X-C-X(2)-(S/T)-X(3)-P-X-C-D-G-(S/A/

71 ts (TMS) with a pair of oppositely oriented, conserved sequences called the alpha-repeats that are im

72 o short, partially complementary, and highly conserved sequences can form a stable RNA duplex at phys

73 t the C. glabrata Ure2p, which does have the conserved sequence, cannot form [URE3] as judged by its

74 We report that GC skew is a conserved sequence characteristic of the CGI promoter cl

75 ch hypervariable region followed by a highly conserved sequence comprising two potential HXH metal-bi

76 xidine dihydrochloride, suggesting that this conserved sequence confers uncoupling potential to V(1)V

77 microscopy observations, we propose that the conserved sequence connecting the MPER with the N-termin

78 We further show that these evolutionarily conserved sequences contain clusters of transcription bi

79 tion is confined to 255 bp of evolutionarily conserved sequence containing functional transcription f

80 2 binding sites that are highly enriched for conserved sequences corresponding to abundant brain miRN

81 We also demonstrated, for Pfim3, that the conserved sequence corresponds to BvgA binding sites.

82 This conserved sequence defines an inaF motif, representative

83 A conserved sequence, derived from the deleted region, enh

84 upon IRP1 binding and illustrate how small, conserved, sequence differences among IRE-mRNAs selectiv

85 In murine cytomegalovirus, poorly conserved sequences distal to the pac2 motif up to 150 b

86 cent structural studies revealed that highly conserved sequences downstream of the phosphorylation si

87 Deletion of one of these conserved sequences (ECR2) from a BAC transgene revealed

88 amer can form a base-paired structure with a conserved sequence element (alpha) located near a 5' spl

89 A cross-species analysis identifies a highly conserved sequence element in LINC-PINT that is essentia

90 promoter was dependent on the action(s) of a conserved sequence element mapping to a chromatin DNase

91 ted by trans-acting factors that recognize a conserved sequence element termed the primer binding sit

92 e function is less closely associated with a conserved sequence element than previously believed.

93 n (MSD) of the HIV-1 glycoprotein gp41 bears conserved sequence elements crucial to the biological fu

94 omoter for L gene expression provided by the conserved sequence elements of the G-L gene junction and

95 B sites of the LTR are among the most highly conserved sequence elements of the HIV-1 genome.

96 Mutations in conserved sequence elements of the sRNA, which allow sRN

97 5.8S rRNA is guided by snoRNA snR43 by using conserved sequence elements that also function to guide

98 These proteins have highly conserved sequence elements that are contained within tw

99 quences in the Theileria genome and identify conserved sequence elements that may be involved in gene

100 Conserved sequence elements upstream of individual other

101 rlaps the tRNA primer binding site, a highly conserved sequence essential for virus replication and d

102 Remarkably, we find that even highly conserved sequences exhibit more functional differences

103 of viral nucleocapsid protein (N) with this conserved sequence facilitates mRNA translation by a uni

104 Whereas this evolutionarily conserved sequence facilitates virus replication with th

105 proved the display of functional data and of conserved sequence features associated with FunFams with

106 Conserved sequence features corresponding to iHMR transc

107 Based on the conserved sequence features we predict that this domain

108 menclature for AT structural, functional and conserved sequence features, based on explicit criteria.

109 recognize the same pMHC epitope often share conserved sequence features, suggesting that it may be p

110 with a set of distinctive and evolutionarily conserved sequence features, which can be utilized to di

111 GC content regions but lack repeats or other conserved sequence features.

112 We postulate that CNDs of these conserved sequences fine-tune developmental pathways by

113 analysis to establish the importance of this conserved sequence for integration and characterize the

114 A highly-conserved sequence from retroviral transmembrane (TM) pr

115 We explore how conserved sequences from both NBDs form ATP-binding site

116 volves proteolytic removal of inhibitory and conserved sequences from the large central B domain whic

117 The larger conserved sequences from the Vista enhancer browser (VEB

118 the gp120 trimer, the inaccessibility of the conserved sequences, highly variable protein sequences,

119 gonists of the MC4R are characterized by the conserved sequence His(6)-Phe(7)-Arg(8)-Trp(9), which is

120 We investigated whether a conserved sequence-HRVW(279)QNRR--in delta subunit contr

121 Indeed, conserved sequences immediately upstream and downstream

122 1783-1795) report that a highly conserved sequence in intron 5 of Tcf7l2 conceals an int

123 We identified a conserved sequence in the C-terminal moiety of pUL56 (67

124 We show that a peptide (p10) derived from a conserved sequence in the C-terminal part of the extrace

125 by ubiquitination is controlled by a highly conserved sequence in the CTR to affect cellular localiz

126 ediated delivery of siRNA targeting a highly conserved sequence in the dengue virus envelope gene (si

127 its duplicated methyltransferase domain and conserved sequence in the double E loop, appears to have

128 nase Greatwall (Gwl), which phosphorylates a conserved sequence in the effector Endosulfine (Endos).

129 otes an intramolecular association between a conserved sequence in the flexible pocket linker and the

130 (mouse K310) located within an evolutionary conserved sequence in the human GR N-terminal domain all

131 Finally, NKX2.1 protein binds a highly conserved sequence in the Lhx6 promoter, and this sequen

132 Furthermore, SCL33 protein bound to a conserved sequence in this intron, indicating auto-regul

133 onal hypotheses on the role of these ancient conserved sequences in comparative cell biology.

134 nd antibodies induced by vaccines containing conserved sequences in HA1 of wild-type influenza A(H5N1

135 We noted that conserved sequences in HSURs 1 and 2 constitute potentia

136 Here, we developed shRNAs targeting conserved sequences in human HD and mouse HD homolog (HD

137 ng and stress response systems by binding to conserved sequences in its target mRNAs and altering the

138 yeast box C/D snoRNAs identified additional conserved sequences in many snoRNAs that are complementa

139 lements (AREs) and microRNA target sites are conserved sequences in messenger RNA (mRNA) 3' untransla

140 Our bioinformatic analysis of conserved sequences in promoters of microRNAs, previousl

141 arcin-ricin loop (SRL) is one of the longest conserved sequences in the 23S ribosomal RNA.

142 We used computational algorithms to find conserved sequences in the 3' untranslated region (UTR)

143 We identify conserved sequences in the 3'UTR of NSF as miR-33 respon

144 tuf gene that identify Staphylococcus genus, conserved sequences in the femB gene that specifically d

145 Twenty-five of the 27 Anopheles miRNAs had conserved sequences in the genome of a divergent relativ

146 genesis approach, we targeted evolutionarily conserved sequences in the intron of the Antirrhinum PLE

147 ant RNA to the X chromosome, suggesting that conserved sequences in the inverted region are important

148 find that mir-125a-5p targets evolutionarily conserved sequences in the Lfng 3' UTR and that preventi

149 presses transcription by directly binding to conserved sequences in the promoters of its target genes

150 By analyzing point mutations in conserved sequences in the T-box DNA-binding domain, we

151 ich permits rapid and sensitive detection of conserved sequences in the tuf gene that identify Staphy

152 Using primers developed from conserved sequences in the Wm82 Rpp4 candidate genes, we

153 es and extends these findings and identifies conserved sequences in zebrafish and human, suggesting f

154 Several families lack this short conserved sequence, including the Brassicaceae, and we p

155 by C proteins revealed that the most-highly conserved sequence is the tetranucleotide spacer separat

156 RGLU1 contains a long, highly evolutionarily conserved sequence known as an Ultraconserved Element (U

157 ne C-terminal-most residues of SSB, a highly conserved sequence known as the SSB-Ct element.

158 Here we show that a conserved sequence located immediately upstream of the C

159 ption by binding to the syp enhancer (SE), a conserved sequence located upstream of four syp promoter

160 l wound enhancers all contain evolutionarily conserved sequences matching binding sites for JUN/FOS a

161 hromosome on a mouse background where highly conserved sequences may confound the analysis.

162 introns and endonucleases, the targeting of conserved sequences, may provide the impetus for the evo

163 he immediate promoter region and an upstream conserved sequence module were each found to contain a C

164 nce and function, and contain several highly conserved sequence modules that are likely involved in r

165 acid substitutions in a region of the highly conserved sequence motif B in the fingers domain on repl

166 Transfer RNAs (tRNAs) require the absolutely conserved sequence motif CCA at their 3'-ends, represent

167 Pf1 residues within a highly conserved sequence motif immediately C-terminal to SID1

168 is for this selectivity is the presence of a conserved sequence motif in H-NS target transcriptons.

169 miR-155 targeted a conserved sequence motif in the 3'UTR of TRF1, resulting

170 sequence and an Arg residue within a highly conserved sequence motif in the channel leading to the R

171 e, a 60-90-residue globular prodomain with a conserved sequence motif including a cysteine engaged in

172 carrying a missense mutation that disrupts a conserved sequence motif of the small GTPase, RAS GENES

173 A highly conserved sequence motif on helix I contributes to posit

174 Plant HSFs of subgroup B lack a conserved sequence motif present in the transcriptional

175 terminus of NBS1 contains an evolutionarily conserved sequence motif that is critical for binding to

176 However, a conserved sequence motif was identified on both negative

177 A conserved sequence motif was identified that contains se

178 rmination occurred immediately upstream of a conserved sequence motif with the general features 3'-C(

179 Together, these results define a conserved sequence motif within an otherwise poorly defi

180 f the phenotype of a mutant missing a highly conserved sequence motif within the catalytic domain of

181 s has pointed toward involvement of a highly conserved sequence motif, E1XXE2RFXYY (from here on refe

182 The aptamer, which does not contain the conserved sequence motif, is specific for the rRNA bindi

183 odule, a repressor helix built from a family conserved sequence motif, PCFXXLP.

184 Biotin synthase contains a highly conserved sequence motif, YNHNLD, in which Asn153 and As

185 larger cytoplasmic domains contains a highly conserved sequence motif.

186 s of other eukaryotes, nor do they contain a conserved sequence motif.

187 promoter to be the (approximate) start of a conserved sequence motif; and (ii) we developed a highly

188 cytochrome P450 (CYP) family 2 sequences, 20 conserved sequence motifs (CSMs) were identified with th

189 In addition, it utilizes two conserved sequence motifs [Thr-h-Gly-Phe-(Asn/Asp)-Glu-X

190 n C. elegans it was shown that the P1 and P2 conserved sequence motifs are required for a gain-of-fun

191 divides CPNs into two groups that share many conserved sequence motifs but differ in both structure a

192 million years of evolution, with one of the conserved sequence motifs encompassing the yar promoter.

193 Several conserved sequence motifs found in other prenyl-diphosph

194 Conserved sequence motifs guide the rational design of l

195 Considerations of conserved sequence motifs in other such molecules sugges

196 l approach, we identified two evolutionarily conserved sequence motifs in the CC subfamilies: a drast

197 y important regions include those containing conserved sequence motifs involved in ATP and RNA bindin

198 (MIT) domains of human VPS4A and VPS4B bind conserved sequence motifs located at the carboxy termini

199 Using the conserved sequence motifs of BAHD members, we searched t

200 alternatively spliced exons and a family of conserved sequence motifs overlapping branchpoints we te

201 the first gene of each TU tend to have more conserved sequence motifs than those of the other genes

202 s a RecA-like core fold and contains all the conserved sequence motifs that are characteristic of the

203 The N terminus of eRF1 contains highly conserved sequence motifs that couple stop codon recogni

204 rize the contribution of this and additional conserved sequence motifs to the regulation of specific

205 ng site estimation suite of tools, BEST, 407 conserved sequence motifs were identified in promoter re

206 8.1, 8.2, and 8.3, and that the TRB CDR3 had conserved sequence motifs which were shared across diffe

207 op GTPases, MAPGAPS correctly aligned weakly conserved sequence motifs within 33 distantly related GT

208 ic analyses, including the identification of conserved sequence motifs, estimation of evolutionary di

209 cription factor (TF) binding, evolutionarily conserved sequence motifs, gene expression, and chromati

210 even transmembrane helices that contain well-conserved sequence motifs, indicating that they are prob

211 Flavitrack was designed to help identify conserved sequence motifs, interpret mutational and stru

212 This feature, together with other conserved sequence motifs, place AaSDR-1 into the "class

213 res of Spc97 and Spc98 suggest functions for conserved sequence motifs, with implications for the gam

214 conserved RNA folding motifs rather than the conserved sequence motifs.

215 ears nuclear localization signals and highly conserved sequence motifs.

216 in TERT, which includes three evolutionarily conserved sequence motifs: CP2, CP, and T.

217 r G protein activators is characterized by a conserved sequence named the Galpha-binding and activati

218 ys, phosphorylation of a serine present in a conserved sequence near the amino terminus of GSK-3 gene

219 Some of the most highly conserved sequences occur in genes encoding RNA binding

220 -Arnt-Sim (PAS) domain that is preceded by a conserved sequence of 25-27 amino acids known as the PAS

221 The most conserved sequence of MFPs is located in their distal C-

222 ylation sites, which are located in a highly conserved sequence of occludin, YETDYTT; Tyr-398 and Tyr

223 observations that: (i) it contains the most conserved sequence of SH2 domains, GSFLVR; (ii) it binds

224 y recognizing its target located in a highly conserved sequence of the 3'-untranslated region (3'-UTR

225 he potential for microRNA binding sites in a conserved sequence of the Nef-3'-LTR, several host micro

226 In contrast with the highly conserved sequence of the protease catalytic domain, the

227 the H2-H3 domain indicating that the highly conserved sequence of the terminal part of H2 is not cri

228 This coil to helix transition involves the conserved sequence of Thr(16)-Pro(17)-Arg(18) (Ser(16)-P

229 plex PCR primers were developed based on the conserved sequences of all available respiratory-virus s

230 ology 2 (SH2) domains are composed of weakly conserved sequences of approximately 100 aa that bind ph

231 sage for all species tested, we predict that conserved sequences of IhtA are necessary for function a

232 We focused on all completely conserved sequences of seven or more nucleotides located

233 fy a nine amino acid motif within the highly conserved sequences of the exon 2b encoded domain that m

234 ative DBD of NRs, sequences of LBD were less conserved: Sequences of THRs, RARs and RXRs were >/=90%

235 Conserved sequences on the 3' and 5' ends of the crRNA a

236 We speculate that the highly conserved sequences on the three duplicated genes in pri

237 nd in only one species, hundreds have either conserved sequence or position within Saccharomyces uORF

238 identified in sequenced Lytechinus BACs, as conserved sequence patches in similar regions of the res

239 They share a conserved sequence pattern and catalyse the displacement

240 lix, containing a hydrophobic surface with a conserved sequence pattern that interacts with key hydro

241 erant 'reading head' in C4BP, which detected conserved sequence patterns hidden within hypervariabili

242 ns involved in pathway interactions revealed conserved sequence patterns that enabled us to unambiguo

243 Late (L) domains containing the highly conserved sequence PPXY were first described for retrovi

244 iate adjacent bases, allowing us to define a conserved sequence preference for the mammalian DNA meth

245 This is the report where conserved sequences present in all the serotypes of Deng

246 ith corneal infection, revealed areas of non-conserved sequence principally in genes for the virus fi

247 ies of teleosts we identified a small highly conserved sequence (R2) located 1.7 kb upstream of the p

248 We show that one of the conserved sequence regions in the C-terminal domain of P

249 JAZ proteins contain two highly conserved sequence regions: the Jas domain that interact

250 Primary sigma factors share four regions of conserved sequence, regions 1-4, which have been further

251 scattering analyses reinforce and extend the conserved sequence relationships of group 4 enzymes and

252 The second stem-loop contains conserved sequences required for base pairing with the m

253 Mutation of conserved sequences revealed that putative transcription

254 alled the YARHG domain after the most highly conserved sequence-segment.

255 ture formed by the interaction of two highly conserved sequence segments.

256 G1 proteins are composed of two stretches of conserved sequences separated by a variable linker seque

257 ant form of RR06 was able to bind to a 19-bp conserved sequence shared by the spr1996 and cbpA promot

258 ues that include the DFGWG motif, the single conserved sequence signature of BAHD super-family member

259 omic sequences enables the identification of conserved sequence signatures and can enrich for coding

260 evels of primary transcripts, are encoded by conserved sequences similar to those found at canonical

261 RNA genes and a novel assay that amplifies a conserved sequence specific for the sicavar gene family

262 st activator Gcn4 functions through a short, conserved sequence-specific motif.

263 lincRNAs can recognize protein targets in a conserved, sequence-specific manner in order to affect c

264 m many two-component systems has established conserved sequence, structural, and mechanistic features

265 ch is crucial for selective amplification of conserved sequences such as rRNA genes.

266 Therefore, we have identified a conserved sequence targeted to the HCV genome that can i

267 Here we found a highly conserved sequence (termed "ISLAD") that is associated w

268 Two intron 4 deletions occur in a highly conserved sequence that is part of the 3' untranslated r

269 e GPR158 C terminus additionally contained a conserved sequence that was capable of enhancing RGS7 GT

270 rs, EvoPrinterHD facilitates the analysis of conserved sequences that are essential for coordinate ge

271 d alignment programs, to characterize highly conserved sequences that are shared among co-regulating

272 erences profile is also generated to portray conserved sequences that are uniquely lost in any one of

273 'universal' overgo-hybridization probes from conserved sequences that can be used to efficiently scre

274 ased experiments have identified 5'-flanking conserved sequences that control pancreatic and beta-cel

275 Ribosomal binding to HP IRESs requires conserved sequences that form a pseudoknot and the adjac

276 lar and leafy spurge have identified several conserved sequences that may be important for their expr

277 vidence of RNA secondary structures or other conserved sequences that might directly control elongati

278 In the HAmg vaccine, highly conserved sequences that were originally covered by glyc

279 ing the Cdc34(tm) mutation, which alters the conserved sequence, the cyclin-dependent protein kinase

280 th short (<200 bp) islands of evolutionarily conserved sequences, the function of most of these unann

281 When flanked by conserved sequences, the self-complementary diSSR (AT)n

282 evolve separately to target the same highly conserved sequences, uniting afterwards to create a comp

283 nstrate that Pbx1 and Emx2 bind in vivo to a conserved sequence upstream of Alx1 and cooperatively ac

284 B1 plus both the proximal part of B1 and non-conserved sequence upstream of B1.

285 ular genetic techniques to identify a highly conserved sequence upstream of the PTEN promoter, sharin

286 on bioinformatic analyses of evolutionarily conserved sequences, we predicted another peptide hormon

287 ansposon SLACS, or spliced leader-associated conserved sequence, which integrates exclusively into th

288 motifs and two additional mutations, in less conserved sequences, which also affect splicing.

289 n signal (NLS) was mapped to a short, highly conserved sequence whose activity was compromised by poi

290 A molecule recognizes a short, approximately conserved sequence within a gene's promoter region and,

291 Tra2beta binds to a highly conserved sequence within E23 and transactivates its spl

292 rs55705857 maps to a highly evolutionarily conserved sequence within the long non-coding RNA CCDC26

293 We identified a conserved sequence within the Muscle creatine kinase (MC

294 The presence of highly conserved sequences within cis-regulatory regions can se

295 The new program also identifies conserved sequences within rearranged DNA, highlights re

296 ce conservation and enables the discovery of conserved sequences within rearranged DNA.

297 s occur throughout TFAP2A, but mostly within conserved sequences within the DNA contact domain of AP-

298 with physiological outcomes usually rely on conserved sequences within the RNA element.

299 gh mutational analysis of the evolutionarily conserved sequences within this enhancer, we identify tw

300 ns, and it is unclear whether including only conserved sequences would yield sufficient cellular immu