ライフサイエンスコーパス: consortia

1 physical and mental health traits from GWAS consortia.

2 ost the activity of biomass-degrading enzyme consortia.

3 nce of large meta-analysis and mega-analysis consortia.

4 n brain transcriptome generated by different consortia.

5 pared to aerobic soil, sludge, and microbial consortia.

6 ocus-specific database curators and mutation consortia.

7 from the SUNLIGHT, GABRIEL and EAGLE eczema consortia.

8 s (13)C fingerprint information in microbial consortia.

9 in large-scale genome-wide association study consortia.

10 sis for genetic association studies in large consortia.

11 le of spatial structures, such as flocks and consortia.

12 ds Genetic Consortium; 213 500 participants) consortia.

13 nt with paediatric oncology drug development consortia.

14 through the international PRACTICAL and BPC3 consortia.

15 rtmentalized systems and synthetic protocell consortia.

16 ciation study data from the Psychiatric GWAS Consortia.

17 ingle investigators to the creation of large consortia.

18 m of bioprocessing using synthetic microbial consortia.

19 TLPB using three different hexane degrading consortia.

20 aits in large well-phenotyped and -genotyped consortia.

21 s to that of research laboratories and small consortia.

22 culture microbes as these approaches disrupt consortia.

23 rease in multicenter neuroimaging trials and consortia.

24 and functional make-up of natural microbial consortia.

25 roarray user community and two international consortia.

26 tiative and discusses examples of successful consortia.

27 ith equivalent data from other international consortia.

28 ping of isolates and of uncultivated natural consortia.

29 ological role of enterococci in the GI tract consortia.

30 automation in large-scale protein structure consortia.

31 ial of proteomics for the study of microbial consortia.

32 oral bacteria may need to include microbial consortia.

33 at we receive from the chromosome sequencing consortia.

34 naerobic methanotrophy, as were multispecies consortia.

35 monospecific aggregates, or in multispecies consortia.

36 ere replicated with results from large-scale consortia.

37 ols; approximately 91% of European ancestry) consortia.

38 p network structures of ENCODE and modENCODE consortia.

39 ence using data from two large breast cancer consortia.

40 meta-analysis results of large international consortia.

41 in 118,816 subjects from three international consortia.

42 ng data from genome-wide association studies consortia.

43 ation scale activities in numerous bacterial consortia.

44 from the SUNLIGHT, GABRIEL and EAGLE Eczema consortia.

45 thropometric Traits and Psychiatric Genomics consortia.

46 roughput sequencing data generated by recent consortia.

47 represents a new generation of epidemiologic consortia.

48 distance between syntrophic partners within consortia.

49 ,725 cases and 9,969 controls from two Asian consortia.

50 in-coding genes established by international consortia.

51 ces and linking them to indigenous microbial consortia.

52 ntial of combining these datasets into large consortia; 4) the ability to use advances in biomedical

53 04 controls), the MIGen and CARDIoGRAM Exome consortia (42 335 cases and 78 240 controls), and Exome

54 Consortia abound in nature, and their cooperative metabo

55 inical trials from investigator-led research consortia accounted for nine of the 16 studies cited mor

56 We establish that these microbial consortia act as cartels, whereby population dynamics pi

57 Gut bacterial consortia adapt by the transfer of plasmids and transcon

58 rnational collaboration in early phase trial consortia addresses these challenges.

59 e first evidence, to our knowledge, that AOM consortia affiliated with all five major ANME clades are

60 by individual investigators and large-scale consortia alike.

61 ves feedback inhibition for the fermentative consortia, allowing for rapid metabolism of organics.

62 ability of sulfide-oxidizing/sulfur-reducing consortia analogous to extant sulfur syntrophies (Thiode

63 ems, deep-sea tubeworms with their microbial consortia and a soil ecosystem manifesting adaptive home

64 With many multicenter consortia and a United Network for Organ Sharing program

65 from different publicly available resources/consortia and a web interface that automates the LD scor

66 e tissues are typically colonized by complex consortia and are inaccessible to observation.

67 ms used to establish and maintain syntrophic consortia and conserve energy from reactions that operat

68 orative studies across pediatric HL research consortia and in conjunction with adult groups for the a

69 new directions, including the development of consortia and large-scale data collection projects and t

70 Together, the existing consortia and regional networks operating in LMICs have

71 Notable consortia and research trial studies have focused on Alz

72 n from pre-existing GWAS or custom-arrays in consortia and single studies.

73 ex computational devices using multicellular consortia and space as key computational elements.

74 igators, research centers, studies, or other consortia and studied 48 different diseases or traits.

75 power, we used summary statistics from GWAS consortia and tested the association of these two GRSs w

76 In this study, the composition of microbial consortia and the occurrence of some important nutraceut

77 iabetes using data from six independent GWAS consortia and the UK Biobank sample (N = 112 151).

78 Large genome-mapping consortia and thousands of genome-wide association studi

79 gest results have come from large-scale mega-consortia and/or meta-analyses that combine data from up

80 Multicenter neuroimaging trials, consortia, and collaboratives enable the acquisition of

81 entralisation of sarcoma care, international consortia, and factors related to tumour biology.

82 n, compare the capabilities of different ARB consortia, and find ARB with useful metabolic capacities

83 cans (AAs) from the NHLBI-ESP and the CHARGE consortia, and performed association tests of sequence d

84 trials performed through cooperative groups, consortia, and single institutions.

85 rers, medical societies, health care quality consortia, and standards and regulatory agencies.

86 cent efforts to engineer synthetic microbial consortia, and we suggest future applications.

87 ng advantage of the scale that collaborative consortia approaches can bring to a problem, the PGC has

88 end has been the emergence of collaborative, consortia approaches.

89 stool-based products, and defined microbial consortia are all in the immediate future.

90 These archaeal/bacterial consortia are already recognized as the major sink of me

91 ly little is known about how these microbial consortia are established in various locations within th

92 These consortia are globally distributed in the environment an

93 However, these consortia are likely to be limited by lack of standardiz

94 tanding of male breast cancer, international consortia are necessary.

95 that highly structured ANME-2/Desulfosarcina consortia are not the sole entities responsible for AOM

96 Kingdom and the type of heavy metal and that consortia are significantly more resistant to heavy meta

97 The assumption that phage consortia are ubiquitous and homogenous across habitats

98 Microbial consortia are ubiquitous in nature and are implicated in

99 -Wide Association Studies identified 55 GWAS consortia as of April 1, 2011.

100 nd demonstrate the scientific value of large consortia-based genetic epidemiology studies.

101 cations within the gut, how members of these consortia behave within their dynamic ecosystems, or wha

102 de range of stakeholders, including research consortia, biorepositories, policy-makers, and funders.

103 new data sets from our ENCODE and modENCODE consortia, bringing the total to over 1,400.

104 turally diverse uncultured methane-oxidizing consortia by measuring stable isotope incorporation for

105 s from the BLUEPRINT, NIH ROADMAP and ENCODE consortia by their cell type.

106 Given that microbial consortia can perform even more complicated tasks and en

107 ltispecies states, and whether large species consortia can spontaneously evolve.

108 nd metaproteomic data suggest that microbial consortia catalysing anaerobic oxidation of methane (AOM

109 robe the translational activity of microbial consortia catalyzing the anaerobic oxidation of methane

110 -deficient and control polyps with bacterial consortia characteristic for different Hydra species and

111 the infrastructure of three well-established consortia (CHARGE, GBPgen, and ICBP) and a nonstandard a

112 enetics (TAG) and Glaxo Smith Kline (Ox-GSK) consortia cohorts (n = 45,691 smokers) and assessed some

113 orative genotyping experiment involving four consortia (Collaborative Oncological Gene-environment St

114 ining balanced functional performance within consortia composed of multiple D. mccartyi subpopulation

115 rganizations, such as companies and academic consortia, conduct large multi-year scientific studies t

116 icroscale within well-structured macroscopic consortia consisting of sulfide-oxidizing anoxygenic pho

117 dechlorination of tetrachloroethene (PCE) by consortia containing bacteria with different reductive d

118 However, different species or consortia contributed to these functions in each individ

119 When D-CarDia and consortia data for hypertension were meta-analysed toget

120 2 233 and control=64 762) for CHD, and other consortia data were used for metabolic traits (fasting i

121 Phage consortia differed between bleached and diseased tissues

122 tories of test data created by international consortia, easily accessible via moderated Web sites, in

123 We convey the importance of consortia efforts and collaboration to gain the large sa

124 As with these first-generation consortia efforts, the GLIOGENE Consortium embraces the

125 es important limitations of first-generation consortia efforts, which comprised a posteriori harmoniz

126 s from major data providers and experimental consortia, electronic submissions from laboratories and

127 e required, including analyses in scientific consortia established to assess main genetic effects, wh

128 been tremendous progress from collaborative consortia examining pooled data from GWASs, often employ

129 has been supporting large team science (TS) consortia focused on gene discovery, fine mapping of loc

130 singly, sorting of individual BONCAT-labeled consortia followed by whole-genome amplification and 16S

131 roaches to building and optimizing synthetic consortia for bioprocessing applications.

132 The use of microbial consortia for bioprocessing has been limited by our abil

133 interest in engineering synthetic microbial consortia for biotechnology development.

134 to develop robust synthetic fungal-bacterial consortia for efficient biosynthesis of valuable product

135 tabolic attributes specializing in microbial consortia for initial and subsequent waves of colonizati

136 er, our results underscore the importance of consortia for investigating the genetic basis of chronic

137 As such, consortia form and often combine available data.

138 Microbial consortia form when multiple species colocalize and comm

139 ced DNA from complex sediment and planktonic consortia from an aquifer adjacent to the Colorado River

140 enome analysis of single cells and microbial consortia from diverse environmental samples including a

141 the suite of members shared among microbial consortia from similar habitats, and is represented by t

142 fer of electrons to the anode from bacterial consortia growing on the anode, as confirmed by cyclic v

143 Wider access to consortia guidelines is needed to establish appropriate

144 Reconstruction of artificial syntrophic consortia has allowed uncultured syntrophic metabolizers

145 time, many research groups and international consortia have already produced BAC libraries and physic

146 Several international consortia have been formed in a remarkable worldwide col

147 Eleven consortia have contributed 316 non-redundant entries and

148 IP-seq experiments, the ENCODE and modENCODE consortia have developed a set of working standards and

149 To this end, the ENCODE and modENCODE consortia have generated large amounts of matched RNA-se

150 Several consortia have pursued genome-wide association studies f

151 Large consortia have revealed hundreds of genetic loci associa

152 In recent years, numerous laboratories and consortia have used neuroimaging to evaluate the risk fo

153 on donor and with open cultures of microbial consortia (i.e., reactor microbiomes) under anaerobic co

154 Research in Genomic Epidemiology and CKDGen consortia identified 16 loci associated with eGFR.

155 With the advent of global neuroimaging consortia, imaging studies are now well powered to disco

156 munity profiles of exoelectrogenic microbial consortia in BESs fed different substrates gives a clear

157 a critical role to multi-ethnic cohorts and consortia in exploring complex phenotypes with respect t

158 e and maternal controls or defined microbial consortia in gnotobiotic mice.

159 engineering of novel microbial organisms and consortia in synthetic biology applications.

160 nity, enables the study of natural microbial consortia in their native habitats.

161 quences of multipartite symbioses, including consortia in which multiple organisms interact with the

162 ) funding was awarded to antibiotic research consortia including researchers based within the UK, inc

163 lability of genome information for microbial consortia, including unculturable species, from environm

164 the functional adaptations of the microbial consortia inhabiting halite nodules.

165 riety factors shape the fungal and bacterial consortia inhabiting wine-grape surfaces.

166 safety include extramural grants and grantee consortia, intramural research activities, and toxicolog

167 ificantly to the development of new research consortia investigating strategies for improving means o

168 creative enterprise such as large scientific consortia is a unique feature in modern scientific resea

169 suggests that bioremediation using microbial consortia is a valid option to reduce environmental meta

170 e number of species in spontaneously evolved consortia is much lower than the number of available res

171 cteroidetes in the thermophilic cellulolytic consortia is proposed.

172 or-cheater dynamics within T. reesei/E. coli consortia lead to stable population equilibria and provi

173 of the FANTOM, and later GENCODE and ENCODE consortia, led to the recognition of the important regul

174 Large-scale consortia mapping the genomic risk architectures of schi

175 nhibition by the culturable bacterial aerobe consortia of 60 nasal microbiomes, and this revealed int

176 are highly adapted members of the intestinal consortia of a range of hosts that spans the animal king

177 s highly adapted members of gastrointestinal consortia of a wide variety of hosts, but for reasons th

178 t development partnerships (PDPs) working in consortia of academic and industrial partners, including

179 Such studies can be conducted as multisite consortia of academic medical centers, combinations of s

180 e methane seeps, this process is mediated by consortia of anaerobic methanotrophic archaea (ANME) tha

181 sion is the direct result of the activity of consortia of antagonistic microorganisms that naturally

182 Summary association results from large consortia of candidate gene or genome-wide association s

183 cterial quorum sensing, potentially allowing consortia of cells to perform complex tasks.

184 ids maintain mutualistic symbioses involving consortia of coinherited organisms.

185 or the development of new materials based on consortia of colloidal objects, and provide a novel micr

186 For consortia of comparable size to the GIANT Consortium, th

187 availability of open-access data from large consortia of genome-wide association studies and populat

188 In addition to single-species aggregates, consortia of metabolically interdependent bacteria and a

189 Consortia of methane-oxidizing archaea and sulphate-redu

190 the means for supporting complex and dynamic consortia of microorganisms during their life cycle.

191 ome of these spatially correlated groups are consortia of phylogenetically diverse and metabolically

192 o that end, it will help to form networks or consortia of researchers and centers for science, techno

193 asingly characterized by large international consortia of researchers that are reliant on large data

194 Biofilms are defined as consortia of sessile microorganisms that are embedded in

195 yntrophic sulfur cycling in the 'pink berry' consortia of the Sippewissett Salt Marsh through an inte

196 The work of two large international consortia offers draft sequence information and detailed

197 al Kingdoms, the type of biosorbent (whether consortia or pure cultures), and the type of metal.

198 It is unclear, however, whether bacterial consortia or single organisms are required to depolymeri

199 transformations are carried out by microbial consortia over short spatiotemporal scales that elude de

200 conduct experiments aimed at analyzing phage consortia over temporal scales, and surprisingly have fo

201 In most studies included in the consortia, participants were of European ancestry, and t

202 cktails produced from PB-degrading microbial consortia (PB-dmc) is a promising approach to optimize t

203 ch of the remainder, the GoT2D and T2D-GENES consortia performed whole-genome sequencing in 2,657 Eur

204 Biofilms, naturally occurring microbial consortia, play numerous important roles in the environm

205 The emergent properties of microbial consortia present a challenge for the systems approach t

206 Three large consortia present comprehensive analyses that identify g

207 byte-size datasets generated by large public consortia projects, however, are already only feasibly s

208 om the ENCODE, Roadmap Epigenomics and other consortia provides a wealth of opportunities to investig

209 Cultivation of microbial consortia provides low-complexity communities that can s

210 ive mathematical model for T. reesei/E. coli consortia, providing insights on key determinants of the

211 oxylic acids with open cultures of microbial consortia (reactor microbiomes), we performed experiment

212 omics, PCR, and microscopy of these purified consortia revealed unexpected diversity of associated ba

213 e networks that revealed potential microbial consortia, some of which were involved in methane cyclin

214 ne the effect of size fractionation on viral consortia structure and function and understand the dive

215 , as well as polygenic score calculations in consortia studies that include multiple birth cohorts.

216 and selective enrichment from environmental consortia such as activated sludge can be challenging.

217 eq), collaborating model organism databases, consortia such as Gene Ontology and other databases with

218 Seq, collaborating model organism databases, consortia such as Gene Ontology, and other databases wit

219 Large consortia such as the 1000 Genomes Project and the ENCOD

220 Consortia such as the ENCyclopedia Of DNA Elements (ENCO

221 rnal researchers, and large collections from consortia such as the ORFeome Collaboration and the NIGM

222 The advent of large genome sequencing consortia, such as the 1000 genomes project, NHLBI Exome

223 Sequencing data from large-scale consortia, such as The Cancer Genome Atlas, as well as s

224 on in the biomass of these methane-oxidizing consortia suggest a possible role in new nitrogen inputs

225 range of symbiotic relationships within AOM consortia than previously thought.

226 motion was more pronounced with multi-strain consortia than with single-strain inocula.

227 The formation of effective international consortia that collaborate and share data is proposed to

228 ntact between host and the complex bacterial consortia that colonize the intestine.

229 Microbial consortia that cooperatively exchange electrons play a k

230 f this analysis was to identify all research consortia that had published the results of a GWAS analy

231 terspecies metabolite exchange in syntrophic consortia that may include sulfate reducing species such

232 interspecies electron transfer in syntrophic consortia that may include sulfate-reducing species (e.g

233 e feedback, as in the case of some bacterial consortia that participate in the cooperative degradatio

234 raditional cheeses harbour complex microbial consortia that play an important role in shaping typical

235 nd 645 controls (n = 1334), from 3 multisite consortia: the Consortium on the Genetics of Endophenoty

236 Despite well-powered sample sizes from consortia, there were no associations of rs2282679 with

237 Through coordinated multicentre consortia, these genomic approaches are likely to transf

238 dent staining of the matrix between cells in consortia, these results provide evidence for syntrophic

239 private datasets hosted by several different consortia through the public website.

240 s the use of public-private partnerships and consortia to accomplish the needed research.

241 al resources from the ENIGMA, CIMBA and BCAC consortia to assess pathogenicity of c.594-2A > C.

242 he major European (ICLLC) and American (GEC) consortia to conduct a genome-wide linkage analysis of 1

243 ed trials, case control studies, and genetic consortia to estimate associations of PCSK9 genetic vari

244 Engineering microbial consortia to express complex biosynthetic pathways effic

245 (ENGAGE) and Oxford-GlaxoSmithKline (Ox-GSK) consortia to follow up the 15 most significant regions (

246 es the potential for methanotrophs and their consortia to generate value while using methane as a car

247 hylactic administration of defined bacterial consortia to individuals with compromised microbiota com

248 The results highlight the potential of consortia to process glycerol in MECs and provide insigh

249 thogen species, promoting individuals and/or consortia to upload genome-scale data sets to contrast t

250 Overall, our data suggest that AOM consortia use specialized biochemical strategies to over

251 B composition in the resistant and sensitive consortia was similar.

252 many published genome-wide association study consortia, we created polygenic profile scores for 24 va

253 data for 10,727 women from two international consortia, we estimated associations between 77 common b

254 ings indicating metabolic handoffs in simple consortia, we find that few organisms within the communi

255 dings with those of the Psychiatric Genetics Consortia, we identified a strong genetic correlation be

256 a and autism GWAS of the Psychiatric Genomic Consortia, we selected three risk-related sets of single

257 e publicly accessible research guidelines on consortia websites.

258 These consortia were comprised of individual investigators, re

259 These consortia, which typically are composed of anaerobic met

260 for cellulose hydrolysis by mixed microbial consortia will complement these isolate studies and may

261 disadvantaged taxa frequently associated in consortia with disease-suppressive activity toward plant

262 Whether in the framework of international consortia with dozens of samples per group, or even with

263 development of clinically relevant synthetic consortia with safe and functionally well-defined strain