ライフサイエンスコーパス: constraint

1 ent leading to stunted growth (developmental constraints).

2 volving under different levels of functional constraint.

3 ethod of multipliers (ADMM) to deal with the constraint.

4 is 0.93 A, compared with 1.34 A without the constraint.

5 ed to close product loops before this global constraint.

6 l knowledge of its anatomy as a regularizing constraint.

7 cs these experiments, while imposing the 1:1 constraint.

8 cross species and is under strict mutational constraint.

9 particularly in neurons with unique spatial constraints.

10 mals that evolved under strong environmental constraints.

11 by model polymer genomes subject to landmark constraints.

12 eriorating clinical conditions or logistical constraints.

13 n of miRNA strand-specificity and underlying constraints.

14 vices that directly incorporates fabrication constraints.

15 ile eliminating traditional economy-of-scale constraints.

16 auge model with quasi-local four-body parity constraints.

17 t the observed residues to identify mutation constraints.

18 umor heterogeneity while satisfying toxicity constraints.

19 and face severe power, performance, and cost constraints.

20 d the crossings are protected by topological constraints.

21 with the measured data and general physical constraints.

22 algorithms that do not exploit these spatial constraints.

23 red as plants adapt to various environmental constraints.

24 t are likely to be species-specific climatic constraints.

25 Neumann entropy, under the validity of some constraints.

26 on is the result of peripheral neural-coding constraints.

27 that were constrained with randomly shuffled constraints.

28 onal requirements with metabolic and spatial constraints.

29 oo weak to persist in the absence of protein constraints.

30 use of biomass for energy under given system constraints.

31 rienting mechanism in response to mechanical constraints.

32 how cells compete for space under geometric constraints.

33 h ocean warming, given current socioeconomic constraints.

34 -and builds a minimal model using only three constraints: 1) protein synthesis, 2) protein degradatio

35 ion or adherence to guidelines included time constraints (8 reviews/overviews); limited staffing reso

36 to partly compensate for these developmental constraints (adaptive growth plasticity).

37 ly incongruent sentence endings only in high-constraint affirmative contexts, but not to high-constra

38 Selective constraint against missense variants in NACC1 makes this

39 Structural constraints also explain one-third of allosteric inhibit

40 the subterranean environment due to relaxed constraint and adaptive evolution.

41 ely fold from the unstructured state without constraint and can be programmed to terminate their fold

42 y provides less information about linguistic constraints and categories.

43 these events are debated because of poor age constraints and contradictory stratigraphic correlations

44 Here, I first consider the constraints and drivers acting on influenza A virus reas

45 duction, while also considering agricultural constraints and human nutritional needs.

46 robial cell function in relation to temporal constraints and location of the microbial cell or habita

47 amilies exhibit stronger sequence divergence constraints and lower rates of functional and expression

48 hitectures that bypass important engineering constraints and performance limitations set by tradition

49 that highlights the importance of geometric constraints and the mediating role of water within the p

50 arge problems (current ME models have 70,000 constraints and variables and will grow larger).

51 at set them apart from other sequences under constraint, and have recently been proposed as useful ma

52 umstances, (3) constraints can breed further constraints, and (4) feedback loops can operate over gen

53 hogen within imposed sample size and/or cost constraints, and demonstrate its application using two s

54 as anatomical and phylogenetic evolutionary constraints, and further empirical testing is required.

55 confirmed the validity of the thermodynamic constraints, and that thermodynamic poise information is

56 backbone are coordinated to overcome steric constraints, and the degradation involves previously und

57 Given these temporal constraints, and the elevated atmospheric CO2 concentrat

58 ation to alpha-globin locus shows that these constraints ( approximately 20%) drive the formation of

59 We find that a core set of 51 constraints are essential but that additional constraint

60 overgrowth outcomes and/or that evolutionary constraints are involved.

61 selection, and that gene-specific functional constraints are more important for the maintenance of ci

62 backbone chains, for which these mechanical constraints are of fundamental importance to their molec

63 onstraints are essential but that additional constraints are still necessary to recover the observed

64 tities in a system, subject to given lattice constraints, are hindered to simultaneously minimize the

65 maging-derived traits is subject to the same constraints as any other genetic study, including string

66 We theoretically examined physical constraints associated with coupling of the proboscis an

67 s ventralis (VS) shortening is intrinsically constraint at maximally 12% strain.

68 stimates to create a framework for measuring constraint at STRs by comparing observed versus expected

69 otherwise difficult to obtain due to steric constraints at high numerical aperture.

70 The inclusion of constraints based on experimental measurements of CO2 up

71 -dependent resource allocation problem using constraint-based analysis.

72 Constraint-based and pattern-based methodologies have be

73 In constraint-based metabolic modelling, physical and bioch

74 Incorporating experimental data into constraint-based models can improve the quality and accu

75 Constraint-based optimization, such as flux balance anal

76 Constraint-Based Reconstruction and Analysis (COBRA) is

77 P solution subject to this reaction deletion constraint becomes a distinct EM.

78 he gap x2 between the proof mass and reverse constraint blocks have significant effect on the shock-r

79 We know examples of such constraints, but we have no systematic understanding abo

80 oops can embed early-life circumstances, (3) constraints can breed further constraints, and (4) feedb

81 active, self-motile particles to topological constraints can give rise to novel non-equilibrium dynam

82 Overall, we demonstrate that geometric constraints can influence three-dimensional cell morphol

83 actors such as communication biases and time constraints can lead to less-than-optimal group decision

84 ful applications in spintronics but symmetry constraints can limit the control over spin polarization

85 sfying annual final energy demand, the model constraints comprise availability of biomass and arable

86 To control for constant-sum constraint, concentration data were transformed using th

87 However, severe financial constraints currently jeopardize these efforts.

88 etabolic modelling, physical and biochemical constraints define a polyhedral convex set of feasible f

89 eration algorithm based on the combinatorial constraints defined by the underlying phylogenetic tree.

90 Specifically, we (i) used sequence-design constraints derived from antibody multiple-sequence alig

91 mtDNA mutations and elucidate the selective constraints driving their fate.

92 evolutionary pressure to adapt to structural constraints, due to the structure of Campylobacter hook,

93 Given size constraints, efficiency was optimal via a circular recei

94 tegration, and importantly, if biomechanical constraints encoded in the body schema influence multise

95 tumorigenesis, and to adapt to the multiple constraints encountered over the course of tumor develop

96 The former constraint ensures that neighbouring pixels correspond t

97 logically similar structures, and the latter constraint ensures that neighbouring pixels have similar

98 esponse modality, sensory features, and time constraints establish that the signal reflects an active

99 thways can also mobilize Cr, no quantitative constraints exist on the associated isotope fractionatio

100 approach is not straightforward, as spatial constraints exist to position the laser beam and the obj

101 ween adaptationist explanations like the IH, constraint explanations, and dysfunction explanations, i

102 The constraint factors that regulate the biased distribution

103 The results do not preclude biological constraints favoring integer ratios, but they suggest th

104 The reversibility constraints follow from heuristic thermodynamic poise ap

105 ater availability acts as the most stringent constraint for life on Earth.

106 ties, but their low mechanical strength is a constraint for practical applications.

107 ehaviour of the Solar System, and provides a constraint for refining numerical solutions for insolati

108 an increasingly stronger role than intrinsic constraints for development time among species with cold

109 ate our approach will motivate using spatial constraints for future molecular control circuit designs

110 plicates are often subject to dosage balance constraints for prolonged evolutionary times, which may

111 ns of sequencing reads to provide structural constraints for RNA secondary structure prediction.

112 Structural constraints for the bound state are obtained from chemic

113 These results provide constraints for the development of models for the bidire

114 Atlantic sector, with lack of observational constraints for the extensive Russian Siberian Arctic, s

115 ies ruling this area, provides excellent age constraints for the firing event of these artifacts.

116 Our results provide experimental constraints for theoretical calculations, which yield at

117 Environmental constraints foster the evolution of this form of social

118 These physical constraints frame the -1/4 power law classically inferre

119 Thus, loss or defects of the LBD abolish constraint from un-liganded LBD as exemplified by consti

120 We show that sparse distance constraints from imino resonances, which can be readily

121 of the OB-PC pathway that satisfies the many constraints from our experimental data.

122 Combining constraints from ssNMR and cryo-electron microscopy (cry

123 ses, as due to multiple functional goals and constraints fulfilled by different cell types and/or cir

124 hoton counting machine, we explain how these constraints give rise to adaptive quantal information sa

125 tworks' engagement: switching under external constraints heavily recruited prefrontal control regions

126 We show that LPS exposure of C57BL/6 WT mice constraints IgE-MC-mediated reactions.

127 A maximum speed constraint imposed by the use of RSPs would indicate a p

128 However, the volume constraint imposed on the FICI requires less power consu

129 The geometric constraints imposed by a tetradentate P4N2 ligand play a

130 The relative importance of intrinsic constraints imposed by evolved physiological trade-offs

131 In practice, the physicochemical constraints imposed by surfactant molecules limit the ac

132 ge and breeding phenology respond jointly to constraints imposed by temperature and resource phenolog

133 y phase of observed genotypes conditional on constraints imposed by the genotypes of other pedigree m

134 the helical conformations formed result from constraints imposed by the relatively rigid and sterical

135 m pole-to-pole despite the potential spatial constraints imposed by their extensive thylakoid network

136 Microbes drive ecosystems under constraints imposed by viruses.

137 progenitors (ETPs) could escape T cell fate constraints imposed normally by a Notch-inductive microe

138 el organisms such as Arabidopsis, is a major constraint in accurate quantification of transcript isof

139 ogy from post-mortem change has been a major constraint in diagnosing potential impact.

140 an equivalent model subject to a sum-to-zero constraint in penalized linear regression, where the cor

141 terol is a critical nutrient requiring tight constraint in the endoplasmic reticulum (ER) due to its

142 The main constraint in the way of optimizing thermoelectric perfo

143 bility in the gastrointestinal tract, steric constraints in crossing biological membranes, and cleari

144 omplexity, highlights the role of functional constraints in determining folding-mechanistic behaviors

145 Therefore, the reliability of the constraints in order to get accurate results is a critic

146 ohols in a steric environment resembling the constraints in pockets of enzymes stabilizing active sit

147 Given the stringent resource constraints in quantum computing, information passed bet

148 werful method for establishing absolute time constraints in sedimentary basins, which improves our un

149 These adjacencies can be included as constraints in structure prediction techniques to predic

150 d activity, thus defining the conformational constraints in the catalytic process.

151 methodology based on a general framework of constraints in the form of conditional probability state

152 Estimates of evolvability and constraints in these modules suggest differential respon

153 An evolutionary constraint is a bias or limitation in phenotypic variati

154 f regulatory elements are excluded, and this constraint is highest immediately upstream of genes.

155 approximately 30% additional to the imposed constraints is found to be specific.

156 tein self-assembly and microscale mechanical constraints is used to form oriented, porous nanofibrill

157 el gene divergence during simplification and constraint leading to CM suggest a deterministic process

158 C might facilitate the relaxation of learned constraints, leading to a successful representational ch

159 ble counterdiabatic protocols given physical constraints, like locality.

160 ound that (1) predispose plants to hydraulic constraints limiting photosynthesis and promoting hydrau

161 ressures suggesting that there may be shared constraints limiting the possible evolutionary trajector

162 The sum constraint makes inference on correlations between uncon

163 This constraint makes scaling of computational imaging system

164 to above a few nanometers due to processing constraints, making it challenging to further suppress t

165 ntake rate not directly related to digestive constraints may determine the dynamics of intake and def

166 Mitigation of capital constraints may provide practicable routes to alleviatio

167 r scenario in which some of those additional constraints/mechanisms are addressed, demonstrating thei

168 ses highlight that, irrespective of resource constraints, ministries of health and other institutions

169 traint affirmative contexts, but not to high-constraint negated ones.

170 The mechanisms by which the constraint of a hard pericarp determines germination tim

171 Without the constraint of air breakdown, a triboelectric charge dens

172 ualization techniques without the rigid grid constraint of cluster heatmaps will perform better at cl

173 whether invasive species operate within the constraint of conservative ecological niches, or if nich

174 ehavioural results, by implementing a simple constraint of continuity for binding successive sounds i

175 that simultaneously shape the expansion and constraint of genomic heterogeneity.

176 hyperpolarized spin state together with the constraint of having to polarize the (13)C spins in a de

177 ons of TGFBR2 result in both SMAD4-dependent constraint of proliferation and SMAD4-independent activa

178 w warming reassembles communities within the constraints of energy supply via regional exchange of sp

179 llenge given the cost, time, and sensitivity constraints of existing technologies.

180 d the stringent linear geometric interaction constraints of halogen bonding (XB), the noncovalent int

181 d to future goals, or at least free from the constraints of immediate environmental inputs.

182 , intermolecular epistasis can alleviate the constraints of individual components, thereby increasing

183 Methodological constraints of measuring SOM decomposition in the field

184 able functionalities challenge the intrinsic constraints of natural materials, revealing tremendous p

185 lity of maternal and progeny cues, costs and constraints of plasticity in parental and progeny genera

186 le, which is a requirement due to the sample constraints of small scale manufacturing.

187 opportunities to reduce OHT risk within the constraints of the overriding need to control the primar

188 these factors are adapted to the functional constraints of the respective circuit.

189 d to provide insight into the reactivity and constraints of these compact and highly oxygenated polyc

190 its overall dynamics by applying rigid body constraint on each residue in molecular dynamics simulat

191 surface chemistry model and provide a strong constraint on further model development.

192 m the two cell lines suggests that selective constraint on gene expression, but neither sequence feat

193 .2), owing to the one-dimensional structural constraint on lattice-scale depolarization dynamics; whe

194 sed on measurements, provides an independent constraint on mercury emissions, helps to improve and re

195 This analysis puts a strong constraint on preindustrial vs. industrial-era LUC emiss

196 ity, resulting from the release of selective constraint on somatic gene networks in embryogenesis, th

197 Nitrate isotope measurements provide a new constraint on the controls of surface nitrate concentrat

198 represents a significant physio-phenological constraint on the diversity and seasonal dynamics of pho

199 nder atmospheric conditions is a significant constraint on the exploitation of this layered material

200 he Junggar Basin, and provides a Carnian age constraint on the lowermost part of the Baijiantan Forma

201 Imposing a further constraint on the maximum entropy distribution also allo

202 quality of activity inference by imposing a constraint on the minimum spike size.

203 od is hypothesized to have been an important constraint on the origins of agriculture.

204 ln(1 + delta(18)O)) provides an alternative constraint on the strengths of the associated cycles inv

205 This characterization framework has no constraint on the target network and can thus be leverag

206 Our data suggest a clear constraint on the way that localization cues are integra

207 The applied constraints on chemical data sets should be derived from

208 To address the constraints on current diagnostics, this study developed

209 nomic status and without known environmental constraints on fetal growth.

210 ssions from over 90 volcanoes, including new constraints on fluxes from Indonesia, Papua New Guinea,

211 Crumple program and can include experimental constraints on global RNA structures such as the minimum

212 ia alone or by NO2(-) during normoxia places constraints on how S-nitrosation occurs in vivo and on i

213 cleavage divisions, which impose significant constraints on metabolic pathways.

214 e seismic tomography to derive unprecedented constraints on multi-stage fluid release from subducting

215 ing an approach that captures the structural constraints on mutability based on the extent of its int

216 Improved constraints on nonstandard neutrino interactions with qu

217 the decadal trends in methane without robust constraints on OH variability, which currently rely pure

218 or earlier prey abundance may release former constraints on other selective pressures to breed early,

219 Understanding the neural constraints on our capacity for sensory uptake is a fund

220 Constraints on phenotypic variation limit the capacity o

221 f the model parameters and the imposition of constraints on possible model solutions.

222 Although constraints on RBC size have been tied to the cell's nee

223 re, these stratigraphic tie points place age constraints on regional plate reorganization events, suc

224 otifs, we determined exact timing separation constraints on rhythmic enzyme activities that allow for

225 ation depth of soft X-rays imposes stringent constraints on sample type, preparation, and analytical

226 paroscopic surgery imposes greater ergonomic constraints on surgeons.

227 This places some constraints on the approaches used in family consent dis

228 orates both solution chemistry and geometric constraints on the calcite solid.

229 Identifying constraints on the evolution of increased resistance has

230 ion is extremely ancient and likely to place constraints on the evolution of surrounding genes.

231 likely reflects a high degree of functional constraints on the genome.

232 In this paper we provide constraints on the geometry and kinematics of the bounda

233 short-range crystalline order and kinematic constraints on the many-body scattering processes in the

234 ges in diets with minimal additional imposed constraints on the model.

235 modularization and differential evolutionary constraints on the modules involved in the signaling cas

236 ous application, the effect of reversibility constraints on the predictive capabilities of metabolic

237 of automatic associations places fundamental constraints on the probability of reaching creative solu

238 tes of cyclization and impose stereochemical constraints on the reactions.

239 se that successful speech processing imposes constraints on the self-organization of synchronous cell

240 It places new constraints on the source of this stray gas and further

241 We leverage real-space constraints on the structure to help guide optimization

242 Constraints on the timescale of shallow water storage af

243 ysiological function, and places fundamental constraints on the transporter's mechanism.

244 PNS has become one of the main constraints on the use of high gradient fields for fast

245 Virus is among the major constraints on tomato production.

246 ic modeling framework by using network-level constraints on transcriptional profiling data significan

247 Determining the genetic constraints on Zika virus is important for understanding

248 e looked to the oculomotor system for design constraints or parameter specification.

249 cause of functional optimization, historical constraint, or blind chance.

250 ith thermodynamically informed reversibility constraints outperformed gene essentiality predictions c

251 ddress precisely the extent of the geometric constraint, permitting us to modulate and investigate th

252 Yet, how DNA is mobilized despite the steric constraints placed by the histone octamer remains unknow

253 ism, with preliminary release of a number of constraints, possibly through the binding of regulatory

254 ent of skull bones might act as a structural constraint, predisposing some articulations to closure,

255 adverse effects, thus bypassing the optical constraints previously limiting experiments.

256 tron reduction of O2 can be explained by the constraint provided by the stannoxane core that makes th

257 physical reasoning, a model can be a set of constraints rather than a physics engine.

258 gm in maize is probably driven by anatomical constraints rather than by biochemical limitations.

259 Instead, constraints related to spermatocyte downsizing may have

260 ments and can be challenging to survey given constraints related to water depth, flow, and time of ye

261 gy on multiple length scales, and mechanical constraints requires a range of investigation tools able

262 However, due to technical constraints, root research has long been stuck in its in

263 Furthermore, because of various constraints, sample sizes of individuals can be quite sm

264 Consequentially, these constraints set a fundamental limit to the maximum speed

265 at mitochondrial catabolic capacity is a key constraint setting an upper limit on the rate of cofacto

266 y calculations that rigorously enforce these constraints show that the interaction energy for methyl

267 introduce additional selection pressures and constraints, significantly influence antibody breadth de

268 tions in the field, especially under abiotic constraints such as soil water deficit (drought [D]) and

269 prioritised for vaccination, although other constraints such as vaccine supply and delivery need to

270 However, little work has focused on how task constraints, such as the response-stimulus interval (RSI

271 When wake-times are enforced by social constraints, such as work or school, artificial light in

272 The new geochronologic constraints suggest a long duration for the period of se

273 factor conditions operates under cholinergic constraint that is mediated by muscarinic receptor-depen

274 is driven largely by inherited connectivity constraints that do not require sensorimotor experience.

275 Here, we focus on the temporal constraints that govern such a process.

276 lso an opportunity to establish sensorimotor constraints that influence how the behavior ends.

277 ers, all of these have significant technical constraints that limit their usefulness.

278 ilitate identifying modules and biosynthetic constraints that may affect the outcome of selection and

279 inevitable enzyme inhibition and alleviates constraints that self-inhibition places on metabolism.

280 tein-coding regions are under high selective constraints, these variants occur at low frequencies, su

281 yme-catalyzed biochemical reactions, and the constraints they experience in bringing forth novel phen

282 sfer activates ATP7B by releasing inhibitory constraints through increased freedom of MBD1-3 motions.

283 Striga is a major biotic constraint to sorghum production in semiarid tropical Af

284 e core particle (NCP) is considered to exert constraints to all DNA-templated processes, including ba

285 tment scale-up need to include health system constraints to be more informative.

286 Metabolic constraints to cell function and survival shape tumor pr

287 oton driven spin diffusion provided distance constraints to characterize protein-lipid interactions a

288 he tumor microenvironment presents metabolic constraints to immunosurveiling cells.

289 We use these observations as constraints to test a sequence of hypotheses for how int

290 e is maintained and the degree of additional constraints varies between institutions.

291 By imposing sparsity constraints we have enhanced the interpretability of the

292 o a number of important physically motivated constraints, we are able to efficiently reconstruct stre

293 Exploiting existing age constraints, we estimate that organic haze developed rap

294 To model these constraints, we extend the LCT to a new structure, the p

295 the importance of considering implementation constraints, when predicting and evaluating the cost-eff

296 fied VZ characteristics suggest altered cell constraints which may contribute to cell delamination.

297 Learned rules could therefore act as constraints which need to be removed in order to change

298 eral multiphase model with a set of physical constraints, which, together with an appropriate minimiz

299 ive surgical adjuncts must address practical constraints whilst minimizing risks of adverse effects.

300 Here, we overcome this constraint with an electrically insulating composite tha