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1 tant role in motivating actions that require considerable effort.
2 iology by improving model quality and saving considerable effort.
3 ci and development of suitable markers takes considerable effort.
4  basis of direct field observations, despite considerable effort.
5 cine introduction can take years and require considerable effort.
6 re unable to achieve advanced access despite considerable efforts.
7 h, Agent Based Modeling (ABM), has attracted considerable efforts.
8                                  In spite of considerable effort, a full understanding of the pathway
9                                 Yet, despite considerable effort, a molecular-level understanding of
10                                      Despite considerable efforts, a comprehensive understanding of t
11                                      Despite considerable efforts, a direct experimental demonstratio
12                                      Despite considerable efforts, a disconnect persists between the
13 eir sustainability is essential and requires considerable effort across a broad spectrum of fishery s
14 e unexpected clinical findings have prompted considerable efforts across academia and industry to tar
15                             However, despite considerable efforts, an understanding of how molecular
16 acterizing complex vocalizations can require considerable effort and a deep intuition about each spec
17 lementation of these programmes will require considerable effort and commitment.
18 l methods change clinical practice only with considerable effort and difficulty.
19                                              Considerable effort and expense have been expended in at
20 g individual samples, these methods can save considerable effort and genotyping costs when relatively
21                             However, despite considerable effort and investment, no drugs have yet ga
22                                          The considerable effort and potential lack of reproducibilit
23                                      Despite considerable effort and resources, no 'causative' geneti
24             These methods are limited by the considerable effort and time required to obtain reliable
25  depend on pre-defined features that require considerable efforts and resources to compute and often
26                                      Despite considerable effort, antichlamydial vaccines have proven
27                                              Considerable efforts are being spent in the pharmaceutic
28 ries information in optoelectronic devices), considerable efforts are directed at the development of
29                                        Thus, considerable efforts are underway in the pharmaceutical
30                                              Considerable efforts are underway to fill this 'THz gap'
31 yfluoroalkyl substances (PFAS) has mobilized considerable efforts around the globe in recent years, p
32                               Thus, there is considerable effort being made to improve the predictive
33                                      Despite considerable effort by the pharmaceutical industry, PAR2
34 e WHO sodium target in New Zealand will take considerable efforts by both food manufacturers and cons
35                                      Despite considerable efforts by chemical biologists to synthesiz
36                                      Despite considerable efforts by many groups over 4 decades, the
37                                              Considerable effort continues to be focused on improveme
38                                              Considerable effort continues to focus on developing a v
39 een one of the most elusive problems despite considerable effort devoted to the study.
40  hepatic resection, the last decade has seen considerable effort directed towards the following areas
41                                 However, the considerable efforts embodied in these early studies unq
42                                      Despite considerable effort examining the effect of IL-10 on spe
43                                              Considerable effort exists within drug discovery to deve
44                               There has been considerable effort focused on developing efficient prog
45  embryonic life in the first trimester, with considerable effort focused on the cell and developmenta
46 ptidic APIs are large molecules that require considerable effort for integrity assurance.
47  but are generally "private", thus requiring considerable effort for their identification.
48  scientific and real-world applications with considerable efforts going into their realizations.
49                             In recent years, considerable effort has been aimed at developing B. subt
50                                              Considerable effort has been applied to separate their l
51 ty for real-world applications, and although considerable effort has been dedicated to improving sens
52                                        While considerable effort has been dedicated to the developmen
53                                   Therefore, considerable effort has been dedicated to the developmen
54                                              Considerable effort has been dedicated to understanding
55                                     Although considerable effort has been devoted to annotating it, t
56                                              Considerable effort has been devoted to comparative stud
57                             For this reason, considerable effort has been devoted to determining the
58                                              Considerable effort has been devoted to elucidating the
59 use of this significant role in oncogenesis, considerable effort has been devoted to elucidating the
60  electronics is reaching its ultimate limit, considerable effort has been devoted to find new materia
61                                              Considerable effort has been devoted to gaining a mechan
62                                              Considerable effort has been devoted to identifying mole
63                                              Considerable effort has been devoted to identifying tran
64                                        Thus, considerable effort has been devoted to mapping the func
65                                              Considerable effort has been devoted to modeling sample
66                                              Considerable effort has been devoted to refining experim
67 , and increased incidence of bone fractures, considerable effort has been devoted to the identificati
68                                     Although considerable effort has been devoted to understanding ho
69                             In recent years, considerable effort has been devoted to understanding th
70                                              Considerable effort has been devoted to unraveling how t
71                                              Considerable effort has been directed at 'top-down' modi
72                                              Considerable effort has been directed at understanding t
73                                              Considerable effort has been directed to develop Mycobac
74                                              Considerable effort has been directed toward controlling
75                                              Considerable effort has been directed toward controlling
76                                     Although considerable effort has been directed toward the mapping
77                                     Although considerable effort has been directed toward understandi
78 ulated acutely by endocytic trafficking, and considerable effort has been directed toward understandi
79                                     Although considerable effort has been directed towards understand
80                                     Although considerable effort has been exerted to define the event
81                                     Although considerable effort has been expended developing drug ca
82                                              Considerable effort has been expended in striving for a
83                     During the past 15 years considerable effort has been expended in trying to estab
84 on is a worldwide public health problem, and considerable effort has been expended on developing an e
85 iting factor in making large alignments, and considerable effort has been expended over the years in
86                                              Considerable effort has been expended to create effectiv
87                                              Considerable effort has been expended to determine wheth
88 key driver in many human cancers; therefore, considerable effort has been expended to develop reliabl
89                                              Considerable effort has been expended to develop statist
90                                              Considerable effort has been expended to develop techniq
91                                              Considerable effort has been expended to increase sustai
92  increased use of gating in nuclear imaging, considerable effort has been expended toward automating
93   In light of the importance of these cells, considerable effort has been focused on understanding th
94                                              Considerable effort has been focused on understanding th
95                             In recent years, considerable effort has been invested in creating AAV va
96                          During recent years considerable effort has been invested in creating physic
97 ogenesis of Alzheimer's disease, and, hence, considerable effort has been invested in defining the me
98 al induction by Spemann and Mangold in 1924, considerable effort has been invested in identifying the
99                                              Considerable effort has been invested in improving pedia
100                                            A considerable effort has been invested in the engineering
101                                              Considerable effort has been invested in the search of s
102 importance of algae for green biotechnology, considerable effort has been invested in understanding t
103                                              Considerable effort has been invested in using IL-2 as a
104                                              Considerable effort has been invested into inoculum stra
105                                              Considerable effort has been made in elucidating the mec
106                                    Recently, considerable effort has been made to analyze the binding
107                                              Considerable effort has been made to better understand w
108 iated with the v-Src and v-Crk-oncoproteins, considerable effort has been made to determine its funct
109                             In recent years, considerable effort has been made to develop cell-based
110                                        While considerable effort has been made to improve access to c
111                                              Considerable effort has been made to improve and harmoni
112                                              Considerable effort has been paid to improving diagnosti
113                                            A considerable effort has been placed in understanding the
114                                     Although considerable effort has been placed on assuring the qual
115                                              Considerable effort has been put forth to identify prote
116 s growing population of long-term survivors, considerable effort has been put forth to identify treat
117                                              Considerable effort has been put forth to understand the
118 ans of modifying histone acetylation status, considerable effort has been put into the development of
119                                              Considerable effort has been put into understanding its
120                                              Considerable effort has been spent in developing transpl
121 ubiquitylated species in biological samples, considerable effort has been spent on methods to purify
122  of the inbred mouse in biomedical research, considerable effort has been undertaken in recent years
123                                              Considerable effort has focused on identifying adjunctiv
124                                        While considerable effort has focused on optimizing neutraliza
125             During the past several decades, considerable effort has focused on self-assembled system
126                                              Considerable effort has focused on the development of se
127                                              Considerable effort has focused on the identification of
128                                              Considerable effort has focused upon modulating the SMN2
129                                              Considerable effort has gone into designing vaccine regi
130                                   Therefore, considerable effort has gone into determining the bioche
131                      Over the past 10 years, considerable effort has gone into improving diagnostic a
132 rmediates in many chemical reactions; hence, considerable effort has gone into investigating their st
133                                              Considerable effort has gone into understanding the mech
134                                              Considerable effort has gone toward identification of di
135 of many of their synthetic counterparts, and considerable effort has made since that time to develop
136                                       Hence, considerable efforts have aimed to predict these process
137                                              Considerable efforts have already been made to develop r
138                                              Considerable efforts have also been devoted towards the
139                                     Although considerable efforts have been dedicated to identifying
140                                              Considerable efforts have been dedicated to preclinical
141                                              Considerable efforts have been devoted in recent years t
142 underlie congenital muscular dystrophies and considerable efforts have been devoted to explore this O
143                                              Considerable efforts have been devoted to improving the
144                                              Considerable efforts have been devoted to this fruitful
145                                              Considerable efforts have been devoted toward uncovering
146 downstream of the T-cell receptor (TCR), and considerable efforts have been directed toward discovery
147                                              Considerable efforts have been directed toward finding i
148                                              Considerable efforts have been directed toward the disco
149                                              Considerable efforts have been directed toward understan
150                                        While considerable efforts have been directed toward understan
151                                              Considerable efforts have been focused on fluorinated or
152                             In recent years, considerable efforts have been invested in elucidating t
153                         To meet such demand, considerable efforts have been invested towards the deve
154                                Consequently, considerable efforts have been made in recent years to f
155                                     Although considerable efforts have been made in the areas of anti
156                                        While considerable efforts have been made in this direction, i
157                                              Considerable efforts have been made over the last decade
158                                     As such, considerable efforts have been made to characterize the
159                        Over the past decade, considerable efforts have been made to degrade commodity
160                                        While considerable efforts have been made to develop phenolic
161                                              Considerable efforts have been made to develop radiolabe
162                                     As such, considerable efforts have been made to develop small-mol
163                                              Considerable efforts have been made to develop technolog
164                                              Considerable efforts have been made to engineer AAV vari
165                                              Considerable efforts have been made to exploit cardiopro
166                                              Considerable efforts have been made to exploit this acti
167                                    Recently, considerable efforts have been made to generate metallos
168                       In the past few years, considerable efforts have been made to identify appropri
169                                              Considerable efforts have been made to identify the gene
170                                    Recently, considerable efforts have been made to produce them in a
171                                              Considerable efforts have been made to regulate the pore
172                                              Considerable efforts have been made to reveal the biolog
173                             In recent years, considerable efforts have been made to spread awareness
174                                              Considerable efforts have been made to synthesize and ch
175 se of their ecological and economic impacts, considerable efforts have been made to understand and pr
176                                              Considerable efforts have been made to understand the or
177                                     Although considerable efforts have been made to understand why al
178                                              Considerable efforts have been recently devoted to integ
179                       Over the last decades, considerable efforts have been undertaken in the develop
180                 Nonetheless, in recent years considerable efforts have ensued to characterize alterna
181                                              Considerable efforts have gone into optimizing this ther
182                                              Considerable efforts have thus been directed at understa
183                Neuroscientists have invested considerable effort in attempting to elucidate the molec
184                                          The considerable effort in computational modeling and experi
185      Despite this, carers continue to invest considerable effort in maintaining continuity in the car
186                             However, despite considerable effort in the 1980s, transmethylation has n
187                 Circadian research has spent considerable effort in the determining clock output path
188     Collaborative study groups have invested considerable effort in the last decade in defining the r
189 and limits its efficiency, thereby requiring considerable effort in the optimization process.
190                                      Despite considerable efforts in designing antimicrobial coatings
191                                              Considerable efforts in electron-transfer theory have yi
192 nowires and nanotubes have been the focus of considerable efforts in energy storage and solar energy
193 n of silicon-based electronics has motivated considerable efforts in exploring new electronic materia
194           They also highlighted the need for considerable efforts in the training of staff in the new
195                                      Despite considerable efforts in understanding the binding intera
196           Historically, researchers have put considerable effort into developing automation systems t
197  have been identified is growing rapidly and considerable effort is being directed towards establishi
198 clinical drug candidates exist and therefore considerable effort is being exerted to employ new tools
199                                              Considerable effort is being expended to define chemopre
200  evolutionary developmental comparisons, and considerable effort is being invested in isolating devel
201                                              Considerable effort is currently focused on understandin
202                                              Considerable effort is directed towards survey and monit
203 s frequently activated in cancer; therefore, considerable effort is focused on identifying compounds
204                                              Considerable effort is focused on identifying transcript
205                           For these reasons, considerable effort is given to repairing even severely
206 stablishment is virtually impossible, and so considerable effort is invested in preventing the range
207 ies is being developed for this purpose, and considerable effort is invested into formally defining t
208             During cell culture development, considerable effort is invested to understand the factor
209                                              Considerable effort is now being focused on evaluating l
210 nly at the stage of fundamental research and considerable effort is required to improve the energy de
211                             For that reason, considerable effort is under way to devise methods of en
212                                      Despite considerable effort, little is known about the mode of a
213 s been in a quarter of a century and despite considerable effort, little progress has been observed i
214                             However, despite considerable efforts, little is known about how enzymes
215 ing contemporary organic chemistry despite a considerable effort made over the last decades.
216                                     Although considerable effort needs to be devoted to the continued
217                                      Despite considerable efforts, no essential cellular receptors fo
218                                      Despite considerable efforts, no reliable method exists to produ
219                      This screen should save considerable effort now wasted on directly cloning unsui
220 associated with Lyme borreliosis has focused considerable effort on the development of a comprehensiv
221                The past 30 years have seen a considerable effort on the part of statisticians to impr
222                              There have been considerable efforts on integration of plasmonic nanostr
223                                      Despite considerable effort, our understanding of the mechanisti
224                                              Considerable effort over the last decade has been direct
225  through beta-adrenergic receptors (AR), and considerable effort over the past 5 decades has been dir
226 porphyrins started flourishing recently with considerable efforts over the past few years, as evidenc
227                             However, despite considerable efforts, Pin1 has remained an elusive drug
228                                      Despite considerable effort placed on vancomycin therapeutic dru
229                                      Despite considerable efforts, quantitative prediction of various
230                                      Despite considerable effort, researchers understand little about
231                                      Despite considerable effort, rigorous interaction mapping in hum
232                                              Considerable effort should be expended to improve Form 2
233                Consequently, many labs spend considerable effort testing methods to find one that wor
234                                  Despite the considerable effort that has been invested in elucidatin
235                  We will try to describe the considerable effort that has gone into collecting eviden
236                                      Despite considerable effort, the complex interactions among diff
237                                      Despite considerable effort, the etiology of these devastating d
238                                      Despite considerable effort, the mechanism is unknown.
239                         However, in spite of considerable effort, the mechanisms by which c-Myc inter
240                                      Despite considerable effort, the mechanisms underlying DR remain
241                                      Despite considerable effort, the slow-exchange limit could not b
242                                      Despite considerable efforts, the instabilities of most optical
243                                      Despite considerable efforts, the mechanisms linking genomic alt
244                                      Despite considerable efforts, the molecular and cellular events
245                                      Despite considerable efforts, the Tumor Mutation Burden (TMB) is
246  for viral membrane fusion; however, despite considerable efforts, these critical host factors have d
247                                      Despite considerable effort, thus far there is no cure or treatm
248                               There has been considerable effort to determine structure-activity rela
249                      Although there has been considerable effort to develop a sensing platform for in
250 a(V)1.7 are insensitive to pain, has spurred considerable effort to develop selective inhibitors of t
251 chievable photon count rates, there has been considerable effort to find strategies to increase the s
252  the copper oxide materials there has been a considerable effort to find universal trends and correla
253                      Although there has been considerable effort to immunophenotype septic patients,
254                           There is currently considerable effort to incorporate both diagnostic and t
255         However, its user interface requires considerable effort to learn, and sometimes requires pro
256                                      Despite considerable effort to produce fuels from lignocellulosi
257  who initially refuse, whereas others expend considerable effort to recruit reluctant respondents.
258                          Currently, there is considerable effort to replace existing precious-metal-c
259                       While there has been a considerable effort to understand the factors driving mR
260               In recent years there has been considerable effort to understand the interaction of nan
261                      Although there has been considerable effort to understand the relationships betw
262 cent ascent of covalent drugs has stimulated considerable efforts to characterize alternative warhead
263                                      Despite considerable efforts to characterize the microbial ecolo
264 ociety for Internal Medicine (DGIM) has made considerable efforts to come to terms with its role and
265                                              Considerable efforts to decipher the biology of DCIS hav
266                                      Despite considerable efforts to define mechanisms that underlie
267                    The past decade witnesses considerable efforts to design acoustic illusion cloak t
268                                              Considerable efforts to develop an effective vaccine for
269 iet, and subsequent weight loss, has spurred considerable efforts to develop antagonists of MCHR1.
270 by steric considerations and there have been considerable efforts to develop more selective processes
271                                      Despite considerable efforts to develop personalized therapy, tr
272 t-induced obesity of MCH KO mice has spurred considerable efforts to develop small molecule MCHR1 ant
273                              There have been considerable efforts to develop therapeutic strategies t
274 to catabolize aromatic compounds has sparked considerable efforts to engineer bacteria to valorize li
275                                      Despite considerable efforts to identify cancer metabolic altera
276 in the context of global change, yet despite considerable efforts to identify environmental drivers o
277 dence of lymphomas worldwide have stimulated considerable efforts to identify factors that contribute
278  of neuronal Ca channel diversity has led to considerable efforts to identify useful classification c
279                                      Despite considerable efforts to improve early detection of ovari
280                                        Thus, considerable efforts to increase parental COVID-19 vacci
281                                              Considerable efforts to make palladium and palladium all
282        Over the past decade, there have been considerable efforts to observe non-abelian quasiparticl
283                                      Despite considerable efforts to sequence hypermutated cancers su
284                                      Despite considerable efforts to stabilize lithium metal anode st
285                          This is a result of considerable efforts to standardize methodology, the ava
286 chnologically useful behaviours have spurred considerable efforts to synthesize a broad array of nega
287                              There have been considerable efforts to synthesize new zeolites with spe
288             In recent years, there have been considerable efforts to translate this solution-based re
289                              There have been considerable efforts to untangle the metabolic underpinn
290 eptor, mGlu5; therefore, our lab has focused considerable effort toward developing mGlu1 positive all
291                                      It took considerable effort until scientists accepted that lipid
292                 Despite intense interest and considerable effort via high-throughput screening, there
293                             However, despite considerable effort, we still cannot predict a priori th
294 es obtained from CD/DVD, in the last decades considerable efforts were devoted to reuse and recycle i
295                                              Considerable efforts were put into machine learning pred
296                                   However, a considerable effort will be required to optimize this ap
297                                      Despite considerable efforts within the microarray community for

 
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