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1 that Golgi-resident enzymes cycle to the ER constitutively.
2 majority of STAT2 is phosphorylated on T387 constitutively.
5 We utilize this technique to transiently or constitutively activate a typical human oncogene, kRASG1
6 as a developmentally controlled potential to constitutively activate GL promoters but that this activ
7 atent membrane protein 1 (LMP1) functions to constitutively activate NF-kappaB signalling, and we obs
8 in this interface displace the macro domain, constitutively activate the ALC1 ATPase independent of P
9 ere, we have shown that MLL-ENL and MLL-AF10 constitutively activate transcription by aberrantly indu
10 e canonical NF-kappaB pathway, which becomes constitutively activated following overexpression of the
11 Here we show that SPHK1 is overexpressed and constitutively activated in primary AML patient blasts b
13 ological CD207(+) dendritic cells (DCs) with constitutively activated mitogen-activated protein kinas
15 ammasomes are mediators of inflammation, and constitutively activated NLRP3 inflammasomes have been l
16 th the overexpression of either wild-type or constitutively activated PDGFRA (platelet-derived growth
17 ssion of the PKC1(R398P) gene, which encodes constitutively activated Pkc1p, rescued crd1Delta growth
18 and dimerization, and inducing apoptosis to constitutively activated STAT3 cancer cells without cyto
19 t encode an abnormal RAS protein locked in a constitutively activated state to drive malignant transf
21 e found that Rho kinase (ROCK) signaling was constitutively activated, resulting in increased cytoske
23 so show that growth/proliferation signals by constitutively-activated EGFR may rely on TGFbeta and a
24 ts of NLRC4, H443P, but not T337A and V341A, constitutively activates caspase-8 and induces apoptotic
26 ed guanine nucleotide-exchange factors or of constitutively active (but not wild-type) forms of these
27 e investigated the responses controlled by a constitutively active (CA) MPK3 in Arabidopsis thalianaC
30 n treatment and adenoviral overexpression of constitutively active AMPK downregulated mitochondrial s
31 Using mice expressing dominant negative and constitutively active Ampk in skeletal muscle, we demons
32 ever, in tumorigenesis, STAT proteins become constitutively active and promote the expression of prog
33 xhaustion, or oncogene activation, mTORC1 is constitutively active and resistant to serum and amino a
35 raint from un-liganded LBD as exemplified by constitutively active AR variants (AR-Vs), which are ass
36 ments that allosterically suppress otherwise constitutively active AR-Vs; one in exon 5 for v6es and
39 ids of the endogenous TTP protein renders it constitutively active as an mRNA-destabilizing factor.
41 whether the EBV LMP2A protein, which mimics constitutively active B cell receptor signaling, is requ
46 eserpine (VMAT inhibitor), and VP16-XlCreb1 (constitutively active CREB) would break the all-or-none
50 mall cell lung cancer xenograft expressing a constitutively active EGFR conformational mutant exhibit
51 ible transgenic line to induce expression of constitutively active ErbB2 (caErbB2) selectively in SCs
54 ress the AMPylation activity mediated by the constitutively active Fic(E247G) mutant in Drosophila S2
55 Here, we show that excessive AMPylation by a constitutively active Fic(E247G) mutant is lethal in Dro
56 overed by MTORC1 inhibition or expression of constitutively active forkhead box protein O1 (FoxO1).
57 t cancer cell lines expressing an inducible, constitutively active form of IkappaB kinase beta (CA-IK
60 AURs was also enhanced in lines expressing a constitutively active form of the BR signaling component
61 ected liver tissues from mice that express a constitutively active form of YAP (YAP(S127A)) and analy
62 tive to changes in free Ca2+, resulting in a constitutively active form under physiological Ca2+-conc
68 sing a forward genetic approach, we isolated constitutively active gain-of-function variants of the A
70 tion of adhesion, we analyzed the effects of constitutively active Galphai1(Q204L) expression on adhe
71 ion, whereas the expression of Gli2DeltaN, a constitutively active Gli2, restored Hh pathway activati
72 In Saccharomyces cerevisiae pho84 mutants, constitutively active Gtr1 suppresses a TORC1 signaling
75 ble for Tr1 cell induction, as expression of constitutively active HRas rescues IRF4 expression and T
76 ing the putative substrate-binding site in a constitutively active Hsp104 variant impairs the recover
77 we report that Igfbp7-deficient mice exhibit constitutively active IGF signaling, presenting with pro
80 enchymal Twist2-Cre to drive expression of a constitutively active inhibitor of NF-kappaB kinase subu
81 hosphatase-1 through the overexpression of a constitutively active inhibitor-1 (I-1c) has been shown
85 l-like ovarian cancer cells by co-expressing constitutively active MEK1 and Src rather than either al
88 expression of the wild-type receptor and its constitutively active mutant form, EGFRvIII, limits sens
89 ted by mutant LRRK2, whereas expression of a constitutively active mutant of NCLX that enhances calci
90 Overexpression of a FAK phosphomimetic and constitutively active mutant p-FAK-Y407E in these cells
93 own previously for rod cells, attenuation of constitutively active opsin can be achieved with the unb
97 e because PTEN deficiency or expression of a constitutively active PI3K rescued function of B cells i
98 by activating PP2A(Cdc55) We discovered that constitutively active Pkc1 can drive cells through a mit
99 c neurons throughout the brain expressed the constitutively active PKM1 isoform, while neural progeni
102 acrophages; while rLm30 expressing r30 via a constitutively active prfA* regulon (rLmIII/a30) express
103 Assembly of the endocytic machinery is a constitutively active process that is important for the
104 Here we show that CK2, a ubiquitous and constitutively active protein kinase, phosphorylates HSJ
107 ansgenic mice with cardiac overexpression of constitutively active Rac1 (RacET) develop an age-depend
108 ike ovarian cancer cells, whereas expressing constitutively active Rac1 leads to EMT in epithelial-li
109 Src are higher in ovarian cancer cells with constitutively active Rac1, we conclude that Rac1 sustai
110 1/2 (MEK1/2) and Src inhibitors can abolish constitutively active Rac1-led EMT and mesenchymal trait
111 matrix degradation by invadopodia, whereas a constitutively active Rac3 can rescue the deficits in in
112 hai1(Q204L) expression on adhesion driven by constitutively active Rap1a(G12V) or its downstream effe
113 is and leading to high expression of ERAS, a constitutively active RAS protein normally expressed onl
114 full activation of signalling downstream of constitutively active RAS with which it interacts in a B
115 gnaling driven by TGFbeta ligand Activin and constitutively active receptors Alk4 and Alk2 remain int
116 s of active ROP2, including those expressing constitutively active ROP2 (CA-ROP2), contain high level
117 CYTOKININ INDEPENDENT1 (CKI1), encoding the constitutively active sensor His kinase that activates M
121 as free from HSP90, exclusively nuclear, and constitutively active similarly as previously reported f
124 Moreover, overexpression of wild-type and constitutively active SOD2 similarly blunted inflammasom
125 M2 isoform of pyruvate kinase (PK) over its constitutively active splice variant M1 isoform is consi
127 This study, along with other studies of constitutively active STAT mutants, provides insight int
128 carboxamide (AICAR) or adenovirus expressing constitutively active subunits of AMPK decreased cue-ind
131 splice variants including AR-V7 function as constitutively active transcription factors in CRPC cell
132 he link between GRHL2 and AR also applied to constitutively active truncated AR variants (ARV), as GR
133 through adeno-associated virus expressing a constitutively active type I receptor significantly redu
135 ; its disruptive effects can be rescued by a constitutively active UNC-9::GFP protein, demonstrating
136 silencing and forced expression of wild-type/constitutively active variants, we provide evidence that
139 cells is stimulated by myristoylated (i.e., constitutively active) Akt and reduced by the Akt-specif
140 g kinase, cyclin H-CDK7-Mat1 (CAK), which is constitutively active, is responsible for the activating
141 programmable transcriptional regulators are constitutively active, precise temporal and spatial cont
142 LRT persistence even when BvgAS is rendered constitutively active, suggesting the presence of BvgAS-
143 strains with altered GAL1 promoter dynamics (constitutively active, synthetic with nucleosome-disfavo
145 Glycogen synthase kinase-3 (GSK-3) is a constitutively active, ubiquitously expressed protein ki
147 dual neurons using dominant-negative (dn) or constitutively-active (ca) forms of nuclear-localized Ca
148 e main IL-4-producing endometrial leukocyte (constitutively and during Chlamydia infection), whereas
150 (OX) OsALMT4 released malate from the roots constitutively and had 2-fold higher malate concentratio
153 newly developed 3D7-derived parasite lines, constitutively and stably expressing DiCre, generated us
154 We observed that EEPD1 and Exo1 interact constitutively, and Exo1 repairs stalled replication for
155 usters of FcgammaRI, but not FcgammaRII, are constitutively associated with nanoclusters of SIRPalpha
159 nt source of type II cytokines and are found constitutively at mucosal surfaces and in visceral adipo
161 Among these, activation of CK1varepsilon, constitutively bound to LRP5/6 through p120-catenin, is
162 escue the phenotype of rdn1-2 when expressed constitutively, but the less related MtRDN3 cannot.
163 ts ligands, RAE-1epsilon, which is expressed constitutively by lymph node endothelial cells and highl
164 ings indicate that L-selectin is transported constitutively by the AP-1 complex, leading to the forma
166 ome inhibitor MG132, suggesting that MKP1 is constitutively degraded through the proteasome in the re
170 acquired the ability to metastasize in vivo constitutively downregulated SNPH and exhibited higher o
171 croscopy show that NEDD4 unrestrained mutant constitutively downregulates the IKS channel, thus confi
172 ibrotic response, while transgenic mice with constitutively elevated adiponectin showed selective dWA
173 s of genotypes including ceh1, a mutant with constitutively elevated levels of both the stress-specif
175 o33 variant to elucidate the consequences of constitutively enhanced alphavbeta3 signaling to the 5-H
178 ured myoblasts and fibroblasts, which do not constitutively express ICAM-1, and myoblasts and fibrobl
179 tudy, we demonstrated that human neutrophils constitutively express Sema3E high-affinity receptor, Pl
180 -expressing T cell lines were constructed to constitutively express the LEDGF-binding VH and these ce
182 We show for the first time that Hmox1 is constitutively expressed at barrier tissues at the inter
187 phaBC) is a small heat shock protein that is constitutively expressed by peripheral nervous system (P
188 w that SOX2, a hallmark protein of NSPCs, is constitutively expressed by virtually all ELCs before, d
189 lla enterica serovar Typhimurium to link the constitutively expressed CspC and CspE proteins with vir
192 The discovery of the hormonally regulated, constitutively expressed IFN has suggested a function fo
195 nate isoleucine (JA-Ile) co-receptor JAZ2 is constitutively expressed in guard cells and modulates st
196 CD27, a member of the TNFR superfamily, is constitutively expressed in most T cells and plays cruci
198 The antimicrobial peptide (AMP) RNase 7 is constitutively expressed in the epidermis of healthy hum
205 olved in regulating membrane potentials were constitutively expressed only in the roots of tolerant i
207 o protein S, the other TAM ligand, which was constitutively expressed postnatally, expression of GAS6
208 Housekeeping genes (HKG) are presumed to be constitutively expressed throughout tissue types but rec
209 all introgressed region carried by RIL 46, a constitutively expressed TIR-NBS-LRR gene was identified
212 ncers identified a new, essential role for a constitutively expressed, lineage-restricted ETS-family
213 The fsrR, tcrA, tcsA and rpoN genes were constitutively expressed, whereas lpiA and acvB were str
219 We demonstrate that transgenic silkworms constitutively expressing Cas9 and guide RNAs targeting
221 urvival of human embryonic stem cells (hESC) constitutively expressing GFP (H9 Cre-LoxP) in deaf guin
223 NN to prevent nodule formation, while plants constitutively expressing MtCLE13 require only SUNN, sug
225 ins STING and IFI16 were eliminated in cells constitutively expressing UL46 and that the accumulation
226 verged Saccharomyces species, GAL genes show constitutively faster activation due to genetically enco
228 tocephalus infection, and their granulocytes constitutively generate threefold more reactive oxygen s
229 thaliana mutant that accumulates zeaxanthin constitutively, have reported that this xanthophyll can
230 uced by a variety of lymphocyte populations, constitutively high IL-22 expression was limited to lymp
235 way, from IRS2 to PDK1 phosphorylation, were constitutively impaired in FL-N/35 primary hepatocytes v
236 e NOTCH3, we report here that NOTCH3 signals constitutively in a panel of basal breast cancer cell li
237 oxicity, appropriate for a protein expressed constitutively in a sensitive mucosal site, such as the
238 he ChaC2 proteins were found to be expressed constitutively in cells, unlike the tightly regulated Ch
239 Importantly, the TLR4 pathway was activated constitutively in KSHV-transformed cells, resulting in c
242 f ex-Foxp3(+) T cells in mice expressing NIK constitutively in Tregs, and these former Tregs produced
244 fferent forms of LGR5, a wild-type form that constitutively internalizes and two mutant forms whose i
247 te, we found that the IRAK1 kinase domain is constitutively monomeric regardless of its phosphorylati
254 1/2 double-knockout neurons, expression of a constitutively open mutant of syntaxin could only minima
256 hromycin in 36% of the strains, and 33% were constitutively or inducibly resistant to clindamycin.
257 adation of normal proteins that happen to be constitutively or inducibly unstable, and in this capaci
261 ase 2 (CK2) binds to the NHE3 C-terminus and constitutively phosphorylates a downstream site (S719) t
262 ion of thermomorphogenesis involves UVR8 and CONSTITUTIVELY PHOTOMORPHOGENIC 1 (COP1)-mediated repres
263 we show that 14 CO-like (COL) proteins bind CONSTITUTIVELY PHOTOMORPHOGENIC1 (COP1) and SUPPRESSOR O
264 subcutaneous tumors engineered to either be constitutively positive (CT26 hPD-L1) or be negative (De
265 rare subpopulation of activated macrophages constitutively positive for IL-12/23 p40 and capable of
267 ollagen and the CLEC2 ligand podoplanin were constitutively present in the lung, whereas the GPVI lig
269 By contrast, dual-pass CRD-NRG1 and NRG3 are constitutively processed by BACE and accumulate on axons
270 he intermediate filament keratin 6a (K6a) is constitutively processed into antimicrobial fragments in
272 are benign tumors of the adrenal gland that constitutively produce the salt-retaining steroid hormon
273 sing high levels of ZIKV prM-E proteins that constitutively produce VLPs as well as a cell line expre
274 cant fraction of DLBCL patients, tumor cells constitutively produced the ELC-CXC chemokine CXCL-8 (IL
276 y conserved MCV LT phosphorylation sites are constitutively recognized by cellular Fbw7, betaTrCP, an
277 k indicates that salivary glands are able to constitutively recruit CD8(+) T cells and retain them as
278 that the basal transcription factor TFIIH is constitutively recruited by ER-Y537S, resulting in ligan
279 from the second trimester of pregnancy also constitutively release type III IFNs and use these IFNs
281 FN)-gamma or epithelial-derived IFN-gamma in constitutively released or Porphyromonas gingivalis lipo
282 rescence4-3 (ref4-3) results in dwarfism and constitutively repressed phenylpropanoid accumulation.
284 p57(Kip2) is a major target of miR-92a that constitutively safeguards podocyte cell cycle quiescence
285 Here, we show that all blood neutrophils constitutively secrete APRIL, and inflammation-associate
286 rge quantities of immunoglobulin A (IgA) are constitutively secreted by intestinal plasma cells to co
290 Interestingly, the MEKK1-MKK2-MPK4 pathway constitutively suppresses MPK3 and MPK6 activities and h
291 en to determine whether IRS-1 is functioning constitutively to maintain VSMCs in their differentiated
292 portion of the N-terminal domain is targeted constitutively to the basolateral membrane irrespective
293 anscription start sites of HSV-1-induced and constitutively transcribed antisense transcripts are hig
297 AX and monoubiquitinated PCNA and FANCD2 are constitutively up-regulated in oxaliplatin-resistant HCT
299 acrophages perform vigorous macropinocytosis constitutively, while proinflammatory cells are virtuall
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