ライフサイエンスコーパス: constitutive activation of

1 and IKK/NF-kappaB pathways and maintained by constitutive activation of a feed-forward inflammatory s

2 st turnover tissues, APC loss results in the constitutive activation of a Wnt target gene program tha

3 by elevated miR-34a expression resulting in constitutive activation of acetylated p65 (lysine 310).

4 ever, induction of this circuit in mice with constitutive activation of AKT and YAP in bile ducts ind

5 This finding is of interest as constitutive activation of AKT has been described in DLB

6 The MAGI3-AKT3 fusion leads to constitutive activation of AKT kinase, which is abolishe

7 Constitutive activation of AKT or Bcl-xL rescued the tra

8 Constitutive activation of Akt or inhibition of GSK3beta

9 nterface and found that most of them lead to constitutive activation of AKT.

10 nactivated by multiple mechanisms, including constitutive activation of AKT/PKB and MAPK/ERK kinases

11 STRN-ALK leads to constitutive activation of ALK kinase via dimerization m

12 RP78 deficient bone marrow (BM) cells showed constitutive activation of all the major UPR signaling p

13 e is most effective in proximal branches via constitutive activation of alpha2 ARs.

14 cysteine substitutions resulted in variable constitutive activation of alphaIIbbeta3 and alphavbeta3

15 PKgamma2(RG) in the kidney, linking lifelong constitutive activation of AMPK to a potential risk for

16 While constitutive activation of AMPK was sufficient to comple

17 ark t(14;18) translocation, which results in constitutive activation of antiapoptotic protein B cell

18 work presented here was to determine whether constitutive activation of autophagy would also block re

19 suggested miR-17 approximately 92's role in constitutive activation of BCR signaling and sensitivity

20 Constitutive activation of beta-catenin in hematopoietic

21 In addition, the constitutive activation of beta-catenin significantly in

22 omas have mutations in CTNNB1 that result in constitutive activation of beta-catenin, so this molecul

23 ers from that associated with loss of APC or constitutive activation of beta-catenin.

24 ed a mouse model with the germ cell-specific constitutive activation of betacatenin using cre recombi

25 ATE-ZIM DOMAIN protein, thereby resulting in constitutive activation of bHLH05 and mimicking jasmonic

26 efects in these strains can be suppressed by constitutive activation of Bnr1.

27 esponses such as callose deposition and that constitutive activation of BR signaling in bri1-EMS-supp

28 The constitutive activation of BR signaling, in contrast, en

29 e morphology defects, growth inhibition, and constitutive activation of BR signaling.

30 Because constitutive activation of BRAF leads to proliferation i

31 Specifically, constitutive activation of Ca(2+) entry by expression of

32 identified in human CRC are associated with constitutive activation of calcineurin, whereas nuclear

33 372R) mutations are neomorphic, resulting in constitutive activation of cAMP and Ca(2+) signaling pat

34 Constitutive activation of CaN also decreases immobility

35 In addition, constitutive activation of CaN in vivo favors 5-HT uptak

36 ion and therefore PF-suture closure, whereas constitutive activation of canonical Wnt causes PF-sutur

37 nce of Wnt4, we generated a mouse model with constitutive activation of canonical Wnt/beta-catenin si

38 n the intestinal epithelium was required for constitutive activation of caspase-8 under steady-state

39 Constitutive activation of CD40 in DCs results in inflam

40 Recently, we have shown that constitutive activation of CD40 signaling in B cells ind

41 howed that loss-of-function of BIR1 leads to constitutive activation of cell death and defense respon

42 Constitutive activation of certain stress response netwo

43 Constitutive activation of certain stress response netwo

44 res even at 12 h of liquid culture, and near constitutive activation of conidiation, indicating that

45 Constitutive activation of DDR proteins has been observe

46 us actin and stable microtubules, indicating constitutive activation of DIAPH1.

47 d kinases inhibits proliferation, suppresses constitutive activation of downstream signaling pathways

48 romotes interaction with Stat5 and Shp2, and constitutive activation of downstream signaling pathways

49 EGF/FGF2-independent proliferation exhibited constitutive activation of EGFR, AKT, and STAT3 and sens

50 Constitutive activation of eIF2Bepsilon is sufficient to

51 t deletion of the N-terminal lobe results in constitutive activation of endogenous PIWI domain-based

52 Constitutive activation of endothelial Nrf2 enhanced EC

53 lts suggest that SAM domain deletion induced constitutive activation of EphA2 kinase activity.

54 elial regeneration and cancer growth through constitutive activation of epidermal growth factor recep

55 On the contrary, constitutive activation of EpoR activated cell prolifera

56 lular signal-regulated kinase (ERK), whereas constitutive activation of ERK in these cells led to res

57 omotes a mitogenic phenotype associated with constitutive activation of ERK.

58 ion of the EIN2 C terminus, concomitant with constitutive activation of ethylene responses in Arabido

59 ck of signaling capacity was associated with constitutive activation of extracellular-regulated kinas

60 -targeted active PTK6 (Palm-PTK6-YF) induces constitutive activation of FAK and cell morphology chang

61 Constitutive activation of FLT3 by internal tandem dupli

62 led that deletion of Akt in liver led to the constitutive activation of Foxo1-dependent gene expressi

63 emonstrated a gain-of-function effect due to constitutive activation of G protein downstream signalin

64 hat in addition to Gq, GHS-R1a also promoted constitutive activation of G13.

65 uxin and GA signaling, we show here that the constitutive activation of GA signaling is sufficient to

66 la mutants can be directly attributed to the constitutive activation of GA signaling.

67 Constitutive activation of Galphaq signaling by mutation

68 However, the inhibition of constitutive activation of gp130DeltaYY was achieved by

69 ti-gp130 mAbs directed against D1, abolished constitutive activation of gp130DeltaYY, highlighting th

70 riants of gp130 were not able to inhibit the constitutive activation of gp130DeltaYY.

71 cells with increased proliferative capacity, constitutive activation of granulocyte macrophage colony

72 er development that often occurs through the constitutive activation of growth factor receptors or th

73 independently of the mTORC1 pathway, whereas constitutive activation of GSK3beta reduces AKT-induced

74 aneous deletion of SSE1 and FES1 resulted in constitutive activation of heat shock protein expression

75 Here, we determined that constitutive activation of hedgehog signaling specifical

76 h-level expression of HRG is associated with constitutive activation of HER3 in SCCHN and thus define

77 Using a genetic model involving constitutive activation of Hh pathway in SF1(+) cells, w

78 ause either inhibition with Hh inhibitors or constitutive activation of Hh signaling activity in tran

79 c mouse models, we show that B-cell-specific constitutive activation of HH/GLI signaling either at th

80 Notably, liver-specific constitutive activation of HIF-2alpha, but not HIF-1alph

81 nhibition of the HIF pathway since ~80% show constitutive activation of HIF.

82 Inactivation of vhl in zebrafish led to constitutive activation of HIF2alpha orthologs and model

83 predispose to paraganglioma tumors that show constitutive activation of hypoxia responses.

84 by loss of the tumor-suppressor VHL, driving constitutive activation of hypoxia-inducible factor-1 (H

85 Notably, constitutive activation of IkappaBalpha/NF-kappaB(p65) i

86 Constitutive activation of IKKbeta in the esophageal epi

87 primary ovarian and breast tumors confirmed constitutive activation of ISGs.

88 cytokines including IL-6 and -13, leading to constitutive activation of JAK/STAT signaling.

89 nitiates an epigenetic switch leading to the constitutive activation of JAK1/STAT3 signalling, which

90 ave an acquired mutation (JAK2V617F) causing constitutive activation of JAK2.

91 domain and how pathogenic mutations lead to constitutive activation of JAK2.

92 e JAK2 c.1849G>T (p.V617F) mutation leads to constitutive activation of Janus kinase (JAK)2 and contr

93 hrombopoietin (TPO) receptor (MPL) to induce constitutive activation of Janus kinase 2 and signal tra

94 Although constitutive activation of Janus kinase 3 (Jak3) leads t

95 kk7 knockout mice (MKK7 cKO), which impaired constitutive activation of JNK in the nervous system.

96 rol is overridden in infected cells to allow constitutive activation of lipogenesis.

97 Gclm KO mice also exhibit constitutive activation of liver AMP-activated protein k

98 ts indicate that the N514Y mutation produces constitutive activation of M(3)-AChR by decreasing the r

99 mas are slow-growing tumours associated with constitutive activation of mammalian target of rapamycin

100 sis complex is a genetic disorder leading to constitutive activation of mammalian target of rapamycin

101 wn genomic alterations in glioma that induce constitutive activation of MAPK are transcriptionally li

102 Interestingly, constitutive activation of miR408 in the spl7 background

103 inhibitor of mitochondrial complex III, and constitutive activation of mitochondrial retrograde sign

104 These data indicate constitutive activation of mitophagy results in reductio

105 We then showed that both inhibition and constitutive activation of mTOR during tutor experiences

106 with S6 and 4EBP phosphorylation in vivo and constitutive activation of mTOR kinase activity in vitro

107 Here we report that, unexpectedly, constitutive activation of mTOR signalling by Tsc1 delet

108 TSC2 deficiency induces constitutive activation of mTOR, leading to a state of i

109 Constitutive activation of mTORC1 by depletion of tubero

110 st, glucose did not suppress mTORC1, and the constitutive activation of mTORC1 failed to suppress pla

111 ession of cone death during disease and that constitutive activation of mTORC1 in cones is sufficient

112 Recent studies have suggested that constitutive activation of mTORC1 in normal cells could

113 Constitutive activation of mTORC1 preserved cones in 2 m

114 ed mTORC1 signaling in vitro and in vivo The constitutive activation of mTORC1 reduced hepatic lipoge

115 Loss of the PTEN tumor suppressor results in constitutive activation of mTORC1 through the Akt-depend

116 gain of function causes fatty liver through constitutive activation of mTorc1, an effect that is rev

117 Expression of JAK2V617F results in constitutive activation of multiple signaling molecules/

118 B-P4 might be a valuable tool to inhibit the constitutive activation of naturally occurring gp130 mut

119 Conversely, constitutive activation of neuronal ALK5 in forebrain ca

120 this epidermal phenotype was associated with constitutive activation of NF-kappaB (RelA) and increase

121 the transglutaminase TG2 has been linked to constitutive activation of NF-kappaB and chemotherapy re

122 ) mouse livers, and this was associated with constitutive activation of NF-kappaB and JNK, along with

123 ver, the molecular mechanisms that result in constitutive activation of NF-kappaB are poorly understo

124 e/paracrine TLR5 signaling loop resulting in constitutive activation of NF-kappaB both in vitro and i

125 egulatory mechanisms that avoid excessive or constitutive activation of NF-kappaB may be associated w

126 Conversely, constitutive activation of NF-kappaB selectively in wild

127 To model constitutive activation of NF-kappaB, we expressed a tra

128 n regulatory network in epithelial cells via constitutive activation of NF-kappaB.

129 In contrast, constitutive activation of NFATc1 nullifies the protecti

130 ls to inflammatory signals, and the abnormal constitutive activation of NFkappaB is important for the

131 ts and that this increase is attributable to constitutive activation of nicotinamide adenine dinucleo

132 in primary T cells, TRAF1 also restricts the constitutive activation of NIK in anti-CD3-activated T c

133 Here we demonstrate in Arabidopsis that the constitutive activation of NIK1, a leucine-rich repeat r

134 -inactive c-IAP2 mutant (c-IAP2(H570A)) have constitutive activation of non-canonical NF-kappaB, resu

135 e formation of all nephron segments and that constitutive activation of Notch in developing nephrons

136 and Hnf1b Consistent with this, we find that constitutive activation of Notch in mesenchymal nephron

137 t of a multistep oncogenic process involving constitutive activation of NOTCH signaling and genetic a

138 Constitutive activation of Notch signaling fully blocked

139 At the molecular level, constitutive activation of Notch signaling inhibits, whe

140 ptosis in cultured human leukemic cells with constitutive activation of Notch signaling.

141 dation of some of these findings showed that constitutive activation of Notch1 deregulated glutamine

142 Accordingly, constitutive activation of Notch1 prevents SC depletion

143 enhanced fear memory generalization, whereas constitutive activation of NR neurons decreased memory g

144 Somatic mutations that lead to constitutive activation of NRAS and KRAS proto-oncogenes

145 ibly providing a scenario similar to that of constitutive activation of Nrf2 found in certain human c

146 duct phenotypes could be recapitulated with constitutive activation of Nrf2 signaling in Keap1(F/F):

147 ation of the Nrf2-Keap1 axis, which leads to constitutive activation of Nrf2.

148 Constitutive activation of nuclear factor kappa B (NF-ka

149 elial-mesenchymal transition (EMT), but also constitutive activation of nuclear factor kappa B (NFkap

150 Mechanistically, CB sparks the constitutive activation of oestrogen receptors alpha (ER

151 This coincides with the constitutive activation of one of the downstream effecto

152 ubicin or nutlin-3 results in continuing and constitutive activation of p53, inhibition of XIAP and s

153 Constitutive activation of PDGFRalpha leads to expansion

154 The Pten phenotype is mimicked by constitutive activation of PI3 kinase and is rescued by

155 4/CD25/CD45RO/CD69 immunophenotype, promoted constitutive activation of PI3K/Akt, IkappaB kinase/NF-k

156 We further show that constitutive activation of PKB in vivo results in a loss

157 ate that the PLCgamma1-R707Q mutation causes constitutive activation of PLCgamma1 and may represent a

158 lterations in MIBC that convergently lead to constitutive activation of PPARgamma/RXRalpha and result

159 vasion phenotypes is mediated in part by the constitutive activation of pro-inflammatory nuclear fact

160 trigger chronic inflammation, which leads to constitutive activation of pro-inflammatory signaling pa

161 Here, we identified constitutive activation of proapoptotic Bax, maintained

162 derailed in B cell malignancies, leading to constitutive activation of prosurvival pathways.

163 ominant-negative Rab4 or Rab4 morpholino and constitutive activation of Rab5 decreases the elongation

164 Constitutive activation of Rac1 also led to podocyte det

165 dividually inhibits Rac1 activation, whereas constitutive activation of Rac1 disturbs the polarized a

166 In this study, we demonstrate that constitutive activation of Raf-1 oncogenic signaling ind

167 RASA1-deficient LECs showed evidence of constitutive activation of Ras in situ.

168 RS2, a direct substrate of FGFR1, as well as constitutive activation of RAS-MAPK signaling.

169 Constitutive activation of Ras-mitogen-activated protein

170 st phosphate uptake system component, causes constitutive activation of RegX3.

171 ncreas-specific deletion of IkappaBalpha had constitutive activation of RelA and a gene expression pr

172 Constitutive activation of RelA up-regulates Spi2A, whic

173 Constitutive activation of RhoA in Swap-70(-/-) DCs was

174 Constitutive activation of RhoA led to increased express

175 Moreover, constitutive activation of RhoA restricted three-dimensi

176 Additionally, constitutive activation of saeRS (saeRS(C)) enhanced the

177 decreased production of such factors, while constitutive activation of saeRS increases virulence, an

178 rfism, compromised pollen tube guidance, and constitutive activation of salicyclic acid-mediated defe

179 pendent of their endogenous Sox2 expression, constitutive activation of Shh signaling in CGNPs result

180 Constitutive activation of signal transducer and activat

181 Constitutive activation of SKN-1 induces a similar trans

182 results indicate that oncogenic Kras induces constitutive activation of SOX9 in HPNE and HPDE cells,

183 g-term plasticity, little is known about how constitutive activation of specific kinase isoforms sust

184 cy of both Insigs in enterocytes resulted in constitutive activation of SREBP and HMGR, leading to an

185 In an attempt to achieve constitutive activation of SRK and thus facilitate analy

186 we furthermore show that plasma LPS leads to constitutive activation of STAT1 through autocrine cytok

187 Cs and the Notch pathway, which involves the constitutive activation of STAT3 and NF-kappaB signaling

188 The constitutive activation of STAT3 and NF-kappaB signaling

189 Constitutive activation of STAT3 imparts resistance to a

190 e resulted in phospho-Stat3 accumulation and constitutive activation of Stat3-driven genetic programs

191 r GC cell lines including AGS cells, showing constitutive activation of STAT3.

192 eement with this model, we observed that the constitutive activation of Stat5 cooperates with the los

193 We have detected constitutive activation of STAT5 in malignant B cells de

194 Importantly, primary T-PLL cells exhibited constitutive activation of STAT5, and targeted pharmacol

195 translocation partner in lipoma), induced by constitutive activation of STAT5, but not by transient c

196 In this study, we demonstrated that constitutive activation of STAT6 in KSHV-associated PEL

197 We hypothesize a constitutive activation of stem cell division kinetics s

198 es dysregulation of apoptosis, mainly due to constitutive activation of survival pathways including J

199 stitutive photomorphogenesis associated with constitutive activation of target genes, elevated levels

200 lacement of Leu(180)-Ile(181) led to partial constitutive activation of TbetaRI, resulting in part fr

201 dependent regulation of TERT and elicits the constitutive activation of telomerase.

202 ing mice with either T cell-specific loss or constitutive activation of TGF-beta signaling, we demons

203 , enabling the intestinal flora to trigger a constitutive activation of the anterior midgut immune re

204 llomavirus 31 (HPV31)-positive cells exhibit constitutive activation of the ATM-dependent DNA damage

205 mphocytic leukemia (CLL) is characterized by constitutive activation of the B-cell receptor (BCR) sig

206 that AP-1, like NF-kappaB, was controlled by constitutive activation of the B-cell receptor signaling

207 ve activating mutations in B-Raf, leading to constitutive activation of the B-Raf/MKK/ERK signaling p

208 In chronic myelogenous leukemia, the constitutive activation of the BCR-ABL kinase transforms

209 or the pathogenesis of these tumors, whereby constitutive activation of the cAMP pathway and EZH1 mut

210 Constitutive activation of the canonical and noncanonica

211 This response is attenuated in mutants with constitutive activation of the corticotropin-releasing f

212 ogous expression of STIM1 p.R304W results in constitutive activation of the CRAC channel in vitro, an

213 These results highlight the importance of constitutive activation of the de novo purine synthesis

214 We show that Pten deletion, or constitutive activation of the downstream kinase AKT, ac

215 It is predicted to prevent constitutive activation of the downstream signaling doma

216 Constitutive activation of the EGFR is common in cancer

217 of chronic energy deprivation, resulting in constitutive activation of the energy-stress sensor AMPK

218 Constitutive activation of the epidermal growth factor r

219 erized by frequent loss of PTCH1, leading to constitutive activation of the Hedgehog pathway.

220 findings indicate that MUC1-C contributes to constitutive activation of the HER2 pathway and that tar

221 ippel-Lindau tumor suppressor and subsequent constitutive activation of the hypoxia-inducible factors

222 tween the IIS and Rag-TORC1 pathways because constitutive activation of the IIS pathway requires Rag

223 nce of CD37 drives tumor development through constitutive activation of the IL-6 signaling pathway.

224 ation of the IkappaB kinase complex prevents constitutive activation of the immune deficiency pathway

225 One such mechanism may be through constitutive activation of the insulin-like growth facto

226 or without TCR stimulation, correlated with constitutive activation of the intrinsic death pathway.

227 Constitutive activation of the JAK/STAT pathway downstre

228 All these aberrations lead to the constitutive activation of the JAK/STAT3 pathway, which

229 ise to growth factor-independent clones with constitutive activation of the Janus kinase (JAK)- signa

230 atic human mutation (p.Ser646Phe) inducing a constitutive activation of the Janus kinase (JAK)/STAT p

231 followed by a persistent, ligand-independent constitutive activation of the kappaOR itself.

232 Constitutive activation of the kinases Akt or protein ki

233 Balloon cells (BCs) in FCDIIB exhibit constitutive activation of the mammalian target of rapam

234 Constitutive activation of the mammalian target of rapam

235 ciency of the transcription factor pCREB and constitutive activation of the MAP kinases phospho-ERK1/

236 ve fitness normalize GSK3beta activity after constitutive activation of the MAPK pathway, commonly th

237 Expression of mutant BRAF(V600E) results in constitutive activation of the MAPK pathway, which can l

238 n BRAF, mainly at codon 600, which result in constitutive activation of the MAPK pathway.

239 vating mutations drive tumorigenesis through constitutive activation of the MAPK pathway.

240 es, elevated baseline expression relied upon constitutive activation of the MAPK pathway.

241 utation in the TSC1 or TSC2 genes leading to constitutive activation of the mechanistic target of rap

242 We present evidence that constitutive activation of the mitogen-activated protein

243 Activating BRAF mutations promote constitutive activation of the mitogen-activated protein

244 nes and enhanced freezing tolerance, whereas constitutive activation of the MKK4/5-MPK3/6 cascade in

245 MORPHOPROTEOMIC TUMOR ANALYSES REVEALED CONSTITUTIVE ACTIVATION OF THE MTOR PATHWAY AS EVIDENCED

246 Structural modeling supported constitutive activation of the mutant STING protein base

247 NF-kappaB in hypoxic breast cancer cells and constitutive activation of the NF-kappaB pathway in CAIX

248 DLBCL (ABC-DLBCL), which is characterized by constitutive activation of the NF-kappaB pathway, carry

249 sed production of inflammatory cytokines and constitutive activation of the NF-kappaB pathway.

250 leted in multiple myeloma (MM), resulting in constitutive activation of the noncanonical nuclear fact

251 Constitutive activation of the nuclear factor-kappa B (N

252 eractions with the targets, thereby enabling constitutive activation of the nuclear factor-kappa B, a

253 ononuclear cells from the patients indicated constitutive activation of the pathway that cannot be fu

254 y, miR-17~92-driven lymphoma cells exhibited constitutive activation of the PI3K and NFkappaB pathway

255 Constitutive activation of the PI3K/mTOR signaling pathw

256 o alters EGF receptor signaling and leads to constitutive activation of the protein kinase Akt.

257 omain-mediated polymerization of EN leads to constitutive activation of the PTK domain and constituti

258 ecked TLR-induced inflammatory responses and constitutive activation of the Pyrin inflammasome.

259 of the cognate sensor QseC leads to robust, constitutive activation of the QseB response regulator b

260 BRAF V600E leads to the constitutive activation of the RAF-MEK-extracellular sig

261 nd/or with PTEN deletion based on the common constitutive activation of the Raf/MEK/ERK and PI3K/AKT

262 There was constitutive activation of the Ras/Raf/ERK pathway p-ERK

263 nal proline-rich motif of FGFR2 inducing the constitutive activation of the receptor, thereby prompti

264 nic mutations in KIT are present, leading to constitutive activation of the receptor, which drives th

265 In contrast, three other mutants showed constitutive activation of the reporter in the roots and

266 rase reporter for monitoring the GSR support constitutive activation of the response in this mutant b

267 nnoma cells, containing merlin mutations and constitutive activation of the Rho/Rac family of GTPases

268 gly, loss of casein kinase 1 activity causes constitutive activation of the RIM pathway, and, accordi

269 Constitutive activation of the signal transducer and act

270 In contrast, constitutive activation of the small GTPase Rap1 restric

271 blastoma consists of four major groups where constitutive activation of the Sonic Hedgehog (SHH) sign

272 This disruption leads to a constitutive activation of the spindle-assembly checkpoi

273 Accordingly, IL6 mediated constitutive activation of the STAT3 pathway, an essenti

274 In conclusion, our studies suggest that constitutive activation of the STAT3-Pim1 pathway repres

275 both adherent and spheroid glioma CSCs show constitutive activation of the STAT3/NF-kappaB signaling

276 IL6-mediated inflammation programs constitutive activation of the TAK1-NFkappaB signaling c

277 In fact, in CD44+/CD24- cells, constitutive activation of the TGF-beta axis was both ne

278 egulation of lysosomal protein expression by constitutive activation of the transcription factor EB (

279 subtype characterized by adverse outcome, is constitutive activation of the transcription factor nucl

280 Constitutive activation of the UPR(mt) by gain of functi

281 Constitutive activation of the Wnt pathway resulting fro

282 Constitutive activation of the Wnt pathway, one of the e

283 Constitutive activation of the Wnt pathway/beta-catenin

284 Constitutive activation of the Wnt/beta-catenin signalin

285 sidues within TM6 and TM7 results in a weak 'constitutive' activation of the pathway.

286 Constitutive activation of this loop in transformed cell

287 romotes osteoblast differentiation in vitro, constitutive activation of this pathway impairs bone for

288 Constitutive activation of this positive feedback loop m

289 Constitutive activation of this signaling module has bee

290 Also, constitutive activation of Toll and IMD pathways by knoc

291 The second-site mutations prevent constitutive activation of TpoR W515K/L, while preservin

292 In multiple forms of cancer, constitutive activation of type I IFN signaling is a cri

293 These mutations confer cGAMP-independent constitutive activation of type I interferon signaling t

294 Emerging evidence suggests that constitutive activation of various signaling pathways li

295 ptor-related protein 5 Wnt coreceptor causes constitutive activation of Wnt signaling, and in adenovi

296 Constitutive activation of Wnt-beta-catenin signaling fu

297 Constitutive activation of Wnt/beta-catenin inhibits oli

298 t common mechanisms of misregulation lead to constitutive activation of WT STATs.

299 Here we show that constitutive activation of XBP1 in tumor-associated DCs

300 Overexpression or constitutive activation of YAP leads to transformation a