ライフサイエンスコーパス: contextual fear conditioning

1 pus is conveyed to the mPFC and amygdala for contextual fear conditioning.

2 bodies reversed the behavioral impairment in contextual fear conditioning.

3 ats at postnatal day (PND) 23 to demonstrate contextual fear conditioning.

4 ctivity, Y-maze spontaneous alternation, and contextual fear conditioning.

5 ry motor activity, sensory responsivity, and contextual fear conditioning.

6 d nicotine withdrawal-associated deficits in contextual fear conditioning.

7 .3 mg/kg/day) withdrawal-induced deficits in contextual fear conditioning.

8 ce learning in a variety of tasks, including contextual fear conditioning.

9 uring acquisition leads to an enhancement of contextual fear conditioning.

10 hippocampal CA1 pyramidal neurons following contextual fear conditioning.

11 pus produced a dose-dependent enhancement of contextual fear conditioning.

12 emory in hippocampus-dependent tasks such as contextual fear conditioning.

13 ediating the enhancing effect of nicotine on contextual fear conditioning.

14 cognitive deficits in a spatial task but not contextual fear conditioning.

15 perforant path stimulation and impairment in contextual fear conditioning.

16 memory for both an explored context and for contextual fear conditioning.

17 nd that this representation helps to support contextual fear conditioning.

18 rom chronic nicotine administration impaired contextual fear conditioning.

19 treatment is associated with impairments in contextual fear conditioning.

20 t reversed withdrawal-associated deficits in contextual fear conditioning.

21 g rats to the context facilitates subsequent contextual fear conditioning.

22 r either initial acquisition or retrieval of contextual fear conditioning.

23 t memory retrieval did not impair subsequent contextual fear conditioning.

24 ion, but not the expression, of auditory and contextual fear conditioning.

25 mice, but not Del mutant mice, have impaired contextual fear conditioning.

26 x plays a critical role in remote memory for contextual fear conditioning.

27 contextual shock experience had no effect on contextual fear conditioning.

28 d ameliorated ethanol-associated deficits in contextual fear conditioning.

29 ditioning did not acquire either auditory or contextual fear conditioning.

30 expression or consolidation, of auditory and contextual fear conditioning.

31 exploration, Morris water maze, and cued and contextual fear conditioning.

32 impairments in the Morris water maze and in contextual fear conditioning.

33 ver; they suffered deficits in both cued and contextual fear conditioning.

34 cleus of the amygdala (LA) shortly following contextual fear conditioning.

35 l magnetic resonance imaging during cued and contextual fear conditioning.

36 pocampus after an associative learning task, contextual fear conditioning.

37 re also eliminated the effect of morphine on contextual fear conditioning.

38 at conjunctive representations contribute to contextual fear conditioning.

39 but show remarkably enhanced performance on contextual fear conditioning.

40 immediately after conditioning also reduces contextual fear conditioning.

41 a time-limited role in the consolidation of contextual fear conditioning.

42 hippocampus were subjected to extinction of contextual fear conditioning.

43 hown to eliminate the effect of isolation on contextual fear conditioning.

44 ffect the requirement for the hippocampus in contextual fear conditioning.

45 g lesions of the hippocampus greatly reduced contextual fear conditioning.

46 l nucleus of the amygdala may play a role in contextual fear conditioning.

47 the BLA in the acquisition and expression of contextual fear conditioning.

48 on of long-term cognitive/explicit memory of contextual fear conditioning.

49 ate-early genes, c-fos and NGFI-A, following contextual fear conditioning.

50 for either the acquisition or expression of contextual fear conditioning.

51 d in long-term but not short-term memory for contextual fear conditioning.

52 of C57 mice on the Morris water task and in contextual fear conditioning.

53 several types of complex learning. including contextual fear conditioning.

54 campal, cortical, or sham lesions, underwent contextual fear conditioning.

55 ate-dependent fear, we used a mouse model of contextual fear conditioning.

56 recognition and placement without affecting contextual fear conditioning.

57 inhibition of excitatory mPFC neurons during contextual fear conditioning.

58 t intrahippocampal scopolamine (Scop) blocks contextual fear conditioning.

59 rmanently tag neurons that are active during contextual fear conditioning.

60 min before water maze acquisition or cue and contextual fear conditioning.

61 ated plus maze task and deficits in cued and contextual fear conditioning.

62 prevented the ischemia-induced impairment in contextual fear conditioning.

63 ch changes in the hippocampus as a result of contextual fear conditioning.

64 c object memory but not Morris water maze or contextual fear conditioning.

65 posure on hippocampal adult neurogenesis and contextual fear conditioning.

66 s of such exposure for hippocampus-dependent contextual fear conditioning.

67 pocampal CA1 and CA3 subfields, and impaired contextual fear conditioning.

68 H3K9 dimethylation in hippocampus following contextual fear conditioning.

69 reased 24 h after context exposure alone and contextual fear conditioning.

70 is upregulated in hippocampus 1 h following contextual fear conditioning.

71 ior to adrenalectomy showed normal long-term contextual-fear conditioning.

72 nicotine-facilitated cued, but not trace or contextual, fear conditioning.

73 port the view that two processes can support contextual fear conditioning: (1) conditioning to the co

74 Specifically, treatment with DHEA-S impaired contextual fear conditioning 24 hr after conditioning bu

75 or fearful locations is widely studied using contextual fear conditioning, a hippocampus-dependent ta

76 udies show that the Syt IV mutation disrupts contextual fear conditioning, a learning task sensitive

77 le rats were ovariectomized and submitted to contextual fear conditioning, a procedure in which rats

78 e that similar brain mechanisms may underlie contextual fear conditioning across species.

79 BLA), and medial prefrontal cortex (mPFC) in contextual fear conditioning, activity within these regi

80 Injecting anisomycin into the VH prior to contextual fear conditioning also greatly reduced long-t

81 area CA1 of the hippocampus was regulated in contextual fear conditioning, an effect dependent on act

82 rate, and survivors show a marked deficit in contextual fear conditioning, an indicator of defective

83 textual fear conditioning; nicotine enhanced contextual fear conditioning and ameliorated ethanol-ass

84 n the CA1 subfield of the hippocampus during contextual fear conditioning and an enhancement of conte

85 ecific behavior of neuronal ensembles during contextual fear conditioning and demonstrate a dissociab

86 S 129 mice performed poorly on wire hang and contextual fear conditioning and exhibited a lower seizu

87 tylase inhibitor sodium butyrate (NaB) after contextual fear conditioning and extinction 1 and/or 14

88 normal object recognition, spatial learning, contextual fear conditioning and extinction learning but

89 a CA1 over several days during predator odor contextual fear conditioning and found that a subset of

90 udy examined the role of ovarian steroids in contextual fear conditioning and hippocampal synaptic pl

91 tudy evaluated the effects of varenicline on contextual fear conditioning and its effects on nicotine

92 e that mice lacking the CX3CR1 receptor show contextual fear conditioning and Morris water maze defic

93 Contrary to expectation, our studies of contextual fear conditioning and novel object recognitio

94 earning but impaired memory consolidation in contextual fear conditioning and novel object recognitio

95 Using contextual fear conditioning and optogenetic inhibition,

96 ine-induced disruption of the acquisition of contextual fear conditioning and prepulse inhibition of

97 both produces a long-lasting enhancement of contextual fear conditioning and protects against ethano

98 oung PS1 cKO;APP Tg mice rescued deficits in contextual fear conditioning and serial spatial reversal

99 1(+/-) mice exhibited behavioral deficits in contextual fear conditioning and social interactions, wh

100 ed age-related cognitive impairments in both contextual fear conditioning and spatial learning and me

101 decreased synaptic plasticity, and impaired contextual fear conditioning and spatial learning and me

102 lated in the adult rat hippocampus following contextual fear conditioning and that DNMT inhibition bl

103 tation of context plays an important role in contextual fear conditioning and that the impairments pr

104 -dependent reference memory tasks, including contextual fear conditioning and the Morris water maze,

105 ed improvement of cognitive deficits in both contextual fear conditioning and the Morris water maze.

106 reversed the TBI-induced deficits in cue and contextual fear conditioning and water maze retention.

107 up-regulated in the rodent hippocampus upon contextual fear-conditioning and identify the vesicular

108 howed significant spatial memory deficits in contextual fear-conditioning and Morris water maze tests

109 t not to its separable features, facilitated contextual fear conditioning, and (b) generalization of

110 6, and 12 months by using sleep recordings, contextual fear conditioning, and immunohistochemistry.

111 in the Y maze, social recognition, trace and contextual fear conditioning, and odor habituation-disha

112 ificantly reversed the behavioral deficit in contextual fear conditioning, and reduced brain Abeta le

113 nic nicotine administration had no effect on contextual fear conditioning, and withdrawal from chroni

114 During contextual fear conditioning animals have to learn the c

115 ice also displayed a selective impairment in contextual fear conditioning, as both cue fear and spati

116 y demonstrated significant impairment in the contextual fear conditioning assay and in the Y-maze in

117 the forms of the Morris water maze (MWM) and contextual fear conditioning at 85 weeks of age showed t

118 ice carrying both transgenes are impaired in contextual fear conditioning at either age.

119 ove memory in scopolamine-challenged mice in contextual fear conditioning, BQCA induces beta-arrestin

120 -fos mRNA in the hippocampus associated with contextual fear conditioning but did not influence Arc m

121 adiponectin-deficient mice exhibited normal contextual fear conditioning but displayed slower extinc

122 ies using these methods found a weakening of contextual fear conditioning but no change in spatial re

123 in-positive neural progenitor cells impaired contextual fear conditioning but not cued conditioning.

124 ns of the POR or PER produced impairments in contextual fear conditioning but not in conditioning to

125 indicate that RSP and POR are necessary for contextual fear conditioning, but it remains unclear whe

126 y rats after hippocampus-dependent trace and contextual fear conditioning, but not after hippocampus-

127 emory impairments on hippocampally dependent contextual fear conditioning, but not hippocampally inde

128 The mutant mice performed normally in contextual fear conditioning, but were impaired in the a

129 conditioning, suggesting that gp120 impairs contextual fear conditioning by binding to its receptors

130 dose of SL327 attenuated the enhancement of contextual fear conditioning by nicotine to levels simil

131 dose-dependently blocked the enhancement of contextual fear conditioning by nicotine, whereas MLA in

132 at ERK 1/2 is involved in the enhancement of contextual fear conditioning by nicotine.

133 esis that the hippocampal formation supports contextual fear conditioning by storing a conjunctive re

134 s argued that the hippocampus contributes to contextual fear conditioning by supporting the acquisiti

135 l double knockout [PS cDKO]) after one-trial contextual fear conditioning by using biochemical, immun

136 ivity wheel running (AWR) and propranolol on contextual fear conditioning (CFC) and messenger RNA (mR

137 This led to recall deficit after contextual fear conditioning (cFC) at 2 months of age in

138 CA1 before an extinction training session of contextual fear conditioning (CFC) blocks retrieval but

139 he role of adult hippocampal neurogenesis in contextual fear conditioning (CFC) is debated.

140 Impaired, hippocampal-dependent, contextual fear conditioning (CFC) is observed in mice a

141 Using a contextual fear conditioning (CFC) paradigm, mice were a

142 ind that in the hours following single-trial contextual fear conditioning (CFC), fast-spiking interne

143 drug infusions modulate the consolidation of contextual fear conditioning (CFC).

144 ss receptors (D1R and D5R) are implicated in contextual fear conditioning (CFC).

145 Acute nicotine administration enhanced contextual fear conditioning, chronic nicotine administr

146 /J mice exhibit reduced long-term memory for contextual fear conditioning compared with C57BL/6J mice

147 ficant improvements in hippocampal-dependent contextual fear conditioning compared with control-treat

148 ly stressed tPA(-/-) mice show a decrease in contextual fear conditioning compared with stressed WT m

149 ze acquisition and retention of both cue and contextual fear conditioning compared with vehicle-treat

150 Contextual fear conditioning consisted of two white nois

151 A variant of contextual fear conditioning, context pre-exposure facil

152 either the VLDL receptor or the apoER2 show contextual fear conditioning deficits.

153 It has been proposed that contextual fear conditioning depends on 2 processes: (a)

154 that tolerance to the effects of nicotine on contextual fear conditioning develops with chronic nicot

155 ist, into the VH disrupted auditory, but not contextual, fear conditioning; DH infusions did not affe

156 Although contextual fear conditioning emerges later in developmen

157 ion of animals with sodium butyrate prior to contextual fear conditioning enhanced formation of long

158 Extensive evidence from contextual fear conditioning experiments suggests that t

159 ycin injections followed normal retrieval of contextual fear conditioning, freezing was impaired the

160 s of hippocampus-dependent memory, including contextual fear conditioning generated by a weak footsho

161 Although the circuit mediating contextual fear conditioning has been extensively descri

162 Studies of contextual fear conditioning have found that ethanol adm

163 the hippocampus after context preexposure or contextual fear conditioning impaired subsequent retenti

164 g BLC function modulate memory for Pavlovian contextual fear conditioning in a manner similar to that

165 expression of several measures of memory for contextual fear conditioning in addition to freezing.

166 t forebrain neurodegeneration, and decreased contextual fear conditioning in adults.

167 r whether the brain mechanisms that underlie contextual fear conditioning in animals are also preserv

168 ng, testing, or both training and testing of contextual fear conditioning in C57BL/6 mice.

169 in adult rodents to identify determinants of contextual fear conditioning in developing rats.

170 studies in rats, these results indicate that contextual fear conditioning in mice also requires the i

171 ained with intra-BLA infusions of APV before contextual fear conditioning in rats that had been fear-

172 l nitric oxide synthase (nNOS) inhibitor, on contextual fear conditioning in rats was examined.

173 on, neither DHbetaE nor MLA had an effect on contextual fear conditioning in the absence of systemic

174 ent study, we examine the mnemonic limits of contextual fear conditioning in the absence of the BLA u

175 ion of MMP-9 transcription was studied after contextual fear conditioning in the adult animals.

176 rapamycin complex 1 (mTORC1) activity after contextual fear conditioning in the CA1 but not CA3 area

177 sical conditioning and hippocampus-dependent contextual fear conditioning in the same animals using t

178 ppocampal synaptic mechanisms in relation to contextual fear conditioning in widely available gene kn

179 Contextual-fear conditioning in adrenalectomized rats wi

180 We found that contextual fear conditioning increased ripple-spindle co

181 Contextual fear conditioning increased the maximum rate

182 erses scopolamine-induced memory deficits in contextual fear conditioning, increases blood flow to th

183 ell recording in wild-type mice suggest that contextual fear conditioning initiates a transcriptional

184 After contextual fear conditioning, injections of the alpha-ad

185 DBA/2 mice in this task is unknown, whereas contextual fear conditioning is a hippocampus-dependent

186 ng in a hippocampus-dependent learning task, contextual fear conditioning is associated with increase

187 Contextual fear conditioning is enhanced by nicotine, bu

188 Contextual fear conditioning is regulated by the hippoca

189 ession of adult neurogenesis does not affect contextual fear conditioning, locomotion or diurnal rhyt

190 We show here that contextual fear conditioning markedly increases MMP-9 tr

191 Strikingly, defective LTP and contextual fear conditioning memory normally associated

192 spatial (Morris water maze) and associative (contextual fear conditioning) memory were observed in le

193 We also studied learning and memory using contextual fear-conditioning, Morris water maze, and nov

194 srupted acquisition but not consolidation of contextual fear conditioning; nicotine enhanced contextu

195 es was evaluated using pre-pulse inhibition, contextual fear conditioning, novel object recognition,

196 spatial memory assayed by the water maze and contextual fear conditioning often does not provide opti

197 TTA expression caused subtle differences in contextual fear conditioning on two of these backgrounds

198 cortex that were previously shown to impair contextual fear conditioning or contextual discriminatio

199 sions of the LA or LA/BA nuclei in rats in a contextual fear conditioning paradigm and unconditioned

200 al hippocampus on the acquisition of a novel contextual fear conditioning paradigm in which a unimoda

201 T prior to behavior analysis in the cued and contextual fear conditioning paradigm, as well as immuno

202 uced Hypophagia test, and cognition, using a contextual fear conditioning paradigm.

203 ong-Evans rats were trained in an unsignaled contextual fear conditioning paradigm.

204 ation of long term association memories in a contextual fear conditioning paradigm.

205 ats were tested in the hippocampus-dependent contextual fear-conditioning paradigm in adulthood.

206 inent deficits in learning and memory in the contextual fear-conditioning paradigm.

207 g and memory as measured by performance in a contextual fear-conditioning paradigm.

208 behavioral performance in an open-field and contextual fear-conditioning paradigm.

209 2J and C57BL/6J inbred mice in two different contextual fear conditioning paradigms and transitive in

210 c lesions of the POR or PER were tested in 2 contextual fear conditioning paradigms.

211 e hippocampal neurodegeneration and disrupts contextual fear conditioning processes in mice and that

212 Impaired contextual fear conditioning produced by damage to the h

213 The enhancement of contextual fear conditioning provides further evidence t

214 In human subjects who underwent olfactory contextual fear conditioning, re-exposure to the odorant

215 the EC, but not in the hippocampus, enhanced contextual fear conditioning relative to control animals

216 ethyltransferase, Mll, displayed deficits in contextual fear conditioning relative to wild-type anima

217 However, the involvement of CeA CRF in contextual fear conditioning remains poorly understood.

218 ent to which the hippocampus participates in contextual fear conditioning remains unclear.

219 Contextual-fear conditioning requires a lengthy retentio

220 We previously demonstrated that contextual fear conditioning results in hippocampal plac

221 xt discrimination and time course studies of contextual fear conditioning revealed strain differences

222 , muscimol, or a CRF ASO into the CeA before contextual fear conditioning showed typical levels of fr

223 mation efficiently to the basal amygdala for contextual fear conditioning.SIGNIFICANCE STATEMENT This

224 Cue and contextual fear conditioning significantly increased pho

225 ta- mice in three distinct behavioral tasks: contextual fear conditioning, spatial learning and socia

226 tor activity, anxiety-like behavior, cue and contextual fear conditioning, startle threshold, and pre

227 The decrease in FTO observed shortly after contextual fear conditioning suggests that FTO normally

228 sure to the conditioning context facilitates contextual fear conditioning supported by immediate shoc

229 or POR before or shortly after training on a contextual fear conditioning task causes deficits in the

230 utely reverses the behavioral deficit in the contextual fear conditioning task in transgenic mouse mo

231 y consolidation of the hippocampal-dependent contextual fear-conditioning task is significantly impai

232 e recognition, novel object recognition, and contextual fear conditioning tasks, but did not affect l

233 n hippocampal-dependent spatial learning and contextual fear conditioning tasks.

234 is water maze, novel object recognition, and contextual fear-conditioning tasks.

235 pus-dependent, short-term fear memory in the contextual fear conditioning test and long-term spatial

236 ng modafinil (0.75 mg/kg) enhanced memory of contextual fear conditioning (tested off-drug 1 week lat

237 ize the potential role of the hippocampus in contextual fear conditioning, the present experiments ex

238 Given the relevance of cued and contextual fear conditioning to post-traumatic stress, b

239 t differ immediately, or at 1 and 3 hr after contextual fear conditioning training.

240 Next, we found that contextual fear conditioning transiently (0.5 h) decreas

241 following a novel experience consisting of a contextual fear conditioning trial.

242 ircuitry outside of the amygdala can mediate contextual fear conditioning under some conditions.

243 These lesions also did not block contextual fear conditioning using startle or freezing a

244 Contextual fear conditioning was also strongly augmented

245 hibitor) that is subthreshold for inhibiting contextual fear conditioning was coadministered with nic

246 naptic development, acquisition of one-trial contextual fear conditioning was impaired after deletion

247 The role of the dorsal hippocampus in contextual fear conditioning was investigated with a con

248 A quantitative trait locus (QTL) analysis of contextual fear conditioning was performed in a B6/D2 F2

249 The deficit in contextual fear conditioning was reversed by D-Cycloseri

250 ve PDE4B inhibitor or vehicle before cue and contextual fear conditioning, water maze training and a

251 line (0.01, 0.1, 1.0 mg/kg) had no effect on contextual fear conditioning when administered alone, bu

252 inhibition of acoustic startle response and contextual fear conditioning when compared with Fmr1 KO

253 Adrenalectomized rats showed reduced contextual-fear conditioning when tested 24 hr after con

254 mpairment in the acquisition of auditory and contextual fear conditioning, whereas injections before

255 Additionally, retrieval of standard contextual fear conditioning, which does not require con

256 Contextual fear conditioning, which is highly conserved

257 and selectively disrupted the acquisition of contextual fear conditioning while sparing tone-shock as

258 The former procedure produces contextual fear conditioning while the latter does not.

259 By combining contextual fear conditioning with lesions of the dorsal

260 tes for regions containing genes influencing contextual fear conditioning, with lod scores ranging fr