ライフサイエンスコーパス: constitutive activation

1 p phosphorylation-dependent kinase result in constitutive activation.

2 acute myeloid leukemia patients and lead to constitutive activation.

3 liform papilla maintenance was shown by Gli2 constitutive activation.

4 but cannot be dephosphorylated, resulting in constitutive activation.

5 sion results in its nuclear localization and constitutive activation.

6 hosphorylated CaMKII (P<0.01), suggestive of constitutive activation.

7 O-GlcNAcylation has been linked to NF-kappaB constitutive activation and cancer development.

8 small molecule inhibitor BMS-777607 blocked constitutive activation and decreased AKT signaling.

9 rced covalent dimerization did not result in constitutive activation and did not affect the ability o

10 ctional data from miR-155 tg NK cells showed constitutive activation and enhanced target cell conjuga

11 Both constitutive activation and loss of Akt kinase activity

12 ation (S623A) into TRPC4G503S suppressed the constitutive activation and partially rescued its functi

13 Loss of ClpC repression in MD mutants causes constitutive activation and severe cellular toxicity.

14 PKC-iota by site-directed mutagenesis led to constitutive activation and unresponsiveness to PIP3 in

15 fied regulatory mechanism was observed after constitutive activation as well as after receptor tyrosi

16 ls, 3C(pro) targets Q167 and Q189 within the constitutive activation domain, resulting in cleavage of

17 Somatic SMO mutations that result in constitutive activation have been described in several t

18 ium between active and inactive forms raises constitutive activation in one receptor type.

19 n of SYK activity eliminated features of the constitutive activation in these cells and partly restor

20 tal arrest and presenting as GC B cells with constitutive activation-induced cytidine deaminase (AID)

21 NF-kappaB constitutive activation is a major factor for the apopto

22 er, our studies indicate that stress-induced constitutive activation is a novel mechanism of kappaOR

23 endocrine therapy via mutation of ERs whose constitutive activation is associated with shorter patie

24 nt, the data suggest that controlled but not constitutive activation is required for gonococcal infec

25 cause different immunological disorders, its constitutive activation leads to various types of cancer

26 High SYK expression by itself drives the constitutive activation observed in these B cells, which

27 st turnover tissues, APC loss results in the constitutive activation of a Wnt target gene program tha

28 by elevated miR-34a expression resulting in constitutive activation of acetylated p65 (lysine 310).

29 ever, induction of this circuit in mice with constitutive activation of AKT and YAP in bile ducts ind

30 This finding is of interest as constitutive activation of AKT has been described in DLB

31 Constitutive activation of AKT or Bcl-xL rescued the tra

32 Constitutive activation of Akt or inhibition of GSK3beta

33 STRN-ALK leads to constitutive activation of ALK kinase via dimerization m

34 e is most effective in proximal branches via constitutive activation of alpha2 ARs.

35 PKgamma2(RG) in the kidney, linking lifelong constitutive activation of AMPK to a potential risk for

36 ark t(14;18) translocation, which results in constitutive activation of antiapoptotic protein B cell

37 work presented here was to determine whether constitutive activation of autophagy would also block re

38 suggested miR-17 approximately 92's role in constitutive activation of BCR signaling and sensitivity

39 Constitutive activation of beta-catenin in hematopoietic

40 In addition, the constitutive activation of beta-catenin significantly in

41 omas have mutations in CTNNB1 that result in constitutive activation of beta-catenin, so this molecul

42 ers from that associated with loss of APC or constitutive activation of beta-catenin.

43 ed a mouse model with the germ cell-specific constitutive activation of betacatenin using cre recombi

44 ATE-ZIM DOMAIN protein, thereby resulting in constitutive activation of bHLH05 and mimicking jasmonic

45 esponses such as callose deposition and that constitutive activation of BR signaling in bri1-EMS-supp

46 The constitutive activation of BR signaling, in contrast, en

47 e morphology defects, growth inhibition, and constitutive activation of BR signaling.

48 Because constitutive activation of BRAF leads to proliferation i

49 Specifically, constitutive activation of Ca(2+) entry by expression of

50 identified in human CRC are associated with constitutive activation of calcineurin, whereas nuclear

51 372R) mutations are neomorphic, resulting in constitutive activation of cAMP and Ca(2+) signaling pat

52 Constitutive activation of CaN also decreases immobility

53 In addition, constitutive activation of CaN in vivo favors 5-HT uptak

54 ion and therefore PF-suture closure, whereas constitutive activation of canonical Wnt causes PF-sutur

55 nce of Wnt4, we generated a mouse model with constitutive activation of canonical Wnt/beta-catenin si

56 n the intestinal epithelium was required for constitutive activation of caspase-8 under steady-state

57 Constitutive activation of CD40 in DCs results in inflam

58 Recently, we have shown that constitutive activation of CD40 signaling in B cells ind

59 howed that loss-of-function of BIR1 leads to constitutive activation of cell death and defense respon

60 Constitutive activation of certain stress response netwo

61 Constitutive activation of certain stress response netwo

62 res even at 12 h of liquid culture, and near constitutive activation of conidiation, indicating that

63 Constitutive activation of DDR proteins has been observe

64 us actin and stable microtubules, indicating constitutive activation of DIAPH1.

65 d kinases inhibits proliferation, suppresses constitutive activation of downstream signaling pathways

66 EGF/FGF2-independent proliferation exhibited constitutive activation of EGFR, AKT, and STAT3 and sens

67 Constitutive activation of eIF2Bepsilon is sufficient to

68 t deletion of the N-terminal lobe results in constitutive activation of endogenous PIWI domain-based

69 Constitutive activation of endothelial Nrf2 enhanced EC

70 lts suggest that SAM domain deletion induced constitutive activation of EphA2 kinase activity.

71 elial regeneration and cancer growth through constitutive activation of epidermal growth factor recep

72 lular signal-regulated kinase (ERK), whereas constitutive activation of ERK in these cells led to res

73 omotes a mitogenic phenotype associated with constitutive activation of ERK.

74 ck of signaling capacity was associated with constitutive activation of extracellular-regulated kinas

75 -targeted active PTK6 (Palm-PTK6-YF) induces constitutive activation of FAK and cell morphology chang

76 Constitutive activation of FLT3 by internal tandem dupli

77 led that deletion of Akt in liver led to the constitutive activation of Foxo1-dependent gene expressi

78 emonstrated a gain-of-function effect due to constitutive activation of G protein downstream signalin

79 hat in addition to Gq, GHS-R1a also promoted constitutive activation of G13.

80 uxin and GA signaling, we show here that the constitutive activation of GA signaling is sufficient to

81 Constitutive activation of Galphaq signaling by mutation

82 ti-gp130 mAbs directed against D1, abolished constitutive activation of gp130DeltaYY, highlighting th

83 cells with increased proliferative capacity, constitutive activation of granulocyte macrophage colony

84 independently of the mTORC1 pathway, whereas constitutive activation of GSK3beta reduces AKT-induced

85 aneous deletion of SSE1 and FES1 resulted in constitutive activation of heat shock protein expression

86 Here, we determined that constitutive activation of hedgehog signaling specifical

87 h-level expression of HRG is associated with constitutive activation of HER3 in SCCHN and thus define

88 Using a genetic model involving constitutive activation of Hh pathway in SF1(+) cells, w

89 ause either inhibition with Hh inhibitors or constitutive activation of Hh signaling activity in tran

90 c mouse models, we show that B-cell-specific constitutive activation of HH/GLI signaling either at th

91 Notably, liver-specific constitutive activation of HIF-2alpha, but not HIF-1alph

92 nhibition of the HIF pathway since ~80% show constitutive activation of HIF.

93 Inactivation of vhl in zebrafish led to constitutive activation of HIF2alpha orthologs and model

94 predispose to paraganglioma tumors that show constitutive activation of hypoxia responses.

95 by loss of the tumor-suppressor VHL, driving constitutive activation of hypoxia-inducible factor-1 (H

96 Notably, constitutive activation of IkappaBalpha/NF-kappaB(p65) i

97 Constitutive activation of IKKbeta in the esophageal epi

98 primary ovarian and breast tumors confirmed constitutive activation of ISGs.

99 cytokines including IL-6 and -13, leading to constitutive activation of JAK/STAT signaling.

100 nitiates an epigenetic switch leading to the constitutive activation of JAK1/STAT3 signalling, which

101 domain and how pathogenic mutations lead to constitutive activation of JAK2.

102 ave an acquired mutation (JAK2V617F) causing constitutive activation of JAK2.

103 e JAK2 c.1849G>T (p.V617F) mutation leads to constitutive activation of Janus kinase (JAK)2 and contr

104 hrombopoietin (TPO) receptor (MPL) to induce constitutive activation of Janus kinase 2 and signal tra

105 Although constitutive activation of Janus kinase 3 (Jak3) leads t

106 kk7 knockout mice (MKK7 cKO), which impaired constitutive activation of JNK in the nervous system.

107 Gclm KO mice also exhibit constitutive activation of liver AMP-activated protein k

108 mas are slow-growing tumours associated with constitutive activation of mammalian target of rapamycin

109 sis complex is a genetic disorder leading to constitutive activation of mammalian target of rapamycin

110 wn genomic alterations in glioma that induce constitutive activation of MAPK are transcriptionally li

111 Interestingly, constitutive activation of miR408 in the spl7 background

112 inhibitor of mitochondrial complex III, and constitutive activation of mitochondrial retrograde sign

113 These data indicate constitutive activation of mitophagy results in reductio

114 We then showed that both inhibition and constitutive activation of mTOR during tutor experiences

115 with S6 and 4EBP phosphorylation in vivo and constitutive activation of mTOR kinase activity in vitro

116 Here we report that, unexpectedly, constitutive activation of mTOR signalling by Tsc1 delet

117 Constitutive activation of mTORC1 by depletion of tubero

118 st, glucose did not suppress mTORC1, and the constitutive activation of mTORC1 failed to suppress pla

119 ession of cone death during disease and that constitutive activation of mTORC1 in cones is sufficient

120 Recent studies have suggested that constitutive activation of mTORC1 in normal cells could

121 Constitutive activation of mTORC1 preserved cones in 2 m

122 ed mTORC1 signaling in vitro and in vivo The constitutive activation of mTORC1 reduced hepatic lipoge

123 Loss of the PTEN tumor suppressor results in constitutive activation of mTORC1 through the Akt-depend

124 gain of function causes fatty liver through constitutive activation of mTorc1, an effect that is rev

125 B-P4 might be a valuable tool to inhibit the constitutive activation of naturally occurring gp130 mut

126 Conversely, constitutive activation of neuronal ALK5 in forebrain ca

127 this epidermal phenotype was associated with constitutive activation of NF-kappaB (RelA) and increase

128 the transglutaminase TG2 has been linked to constitutive activation of NF-kappaB and chemotherapy re

129 ) mouse livers, and this was associated with constitutive activation of NF-kappaB and JNK, along with

130 e/paracrine TLR5 signaling loop resulting in constitutive activation of NF-kappaB both in vitro and i

131 egulatory mechanisms that avoid excessive or constitutive activation of NF-kappaB may be associated w

132 Conversely, constitutive activation of NF-kappaB selectively in wild

133 To model constitutive activation of NF-kappaB, we expressed a tra

134 n regulatory network in epithelial cells via constitutive activation of NF-kappaB.

135 In contrast, constitutive activation of NFATc1 nullifies the protecti

136 ls to inflammatory signals, and the abnormal constitutive activation of NFkappaB is important for the

137 ts and that this increase is attributable to constitutive activation of nicotinamide adenine dinucleo

138 in primary T cells, TRAF1 also restricts the constitutive activation of NIK in anti-CD3-activated T c

139 Here we demonstrate in Arabidopsis that the constitutive activation of NIK1, a leucine-rich repeat r

140 -inactive c-IAP2 mutant (c-IAP2(H570A)) have constitutive activation of non-canonical NF-kappaB, resu

141 e formation of all nephron segments and that constitutive activation of Notch in developing nephrons

142 and Hnf1b Consistent with this, we find that constitutive activation of Notch in mesenchymal nephron

143 Constitutive activation of Notch signaling fully blocked

144 At the molecular level, constitutive activation of Notch signaling inhibits, whe

145 ptosis in cultured human leukemic cells with constitutive activation of Notch signaling.

146 dation of some of these findings showed that constitutive activation of Notch1 deregulated glutamine

147 Accordingly, constitutive activation of Notch1 prevents SC depletion

148 enhanced fear memory generalization, whereas constitutive activation of NR neurons decreased memory g

149 Somatic mutations that lead to constitutive activation of NRAS and KRAS proto-oncogenes

150 ibly providing a scenario similar to that of constitutive activation of Nrf2 found in certain human c

151 duct phenotypes could be recapitulated with constitutive activation of Nrf2 signaling in Keap1(F/F):

152 ation of the Nrf2-Keap1 axis, which leads to constitutive activation of Nrf2.

153 Constitutive activation of nuclear factor kappa B (NF-ka

154 elial-mesenchymal transition (EMT), but also constitutive activation of nuclear factor kappa B (NFkap

155 Mechanistically, CB sparks the constitutive activation of oestrogen receptors alpha (ER

156 This coincides with the constitutive activation of one of the downstream effecto

157 ubicin or nutlin-3 results in continuing and constitutive activation of p53, inhibition of XIAP and s

158 Constitutive activation of PDGFRalpha leads to expansion

159 The Pten phenotype is mimicked by constitutive activation of PI3 kinase and is rescued by

160 We further show that constitutive activation of PKB in vivo results in a loss

161 ate that the PLCgamma1-R707Q mutation causes constitutive activation of PLCgamma1 and may represent a

162 lterations in MIBC that convergently lead to constitutive activation of PPARgamma/RXRalpha and result

163 vasion phenotypes is mediated in part by the constitutive activation of pro-inflammatory nuclear fact

164 trigger chronic inflammation, which leads to constitutive activation of pro-inflammatory signaling pa

165 Here, we identified constitutive activation of proapoptotic Bax, maintained

166 derailed in B cell malignancies, leading to constitutive activation of prosurvival pathways.

167 ominant-negative Rab4 or Rab4 morpholino and constitutive activation of Rab5 decreases the elongation

168 Constitutive activation of Rac1 also led to podocyte det

169 In this study, we demonstrate that constitutive activation of Raf-1 oncogenic signaling ind

170 RASA1-deficient LECs showed evidence of constitutive activation of Ras in situ.

171 RS2, a direct substrate of FGFR1, as well as constitutive activation of RAS-MAPK signaling.

172 Constitutive activation of Ras-mitogen-activated protein

173 st phosphate uptake system component, causes constitutive activation of RegX3.

174 ncreas-specific deletion of IkappaBalpha had constitutive activation of RelA and a gene expression pr

175 Constitutive activation of RelA up-regulates Spi2A, whic

176 Constitutive activation of RhoA in Swap-70(-/-) DCs was

177 Constitutive activation of RhoA led to increased express

178 Moreover, constitutive activation of RhoA restricted three-dimensi

179 Additionally, constitutive activation of saeRS (saeRS(C)) enhanced the

180 decreased production of such factors, while constitutive activation of saeRS increases virulence, an

181 rfism, compromised pollen tube guidance, and constitutive activation of salicyclic acid-mediated defe

182 pendent of their endogenous Sox2 expression, constitutive activation of Shh signaling in CGNPs result

183 Constitutive activation of signal transducer and activat

184 Constitutive activation of SKN-1 induces a similar trans

185 results indicate that oncogenic Kras induces constitutive activation of SOX9 in HPNE and HPDE cells,

186 g-term plasticity, little is known about how constitutive activation of specific kinase isoforms sust

187 cy of both Insigs in enterocytes resulted in constitutive activation of SREBP and HMGR, leading to an

188 In an attempt to achieve constitutive activation of SRK and thus facilitate analy

189 we furthermore show that plasma LPS leads to constitutive activation of STAT1 through autocrine cytok

190 Cs and the Notch pathway, which involves the constitutive activation of STAT3 and NF-kappaB signaling

191 The constitutive activation of STAT3 and NF-kappaB signaling

192 Constitutive activation of STAT3 imparts resistance to a

193 e resulted in phospho-Stat3 accumulation and constitutive activation of Stat3-driven genetic programs

194 r GC cell lines including AGS cells, showing constitutive activation of STAT3.

195 eement with this model, we observed that the constitutive activation of Stat5 cooperates with the los

196 We have detected constitutive activation of STAT5 in malignant B cells de

197 Importantly, primary T-PLL cells exhibited constitutive activation of STAT5, and targeted pharmacol

198 translocation partner in lipoma), induced by constitutive activation of STAT5, but not by transient c

199 In this study, we demonstrated that constitutive activation of STAT6 in KSHV-associated PEL

200 We hypothesize a constitutive activation of stem cell division kinetics s

201 es dysregulation of apoptosis, mainly due to constitutive activation of survival pathways including J

202 stitutive photomorphogenesis associated with constitutive activation of target genes, elevated levels

203 dependent regulation of TERT and elicits the constitutive activation of telomerase.

204 ing mice with either T cell-specific loss or constitutive activation of TGF-beta signaling, we demons

205 , enabling the intestinal flora to trigger a constitutive activation of the anterior midgut immune re

206 llomavirus 31 (HPV31)-positive cells exhibit constitutive activation of the ATM-dependent DNA damage

207 mphocytic leukemia (CLL) is characterized by constitutive activation of the B-cell receptor (BCR) sig

208 that AP-1, like NF-kappaB, was controlled by constitutive activation of the B-cell receptor signaling

209 ve activating mutations in B-Raf, leading to constitutive activation of the B-Raf/MKK/ERK signaling p

210 In chronic myelogenous leukemia, the constitutive activation of the BCR-ABL kinase transforms

211 or the pathogenesis of these tumors, whereby constitutive activation of the cAMP pathway and EZH1 mut

212 Constitutive activation of the canonical and noncanonica

213 This response is attenuated in mutants with constitutive activation of the corticotropin-releasing f

214 ogous expression of STIM1 p.R304W results in constitutive activation of the CRAC channel in vitro, an

215 These results highlight the importance of constitutive activation of the de novo purine synthesis

216 We show that Pten deletion, or constitutive activation of the downstream kinase AKT, ac

217 Constitutive activation of the EGFR is common in cancer

218 of chronic energy deprivation, resulting in constitutive activation of the energy-stress sensor AMPK

219 Constitutive activation of the epidermal growth factor r

220 erized by frequent loss of PTCH1, leading to constitutive activation of the Hedgehog pathway.

221 findings indicate that MUC1-C contributes to constitutive activation of the HER2 pathway and that tar

222 ippel-Lindau tumor suppressor and subsequent constitutive activation of the hypoxia-inducible factors

223 tween the IIS and Rag-TORC1 pathways because constitutive activation of the IIS pathway requires Rag

224 nce of CD37 drives tumor development through constitutive activation of the IL-6 signaling pathway.

225 ation of the IkappaB kinase complex prevents constitutive activation of the immune deficiency pathway

226 One such mechanism may be through constitutive activation of the insulin-like growth facto

227 Constitutive activation of the JAK/STAT pathway downstre

228 All these aberrations lead to the constitutive activation of the JAK/STAT3 pathway, which

229 ise to growth factor-independent clones with constitutive activation of the Janus kinase (JAK)- signa

230 atic human mutation (p.Ser646Phe) inducing a constitutive activation of the Janus kinase (JAK)/STAT p

231 followed by a persistent, ligand-independent constitutive activation of the kappaOR itself.

232 Balloon cells (BCs) in FCDIIB exhibit constitutive activation of the mammalian target of rapam

233 Constitutive activation of the mammalian target of rapam

234 ve fitness normalize GSK3beta activity after constitutive activation of the MAPK pathway, commonly th

235 n BRAF, mainly at codon 600, which result in constitutive activation of the MAPK pathway.

236 vating mutations drive tumorigenesis through constitutive activation of the MAPK pathway.

237 es, elevated baseline expression relied upon constitutive activation of the MAPK pathway.

238 utation in the TSC1 or TSC2 genes leading to constitutive activation of the mechanistic target of rap

239 We present evidence that constitutive activation of the mitogen-activated protein

240 Activating BRAF mutations promote constitutive activation of the mitogen-activated protein

241 nes and enhanced freezing tolerance, whereas constitutive activation of the MKK4/5-MPK3/6 cascade in

242 MORPHOPROTEOMIC TUMOR ANALYSES REVEALED CONSTITUTIVE ACTIVATION OF THE MTOR PATHWAY AS EVIDENCED

243 Structural modeling supported constitutive activation of the mutant STING protein base

244 NF-kappaB in hypoxic breast cancer cells and constitutive activation of the NF-kappaB pathway in CAIX

245 DLBCL (ABC-DLBCL), which is characterized by constitutive activation of the NF-kappaB pathway, carry

246 leted in multiple myeloma (MM), resulting in constitutive activation of the noncanonical nuclear fact

247 Constitutive activation of the nuclear factor-kappa B (N

248 eractions with the targets, thereby enabling constitutive activation of the nuclear factor-kappa B, a

249 ononuclear cells from the patients indicated constitutive activation of the pathway that cannot be fu

250 y, miR-17~92-driven lymphoma cells exhibited constitutive activation of the PI3K and NFkappaB pathway

251 Constitutive activation of the PI3K/mTOR signaling pathw

252 o alters EGF receptor signaling and leads to constitutive activation of the protein kinase Akt.

253 omain-mediated polymerization of EN leads to constitutive activation of the PTK domain and constituti

254 ecked TLR-induced inflammatory responses and constitutive activation of the Pyrin inflammasome.

255 of the cognate sensor QseC leads to robust, constitutive activation of the QseB response regulator b

256 BRAF V600E leads to the constitutive activation of the RAF-MEK-extracellular sig

257 nd/or with PTEN deletion based on the common constitutive activation of the Raf/MEK/ERK and PI3K/AKT

258 There was constitutive activation of the Ras/Raf/ERK pathway p-ERK

259 nal proline-rich motif of FGFR2 inducing the constitutive activation of the receptor, thereby prompti

260 nic mutations in KIT are present, leading to constitutive activation of the receptor, which drives th

261 In contrast, three other mutants showed constitutive activation of the reporter in the roots and

262 rase reporter for monitoring the GSR support constitutive activation of the response in this mutant b

263 nnoma cells, containing merlin mutations and constitutive activation of the Rho/Rac family of GTPases

264 gly, loss of casein kinase 1 activity causes constitutive activation of the RIM pathway, and, accordi

265 Constitutive activation of the signal transducer and act

266 In contrast, constitutive activation of the small GTPase Rap1 restric

267 blastoma consists of four major groups where constitutive activation of the Sonic Hedgehog (SHH) sign

268 This disruption leads to a constitutive activation of the spindle-assembly checkpoi

269 Accordingly, IL6 mediated constitutive activation of the STAT3 pathway, an essenti

270 In conclusion, our studies suggest that constitutive activation of the STAT3-Pim1 pathway repres

271 both adherent and spheroid glioma CSCs show constitutive activation of the STAT3/NF-kappaB signaling

272 IL6-mediated inflammation programs constitutive activation of the TAK1-NFkappaB signaling c

273 In fact, in CD44+/CD24- cells, constitutive activation of the TGF-beta axis was both ne

274 egulation of lysosomal protein expression by constitutive activation of the transcription factor EB (

275 subtype characterized by adverse outcome, is constitutive activation of the transcription factor nucl

276 Constitutive activation of the UPR(mt) by gain of functi

277 Constitutive activation of the Wnt pathway resulting fro

278 Constitutive activation of the Wnt pathway, one of the e

279 Constitutive activation of the Wnt pathway/beta-catenin

280 Constitutive activation of the Wnt/beta-catenin signalin

281 Constitutive activation of this loop in transformed cell

282 romotes osteoblast differentiation in vitro, constitutive activation of this pathway impairs bone for

283 Also, constitutive activation of Toll and IMD pathways by knoc

284 The second-site mutations prevent constitutive activation of TpoR W515K/L, while preservin

285 In multiple forms of cancer, constitutive activation of type I IFN signaling is a cri

286 These mutations confer cGAMP-independent constitutive activation of type I interferon signaling t

287 Emerging evidence suggests that constitutive activation of various signaling pathways li

288 ptor-related protein 5 Wnt coreceptor causes constitutive activation of Wnt signaling, and in adenovi

289 Constitutive activation of Wnt-beta-catenin signaling fu

290 Constitutive activation of Wnt/beta-catenin inhibits oli

291 t common mechanisms of misregulation lead to constitutive activation of WT STATs.

292 Here we show that constitutive activation of XBP1 in tumor-associated DCs

293 Overexpression or constitutive activation of YAP leads to transformation a

294 sidues within TM6 and TM7 results in a weak 'constitutive' activation of the pathway.

295 Aberration in STAT3 activity due to constitutive activation or mutations leads to diseases s

296 Constitutive activation or overactivation of Ras signali

297 We propose that constitutive activation results from a lessened intrinsi

298 showed that different JAK3 mutations induce constitutive activation through distinct mechanisms, poi

299 nd Q61L, suggests that these mutations cause constitutive activation through two different mechanisms

300 This constitutive activation was abrogated by ex vivo treatme