ライフサイエンスコーパス: constant region

1 bination (CSR) alters the Ig heavy (H) chain constant region.

2 n spots corresponding to the IgA heavy chain constant region.

3 result from an alteration in the light-chain constant region.

4 f Pref-1 fused to human immunoglobulin-gamma constant region.

5 constant region and extends mutations to the constant region.

6 switch (S) regions that precede exons of the constant region.

7 omatin at the variable region but not at the constant region.

8 each containing heavy chains with the Calpha constant region.

9 region replaced by that encoding human kappa constant region.

10 human IgG2, IgG3, IgG4, or IgA1 heavy-chain constant region.

11 by replacing the human gamma4 with a gamma2 constant region.

12 and third domains of human IgG1 heavy-chain constant region.

13 CS protection may have resided in the sTCR constant region.

14 in fused in frame to a rabbit immunoglobulin constant region.

15 bodies (MAbs) with human gamma 1 heavy-chain constant regions.

16 complete mAbs with human gamma 1 heavy chain constant regions.

17 o an expression vector containing human IgG1 constant regions.

18 rminal variable regions and carboxy-terminal constant regions.

19 man gamma1 heavy chain and kappa light chain constant regions.

20 a or Vbeta regions fused to xenogeneic human constant regions.

21 domains of a cynomolgus macaque mAb to human constant regions.

22 h contain rearranging segmental elements and constant regions.

23 quence discontinuous residues of HIV-1 gp120 constant regions.

24 wild-type or shuffled human IgG heavy-chain constant regions.

25 ctors containing human kappa and IgG1 or IgM constant regions.

26 ntained the human kappa light-chain and IgG1 constant regions.

27 conserved in both alpha and beta TCR chains constant regions.

28 he ABL 364 antibody with human framework and constant regions.

29 rived from human/humanized monoclonals, with constant regions.

30 gth IgG (MAbs) with human gamma1 heavy chain constant regions.

31 IgG1 and IgG3 mAbs having human IgG1 or IgG3 constant regions.

32 ibodies (MAbs) with human gamma1 heavy-chain constant regions.

33 patibility of Dmu with the kappa-joining and constant regions.

34 plicing within the zebrafish "variable" and "constant" regions.

35 ne-for-valine substitution at position 84 in constant region 1 and an isoleucine-for-methionine subst

36 induced HIV-1 envelope variable region 2 and constant region 1 antibodies synergize for recognition o

37 r-methionine substitution at position 434 in constant region 4.

38 e crossed to mice with disruption of the TCR constant region alpha gene to create animals with a sing

39 racetylation of histones associated with the constant region and extends mutations to the constant re

40 been replaced by that encoding human epsilon constant region and gene segment encoding kappa constant

41 as the junction between the heavy (H) chain constant region and IL-2.

42 ion, while zinc was bound to the heavy chain constant region and iron was not bound with the identifi

43 n which a Vn was associated with the gamma2a constant region and its intervening and immediate flanki

44 in variable (Igh-V) region compared with the constant region and partially transcribed Igh RNAs, sugg

45 nt of the potential restriction sites in the constant regions and 47% of the potential restriction si

46 xpressing a chimeric TCR comprised of murine constant regions and human variable regions specific for

47 antigen binding, or the presence of antibody constant regions and increases, on average, as sequence

48 These studies, like those of porcine Ig constant regions and MHC genes, also indicate unexpected

49 by TCR adenoviruses required the xenogeneic constant regions and was mediated by CD8+ T cells.

50 n of a second disulfide bond between the TCR constant regions and/or creation of a chimeric protein i

51 To this end, chimerized (rat V domains/mouse constant regions) and murinized (95% mouse sequence) DTA

52 glycosylated at conserved positions in their constant regions, and the presence of carbohydrate can b

53 with targeted deletion of the IgA switch and constant regions are completely deficient in IgA and exh

54 However, omp1 constant regions are rarely sequenced yet, they may cont

55 flanks in immunoglobulin (Ig) genes, whereas constant regions are spared.

56 Preceding antibody constant regions are switch (S) regions varying in lengt

57 containing murine variable regions and human constant regions as calibrators or controls in immunoass

58 ion is not contributed to nor constrained by constant regions; (b) in consequence, the landscape of f

59 ne configuration, the same core variable and constant regions but contains different numbers of uniqu

60 u constant region with one of the downstream constant regions by recombination between the donor and

61 s, three J gamma gene segments, and a single constant region C gamma gene were identified in the avia

62 have undergone the unusual class switch from constant region C mu to C delta (C delta-CS).

63 d IgH Cmu exons with a set of downstream IgH constant region (C(H)) exons.

64 joining region (J(kappa)) to the kappa-chain constant region (C(kappa)).

65 be expressed with any one of the downstream constant region (C) genes to encode antibodies with many

66 (CSR) replaces initially expressed Cmu (IgM) constant regions (C(H)) exons with downstream C(H) exons

67 ssociation, reactivity to three peptides (in constant regions C1 and C3 and variable region V3 of gp1

68 Reactivity to six peptides (in constant regions C3, C4, and C5 of gp120 and in gp41) co

69 r domain was fused with a mutated human IgG1 constant region (CD83Ig) and expressed by stable transfe

70 that replaces one immunoglobulin heavy-chain constant region (Ch) gene with another.

71 The Ig heavy chain (IgH) constant region (CH) genes are organized from 5' to 3' i

72 of "switch" transcripts from the heavy chain constant region (CH) genes targeted for rearrangement.

73 s in the expression of different heavy chain constant region (CH) genes without a change in the Ab va

74 he second domain of the antibody heavy chain constant region (CH2).

75 The constant region CH3 domain remained unchanged, implying

76 immunoglobulin (MsIg) heavy- and light-chain constant regions chains, respectively.

77 gher than for a murine variable region/human constant region chimeric Fab.

78 les Igh variable region exons upstream of mu constant region (Cmu) exons, which are the first of seve

79 ication of cDNA ends) and a highly conserved constant region consensus amino acid sequence to isolate

80 ether Ig variable regions, in the absence of constant regions, could be immunotherapeutic in this mod

81 of the light chain on different human gamma constant regions (creating inside-out molecules).

82 cine efficacy, and xenogeneic immunoglobulin constant region determinants were required for immunogen

83 mer that bears no resemblance to variable or constant region dimers in an antibody.

84 detect binding of either BiP protein to the constant region domain.

85 Using a panel of human IgA1/IgG1 constant region "domain swap" mutants, the binding site

86 b was joined to either human kappa or lambda constant region domains and expressed with mouse-human c

87 to the tail-piece, structural motifs in the constant region domains are critical for polymer assembl

88 The contribution of all three constant region domains to immunoglobulin half-life may

89 fting the mAb variable regions onto the IgG2 constant region dramatically enhanced the tumor inhibito

90 ns covalently linked to human immunoglobulin constant regions enhanced mAb MK2-23 immunogenicity in B

91 Its constant region exhibits an elongated shape with flexibi

92 CSR changes the heavy chain constant region exons (Ch) expressed with a given variab

93 In mice, six additional sets of constant region exons (CHs) lie 100-200 kilobases downst

94 s with one of several sets of downstream IgH constant region exons (e.g., C gamma, C epsilon, or C al

95 B cells can change expressed Ig heavy chain constant region exons by class switch recombination (CSR

96 ass switch recombination (CSR) exchanges IgH constant region exons in peripheral B cells.

97 can be altered by changing the expressed IgH constant region exons through IgH class switch recombina

98 ch recombination (CSR) replaces the IgH C mu constant region exons with one of several sets of downst

99 s of duck alpha and mu are each encoded by 4 constant region exons, and the hydrophobic C-terminal re

100 ot detect antisense transcripts from the Cmu constant region exons, which lie between the IgH variabl

101 t lie upstream of the various Ig heavy chain constant region exons.

102 an intergenic region from Igh Ds, J(H)s, and constant region exons.

103 rPcdh1 has both alpha and gamma variable and constant region exons.

104 transcriptional orientation as adjacent Cmu constant region exons.

105 with one VH, two DH, one JH, and one set of constant region exons.

106 that flank immunoglobulin heavy chain (IgH) constant region exons.

107 cellular domains are encoded by three small "constant" region exons located downstream from a tandem

108 ted to the interaction of protein A with the constant region (Fc) and heavy chain variable domain (VH

109 Knockout mice lacking either the antibody constant region (Fc) receptor or the substance P recepto

110 o the asparagine 297 residue in the antibody constant region (Fc).

111 b) and the other present on the conserved HC constant region (Fc).

112 he various effector molecules to which their constant regions (Fc domains) engage.

113 ctures of the complex between immunoglobulin constant regions (Fc) and their Fc-respective receptors

114 d across the NTS, with five occurring in the constant regions flanking the VIR region and two occurri

115 with Id proteins modified to include foreign constant regions, foreign constant regions plus GM-CSF,

116 The neonatal constant region fragment (Fc) receptor (FcRn), which is

117 e we show that the VDJ can be expressed with constant regions from different clusters, although IgH g

118 in-specific single-chain antibody, 3A8, with constant regions from the murine IgG1kappa, Guy's 13.

119 To investigate the role of antibody constant region function in toxin neutralization, we gen

120 Ab variants with effector function (IgG1 constant region (G1)) or without effector function (IgG2

121 recombinant IgG antibody containing a novel constant region, G1Deltanab, devoid of in vitro cytotoxi

122 or without effector function (IgG2/G4 fusion constant region (G2G4)) exhibited high antitumor activit

123 the most 3' immunoglobulin (Ig) heavy chain constant region gene (Calpha) contains a series of trans

124 an intrachromosomal deletion whereby the IgM constant region gene (Cmu) is replaced by a downstream c

125 transcription of the germ line (GL) Ig alpha constant region gene and to direct class switching to Ig

126 sion model integrating whole blood TCR gamma constant region gene expression levels and age and sex (

127 TCR gamma constant region gene expression levels and clinical data

128 stimulate transcription from the GL Ig alpha constant region gene promoter.

129 is induced by transcription of the Ig gamma1 constant region gene segment (Cgamma1).

130 cient mouse by disrupting the gamma3 H chain constant region gene via targeted mutagenesis.

131 eukemia cell line (MEL), the most distal IgH constant region gene, C alpha, replicates early in S; ot

132 eavy chain constant region with a downstream constant region gene, thereby altering the effector func

133 egion gene (Cmu) is replaced by a downstream constant region gene.

134 (S) regions that precede each Ig heavy chain constant region gene.

135 ng the CH1 domain of the gamma 3 heavy-chain constant region gene.

136 , each of which is associated with a H chain constant region gene.

137 d D-region genes, J-region genes, and the mu constant-region gene.

138 riable (AV and BV), joining (AJ and BJ), and constant region genes (AC and BC).

139 ombination and deletion process by which Igh constant region genes are exchanged.

140 ha, replicates early in S; other heavy chain constant region genes, joining and diversity segments, a

141 rious switch DNA regions located upstream of constant region genes.

142 s by a regulatory region that lies 3' of the constant region genes.

143 recombination to transgenic gamma and alpha constant region genes.

144 t between micro and gamma, alpha, or epsilon constant region genes.

145 ines, germline transcription of some H chain constant regions genes is severely impaired.

146 orks progress in both directions through the constant-region genes, which is consistent with the acti

147 ogress in one direction through the examined constant-region genes.

148 I strain, whose gene segment encoding gamma1 constant region has been replaced by that encoding human

149 m of ADSF by fusing it to the human IgGgamma constant region (hFc).

150 three Ig domains of VEGF receptor 1 to an Ig constant region; however, this fusion protein has very p

151 ing human gamma4 heavy and kappa light chain constant regions (HuEP5C7.g4).

152 s originating upstream of the immunoglobulin constant region (I transcripts) are required to direct a

153 implications regarding the selection of the constant region in anti-CD200 immunotherapy of cancer pa

154 nduced sterile transcripts from the TCRgamma constant region in cultured thymocytes from IL-7(-/-)RAG

155 umin of nearly all isotypes 3' of the gamma1 constant region in the IgH locus, indicating that class

156 d by targeted deletion of the IgA switch and constant regions in embryonic stem cells.

157 the evolution of switch regions and multiple constant regions in the IgH locus.

158 r human counterparts while leaving the mouse constant regions intact, using a unique in situ humaniza

159 Mb) into the mouse genome, leaving the mouse constant regions intact.

160 The heavy chain constant region is a modified IgG4 containing two single

161 ypermutation or gene conversion, whereas the constant region is altered by class-switch recombination

162 As the Deltanab constant region is uninformative in mice, F(ab')2 B2G1 w

163 changes a glycine to a valine in the lambda1 constant region, is responsible for this defect.

164 These results establish that constant region isotype influences toxin neutralization

165 All LAP2 isoforms have the same N-terminal 'constant' region (LAP2-c), which includes the LEM domain

166 e region-like N-terminal domain and three Ig constant region-like domains termed A1, A2, and B2.

167 n, and various amounts of the immunoglobulin constant-region-like domains.

168 e between the human and mouse immunoglobulin constant regions limit the utility of these mice.

169 Regulatory elements within the heavy chain constant region locus are required for Myc translocation

170 We conclude that the heavy chain constant region locus itself includes all of the element

171 at a transgene containing the Ig heavy chain constant region locus, inserted into five different chro

172 arranged VDJ gene and the entire heavy chain constant region locus.

173 anged VDJ gene and the entire murine H chain constant region locus.

174 ing a transgene of the entire murine H chain constant region locus.

175 ed a BAC transgene of the entire heavy chain constant region locus.

176 bodies by grafting full-length proteins into constant region loops of a full-length antibody or an an

177 LL-1; with murine variable regions and human constant regions) MoAb on the growth of various human ly

178 human HPA-1a-specific scFv (B2) with an IgG1 constant region modified to minimize Fcgamma receptor-de

179 all of a cavity within the TCR Ti-alpha/beta constant region module (CalphaCbeta) while the CD and EF

180 ranging gene segments (VH-D1-D2-JH) with one constant region, mu or omega.

181 e transmembrane domain of the mu-heavy-chain constant region (MuMT; B-cell and antibody deficient) or

182 d of the surface domain of EnvJ fused to the constant region of a rabbit IgG and mass spectrometry we

183 ein of subgroup E (RAV-0) virus fused to the constant region of a rabbit immunoglobulin.

184 RG7356 is a humanized antibody targeting the constant region of CD44 that shows antitumor efficacy in

185 l association between anaphylatoxins and the constant region of F(ab)2.

186 s were found to respond to an epitope from a constant region of FliC, enabling them to cross-react wi

187 To reduce unwanted side effects, the constant region of hLL1 was changed from gamma1 to gamma

188 e amino terminal portion of SC1/ECM2 and the constant region of human Ig preferentially bound to pre-

189 was constructed containing a portion of the constant region of human IgG1 (Fc) at the amino terminus

190 The CH3-ScFv antibody, which maintains the constant region of human IgG3, has some of the associate

191 expressed amino terminal to the heavy-chain constant region of human immunoglobulin G containing the

192 ave solved the solution NMR structure of the constant region of human LAP2 (residues 1-168).

193 cleave the IgA1 hinge in the context of the constant region of IgA1 or IgA2m(1) but not in the conte

194 ectly for a rabbit Cdelta locus encoding the constant region of IgD, we determined the nucleotide seq

195 tments with the fusion protein consisting of constant region of IgG and extracellular domain of lymph

196 ine traps' consisting of fusions between the constant region of IgG and the extracellular domains of

197 Receptors (FcgammaRs) for the constant region of immunoglobulin G (IgG) are an importa

198 gamma receptors, which are specific for the constant region of immunoglobulin G.

199 mber of the kindred revealed mutation in the constant region of kappa light-chain, with cysteine repl

200 short interfering RNA (siRNA) targeting the constant region of lambda light chains that substantiall

201 at the carboxyl terminus of the heavy-chain constant region of MAb-chB72.3.

202 for this bactericidal activity and that the constant region of the Ab is dispensable.

203 onstrate that introducing cysteines into the constant region of the alpha and beta chains can promote

204 work has implicated the third domain of the constant region of the epsilon-heavy chain (Cepsilon3) i

205 recombination process, leads to a change in constant region of the expressed antibody.

206 0, TT833S, were genetically grafted into the constant region of the heavy chain of the humanized anti

207 several racemized amino acid residues in the constant region of the heavy chains of the three IgG sub

208 C6 contains a recombination event within the constant region of the hexon gene.

209 ein identified sequences compatible with the constant region of the immunoglobulin kappa light-chain.

210 meshift mutation in nucleotides encoding the constant region of the molecule.

211 quail Tva extracellular region fused to the constant region of the mouse immunoglobulin G (IgG) prot

212 d to two epitope tags (sTva) or fused to the constant region of the mouse immunoglobulin G heavy chai

213 ng of 28 randomized positions flanked by two constant regions of 22 residues each.

214 g N- linked carbohydrates in the heavy chain constant regions of all isotypes and O-linked carbohydra

215 t challenges in engineering the variable and constant regions of antibody fragments and full-length a

216 extracellular domain linked to the hinge and constant regions of human IgG gamma 1.

217 afted, respectively, onto genes encoding the constant regions of human Igkappa and human IgG1, transf

218 (CDR) of murine OKT4A and the framework and constant regions of human light (kappa) and heavy chains

219 Given the similarity among constant regions of Ig and MHC molecules, these findings

220 Thus, AID does not gain access to the 5' and constant regions of Ig genes.

221 etermine the aggregation-prone motifs in the constant regions of IgG1 classes of antibodies.

222 s the use of genes encoding the variable and constant regions of immunoglobulin, changing avidity, an

223 Peptides containing constant regions of MOMP were recognized equally by all

224 ns of protein G (which likewise binds to the constant regions of mouse IgG) decreased the affinity of

225 oving conserved N-glycoslyation sites in the constant regions of TCR alpha or beta chains could incre

226 interest can be normalized to those from the constant regions of the immunoglobulins used for the IP.

227 to include foreign constant regions, foreign constant regions plus GM-CSF, or linkage to keyhole limp

228 Together with IgA quantities and constant region post-translational modifications, repert

229 e region (TCRBV) families were paired with a constant region primer to polymerase chain reaction to a

230 cDNA using the seven VH family-specific and constant region primers.

231 stant region and gene segment encoding kappa constant region replaced by that encoding human kappa co

232 e variable sequences, or the J(H) and the 5' constant regions, respectively.

233 M3 mice with a chimeric IgE containing human constant regions resulted in the development of a robust

234 several joining regions, and are spliced to constant region segments.

235 status of HCL, RNA transcripts of V(H)DJ(H)--constant region sequences from 5 cases of typical HCL, a

236 Based on framework and constant region sequences from full-length cDNAs and int

237 g into expression vectors that contain human constant region sequences.

238 ariable region sequences were fused to human constant region sequences.

239 screening strategy to eliminate undesirable constant region-specific antibodies and select for anti-

240 ted that the accessibility of Ig heavy chain constant regions targeted for CSR was established after

241 to the HPA-1a epitope but carries a modified constant region that does not bind to Fcgamma receptors.

242 body was designed as an IgG1 antibody with a constant region that lacks the ability to interact with

243 ficiency resulted in defective CSR to distal constant regions that might reflect an impaired ability

244 in the Igkappa sterile transcript, the kappa constant region, the Ekappai and Ekappa3' enhancers, and

245 gene encodes both human mu and human gamma 1 constant regions, the latter of which is expressed via i

246 over, since the motifs identified are in the constant regions, they are applicable for all antibodies

247 e by comparing HIV-1 sequences in the second constant region through the fifth hypervariable region (

248 imately 700-bp sequences covering the second constant region through the fifth variable region (C2 to

249 es, and the variable regions joined to human constant regions to generate a mAb (h-13F6) appropriate

250 o parse the contributions of both random and constant regions to the secondary structures of more tha

251 n-4 (IL-4) by producing specific germline Ig constant region transcripts and by forming switch region

252 h process in DLBCL, 4 cases of tumor-derived constant region transcripts of all isotypes were investi

253 genome is characterized by variable and more constant regions, unequal nucleotide frequencies, and pr

254 in the immunoglobulin G1 (IgG1) heavy chain constant region, virus neutralization, and natural kille

255 This same Vn, when associated with the mu constant region (Vn/mu), mutated at a 1000-fold lower ra

256 tution in the CH2 domain of the human gamma1 constant region was made by polymerase chain reaction mu

257 chimeric antibodies in which the human IgG1 constant region was paired with three murine fHbp-specif

258 The IgG1 heavy-chain constant region was then replaced with the human IgG2, I

259 ion of a chimeric protein in which the human constant regions were replaced by murine homologs result

260 from DNAs encoding the desired variable and constant regions, which allows antibodies of different i

261 transmembrane component and the heavy chain constant region, while zinc was bound to the heavy chain

262 nation (CSR) replaces the Ig(mu) heavy chain constant region with a downstream constant region gene,

263 CSR involves the replacement of the mu constant region with one of the downstream constant regi

264 he same variable regions and different human constant regions with their unique combination of effect

265 a "functional-sidedness" to the alphabetaTCR constant region, with dimerization occurring on the side

266 genetic location, whereas the retained mouse constant regions would allow for optimal interactions an