ライフサイエンスコーパス: constitutively active

1 Conversely, the p.Tyr64Asp substitution is constitutively active.

2 that loss of regulation renders the myosin V constitutively active.

3 te domain, consequently rendering the kinase constitutively active.

4 ur data demonstrate that alphaT-catenin is a constitutively active actin-binding protein that can phy

5 report here the 3.3 A crystal structure of a constitutively active, agonist-bound neurotensin recepto

6 nock-out (cKO) retinas, and misexpression of constitutively active Akt (Akt-CA) in retinal explants p

7 son transfection system with transduction of constitutively active AKT (myr-AKT) and Yes-associated p

8 The transposase-mediated transduction of constitutively active AKT and Yes-associated protein in

9 Expression of a constitutively active Akt construct partially relieved c

10 Introduction of constitutively active AKT in GSCs compromised hypertherm

11 Conversely, constitutively active Akt induced HSF-1 phosphorylation

12 creased Sort1 protein, whereas expression of constitutively active AKT induced Sort1 protein in AML12

13 mulation of AKT by IGF-I, mimicked also by a constitutively active AKT mutant, reduced oxidative stre

14 tic activity of MGLL and overexpression of a constitutively active Akt rescued cells from inhibition

15 Overexpression of constitutively active AKT resulted in the downregulation

16 s issue, we generated murine liver tumors by constitutively active AKT-1 (AKT) and beta-catenin (CAT)

17 cells is stimulated by myristoylated (i.e., constitutively active) Akt and reduced by the Akt-specif

18 Expression of constitutively active Akt1 strongly inhibited network fo

19 ts in CAPE-treated embryos are suppressed by constitutively active Akt1.

20 n treatment and adenoviral overexpression of constitutively active AMPK downregulated mitochondrial s

21 nfectious virions, while overexpression of a constitutively active AMPK had the opposite effects.

22 Using mice expressing dominant negative and constitutively active Ampk in skeletal muscle, we demons

23 ofuranoside, metformin, or overexpression of constitutively active AMPK markedly attenuated TGF-beta1

24 wo different fractions of IGF1R, one that is constitutively active and a second that is activated by

25 data to reveal how these mutations lead to a constitutively active and antiestrogen-resistant ERalpha

26 the WT-AT1 receptor, the N111G-AT1 receptor (constitutively active and biased for the Gq/11 pathway),

27 r trafficking by chemical inhibitors or with constitutively active and dominant negative Rab expressi

28 The JAK2V617F mutation, which renders JAK2 constitutively active and has been linked to myeloprolif

29 8G cells, estrogen-ERalpha target genes were constitutively active and partially antiestrogen resista

30 ever, in tumorigenesis, STAT proteins become constitutively active and promote the expression of prog

31 xhaustion, or oncogene activation, mTORC1 is constitutively active and resistant to serum and amino a

32 TRPV6 channels are constitutively active and their open probability depends

33 e the canonical effectors, BOK appears to be constitutively active and unresponsive to antagonistic e

34 pecifically, the expression of truncated and constitutively active AR variant 7 (AR-V7).

35 raint from un-liganded LBD as exemplified by constitutively active AR variants (AR-Vs), which are ass

36 Our findings identify a novel constitutively active AR-V, ARv5es and establish a metho

37 ments that allosterically suppress otherwise constitutively active AR-Vs; one in exon 5 for v6es and

38 response to therapy is the expression of the constitutively-active AR-V7 splice variant generated by

39 Finally, expression of constitutively active ARF1 in fibroblasts induced format

40 This phenotype is suppressed by constitutively active arl-8 or unc-104 mutants.

41 of Glu-87 to Ala or Gly rendered the protein constitutively active as a kinase, but with lower autoph

42 ids of the endogenous TTP protein renders it constitutively active as an mRNA-destabilizing factor.

43 free radical-producing E. coli mutant, but a constitutively active atfs-1 mutant growing on wild-type

44 Conversely, overexpressing constitutively active Atg7, which forces autophagy and r

45 whether the EBV LMP2A protein, which mimics constitutively active B cell receptor signaling, is requ

46 It is thought that KRAS oncoproteins are constitutively active because their guanosine triphospha

47 and colon (SW480, HCT116) cancer cells with constitutively active beta-catenin signaling, SAMe and M

48 Delivery of constitutively active beta-catenin yielded insights into

49 basal progenitor cell-specific expression of constitutively active BMP promoted squamous differentiat

50 Both constructs were constitutively active but were monomeric as determined b

51 ed guanine nucleotide-exchange factors or of constitutively active (but not wild-type) forms of these

52 Conversely, overexpression of constitutively active c-Abl in hA53Talpha-syn mice accel

53 By co-expressing a constitutively active CA-FOXO3a and WT or a nonubiquitin

54 e investigated the responses controlled by a constitutively active (CA) MPK3 in Arabidopsis thalianaC

55 Renal expression of the constitutively active (CA)-SPAK mutant was specifically

56 dual neurons using dominant-negative (dn) or constitutively-active (ca) forms of nuclear-localized Ca

57 atin-like 7 channel (TRPM7) is a ubiquitous, constitutively active cation channel with a cytosolic al

58 in, latent membrane protein 1 (LMP1), mimics constitutively active CD40 and is essential for outgrowt

59 Here, the effects of constitutively active CD40 in DCs on atherosclerosis wer

60 In FliI-knockdown cells, transfection with constitutively active Cdc42 did not enable protrusion fo

61 Additional BCR stimulation of these constitutively active cells, however, led to reduced act

62 -deficient in guard cells only, expressing a constitutively active chlorophyllase in a guard cell spe

63 overexpression of Coronin 1B together with a constitutively active Cofilin mutant.

64 ic protein tyrosine kinase (Lck) exists in a constitutively active conformation, compared with <20% i

65 n homology) domains, revealing that it has a constitutively active conformation.

66 eserpine (VMAT inhibitor), and VP16-XlCreb1 (constitutively active CREB) would break the all-or-none

67 ly mimicked in WT neurons upon expression of constitutively active CRMP2 (CRMP2(T/A)).

68 Ectopic expression of a constitutively active DELLA protein in the epidermis is

69 sembly in cells generally assumed that CP is constitutively active, diffusing freely to find and cap

70 constraints on the activation loop yielded a constitutively active dimer, providing clues regarding h

71 ignal either as active monomers (class 1) or constitutively active dimers (class 2).

72 eceptor-mimic mastoparan plus GTPgammaS, and constitutively active eGFP-Galphai1 was predominantly di

73 In mice with constitutively active EGFR [EGFR(DSK5) mice], we find th

74 mall cell lung cancer xenograft expressing a constitutively active EGFR conformational mutant exhibit

75 Furthermore, in knock-in mice harboring constitutively active eNOS, elevated CRP did not invoke

76 ible transgenic line to induce expression of constitutively active ErbB2 (caErbB2) selectively in SCs

77 d D538G ERs, the two most commonly occurring constitutively active ERs.

78 therapy-resistant tumors driven by different constitutively active ERs.

79 ress the AMPylation activity mediated by the constitutively active Fic(E247G) mutant in Drosophila S2

80 Here, we show that excessive AMPylation by a constitutively active Fic(E247G) mutant is lethal in Dro

81 Constitutively active FLT3-ITD promotes the expansion of

82 overed by MTORC1 inhibition or expression of constitutively active forkhead box protein O1 (FoxO1).

83 Expression of a constitutively active form of AKT1 restored proliferatio

84 We co-delivered a transposon encoding a constitutively active form of Akt2 (myrAkt2).

85 Cell-type-specific expression of a constitutively active form of BZR1 confirms that the hig

86 t cancer cell lines expressing an inducible, constitutively active form of IkappaB kinase beta (CA-IK

87 hageal epithelia, leading to expression of a constitutively active form of IKKbeta (IKKbetaca) in epi

88 N(pro) Additionally, N(pro) interacts with a constitutively active form of IRF3 bound to its transcri

89 ation state of IRF3, since N(pro) binds to a constitutively active form of IRF3 in the presence of it

90 mice with LSL-KrasG12D mice, which express a constitutively active form of KRAS after Cre recombinati

91 A constitutively active form of mDia2 rescues the defect i

92 Misexpression of the constitutively active form of Notch, a suppressor of neu

93 Co-electroporation with a constitutively active form of PI3K rescued migration.

94 Expression of a constitutively active form of RAC1 (RACV12) in mice resu

95 brane SNARE protein SYX-5 colocalizes with a constitutively active form of RAL-1 at the plasma membra

96 A constitutively active form of SRF/Mkl1 was not sufficien

97 ors of transcription 3 inhibitor NSC74859; a constitutively active form of STAT3 was expressed in col

98 tiate leukemia, we crossed mice expressing a constitutively active form of STAT5 (Stat5b-CA) with mic

99 AURs was also enhanced in lines expressing a constitutively active form of the BR signaling component

100 We sought to determine whether expressing a constitutively active form of the GTPase Rheb (caRheb) i

101 amplified and may be truncated to generate a constitutively active form of the receptor called EGFRvI

102 d in T cells by inducing the expression of a constitutively active form of the upstream activator Ika

103 ected liver tissues from mice that express a constitutively active form of YAP (YAP(S127A)) and analy

104 tive to changes in free Ca2+, resulting in a constitutively active form under physiological Ca2+-conc

105 Because the kinase is generated in a constitutively active form, its expression levels are re

106 Moreover, expression of constitutively active forms of Akt1 and Akt2 restores th

107 Targeting of a constitutively active FoxM1 construct or the activation

108 Recruiting a constitutively active FoxM1 construct or the activation

109 Introduction of constitutively active FOXO1 mutant triggered cell cycle

110 hibitor AS1842856 or adenoviral infection of constitutively active FOXO1.

111 Our previous studies have shown that a constitutively active fusion protein of porcine interfer

112 enerated FXR-null mice with re-expression of constitutively active FXR in enterocytes (FXR(-/-)iVP16F

113 We focused on the constitutively active G12V K-Ras and two of its variants

114 fused with a fluorescent protein label, the constitutively active G12V mutant H-Ras.

115 Here, we generated a constitutively active gain-of-function (GOF) mutant of T

116 sing a forward genetic approach, we isolated constitutively active gain-of-function variants of the A

117 E activation inhibitors that did not inhibit constitutively active Galpha13-dependent SRE activation.

118 Co-expression of Gbetagamma, but not constitutively active Galphai or Galphao, inhibited TRPM

119 tion of adhesion, we analyzed the effects of constitutively active Galphai1(Q204L) expression on adhe

120 Co-expression of constitutively active Galphao prevented the RGS7-RGS7 in

121 eptor, m1, and thrombin receptor, PAR-1) and constitutively active GalphaqQL and Galpha(1)(2)/(1)(3)Q

122 alpha-Gbetagamma interaction (resulting in a constitutively active Gbetagamma) or through the disrupt

123 ion, whereas the expression of Gli2DeltaN, a constitutively active Gli2, restored Hh pathway activati

124 Expression of a constitutively active Gq protein in mice reduces UCP1 ex

125 combinant adenoviruses expressing wild type, constitutively active (GTP bound), or dominant-negative

126 In Saccharomyces cerevisiae pho84 mutants, constitutively active Gtr1 suppresses a TORC1 signaling

127 Overexpression of Gtr1 and a constitutively active Gtr1(Q67L) mutant suppresses TORC1

128 Here, we demonstrate that constitutively active Hedgehog signaling in murine inter

129 ble for Tr1 cell induction, as expression of constitutively active HRas rescues IRF4 expression and T

130 ing the putative substrate-binding site in a constitutively active Hsp104 variant impairs the recover

131 we report that Igfbp7-deficient mice exhibit constitutively active IGF signaling, presenting with pro

132 pe and transgenic mice capable of expressing constitutively active IkappaB kinase beta (CAIKKbeta) in

133 T cell-restricted constitutively active IKKbeta augmented the frequency of

134 Transfer of constitutively active IKKbeta-transduced T cells also bo

135 In contrast, flies with a constitutively active immune system had microbiota readi

136 Our data show that, in Drosophila, constitutively active immunity shapes the structure and

137 egetative development in Arabidopsis, but is constitutively active in anthers of unstressed plants.

138 found to be overexpressed, delocalized, and constitutively active in CLL cells.

139 Notch receptor 1 was constitutively active in freshly isolated human blood eo

140 and activator of transcription 3 (STAT3) is constitutively active in KSHV-associated cancers, KSHV a

141 tested by studying a V600F mutant, which was constitutively active in the absence of the negative cha

142 herefore, despite divergence, both pores are constitutively active in the absence of their partners a

143 We show that autophagy is constitutively active in the epidermal granular layer wh

144 enchymal Twist2-Cre to drive expression of a constitutively active inhibitor of NF-kappaB kinase subu

145 hosphatase-1 through the overexpression of a constitutively active inhibitor-1 (I-1c) has been shown

146 integrin beta-1 signalling, by expressing a constitutively active integrin beta-1 (CA*beta1) in the

147 but it is enhanced after overexpression of a constitutively active intracellular domain of NOTCH1.

148 Here, we report that expression of the constitutively active intracellular domain of Notch4 (N4

149 ore, which widen it, cause the channel to be constitutively active, irrespective of Ca(2+).

150 g kinase, cyclin H-CDK7-Mat1 (CAK), which is constitutively active, is responsible for the activating

151 In summary, we have identified a novel and constitutively active isoform of the RON tyrosine kinase

152 We show that different PKMs, the constitutively active isoforms of PKCs generated by calp

153 loss is not fully rescued by expression of a constitutively active Jak2 allele.

154 with a myeloproliferative neoplasm due to a constitutively active JAK2V617F mutation.

155 g-induced increase in ADM in the presence of constitutively active K-ras mutation.

156 ycogen synthase kinase 3beta (GSK3beta) is a constitutively active kinase known to promote cell death

157 Bcr-Abl is a constitutively active kinase that causes chronic myeloge

158 e casein kinase 2 (CK2) is a pleiotropic and constitutively active kinase that plays crucial roles in

159 ow that controlled recruitment of truncated, constitutively active kinesin-1 motors to the nuclear en

160 Overproduction of wild-type or constitutively active Lyn inhibited production of TNF-al

161 s prevented by dominant negative MEF2, while constitutively active MEF2 is able to induce myofibre hy

162 Expression of a constitutively active Mek1 (Mek1(DD)), the known ERK act

163 l-like ovarian cancer cells by co-expressing constitutively active MEK1 and Src rather than either al

164 d skin tumorigenesis, in which expression of constitutively active MEK1 in differentiating epidermal

165 Expression of constitutively active mitogen activated kinase kinase 6,

166 Constitutively active MKK6, an immediate upstream activa

167 Conversely, constitutively active mTORC1 led to DZ enrichment but lo

168 ersed by expression of 3'UTR-less IGF-1R and constitutively active mTORC1.

169 n ECs, whereas EC-targeted overexpression of constitutively active mutant ADF reduces actin polymeriz

170 A constitutively active mutant form of FGFR3 decreased BPV

171 an invasive capacity of EGFR variant III, a constitutively active mutant form of the receptor common

172 expression of the wild-type receptor and its constitutively active mutant form, EGFRvIII, limits sens

173 Constitutively active mutant KRas displays a reduced rat

174 VUF11211 acts as an inverse agonist at a constitutively active mutant of CXCR3.

175 ter opening the TRPM1 channels with light, a constitutively active mutant of Galphao closed the chann

176 tional activity of beta-catenin induced by a constitutively active mutant of lipoprotein receptor-rel

177 Adenoviral expression of a constitutively active mutant of MEK5 is sufficient to at

178 ted by mutant LRRK2, whereas expression of a constitutively active mutant of NCLX that enhances calci

179 stimulated with FSH or expressing PKA-CQR, a constitutively active mutant of PKA.

180 nd secondary foci, whereas TICs expressing a constitutively active mutant of RhoA produced circumscri

181 ng cap-dependent translation by expressing a constitutively active mutant of the translational repres

182 Overexpression of a FAK phosphomimetic and constitutively active mutant p-FAK-Y407E in these cells

183 s of transgenic mice, in which expression of constitutively active mutant PI3K was induced in primord

184 Mice expressing a constitutively active mutant PTH1R exhibited a dramatic

185 Using the constitutively active mutant ptoL205D, we identify a pot

186 e the effects of disease-causing G proteins (constitutively active mutants) and/or GPCR signaling.

187 ns that capture the conformational change of constitutively active mutants, we tentatively identified

188 sence of an agonist; and naturally occurring constitutively active mutations in receptors have been i

189 Constitutively active MYC and reactivated telomerase oft

190 of an actomyosin cable around the wound, and constitutively active myosin II regulatory light chain s

191 A constitutively active myristoylated form of Akt1 did not

192 However, mice overexpressing a constitutively active Nfatc1 isoform in the skin epithel

193 The constitutively active Nlrp3(A350V) mutation abolished th

194 ty and gene expression upon stimulation with constitutively active Notch1 in presence of myocardin or

195 In contrast, constitutively active NRAS expression induced ETS1 and C

196 ains the reduced neurotensin efficacy in the constitutively active NTSR1 and a facilitated initial en

197 line missense mutations, which give rise to constitutively active oncogenic RET, were found to cause

198 own previously for rod cells, attenuation of constitutively active opsin can be achieved with the unb

199 1-cis-retinal and the accumulation of toxic, constitutively active opsin.

200 Further investigations using constitutively active or dominant-negative forms of Rab

201 Targeted delivery of two mutants of S6K1, constitutively active or dominant-negative, to the media

202 Here, we discovered several constitutively active Orai1 and Orai3 mutants, containin

203 owed that 2-APB potentiated Cs(+) current on constitutively active Orai1-V102C/A/G mutants independen

204 ve photosensitizing molecule, resulting in a constitutively active photosensitizer inside the cell.

205 e because PTEN deficiency or expression of a constitutively active PI3K rescued function of B cells i

206 by activating PP2A(Cdc55) We discovered that constitutively active Pkc1 can drive cells through a mit

207 Further, expression of constitutively active PKCiota decreases NF-kappaB activi

208 c neurons throughout the brain expressed the constitutively active PKM1 isoform, while neural progeni

209 Transfection of constitutively active plasmids revealed that Slit2 inhib

210 A)-mediated knockdown, and overexpression of constitutively active PLK1 (PLK1(CA) ).

211 wth and metastasis, which was rescued by the constitutively active PPP1R1A.

212 ladelphia chromosome positive), which mimics constitutively active pre-BCR signalling.

213 programmable transcriptional regulators are constitutively active, precise temporal and spatial cont

214 acrophages; while rLm30 expressing r30 via a constitutively active prfA* regulon (rLmIII/a30) express

215 Assembly of the endocytic machinery is a constitutively active process that is important for the

216 ative promoters in silent gene clusters with constitutively active promoters.

217 Here we show that CK2, a ubiquitous and constitutively active protein kinase, phosphorylates HSJ

218 Inhibition of Akt activity by constitutively active PTEN similarly decreases crestin e

219 f synaptic vesicles, which can be rescued by constitutively active Rab26.

220 ansgenic mice with cardiac overexpression of constitutively active Rac1 (RacET) develop an age-depend

221 ike ovarian cancer cells, whereas expressing constitutively active Rac1 leads to EMT in epithelial-li

222 Moreover, overexpression of constitutively active Rac1 partially rescued the apoptos

223 On expression of constitutively active Rac1, however, podocytes changed s

224 Src are higher in ovarian cancer cells with constitutively active Rac1, we conclude that Rac1 sustai

225 1/2 (MEK1/2) and Src inhibitors can abolish constitutively active Rac1-led EMT and mesenchymal trait

226 matrix degradation by invadopodia, whereas a constitutively active Rac3 can rescue the deficits in in

227 However, constitutively active Rag guanosine triphosphatases prev

228 hai1(Q204L) expression on adhesion driven by constitutively active Rap1a(G12V) or its downstream effe

229 Transfection with a construct expressing a constitutively active RAS mutant increased LPS-induced a

230 Expression of constitutively active Ras mutants or inhibition of GSK3

231 is and leading to high expression of ERAS, a constitutively active RAS protein normally expressed onl

232 full activation of signalling downstream of constitutively active RAS with which it interacts in a B

233 we show that substitutions analogous to the constitutively active Ras-G12V mutation in dMiro's N-ter

234 gnaling driven by TGFbeta ligand Activin and constitutively active receptors Alk4 and Alk2 remain int

235 elevated mGluR5 signaling is associated with constitutively active receptors and increased and imbala

236 2(LKO) mice, suggesting that this pathway is constitutively active regardless of the status of the TG

237 e transduced neurons postinjury to express a constitutively active Rheb to enhance their intrinsic gr

238 Expression of a constitutively active Rho GTPase, however, restored infl

239 Moreover, by using constitutively active Rho small G-protein (Rho QL) as we

240 we investigated the effects of expressing a constitutively active RhoA GTPase (RhoAV14) in the AH ou

241 abolished the localization of NMIIB, whereas constitutively active RhoA induced NMIIA at the cleavage

242 y a dominant-negative PLCdelta1 mutant and a constitutively active RhoA mutant.

243 is rescued by overexpression of wild-type or constitutively active RhoA.

244 s of active ROP2, including those expressing constitutively active ROP2 (CA-ROP2), contain high level

245 CYTOKININ INDEPENDENT1 (CKI1), encoding the constitutively active sensor His kinase that activates M

246 dministration and transgenic mice carrying a constitutively active SHP2 mutation.

247 Overexpression of constitutively active SHP2 reduced the responsiveness of

248 hetic analogues, 30, 31, 33, and 36, inhibit constitutively active signal transducer and activator of

249 M also suppressed the constitutively active simian virus 40 (SV40) promoter an

250 as free from HSP90, exclusively nuclear, and constitutively active similarly as previously reported f

251 Here, we show that expression of constitutively active SMAD2/3 significantly improves the

252 Here by inducing expression of constitutively active Smoothened (SmoM2) or Gli2 (DeltaN

253 Moreover, overexpression of wild-type and constitutively active SOD2 similarly blunted inflammasom

254 We found that constitutively active Sonic hedgehog (Shh) signaling exp

255 M2 isoform of pyruvate kinase (PK) over its constitutively active splice variant M1 isoform is consi

256 Constitutively active Src blocked the anti-invasive effe

257 Furthermore, expression of constitutively active Sre1, a transcriptional activator

258 F-VP16iHep mice, which conditionally express constitutively active SRF-VP16 in hepatocytes, thereby c

259 Transgenic tomato overexpressing constitutively active stable DELLA proteins (S-della) di

260 This study, along with other studies of constitutively active STAT mutants, provides insight int

261 Expression of constitutively active STAT3 also caused hMSH3 to translo

262 addition, YKL-40 expression was enhanced by constitutively active STAT3 and inhibited by dominant-ne

263 Src-transformed murine fibroblasts harboring constitutively active STAT3.

264 nts' tumor-derived xenograft cells harboring constitutively active Stat3.

265 part by Erk1/2(MAPK)-dependent modulation of constitutively active Stat3.

266 transduction of developing Th9 cells with a constitutively active STAT5 eliminates the ability of IL

267 RF4 expression are rescued by either IL-2 or constitutively active STAT5, but not NFATc1.

268 of a phosphomimetic MLC-4 mutant mimicking a constitutively active state also impairs ovulation.

269 carboxamide (AICAR) or adenovirus expressing constitutively active subunits of AMPK decreased cue-ind

270 ntain point mutations in Pdr1 that render it constitutively active, suggesting that this transcriptio

271 LRT persistence even when BvgAS is rendered constitutively active, suggesting the presence of BvgAS-

272 Conversely, a strain containing a constitutively active SurR variant displays a growth phe

273 strains with altered GAL1 promoter dynamics (constitutively active, synthetic with nucleosome-disfavo

274 Consistently, expression of constitutively active TEL-SYK counteracted the apoptotic

275 Moreover, constitutively active transcription factor Hac1p restore

276 Our study shows that inoculation with a constitutively active transcription factor, namely, a fu

277 splice variants including AR-V7 function as constitutively active transcription factors in CRPC cell

278 inhibitor of both full-length AR (AR-FL) and constitutively active truncated AR splice variants (AR-V

279 he link between GRHL2 and AR also applied to constitutively active truncated AR variants (ARV), as GR

280 tumorigenic MI line harbored membrane-bound, constitutively active, truncated EGFR.

281 through adeno-associated virus expressing a constitutively active type I receptor significantly redu

282 neoplasia characterized by expression of the constitutively active tyrosine kinase BCR/Abl.

283 non-natural gene fusion EML4-ALK encoding a constitutively active tyrosine kinase that is associated

284 n by the oncogenic fusion protein BCR-ABL, a constitutively active tyrosine kinase.

285 Glycogen synthase kinase-3 (GSK-3) is a constitutively active, ubiquitously expressed protein ki

286 ; its disruptive effects can be rescued by a constitutively active UNC-9::GFP protein, demonstrating

287 ement with a predominantly nuclear activity, constitutively active UVR8(W285A) accumulated in the nuc

288 silencing and forced expression of wild-type/constitutively active variants, we provide evidence that

289 pon activation by either overexpression of a constitutively active vector or ligand binding (Neuregul

290 phology, but overexpression of the truncated constitutively active version largely replicates the pah

291 In the present study, we introduce a constitutively active version of phytochrome B-Y276H (YH

292 omain, and deletion of R2R3 or expression of constitutively active vinculin generates stable force-in

293 e causative agent of Kaposi's sarcoma, and a constitutively active viral G protein-coupled receptor (

294 Further, overexpression of wild-type YAP, or constitutively active YAP in immortalized FTSECs, induce

295 Furthermore, induction of constitutively active YAP in ovarian grafts of transgeni

296 In vivo, constitutively active YAP lowers plasma glucose levels a

297 ponse to glucagon and dexamethasone, whereas constitutively active YAP suppresses it.

298 matory phenotypes, whereas overexpression of constitutively active YAP was sufficient to promote EC p

299 on of the ERf signal transduction cascade by constitutively active YODA rescues stomata clustering in

300 We conclude that a pool of constitutively active ZIPK is involved in regulation of