ライフサイエンスコーパス: constrict

1 crovascular networks maintain the ability to constrict.

2 ein FtsZ into a cytokinetic ring, which then constricts.

3 size, which was enhanced when the cavity was constricted.

4 renaline (NA, non-selective alphaAR agonist) constricted 1A, 2A and 3A with similar potency and effic

5 6 microm, P < 0.05) but the venules remained constricted (223 +/- 24 microm).

6 onventional myosin-II (Myo2) to assemble and constrict a contractile ring of actin filaments.

7 tes accomplish cell division by building and constricting a medial actomyosin-based cytokinetic ring

8 d by active crawling on the substrate and by constricting a supracellular actomyosin cable.

9 e cycle period, the cell begins to divide by constricting about its equator, ultimately affording two

10 Structural and ligand-binding data reveal a constricted active site able to accommodate RDX and smal

11 that a glutamate gatekeeper and a sterically constricted active site confer specificity for N(8)-acet

12 Molecular modeling indicates that the constricted active site of wild-type pol iota becomes mo

13 rs leading to tension may cooperate with the constricting activity of dynamin to induce fission.

14 at 2.9 angstrom resolution, which revealed a constricted adenine-binding pocket, suggesting the reaso

15 and type 2 cysLT receptors (CysLTRs), which constrict airway smooth muscle, but elicits airflow obst

16 articular, DIs are potent bronchodilators of constricted airways in nonasthmatic subjects but not in

17 unidentified intercellular signaling between constricted airways, the parenchyma, and the surrounding

18 ny eukaryotic cells divide by assembling and constricting an actin- and myosin-based contractile ring

19 , arterioles in FGF9-expressing tumors could constrict and dilate in response to adrenergic and nitri

20 role of the actin cytoskeleton in CME is to constrict and elongate the bud neck and drive the endocy

21 Prostaglandins that constrict and relax airways are synthesized in reactions

22 engineered dynamin displayed the capacity to constrict and sever membrane tubes.

23 Dynamin hydrolyzes GTP to constrict and sever membranes.

24 (S)FtsN depended on the ability of cells to constrict and, thus, on the activity of (E)FtsN.

25 resultant tubes are grossly misshapen, with constricted and distended regions all along their length

26 NG-nitro-L-arginine methyl ester (L-NAME) constricted and indomethacin dilated the arteries.

27 family members, the LasA active site is less constricted and utilizes a different set of metal ligand

28 ion sites in many aerial hyphae had finished constricting and chains of spores were evident.

29 duces membrane curvature and lipid ordering, constricting and destabilizing the membrane neck, causin

30 initially proposed to act as a machine that constricts and cuts the neck of nascent vesicles in a GT

31 mote an iris-like conformational change that constricts and dehydrates the ion pore, creating a 13.5

32 Defects arise as the contractile ring constricts and disassembles, resulting in delays in cell

33 g cytokinesis, a contractile actomyosin ring constricts and divides the cell in two.

34 It constricts and rigidifies the DEKA pore to bind Na(+) op

35 amphipathic peptide domain, to bind, deform, constrict, and destabilize membranes.

36 An open ring is able to constrict, and rings repair from successive cuts.

37 Roof-forming cells constrict apically and express high levels of Broad prot

38 While LECs are migrating they also constrict apically, and changes in activity of the small

39 roposing that MX1 forms ring structures that constrict around viral nucleoprotein complexes.

40 t vasodilatatory effect on phenylephrine pre-constricted arterial rings, which was partially abolishe

41 nhibits alpha1) elevate myocyte Ca(2)(+) and constrict arteries from alpha1(+/-), as well as alpha2(+

42 In fact, DT-2 constricted arteries beyond their starting (pre-8-Br-cGM

43 tor that increases extracellular ATP levels, constricted arterioles by 58.0 +/- 3.8% (P < 0.001 for b

44 human VPCs were injected in proximity to the constricted artery.

45 ms a ring-shaped structure (the Z ring) that constricts as the bacterium divides.

46 It is striking that Chs2-S217A constricts asymmetrically with the actomyosin ring (AMR)

47 These slowly assembled contractile rings constricted at a normal rate but with more variability,

48 The PKD2 ion permeation pathway is constricted at the selectivity filter and near the cytop

49 The constricted axons increase axial resistance to action po

50 ind that myelin infolding is often linked to constricted axons with signs of impaired axonal transpor

51 The skin is scaled, constricting bands encircle the tail and digits, the foo

52 the swimmer is suppressed as the channel is constricted below a critical radius, for which the magni

53 hat the permeation pathway in the open state constricts below the gate, restricting the passage to la

54 tioselective synthesis and SAR of sterically constricted benzofurans at RXR.

55 Administration of IL-12 is able to constrict blood vessels in the tumor in the absence of I

56 omato lectin staining demonstrated fewer and constricted blood vessels within the intracranial tumor

57 ring around the mitochondrion and appears to constrict both outer and inner mitochondrial membranes.

58 multiple locations into discrete tracks that constrict broad regions of cell contact into adhesive an

59 hich a lateral opening in the barrel wall is constricted, but which is otherwise structurally identic

60 When this adaptive range is constricted by diminished dosage of 22q11 genes, embryos

61 bps (syn purine base, HG hydrogen bonds and constricted C1'-C1' distance across the bp) to search fo

62 ith syn purines lacking HG hydrogen bonds or constricted C1'-C1' distances that are analogous to conf

63 icyte death in rigor, which may irreversibly constrict capillaries and damage the blood-brain barrier

64 eceptor activity causes pericytes to locally constrict capillaries, which reduces blood flow to ische

65 In simulated ischaemia, some pericytes constricted capillaries.

66 Our evidence suggests that Dachs constricts cell-cell junctions to alter the geometry of

67 etermines organ shape, first by mechanically constricting cells and second through recruitment of Per

68 enriched at the apical junctions of apically constricting cells and that MRCK-1 and myosin activity a

69 ablations of actomyosin networks reveal that constricting cells have higher cortical tension, generat

70 ata that confirm that the volume of apically constricting cells is conserved throughout the entire co

71 l) tyrosine kinase depletion causes apically constricting cells to undergo aberrant basal cell extrus

72 embryo dissipates tensile forces required by constricting cells via their neighbors, thereby allowing

73 Myosin II accumulates specifically around constricting cells, and its disruption dysregulates cons

74 cell-cell contact-free surfaces of apically constricting cells, downstream of cell fate determinatio

75 ed TRPM4 currents in smooth muscle cells and constricted cerebral arteries from both groups.

76 oncentrations obtained during binge drinking constricts cerebral arteries in several species, includi

77 Cocaine affects neuronal activity and constricts cerebral blood vessels, making it difficult t

78 les move along the dorsal side of the cells, constrict, close, and eventually disassemble ( approxima

79 of dynamin tetramers stimulates formation of constricted coated pits at the plasma membrane by regula

80 zed epithelium surrounded the surface of the constricted collagen matrix.

81 trapped at the interface by the increasingly constricted collagen pore network.

82 es on other K(+) channels do not support the constricted conformation as the C-type inactivated state

83 The constricted conformation can be blocked by substituting

84 tivity filter led to the conclusion that the constricted conformation does not correspond to the C-ty

85 However, the functional significance of the constricted conformation has become a matter of debate.

86 revent inactivation, which suggests that the constricted conformation is not the C-type inactivated s

87 tational results support the notion that the constricted conformation of the selectivity filter corre

88 and KvAP channels, we show that blocking the constricted conformation of the selectivity filter does

89 In this study, we address whether the constricted conformation of the selectivity filter is in

90 at low K(+) or in the open state revealed a constricted conformation of the selectivity filter, whic

91 ular gate revealed a selectivity filter in a constricted conformation similar to the structure observ

92 ent the selectivity filter from adopting the constricted conformation.

93 g the buried water molecules stabilizing the constricted conformation.

94 hat this inactivated state corresponds to a "constricted" conformation of the selectivity filter.

95 and change from a cylindrical to an apically constricted, conical shape.

96 y visual flicker, limited to an annulus that constricts content complexity to simple moving grey blob

97 Thus, cardiac pericytes constrict coronary capillaries and reduce microvascular

98 cardiac catheterization suggest that cocaine constricts coronary microvessels, yet direct evidence is

99 been discovered, providing new insight into constricted crystal growth mechanisms underlying confine

100 f-prediction, potentially motivating several constricting defense mechanisms.

101 Although originally designed to constrict dilated intracranial blood vessels, the mechan

102 lobular adiponectin (gAd) and insulin on pre-constricted distal saphenous arteries.

103 ropagated at approximately 2 microm s(-1) to constrict distant pericytes.

104 he formation of aerial hyphae with partially constricted division sites but no clear separation of pr

105 increases mitochondrial-derived H2O2, which constricts ductal smooth muscle cells by raising intrace

106 ive mice have higher [Ca(2+)]i, and are more constricted, due, primarily, to elevated SNA and some in

107 localises to precisely those cells that will constrict during cranial neural tube closure and appears

108 hase, demonstrating that phagocytes actively constrict during late-stage phagocytosis.

109 e FtsZ establishes the cytokinetic ring that constricts during cell division.

110 SC51322 blunted the constricting effect of Ang II on in vitro-perfused pregl

111 The direct constricting effect of DT-2 was essentially abolished in

112 ted steric hindrance by active site residues constricts entry to the adenosine pocket as compared to

113 cargo to allow centripetal growth of a neck constricting ESCRT-III spiral.

114 clinical findings of reduced visual acuity, constricted fields, and reduced electroretinograms (ERGs

115 isynthetic channel that is unable to adopt a constricted filter but inactivates like WT channels chal

116 ent from K(+) ion binding to channels with a constricted filter, suggesting that the structures of th

117 f channels with conductive, inactivated, and constricted filters using isothermal titration calorimet

118 l cliffs may be glacial relicts whose ranges constricted following the last glacial maximum.

119 orce and to actomyosin-based circumferential constricting forces is mediated by FBN-1, a ZP domain pr

120 Further, we found that a slowly constricting fzlA mutant strain develops 'pointy' poles,

121 potency for LTE(4) than LTC(4) or LTD(4) in constricting guinea pig trachea in vitro and comparable

122 anging between 20/200 and 20/400, moderately constricted GVFs, normal DATs, reduced rod b-wave amplit

123 TOR, was increased by 3.8-fold in the aortic-constricted heart.

124 predacious fungi that catch nematodes using constricting hyphal rings.

125 ation, M(H), at 2 K for 1a showed an unusual constricted hysteresis loop with a coercive field, H(cr)

126 ring closure but does cause the particle to constrict in a two-step process that correlates with the

127 pulmonary (but not aortic) endothelial cells constrict in hypoxia.

128 ogical mechanism by which pulmonary arteries constrict in hypoxic lung areas in order to redirect blo

129 re suggested that the helix of dynamin could constrict in order to promote fission of the enclosed me

130 on observed in the normal retina, arterioles constrict in response to an oxygen deficiency.

131 the innate ability of resistance arteries to constrict in response to elevations in intraluminal pres

132 However, rings constrict in some cells in the absence of Myosin-2 activ

133 phila melanogaster embryos, actomyosin rings constrict in two sequential and mechanistically distinct

134 retinal arterioles developed basal tone and constricted in a manner dependent on concentration to ET

135 The residual seeing visual field was constricted in all cases when compared with normative da

136 Arteries dilated and constricted in response to 16 and 60 mM potassium, respe

137 a helical polymer; second, dynamin oligomer constricts in the presence of GTP; and third, dynamin ca

138 ytosolic Ca(2+) levels in potassium chloride-constricted intact arteries isolated from mouse mesenter

139 ex, allowing five of the six VAT subunits to constrict into a tight helix that grips an 80 A stretch

140 Ps into assemblies at the midcell which then constrict inwards as peptidoglycan is synthesised, event

141 K(+)](o) <10 mM dilated and [K(+)](o) >20 mM constricted isolated brain cortex parenchymal arterioles

142 lls normally elongated along the a-p axis to constrict isotropically, which suggests that apical cons

143 s promote individual freedom, whereas others constrict it so as to maintain elites' power and privile

144 impinges on the benzene ring of Y11 so as to constrict its movement and as a consequence, firmly clos

145 On catheterization, constricted Kir6.2-KO displayed compromised myocardial p

146 elial cells in both mutants fail to apically constrict, leading to craniorachischisis.

147 onformation, while the intracellular-half is constricted, leading to a loss of both water and permean

148 Together, these data suggest that a slightly constricted life space may be a marker and/or risk facto

149 A(D-ala77) channel can adopt an asymmetrical constricted-like nonconductive conformation and that the

150 establish the ability of full-length Drp1 to constrict lipid bilayers through a GTP hydrolysis-depend

151 n C. crescentus and E. coli cells and inside constricting liposomes by means of electron cryomicrosco

152 contract and thereby microvascular lumens to constrict, little is known about the events linking angi

153 turkey (Meleagris gallopavo) as a similarly constricted locus, with 34 genes identified within a 0.2

154 sm, has led to the evolution of an abdominal constricting mechanism, which enhances short-term surviv

155 ture and fluidity, mediating the scission of constricted membrane necks in multiple biological pathwa

156 ble around the necks of budding vesicles and constrict membranes in a GTP-dependent process, resultin

157 ochondrial outer membrane; Drp1 then further constricts membranes until mitochondrial fission occurs.

158 ss, (ii) the velocity of the cell entering a constricted microchannel (entry velocity), and (iii) the

159 ets a locus in chromosome-1 indeed show that constricted migration delays DNA damage.

160 Here, constricted migration of two human cancer cell types and

161 Phenotypic differences that arise from constricted migration of U2OS clones are further illustr

162 y, knockdown, myosin-II inhibition, and even constricted migration that disrupts and segregates lamin

163 nucleoplasmic patterns of damage similar to constricted migration.

164 process involving ER tubules encircling and constricting mitochondria.

165 hich the pupil of a directly illuminated eye constricts more than the pupil of the consensual (not il

166 NA overflow in MA than in MV; (vi) UK 14,304 constricted MV but not MA while yohimbine reduced constr

167 ontribution of proteins that localize to the constricted neck.

168 en a diffusion barrier is established at the constricting neck of a fully formed coated pit and immed

169 into small vesicles connected through highly constricted necks.

170 and distant normal liver tissue primarily by constricting normal distal liver vessels and in turn inc

171 complex is open on the cytoplasmic side and constricted on the extracellular side.

172 from the mother plugs and passed through the constricted opening of the T-junction.

173 GM2AP, revealing a hydrophobic pocket with a constricted opening.

174 4-S5 linker helices, which are positioned to constrict or dilate the S6 inner helices of the pore.

175 arized comet tail in association with highly constricted or fully endocytosed CCSs.

176 ring frequently detaches from the cortex and constricts or collapses to one side of the cell, and the

177 tightly against each other forming the most constricted part of the tunnel; the second shows that th

178 c restriction in flies, it did not yield the constricted phenotype.

179 t localizes in a ring at the leading edge of constricting plasma membranes during cell division.

180 roduced together with FtsX), but these rings constricted poorly.

181 , are stacked in midplane and characterize a constricted pore of 10- to 20-nm diameter.

182 (2+) ion resolved within each monomer with a constricted pore; this is likely to correspond to a clos

183 When cells migrate through constricting pores, they incur DNA damage and develop ge

184 evering process displayed long-lived, highly constricted prefission intermediates that contributed to

185 CaV1.2/CaV3.1, was first shown to depolarize/constrict pressurized rat cerebral arteries; no effect w

186 andibular joint, a flexible spine capable of constricting prey, and the presence of vertebrate remain

187 t immunological memory can 'overfill' and/or constrict prior memory responses.

188 er a corneal flap at the center of the light-constricted pupil created with a femtosecond laser.

189 ously switched between a state of rest and a constricted pupil, and one of active locomotion and a di

190 s imaged in situ through cranial window also constricted rapidly in response to local application of

191 These compounds relax pre-constricted rat aortic rings similar to known HNO donors

192 lary defects, although they principally have constricted rather than dilated pupils.

193 ontrol levels in the left ventricle of aorta-constricted rats in vivo and phenylephrine (PE)-treated

194 Its selectivity is largely determined by a constricted region of its open pore known as the selecti

195 The dynamics of ligand movement through the constricted region of the acetylcholinesterase gorge is

196 ic CO and the CO-releasing molecule (CORM)-3 constricted renal arteries and increased O2*- production

197 by a progressive fall in PrP(C) level, which constricts replication rate and thereby causes the plate

198 Folr1-deficient neural plate cells fail to constrict, resulting in widening of the neural plate mid

199 Myosin II to transition to a compact, fully constricted ring.

200 e centres of septa surrounded by an adjacent constricting ring containing Pbp2b, Pbp1a and regulators

201 sm continuously reassembles and remodels the constricting ring.

202 brane-anchored complexes called nodes in the constricting ring.

203 Myo51 alone cannot constrict rings but increases the constriction rate by M

204 Four constricted rings consisting of conserved interior beta-

205 ery to explore the biophysical properties of constricting rings in Caenorhabditis elegans embryos.

206 We show that the constricting rings of Drechslerella doedycoides catch ea

207 with specific structural features including constricting rings, helical scaffolds, and hydrophobic m

208 The pore contains a constricted selectivity filter that can accommodate seve

209 ls together to generate protein "loops" that constrict separation of the DNA from the histone surface

210 es from that of other PBPs to the centres of constricting septa in mid-to-late divisional cells resol

211 d separate positioning of Pbp2x and Pbp1a in constricting septa, consistent with two separable PG syn

212 I spectrin is necessary for formation of the constricted shape of the spine neck, which in turn contr

213 le cells (FC) from a columnar to an apically constricted shape.

214 ger loop and ribosomal protein L24 lead to a constricted signal sequence-binding pocket possibly prev

215 1 (yeast/mammals), which form spirals around constricted sites on mitochondria.

216 y a dynamin-related GTPase that assembles at constricted sites on the organelle.

217 Burmese pythons, giant constricting snakes native to Asia, now are found throug

218 Bath-applied VP significantly constricted SON arterioles (Delta-41 +/- 7%) via activat

219 contacts form between the ER and endosome at constricted sorting domains, and free diffusion of cargo

220 d through the 4-microm channels emerged from constricted space with deformations whose shape-recovery

221 Cellular migrations through constricted spaces are a crucial aspect of many developm

222 leton are coordinated to move nuclei through constricted spaces.

223 ells, are interrupted by pauses in which the constricted state of the cell apex is maintained.

224 , whereas expression of twist stabilizes the constricted state of the cell apex.

225 ion occupancy at the S1 binding site in the constricted state of the selectivity filter of the KcsA

226 5 compromised embryos and Rab35 localizes to constricting surfaces.Various stages of tissue morphogen

227 ively, these findings establish that obesity constricts T-cell diversity by accelerating age-related

228 , suggesting a specific action of cocaine to constrict terminal feed arteries.

229 code cells are both longer and less apically constricted than control cells, thereby reducing epithel

230 e site pocket in which lactate binds is more constricted than that of medium-chain dehydrogenases suc

231 e amino acid differences in the binding site constrict the A ring binding domain in CeTb, which inter

232 tile forces are generated inside the cell to constrict the division site or to haul the rear of the c

233 em to require additional molecular motors to constrict the division site.

234 We demonstrate that deletions designed to constrict the DNA-binding ring of Ku80 disrupt nonhomolo

235 A truncated RTNLB3, unable to constrict the ER, was not recruited to the cell plate at

236 These Z rings could constrict the liposomes and in some cases appeared to co

237 Fission requires dynamin to first constrict the membrane.

238 and ESCRT-III proteins function together to constrict the necks of budding vesicles.

239 sue, Hatch and Hetzer show that actin fibers constrict the nucleus, causing chromatin protrusions and

240 ginine residue, both highly conserved, which constrict the permeation pathway.

241 xide units and adjusting the link metrics to constrict the pore dimensions; however, a large pore vol

242 icate that two pore-occluding phenylalanines constrict the pore.

243 progressive exhaustion of the naive pool and constrict the T cell repertoire.

244 and urethral sphincteric mechanisms at rest constrict the urethral lumen and keep urethral closure p

245 Ser-132 to Thr and Ala-133 to Ser apparently constricted the active site cavity resulting in producti

246 bstitution of the Ala(286) to Phe apparently constricted the active site cavity, and the A286F mutant

247 Knockout of Khdrbs1 constricted the pool of proliferating NPCs by accelerati

248 d by melanocortin 4 receptor deficiency also constricted the T-cell repertoire diversity, recapitulat

249 heart failure (HF) was induced in felines by constricting the ascending aorta.

250 uction were induced in ten dogs by partially constricting the endotracheal tube.

251 t of feedback to cGMP synthesis in spatially constricting the fall of cGMP during the single-photon r

252 myosin II rings therefore play a key role in constricting the neck of budding bulk endosomes before d

253 scission by scaffolding the membrane bud and constricting the neck to the point of scission.

254 , we propose a "ring cycle" for dilating and constricting the nuclear pore.

255 n isomerization that controls selectivity by constricting the opening through which acceptors must pa

256 uxtaposed with the DNA target sequence, thus constricting the range of targetable sites.

257 sphincter, facilitates urinary continence by constricting the urethra.

258 nine-residue segment of the pocket edge that constricts the active site opening, or "pore", that siev

259 a chronic Th2 inflammation in the lungs that constricts the airways and presents as coughing and whee

260 ring are believed to generate the force that constricts the cell into two daughters.

261 ruits, it drives peptidoglycan synthesis and constricts the cell.

262 graphitic nanostructure production not only constricts the conductive pathways but also limits the a

263 tive site hydrophobic loop on ligand binding constricts the entrance to the active site.

264 wherein FtsZ itself generates the force that constricts the membrane in a GTP-hydrolysis-driven cycle

265 mRNA latch conformation to a closed one that constricts the mRNA entry channel and narrows the P site

266 selection: an asparagine/histidine ring that constricts the narrow end of the funnel serves as a broa

267 uanosine triphosphatase that polymerizes and constricts the organelle.

268 In the Ile(553) --> Phe mutant, which constricts the putative O(2) binding channel, k(cat)/K(M

269 CRF constricts the small bowel and increases fructose malabs

270 r curcumin dilated, whereas micromolar doses constricted, the arterioles.

271 Subsequently, cardiomyocytes constrict their abluminal surface, moving their cell bod

272 iately precedes invagination, endoderm cells constrict their apices because of Rho/Rho-kinase-depende

273 Rather, we observe that endodermal cells constrict their apices, adopting bottle-like morphologie

274 a gastrulation, the ventral mesodermal cells constrict their apices, undergo a series of coordinated

275 nduced in TNC knockout and wild-type mice by constricting their abdominal aorta or by infusion of ang

276 ds to death in infancy because of a severely constricted thoracic cage and respiratory insufficiency;

277 d in the upper common oviduct that relax and constrict throughout sperm storage and egg movement.

278 r-bud neck cooperate in maintaining the neck constricted throughout the cell cycle, a vital function

279 Contractile rings constrict to a greater degree, resulting in smaller ring

280 +), arterioles lost basal tone and failed to constrict to ET-1.

281 e apical tips of elongating epithelial cells constrict to form an anchor point before fiber cell diff

282 most important being that pulmonary arteries constrict to moderate physiological (20-60 mmHg PO2) hyp

283 young skin exhibits the capacity to further constrict to NA in a dose-dependent manner.

284 ing on their inner surface to form buds that constrict to vesicles.

285 Ni-63 is constricted to a small surface area of the microelectrod

286 to FG repeats, thereby linking the ratio of constricted to dilated nuclear pores to cellular transpo

287 asal tone at 55 cmH(2)O luminal pressure and constricted to ET-1 (0.1 nM) with a 40 +/- 6% reduction

288 tigate how the neck of the budding endosomes constricts to allow efficient recruitment of the fission

289 ry cytoskeletal element of the Z ring, which constricts to divide bacteria, assembles into short, one

290 tsZ and a dozen other division proteins, and constricts to divide the cell.

291 The embryonic chicken iris constricts to light ex vivo, but with characteristics at

292 settes, cells are polarized with apical ends constricted towards the rosette center and nuclei basall

293 tivation by A769662 caused phenylephrine pre-constricted UtA from normoxic or hypoxic pregnant mice t

294 ctivation of [Cu(bcppm)H2O] generates a pore-constricted version of the material through concomitant

295 have proposed that the extent to which RBCs constrict vs. dilate vessels is, at least partly, contro

296 the colliculus region and was significantly constricted where it enters the bladder, which could con

297 mitosis, where it formed a ring that did not constrict with actomyosin ring (cytokinetic actomyosin r

298 sayed in pressurized mesenteric arteries pre-constricted with endothelin-1.

299 cells, strands slowly close into rings that constrict without the normal ~25-min maturation period.

300 a mesoderm, linked epithelial cells apically constrict, without cell extrusion or intercalation, to f