ライフサイエンスコーパス: constraint imposed by

1 uding man), one cause of these failures is a constraint imposed by a small minority of females in the

2 Demographic stochasticity and the constraints imposed by a finite lattice size appear to p

3 CAR for cell entry because of the geometric constraints imposed by a rigid fiber.

4 This order, combined with the constraints imposed by a strong negative selection, was

5 The geometric constraints imposed by a tetradentate P4N2 ligand play a

6 evolved: they would have had to overcome the constraints imposed by an endogenous system operating to

7 energetic modelling approach to explore the constraints imposed by an obligate scavenging lifestyle,

8 g sequence of HAV, consistent with noncoding constraints imposed by an underlying RNA secondary struc

9 of >10(12 )independent sequences without the constraints imposed by any in vivo step.

10 cognate guard protein, as well as functional constraints imposed by biochemical activities or interac

11 It is proposed that developmental constraints imposed by both this retinally driven mechan

12 in antibody responses may reflect structural constraints imposed by C region on V region binding.

13 ase, where s is determined only by geometric constraints imposed by c(0), a c(0) > 0 will impede such

14 ssor by preventing release of cells from the constraints imposed by cadherin-mediated cell-cell adhes

15 its original state, indicating evolutionary constraints imposed by catalytic requirements.

16 dsorption is highly sensitive to topological constraints imposed by CBN surface structure; in particu

17 We propose that topological constraints imposed by chromosome length and perinuclear

18 Constraints imposed by comorbidities (notably cardiovasc

19 of Aux/IAA duplication include evolutionary constraints imposed by complex interactions among protei

20 e we directly address whether conformational constraints imposed by cotranslational folding affect th

21 as essentially the same geometry despite the constraints imposed by covalent linkage of the cysteine

22 capes also identify differential specificity constraints imposed by diverse structural folds of natur

23 Constraints imposed by earlier studies and the experimen

24 chieve their proper localizations within the constraints imposed by embryonic development.

25 , and oxides) is challenging due to activity constraints imposed by energy scaling relationships.

26 The relative importance of intrinsic constraints imposed by evolved physiological trade-offs

27 linkage disequilibrium (LD) patterns and the constraints imposed by family structure when assigning i

28 ogical pattern covariations, the role of the constraints imposed by finite resource supply, and a com

29 vation of ubiquitin is assumed to arise from constraints imposed by folding, stability, and interacti

30 Despite the constraints imposed by four disulfides, this "straitjack

31 ve developed under the conditions of spatial constraints imposed by green belts and hard urban bounda

32 ustrates both their intrinsic plasticity and constraints imposed by hexamer assembly.

33 We demonstrate functional constraints imposed by HIV clade relating to the residue

34 parasites harm their hosts, and suggest that constraints imposed by host ecology can lead to populati

35 fied genomic regions between strains without constraints imposed by in vitro manipulations.

36 Constraints imposed by integrating regulatory data have

37 ible conformers are presumably disallowed by constraints imposed by inter-ring contacts.

38 bound conformation accompanying loss of the constraint imposed by interactions of the alpha-domain.

39 not sampled by OX-GG adducts because of the constraints imposed by its cyclohexane ring, which may e

40 2 side chain residues on Ab affinity and the constraints imposed by L chain mutations in maintaining

41 Steric constraints imposed by L(2) prevent the large BF4(-) ani

42 vely long distances, because the biophysical constraints imposed by liquid transport in hyphae and in

43 matrices as well as considering the physical constraints imposed by local structure.

44 However, there may be situations where constraints imposed by market institutions dominate stra

45 way to elucidate the evolutionary mechanical constraints imposed by nature upon individual subcellula

46 heir vascular walls are thinner owing to the constraints imposed by neighboring bone spicules, which

47 In these cases, the mechanical constraints imposed by neighboring cells triggered this

48 key determinant of H1 CTD structure and that constraints imposed by neighboring nucleosomes cause lin

49 on individual wall properties, as mechanical constraints imposed by neighbors appear to be important.

50 This is in the context of constraints imposed by networks of cell walls that both

51 l manner to maximize performance, within the constraints imposed by neural noise.

52 h synaptic connections are formed within the constraints imposed by neuron morphology, we compared th

53 re clusters) on the basis of the geometrical constraints imposed by nuclear size and shape.

54 cient translocation in vivo despite temporal constraints imposed by ongoing translation and a crowded

55 3 domain is regulated both by conformational constraints imposed by other domains and by plasmin- med

56 hain to study its innate kinetics, free from constraints imposed by other regions of the molecule.

57 tible with Na+ binding in trypsin because of constraints imposed by P225 on the protein backbone.

58 r diversity and pattern; however, structural constraints imposed by plant cell walls and the absence

59 -ATPase functions to overcome conformational constraints imposed by PLB on the N-domain of the Ca-ATP

60 for these groups, in contrast to the steric constraints imposed by propeller loops in human telomeri

61 These results indicate that the structural constraints imposed by protein architecture play a domin

62 First, we can rationalize them in terms of constraints imposed by protein structure: We find that p

63 ating eddy feedbacks on upwelling within the constraints imposed by reconstructions of winds and Anta

64 e physical requirements that arise under the constraints imposed by river dynamics--every spanning tr

65 not from evolutionary optimization but from constraints imposed by rules intrinsic to RNA polymer fo

66 a1 transcripts may reflect certain molecular constraints imposed by scid on the resolution of Vlambda

67 midpoint attractor interacts with geometric constraints imposed by sea level and the mountaintop to

68 ssembly reflect the interplay between steric constraints imposed by short linkers and the bulk of the

69 rimental data that allow us to determine the constraints imposed by signaling specificity on these pa

70 onal change is suggested without geometrical constraints imposed by small cavitands.

71 apt to create a decision surface without the constraints imposed by statistical classifiers.

72 Finally, we find that the constraint imposed by stickiness on protein divergence i

73 h sequence conservation as expected from the constraints imposed by structure.

74 In practice, the physicochemical constraints imposed by surfactant molecules limit the ac

75 ge and breeding phenology respond jointly to constraints imposed by temperature and resource phenolog

76 g selection pressures beyond the biophysical constraints imposed by TF-DNA interactions.

77 anges in distance by available FRET pairs (a constraint imposed by the dimensions of the enzyme), a D

78 The observation can be explained by the constraint imposed by the fundamental feedback structure

79 ration, phytoplankton overcame the metabolic constraint imposed by the greater temperature sensitivit

80 Removal of the conformational constraint imposed by the proline ring likely raises the

81 tion of the 3-4 amide and the conformational constraint imposed by the seven-membered ring, both of w

82 A maximum speed constraint imposed by the use of RSPs would indicate a p

83 This unusual scenario likely arises from the constraints imposed by the 222 symmetry of the enzyme.

84 by utilizing an excitonic coupling model and constraints imposed by the 3JCalphaHNH coupling constant

85 could not be explained in terms of possible constraints imposed by the 5-fluoroorotate selection.

86 terest for protein engineering, the sequence constraints imposed by the adjoining SECIS element sever

87 Using constraints imposed by the amino acid residues identifie

88 set of HEL determinants owing to processing constraints imposed by the background genes?

89 cts from the protein but likely results from constraints imposed by the bicyclo[3.1.0]hexane scaffold

90 systems during the fabrication process, the constraints imposed by the biomolecules due to the limit

91 relative to dG:dC as a result of structural constraints imposed by the C-nucleotide character of CdG

92 les is determined, in part, by the geometric constraints imposed by the catalytic sites.

93 ude of biochemical activities and by spatial constraints imposed by the cell boundary.

94 The nonrandom spindle positioning is due to constraints imposed by the cell cortex in flat cells tha

95 of nutrients by the fungus was restricted by constraints imposed by the cellular structure of the dif

96 Understanding the specific constraints imposed by the CNS on local T cell activity

97 rences in specific DNA contacts but from the constraints imposed by the configuration of the componen

98 l properties of the protein polymers and the constraints imposed by the curved cell membrane.

99 ased on these results, we postulate that the constraints imposed by the cyclohexane ring of OX affect

100 d on the overall objective of the study, and constraints imposed by the data, to define the appropria

101 e as an immobilized competitor that overcame constraints imposed by the deep binding cleft and struct

102 It was found that constraints imposed by the disulfide bond confer an unex

103 t thymines in double helical DNA, due to the constraints imposed by the DNA structure; the 5S configu

104 ence that these are in part a consequence of constraints imposed by the dosage compensation mechanism

105 evaluating their actions in relation to the constraints imposed by the environment.

106 g place in enzymatic sites, where structural constraints imposed by the enzyme cavity can impart ster

107 tivity appears to be a direct consequence of constraints imposed by the enzyme on the orientation of

108 Apparently, the quaternary constraints imposed by the fimbrial shaft on the adhesin

109 ate are avoided by the strict stereochemical constraints imposed by the folate-binding funnel.

110 of the A-DNA stems to B-DNA stems within the constraints imposed by the four-base loop that caps the

111 tion of free-oscillation data and additional constraints imposed by the free-air gravity anomaly, lat

112 te of 0.15 degrees per year--consistent with constraints imposed by the free-oscillation data.

113 symmetry considerations and by the geometric constraints imposed by the frozen matrix.

114 induced unfolding was hindered by the steric constraints imposed by the gel pores such that more dena

115 This methodology not only removes the constraints imposed by the genetic code on our ability t

116 y phase of observed genotypes conditional on constraints imposed by the genotypes of other pedigree m

117 lar cortical neurons that reflects the tight constraints imposed by the geometry of 3D vision.

118 between local chiral interactions and global constraints imposed by the geometry of the self-assemble

119 alpha(IIb)beta(3) molecule and disruption of constraints imposed by the heteromeric association of th

120 volved and refined to be compatible with the constraints imposed by the host endogenous macromolecula

121 Because of highly restrictive constraints imposed by the host, it is more likely that

122 quasispecies virus population and the immune constraints imposed by the host.

123 e LOS of mutant 559 may be due to structural constraints imposed by the incomplete biosynthesis of th

124 elated patterns of sequence evolution due to constraints imposed by the interaction, and molecular ar

125 eA-catalyzed reaction is consistent with the constraints imposed by the kinetic mechanism determined

126 Due to experimental constraints imposed by the lack of genetic tools and the

127 NA is reduced and presumably reflects steric constraints imposed by the large size of the polycyclic

128 xes and consequent inability to overcome the constraints imposed by the lattice contacts.

129 ciency is attributed here to the anisotropic constraints imposed by the membrane, which are not incor

130 ibutions, combined with backbone topological constraints imposed by the model pore, result in milesto

131 d state that is proposed to exist because of constraints imposed by the nature of the CO/CO2 reaction

132 It is useful to begin by considering constraints imposed by the nature of the protein synthet

133 they are to the varied, sometimes stringent, constraints imposed by the need for real-world precision

134 ntrol information flow, our results identify constraints imposed by the need to avoid interference be

135 physiological impact of gene sharing and the constraints imposed by the need to maintain the original

136 ewest possible stem divisions subject to the constraints imposed by the need to renew the tissue.

137 fficking of stem cells allows them to escape constraints imposed by the niche, enabling self-preserva

138 The latter adaptations are constraints imposed by the overriding requirement for ex

139 Physical and chemical constraints imposed by the periinfarct glial scar may co

140 o the commensurate nature of the geometrical constraints imposed by the pi-pi interactions and only t

141 ld-type peroxo intermediate models including constraints imposed by the protein also identify the cis

142 In particular, the 50 degrees kinks are constraints imposed by the protein rather than a feature

143 Within the constraints imposed by the protein subunits, the DNA can

144 v spike configuration and by avoiding steric constraints imposed by the quaternary structure of the f

145 in drug design, and show their basis in the constraints imposed by the range of allowable mutation i

146 e dosage constraints, such that the relative constraints imposed by the recent WGD are still being re

147 fragment (deltaKD) freed from autoinhibitory constraints imposed by the regulatory domain is catalyti

148 rthermore, the elimination of the structural constraints imposed by the regulatory subunits within th

149 the helical conformations formed result from constraints imposed by the relatively rigid and sterical

150 e sulfuryl-group transfer mechanism, and (3) constraints imposed by the residues lining the substrate

151 We suggest that geometric constraints imposed by the reverse micelles need to be c

152 during synthesis and is mediated by spatial constraints imposed by the ribosomal exit tunnel as well

153 the SecM protein evolved as a consequence of constraints imposed by the ribosome and the Sec machiner

154 in the organism does not depend on physical constraints imposed by the shape or size of specific org

155 Constraints imposed by the specific function of CYP51 ha

156 Using constraints imposed by the spin-spin interactions, a pac

157 otides that are energy-minimized, subject to constraints imposed by the sugar-phosphate backbone segm

158 By using a virtual bond to model the constraints imposed by the sugar-phosphate backbone, twi

159 Based on the constraints imposed by the suggested integral control, w

160 liminating mechanical and geometrical design constraints imposed by the supporting semiconductor wafe

161 18 rearrangement is explained through steric constraints imposed by the surrounding hemicarcerand on

162 However, there are constraints imposed by the three-dimensional protein str

163 and incorrect nucleotides by using geometric constraints imposed by the tight fit of the active site

164 Our results, together with constraints imposed by the time scales of development, s

165 the first and third levels and highlighting constraints imposed by the two-qubit representation.

166 The intrinsic manifold presumably reflects constraints imposed by the underlying neural circuitry.

167 ignatures of perovskites--owing to geometric constraints imposed by the underlying substrate.

168 te vaccine molecules for P. vivax, given the constraints imposed by the use of primate models and the

169 The steric constraints, imposed by the substitution mode of the 1,5

170 m pole-to-pole despite the potential spatial constraints imposed by their extensive thylakoid network

171 y and this is likely to be determined by the constraints imposed by their position within the CSC rat

172 Distance constraints imposed by these cross-links provide experim

173 ee to advocate for their patients within the constraints imposed by this public process.

174 d unfolding may be due in part to the steric constraints imposed by this structural element, together

175 ls of F-actin-tropomyosin filaments, free of constraints imposed by troponin or other actin-binding p

176 nalysis, being less dependent on the spatial constraints imposed by underlying vasculature.

177 atural instability of retroviral repeats and constraints imposed by virion packaging limits.

178 Microbes drive ecosystems under constraints imposed by viruses.