ライフサイエンスコーパス: constellation

1 tead maintained them as specific sets (i.e., constellations).

2 cleolytic activity and shown the active site constellation.

3 stant lies beyond the bounds of this optimal constellation.

4 ubsequently contribute to behaviors in P&N's constellation.

5 eins and under each patient's unique genetic constellation.

6 less certain about the utility of behavioral constellations.

7 vorable side-chain interactions that we call constellations.

8 rried by specific excreted proteins or their constellations.

9 rds form diverse and transient internal gene constellations.

10 ime and distance, resulting in transient AIV constellations.

11 oiled coils and found that one type of triad constellation (a'-a-a') exerts a strong effect on pairin

12 The CMV donor or recipient serological constellation also predicted the incidence of graft reje

13 r vice versa, switches the isoform's dimeric constellation and lipid binding site.

14 t to measure in situ, is located within this constellation and that the behaviour of the system is co

15 e the flexibility of this bond across family constellations and its unique contribution to child well

16 ypes were observed, resulting in new genetic constellations and reassortant viruses.

17 exceptional gem diamonds like the Cullinan, Constellation, and Koh-i-Noor carry direct evidence of c

18 that the present-oriented behaviours of the constellation are a contextually appropriate response to

19 bations that propagate through the satellite constellation at galactic velocities 300 km s(-1).

20 Our findings suggest that viral gene constellations circulating among diving ducks can contri

21 Our results suggest that viral gene constellations circulating among diving ducks can contri

22 alysis of 685 women who showed a serological constellation consistent with primary infection in pregn

23 ifferent seasons maintained identical allele constellations, consistent with the notion that certain

24 This protein constellation consists of many conserved RBPs, some of w

25 aperture radar measurements from the Italian constellation COSMO-SkyMed and the European sensor Senti

26 lizing different active and inactive helical constellations during the seven-trans-membrane receptor

27 The genetic DSG2 constellations encountered are compatible with loss of a

28 circulating cytokines, unique neurohormonal constellations, endotoxin-lipoprotein interaction, rever

29 study provide evidence that group A HRV gene constellations exist and may be influenced by interactio

30 in family life; chart brain-hormone-behavior constellations for the mature, child-orientated coparent

31 is further indicate that certain active site constellations furnish an unexpectedly large pK(a) depre

32 d that all 39 viruses had identical genotype constellations (G10-P[11]-I2-R2-C2-M2-A1-N1-T1-E2-H3), t

33 es, thereby defining novel allele level gene constellations (GCs) and illuminating putative reassortm

34 ral models regarding potential donor-patient constellations have been described that have demonstrate

35 oring reassortment, as evident from the gene constellations identified by this study.

36 ractions, and our analysis of a few specific constellations illustrates a general, multipronged appro

37 s the consequences of such preserved network constellation in mental disease, drug discovery, and int

38 lted in the circulation of different genomic constellations in pigs.

39 n recent years and represents a novel genome constellation, indicating that it may be a product of a

40 This constellation is often referred to as 'tumefactive multi

41 ed a recombinant virus (rH1N1) with the same constellation makeup as the pandemic H1N1/2009 virus to

42 To understand how different genetic constellations may relate to viral fitness, we compared

43 ensitivity (allodynia) is one component of a constellation of "illness behaviors" triggered by TNF-al

44 A constellation of (i) types of genetic variation, (ii) mo

45 ith previous mutational studies, highlight a constellation of 11 amino acids that are conserved in al

46 The World Health Organization lists a constellation of 17 tropical diseases that afflict appro

47 In summary, BTBR ob/ob mice develop a constellation of abnormalities that closely resemble adv

48 nsesterification steps of resolution using a constellation of active site residues similar to that fo

49 letic group and homology modeling revealed a constellation of active site residues similar to that in

50 e presence of steatosis is associated with a constellation of adverse alterations in glucose, fatty a

51 e metastatic lesions to capture the evolving constellation of alterations during progression.

52 er malignancies, our findings suggest that a constellation of alternate genetic abnormalities may con

53 ite-specific DNA recombinases use an unusual constellation of amino acids to catalyze the formation a

54 Furthermore, the constellation of anomalies in Wtx null mice suggests tha

55 g studies in mice that Ihh is regulated by a constellation of at least nine enhancers with individual

56 nd sister developed a previously undescribed constellation of autoimmune manifestations within their

57 Moreover, a similar constellation of autoimmunity was evident in mice that e

58 h dorsal and ventral hippocampus, produced a constellation of behaviors, combining aspects of both se

59 The constellation of behavioural change, raised CSF protein

60 at can be ubiquitously applied to detect the constellation of biomolecules in diverse clinical sample

61 The constellation of biophysical abnormalities for some muta

62 a genetic disease characterized by a complex constellation of birth defects (Coloboma of the eye, Hea

63 correlated with the default-mode network, a constellation of brain areas associated with spontaneous

64 Affected individuals displayed a constellation of brain malformations including cortical

65 Metabolic syndrome (MetS), defined by a constellation of cardiometabolic pathologies, is highly

66 The constellation of cardiovascular defects resembles a seve

67 he moderately reddened star HD 124314 in the constellation of Centaurus.

68 They develop a constellation of changes that mimic the pathology associ

69 uncompensated acidic charges than EcCS; this constellation of charged residues is stable in varied pH

70 A constellation of charged residues on and around the argi

71 nosis has been difficult and has relied on a constellation of clinical and histopathologic variables.

72 The diagnosis of HLH is based on a constellation of clinical and laboratory abnormalities,

73 ury (TRALI) was coined in 1983 to describe a constellation of clinical and laboratory features seen w

74 Symptomatic infants demonstrate a constellation of clinical features that reflect placenta

75 An SSI is diagnosed by a constellation of clinical findings occurring within 30 d

76 ations cause Alagille syndrome, comprising a constellation of clinical findings, including biliary, c

77 MetS is a constellation of clinical risk factors for cardiovascula

78 einker disease displaying a somewhat unusual constellation of clinicopathological features, which ove

79 ell activation is critically impacted by the constellation of co-stimulatory and co-inhibitory recept

80 atment in humans and other mammals induces a constellation of cognitive deficits, including impairmen

81 cose homeostasis is the central feature of a constellation of comorbidities that define the metabolic

82 Although no single feature defines EoE, a constellation of compatible demographic, clinical, endos

83 t is currently unknown whether this specific constellation of components has particular relevance for

84 experience) disease-related complications, a constellation of comprehensive nonpharmacologic manageme

85 ly irreducible conceptual structure (MICS, a constellation of concepts in qualia space), and the set

86 ax-group protein Kismet, result in a complex constellation of congenital anomalies called CHARGE synd

87 within chromosome 22q11 and clinically by a constellation of congenital malformations of the aortic

88 determinants of adrenodoxin recognition as a constellation of conserved residues from helices K, K'',

89 AGRP neuron projection populations reveals a constellation of core forebrain nodes, which are part of

90 ransplantation is potently influenced by the constellation of cosignaling molecules expressed by immu

91 f ANK suggests that the protein is part of a constellation of critical components that interact to re

92 iteria were developed to determine whether a constellation of CT findings (small indented calcified k

93 To understand the constellation of Cu-responsive genes in C. neoformans an

94 Some investigators hypothesize that this constellation of defects results from genetic or environ

95 This constellation of defects was consistent with a primary d

96 We hypothesize that this constellation of deficits associated with reading disord

97 olleagues regarding our proposed behavioural constellation of deprivation (BCD) and our thoughts on i

98 Pepper & Nettle explain the behavioral constellation of deprivation (BCD) in terms of differenc

99 s a welcome and timely idea, the behavioural constellation of deprivation (BCD) needs to explain how

100 nces shape the development of the behavioral constellation of deprivation (BCD) proposed by Pepper &

101 Pepper & Nettle's theory of the behavioral constellation of deprivation (BCD) would benefit from te

102 iving rise to key features of the behavioral constellation of deprivation (BCD).

103 esses underlying what they call a behavioral constellation of deprivation (BCD).

104 ble routes to alleviation of the behavioural constellation of deprivation.

105 ommon cause of what they call the behavioral constellation of deprivation.

106 status (SES), which we call "the behavioural constellation of deprivation." We propose that the relat

107 a cause of human disease and infer that the constellation of developmental abnormalities seen in Noo

108 w disruption of this gene might generate the constellation of developmental and degenerative Troyer s

109 yed versus current rewards, is elevated in a constellation of diseases and behavioral conditions.

110 ce of self-recognition via TLR8 results in a constellation of diseases, strikingly distinct from thos

111 ts our very incomplete understanding of this constellation of diseases.

112 delineate the underlying brain basis of this constellation of disorders.

113 toward a cued platform in the presence of a constellation of distal landmarks located outside the po

114 Our data point to a constellation of early language delay and WMH phenotypes

115 ed by exposure to maltreatment, leading to a constellation of ecophenotypes.

116 ly occupy the apoplastic space and deliver a constellation of effectors that collectively suppress ba

117 ment in affected LQTS patients relies upon a constellation of electrocardiographic, clinical, and gen

118 The constellation of elongation of the transverse arch, aort

119 he known targets of neddylation but also the constellation of enzymes and complexes known to regulate

120 (2) acute rejections were characterized by a constellation of excreted proteins.

121 um, the Viscum mitogenome possesses a unique constellation of extremely unusual features, a subset of

122 cognition, balance, and sleep are among the constellation of factors that bear on cardiorespiratory

123 in biology would be afforded by knowing the constellation of factors that constitute these domains a

124 ical presentation and management relate to a constellation of factors, both pulmonary and cardiac.

125 abolic syndrome, which is characterized by a constellation of fasting hyperglycemia, hypertriglycerid

126 Investigation revealed a constellation of features that distinguishes IDH1(R132MU

127 In summary, we have identified a novel constellation of features that should strongly suggest P

128 facial features, there was no characteristic constellation of features that would elicit clinical sus

129 This constellation of features, collectively known as myotoni

130 We report a constellation of feed-forward loops formed by the pancre

131 s of immune dysregulation, presenting with a constellation of fevers, rashes, and mucosal symptoms in

132 c of the Waterhouse-Friderichsen syndrome, a constellation of findings usually associated with fulmin

133 based on the rapid development of a complex constellation of findings with sudden cardiovascular col

134 The insulin resistance syndrome refers to a constellation of findings, including glucose intolerance

135 t dysfunction definitions include a variable constellation of findings, including hyperbilirubinemia,

136 des stream health and function, and causes a constellation of flow, water quality, and ecological sym

137 The constellation of frailty, disability and comorbidity pre

138 rus is characterized by a previously unknown constellation of gene segments derived from North Americ

139 nt H1N2 virus population was obtained with a constellation of gene segments, most of which, except fo

140 psis thaliana upregulate the expression of a constellation of genes dependent on the membrane-associa

141 Quorum-sensing controls a constellation of genes in the opportunistic pathogen Pse

142 s rather than by acting directly on the full constellation of genes involved in sex-specific differen

143 Our study of this naturally occurring constellation of genetic markers has provided insights i

144 oreover, PrP(Sc) of CWD exhibited a distinct constellation of glycoforms distinguishable from that of

145 ir disciplinary silos to address this urgent constellation of health threats.

146 Autism spectrum disorders (ASDs) comprise a constellation of highly heritable neuropsychiatric disor

147 1) assess the presence and significance of a constellation of histological lesions and (2) identify c

148 ion, hyperexpanded GAAs induced a particular constellation of histone modifications typically associa

149 physiologic signature that correlates with a constellation of homeostatic mechanisms in both health a

150 Thus, it could arrange the entire constellation of human visual areas in a unified functio

151 plex ligand specifically and used a distinct constellation of I-E(k) contact residues for each intera

152 AR-delta(-/-) mice occurred as a result of a constellation of immune system aberrations that included

153 icular dysgenesis syndrome (TDS), a proposed constellation of increasingly common male reproductive t

154 e analyses have revealed that, rather than a constellation of individual species, a healthy microbiot

155 tinct layers, each in receipt of a different constellation of inputs, makes it important to identify

156 range of mental activities and consists of a constellation of interconnected areas that are built fro

157 of phosphorylated Ser and Thr residues in a constellation of intracellular targets.

158 A constellation of intrinsic and extrinsic cellular mechan

159 interventions targeted to the cell-specific constellation of ion channels expressed in each menthol-

160 could act as functional "reporters" for the constellation of ion channels/exchangers expressed in ea

161 The constellation of known lipoproteins and other players in

162 The constellation of lambda-restricted monoclonal gammopathy

163 Multiple articles describe a constellation of language, personality, and social-behav

164 is difficult to determine whether a specific constellation of lesions observed across a cohort of mul

165 Because of their unusual constellation of life-history traits, primates play an i

166 shared by majority of C2 domains, the actual constellation of lipid-binding residues (predominantly b

167 The constellation of little public health infrastructure, lo

168 ressing cells in skeletal muscle displayed a constellation of markers diagnostic of fibro/adipogenic

169 Patients with WBS have a characteristic constellation of medical and cognitive findings, with a

170 ized cycling endosomes that contain a unique constellation of membrane proteins.

171 A constellation of metabolic and cardiovascular derangemen

172 resistance by engaging a naturally occurring constellation of MHC-promiscuous autoreactive T-cell clo

173 Moreover, the constellation of molecular defects associated with the l

174 to absent speech, dysmorphic features, and a constellation of more variable clinical features, most p

175 term neonates are surviving with an evolving constellation of motor and cognitive disabilities that a

176 n leukocytes on blood smears, coupled with a constellation of multisystem abnormalities and a pruriti

177 Efficient enteric replication required a constellation of murine genes encoding VP3, NSP2, and NS

178 The constellation of mutations identified in these patients

179 This constellation of ndrg4 cardiac defects phenocopies those

180 ocal features of chromatin structure and the constellation of nearby regulatory elements as well as t

181 o humor processing and not part of a general constellation of neural activity in response to reward.

182 Autism spectrum disorder (ASD) is a constellation of neurodevelopmental presentations with h

183 cells establish their neural ranking in the constellation of neurons in the brainstem.

184 MECP2 aberrations result in a constellation of neuropsychiatric abnormalities, whereby

185 TBIs suffer from Post-Concussion Syndrome, a constellation of neuropsychiatric symptoms that includes

186 of these diseases than is the presence of a constellation of obesity-related abnormalities now known

187 ), normal visual acuity in each eye, and the constellation of ocular motor deficits that typify human

188 epistatic interactions between groESL and a constellation of other genes) and preserve the different

189 ble and desirable phenotypes with an optimal constellation of parameter values for the system.

190 UVR) is a complete carcinogen that elicits a constellation of pathological events, including direct D

191 alent congenital birth defects, results in a constellation of phenotypes collectively termed Down syn

192 pre-clinical studies aimed at improving the constellation of phenotypes in a mouse model of RTT.

193 Our study reveals the constellation of phenotypes that can arise from a single

194 chronic CSC and is characterized by a unique constellation of phenotypic and multimethod imaging feat

195 Stress affects a constellation of physiological systems in the body and e

196 s seems to be determined by the presence and constellation of polar side chains that act in concert w

197 isk factor for gastroschisis and is one of a constellation of potentially preventable exposures which

198 nical diagnosis is based on recognition of a constellation of presenting features.

199 y reduced the MI-triggered upregulation of a constellation of proinflammatory genes.

200 Aplidin is associated with suppression of a constellation of proliferative/antiapoptotic genes (e.g.

201 B(1)) in the retina is known, but recently a constellation of proteins has been identified that produ

202 This constellation of PVL and neuronal/axonal disease is suff

203 terized by severe short stature and a unique constellation of radiographic findings.

204 ure of neuropsychiatric disorders includes a constellation of rare mutations in many different genes.

205 matin-modifying enzymes, and by binding to a constellation of regulatory DNA elements.

206 A constellation of related genetic diseases are caused by

207 the Ud and WSN M1 proteins indicated that a constellation of residues are responsible for the differ

208 form of the kinase, for targeting the global constellation of residues at the ATP site or less conser

209 This constellation of residues is poised to activate the subs

210 coordinating histidine residue, assembles a constellation of residues that resembles a modified cata

211 death worldwide and is commonly caused by a constellation of risk factors called the metabolic syndr

212 The metabolic syndrome is a constellation of risk factors of metabolic origin that a

213 The results demonstrate that the same constellation of second messengers and kinases is involv

214 lt suggests that the functionally integrated constellation of signaling molecules in a particular typ

215 because they express their own unique set or constellation of signaling molecules, including receptor

216 S: NAS has traditionally been described as a constellation of signs/symptoms displayed by the neonate

217 ered in epidemiological surveys to reflect a constellation of skin conditions and to summarize the bu

218 UNX1 or BCR-ABL1 translocations as well as a constellation of somatic structural DNA alterations in a

219 ations of any of these histidines produced a constellation of spectroscopic changes that involve not

220 suggesting that this trait involves a unique constellation of stress factors.

221 Most tumors harbor a constellation of structural genomic alterations that may

222 This constellation of suppressor genes is uncommon among the

223 tion, patients often report a well-described constellation of symptoms and signs.

224 Although the patient's constellation of symptoms are classically representative

225 e considered as a discrete diagnosis or as a constellation of symptoms characterized by central nervo

226 he offspring, the most devastating being the constellation of symptoms collectively referred to as fe

227 hat inflammatory processes may underlie this constellation of symptoms has not been examined.

228 of exclusion, MAL syndrome involves a vague constellation of symptoms including epigastric pain, pos

229 RECENT FINDINGS: PCS is a constellation of symptoms related to head injury includi

230 nder ENDO conditions could contribute to the constellation of symptoms that ensue.

231 e recognised as pathogenic in man, causing a constellation of symptoms, including epilepsy, ataxia, s

232 patterns, cognition and the production of a constellation of symptoms, termed 'sickness behaviour'.

233 um disorders are a genetically heterogeneous constellation of syndromes characterized by impairments

234 animals studied represented the full genetic constellation of the challenge stock.

235 A constellation of three or more high-risk clinical featur

236 of hepatic glucose production, leading to a constellation of tissue abnormalities that has been refe

237 hereas no nonhuman animal possesses the full constellation of traits that define the human mind, homo

238 oarray-based expression analysis, revealed a constellation of transcripts that are specifically enric

239 fancy, congenital fibrosis syndrome, and the constellation of unique eye movements that accompany Jou

240 focal neurologic abnormalities, including a constellation of upper motor neuron signs (n = 19), atax

241 It examines the constellation of various diverse health-system strengthe

242 nction, in its broadest sense, encompasses a constellation of various nonadaptive alterations in func

243 4 different genotypes distinct from the gene constellation of viruses circulating prior to 1979.

244 alignments, each optimal under a particular constellation of weights.

245 This constellation of widespread neuropatho-logic changes was

246 litating GT and CSR can be formed by varying constellations of 3' RR elements.

247 , urodynamic studies may demonstrate typical constellations of abnormalities, but no pathognomonic fe

248 ransferases in this fold might show distinct constellations of active site residues.

249 n chaperoning tumor- or tissue-type-specific constellations of client proteins with critical involvem

250 Constellations of core promoters can generally be reduce

251 These constellations of critical residues are unique to LigD-l

252 ng system organization, 5HT neuron subtypes, constellations of differentially expressed genes disting

253 a regression tree-based rule that identifies constellations of distinguishing factors.

254 Cells detected distinct constellations of face parts.

255 Within each backbone group, we identified constellations of factors that were most predictive of o

256 With differing constellations of genes, the A. actinomycetemcomitans cl

257 -VP2-VP3-NSP1-NSP2-NSP3-NSP4-NSP5/6 genotype constellations of I1-R1-C1-M1-A1-N1-T1-E1-H1.

258 These constellations of immunologic changes provide a "fingerp

259 ntify them and investigate the cell-specific constellations of ion channels and receptors functionall

260 complex; therefore, it was hypothesized that constellations of MM parameters, reflecting this complex

261 not differentiation alone); (2) variation in constellations of people and processes within and across

262 This experimental approach can uncover constellations of plasma membrane macromolecules that ar

263 r the combined use of anti-TG2 and different constellations of potential blood-based CD markers compa

264 These were strikingly different from the constellations of receptors and ion channels found in su

265 These constellations of regions overlapped with frontolimbic r

266 ractions between selected residues, or among constellations of residues, in small folding motifs.

267 and TTBK2), phosphorylate human SV2A at two constellations of residues, namely Cluster-1 (Ser42, Ser

268 tion that will help prioritize the strongest constellations of results.

269 Amino acid replacements produced different constellations of signaling defects at each residue, ind

270 omprise multiple subtypes harboring distinct constellations of somatic structural DNA rearrangements

271 Hz frequency band, reliably reflect spatial constellations of spiking cells, embedded within non-spi

272 fied new ALL subtypes, each characterized by constellations of structural and sequence alterations th

273 are linked together by dynamically changing constellations of synaptic weights ("synapsembles").

274 enable to extract assemblies with arbitrary constellations of time lags, and at multiple temporal sc

275 We broadly analyzed the combinations (constellations) of receptors and ion channels expressed

276 a significant degree of divergence in genome constellation, organization, and protein sequences.

277 nt swine influenza virus, with the same gene constellation pattern as the pandemic H1N1/2009 virus an

278 er the future may not be the essence of this constellation; perhaps not quite being, either in the pr

279 re we demonstrate the broad applicability of constellation pharmacology by extending it to the CNS an

280 esults demonstrate the predictive utility of constellation pharmacology for defining modulatory input

281 Using an experimental strategy called constellation pharmacology, we demonstrate that we can d

282 Using constellation pharmacology, we found that these substanc

283 We refer to this paradigm as "constellation pharmacology."

284 ystem using an experimental strategy called "constellation pharmacology." Here we demonstrate the bro

285 This reciprocal constellation prevents interference by redundant partner

286 Both antigenic constellations promoted T cell proliferation and effecto

287 53, resembling standard or high-risk genetic constellations, respectively.

288 including the Korean isolates, share a gene constellation similar to that of the Penfold Park, Hong

289 s is much more divergent and broad than such constellations suggest.

290 ry hypertrophic osteoarthropathy, a clinical constellation that develops secondary to various acquire

291 knob domains that have to be in the spatial constellation that is present in viral particles.

292 dings lies in the identification of a tissue constellation that melds cell-autonomous mechanisms of i

293 n, lipoatrophy, and hypoglycemia, a clinical constellation that resembles the human syndrome of lepre

294 neral population contains informative family constellations that can complement more traditional adop

295 12P[8] strains were similar in their genomic constellation to locally cocirculating strains and to a

296 The mixed constellation topology glycodendrimersomes were demonstr

297 ng revealed that the isolates had genotype 2 constellations typical of DS-1-like viruses (G2P[4]-I2-R

298 p genome sequencing 13 distinct viral genome constellations were differentiated.

299 o or one carbohydrate head groups or a mixed constellation with a noncarbohydrate hydrophilic arm.

300 nt intragenic deletions of PAX5 or VPREB1 in constellation with the fusion of TCF3 and HLF.