ライフサイエンスコーパス: constant domain

1 ional changes occur in a loop in the H chain constant domain.

2 ntracellular interactions has focused on the constant domain.

3 A for the variable domain and 0.7 A for the constant domain.

4 in variable domain linked to the kappa-chain constant domain.

5 le (VH)-encoded "elbow" between variable and constant domains.

6 at several positions, including variable and constant domains.

7 one antigen-binding domain, the VHH, and two constant domains.

8 the H and L chains in both the variable and constant domains.

9 e unpaired cysteine residues commonly in the constant domains.

10 ntibody was engineered to contain human IgG1 constant domains.

11 local dyad axis, exact only with respect to constant domains.

12 te consequence of deletion of the CH1 and CL constant domains.

13 the Cys at the N terminus of the heavy chain constant domain 1 (C(H)1) (Kabat position 127) to a Ser

14 ive expression of T cell receptor beta-chain constant domains 1 and 2 (TRBC1 and TRBC2).

15 HuCC49 deltaCH2 is a heavy chain constant domain 2 domain-deleted antibody under developm

16 ingle N-linked oligomannose structure in the constant domain 3 (Cepsilon3) of IgE, at asparagine-394

17 boundary region between the second and third constant domains--a site analogous to that recognized by

18 nization: a membrane-proximal immunoglobulin constant domain and a membrane-distal immunoglobulin var

19 L) chains owing to the deletion of the first constant domain and a reshaped surface at the VHH side,

20 the atomic resolution structure of the IgNAR constant domains and a structural model of this heavy ch

21 s of E559 were replaced with human IgG1kappa constant domains and the resulting chimeric mouse-human

22 the elbow angle between the variable and the constant domains, and it is significantly larger for bin

23 strategy to prevent TCR mispairing: swapping constant domains between the alpha and beta chains of a

24 position 442 (EU/OU numbering) in the third constant domain (C(H)3) of the heavy chain of several Ig

25 ural isoforms are defined by the light chain constant domain (C(L)) and the heavy chain C(H)1 domain

26 We identified two constant domains, C1 and C3, that act as dimerization mo

27 We found that folding of the TCR alpha chain constant domain Calpha is dependent on alphabeta heterod

28 nstant domain, hinge region, and heavy-chain constant domains CH1 and CH2 are observed, leaving glyco

29 ain synthesis, BiP binds stably to the first constant domain (CH1) of the heavy chain, causing it to

30 y chain (HC) bearing a deletion of the first constant domain (CH1).

31 both chains, the region between heavy-chain constant domains CH2 and CH3, and the disulfide bond (S-

32 TCR signaling domains +/- an IgG heavy chain constant domain (CH2CH3) to create a series of vector co

33 the disulfide bond (S-S)-linked heavy-chain constant domain CH3.

34 plus up to approximately 60 residues of the constant domain (CL).

35 The TCRbeta chain constant domain contains an unusually elongated, solvent

36 Two modifications to the constant domain control antibody activity: theirreversib

37 alian IgG has three rather than the four IgM constant domains; deletion of the ancestral IgM C2 domai

38 , the first constant domain of mu, and seven constant domains encoded by a delta gene homolog.

39 the splice donor site at the end of the last constant domain exon (D7) is ignored and transcription c

40 h could be broadly implemented across the Ig constant domain family.

41 d in vitro folding studies revealed that the constant domain folds rapidly and stably even in the abs

42 e soluble human insulin receptor (HIRs) with constant domains from immunoglobulin Fc and lambda subun

43 few cleavages in the S-S-linked light-chain constant domain, hinge region, and heavy-chain constant

44 ns of the N-terminal variable domain and the constant domains, however, greatly affected receptor act

45 gned the neutralization epitope to the third constant domain, immediately C terminal to the V3 loop.

46 disulfide bridge that links the variable and constant domains in addition to the two intrachain disul

47 respective regions between the variable and constant domains in both chains, the region between heav

48 The constant domain influences antigen recognition through e

49 Although other heavy chain-constant domains interact transiently with BiP, in the a

50 vely, these results verify the importance of constant domain interactions in antibody variable domain

51 n of one CD3epsilon subunit within the rigid constant domain module has implications for the mechanis

52 localized site is embedded within the rigid constant domain module has implications for the mechanis

53 eric D10 TCR suggesting that neither the TCR constant domains nor potential N- or O-linked carbohydra

54 e single-chain TCR genetically linked to the constant domain of an IgG1 H chain.

55 ng is a recombination event that changes the constant domain of antibody genes and is catalyzed by ac

56 s are more involved in this process than the constant domain of Apo(a).

57 monstrate that N-linked glycosylation in the constant domain of human IgA1 plays an important role in

58 ning the extracellular domain of ILA and the constant domain of human IgG (ILA-IgG) also inhibited ly

59 n-consensus asparaginyl residue in the C(H)1 constant domain of IgG1 and IgG2 antibodies.

60 were created by exchanging each variable and constant domain of JR-CSF gp120 with that of JR-FL or wi

61 ains a rearranged variable domain, the first constant domain of mu, and seven constant domains encode

62 One epitope mapped to the constant domain of RAP-1 (amino acids [aa] 144 to 187),

63 ely map the T-cell epitope identified in the constant domain of RAP-1 to aa 159 to 187 (FVVSLLKKNVVRD

64 ant effects were conferred by changes in the constant domain of the light chain.

65 lutamine-to-proline change within the second constant domain of the surface protein (SU); a threonine

66 n the interfacial region of the variable and constant domains of different murine antibody antigen-bi

67 The murine constant domains of E559 were replaced with human IgG1ka

68 or extracellular domain with hinge and C2/C3 constant domains of human IgG1 or IgG3 heavy chains were

69 racellular domain of B7.2, and the hinge and constant domains of murine IgG2a.

70 of the elbow angle between the variable and constant domains of the Fab.

71 cats, cloned and sequenced the variable and constant domains of the feline heavy chains of IgG1a (IG

72 coded beads having capture sequences for the constant domains of the T-cell receptor alpha and beta c

73 regions between the variable domains and the constant domains of these antibodies.

74 nterface exchange between the TCR alpha/beta constant domain pair and the IgG1 CH3 homodimer was evid

75 erfaces of two different immunoglobulin (Ig) constant domain pairs are exchanged in part or fully to

76 ceptor (TCR) alpha/beta, and TCR gamma/delta constant domain pairs, and we found that they successful

77 ibody, when engineered to contain human IgG1 constant domains, possesses effector cell-mediated antit

78 tching," intramolecular interactions between constant domains promote homophilic binding.

79 ion via their variable domains, the antibody constant domain provides a functional link between innat

80 es in the orientations of their variable and constant domains, reflected by a 32 degrees difference i

81 Different constant domain residues in solanezumab/crenezumab/chime

82 to and activate lymphoid cells, perhaps via constant domains, resulting in protection of CS effector

83 d light chain V domains expressed in the IgM constant domain scaffold compared with the IgG scaffold.

84 ndicate a favorable effect of the remote IgM constant domain scaffold on the integrity of the V-domai

85 th of which are present in the IgG1 and IgG2 constant domain sequences, and Asn-35, which was present

86 ody was constructed such that the IgG1 C(H)3 constant domain serves as the oligomerization domain and

87 binding arms that engage CD3 and EpCAM and a constant domain that recruits Fc receptor-bearing cells,

88 s many V, J and D segments that combine with constant domains to produce either an alpha or a delta c

89 Rituximab) is a chimeric mAb with human IgG1 constant domains used in the therapy of non-Hodgkin's B

90 relationships, whereas no alteration of the constant domains was found.

91 gn of therapeutics are antibody variable and constant domains, which are responsible for antigen bind