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2 (CNVs), and other structural variants (SVs) continually accumulate as cells divide during developmen
3 upporting a scenario where amplified repeats continually accumulate due to infrequent DNA removal.
7 an extremely high surface area, the deposits continually accumulating, even in the case of galvanosta
8 nvironment, an animal's sensory neurons must continually adapt to persistent cues while remaining res
10 f urology, gynecology and urogynecology have continually adapted new techniques in pelvic organ prola
16 ghly motile organelles whose distribution is continually adjusted by neuronal activity via Ca(2+)-dep
19 cells can survive telomere sequence loss by continually amplifying and rearranging heterochromatic s
20 rane was placed in a brass reservoir, heated continually, and the released hydrogen gas was directly
28 newborn blood spot screening (NBS) has been continually assessed and its use has gradually expanded.
29 Surprisingly, PCNA was expressed in tumors continually at a high level throughout the entire 24-hou
30 are notorious for their unpleasant behavior-continually at risk of misfolding, collecting damage, ag
34 sequence, structure, and regulation, but are continually being created and destroyed, with the result
36 pplications, and new chemical substances are continually being developed and introduced into commerce
38 r with a diverse range of biologic functions continually being identified throughout the cell cycle.
39 species as well as tree pollen allergens are continually being identified, making research in this fi
44 e system with other aspects of physiology is continually being revealed and in some cases studied in
46 computational modeling, important steps are continually being taken to enhance its accessibility and
47 udy shows that marginal zone B cells migrate continually between marginal zone and follicles and esta
48 inase driving the phosphocycling of ezrin to continually bias its function to the apical membrane.
52 suggest a negative regulatory mechanism that continually buffers immune signaling by controlling the
54 n effective therapy to combat the illness is continually challenged by the emergence of drug resistan
55 Territories emerge as dynamic objects that continually change shape and slowly move without settlin
56 om un-cross-linked fibrin or collagen type I continually changes in response to repeated large-strain
57 , these dynamics imply highly heterogeneous, continually changing conditions over time and/or space a
58 habenula (LHb) enables dynamic responses to continually changing contexts and environmental conditio
61 motility mechanism must be adaptable to the continually changing surface conditions encountered duri
62 find objects of interest in a cluttered and continually changing visual environment, humans must oft
64 tumor progression, immune system phagocytes continually clear apoptotic cancer cells in a process kn
65 eology and genetics, and new information has continually come to light as theory, data acquisition, a
66 resses from various environmental challenges continually confront plants, and their responses are imp
70 n injury and regenerate injured muscles, but continually decline during regeneration, suggesting an i
72 ntial expression in the bundle sheath showed continually decreasing expression from bundle sheath to
73 es stringent challenges to timer circuits by continually diluting out timer components in proliferati
77 contrast to wild-type hepatocytes, which are continually dividing during hepatic outgrowth and thus d
79 a respiratory tubes (tracheae) that elongate continually during larval growth, despite being lined wi
81 ad clinical improvement, all 3 patients with continually elevated BDG had poor clinical outcomes (str
86 distributed among all GCs in lymph nodes and continually emigrated into the follicle and neighboring
88 re we identified macrophage populations that continually engulf ACs in distinct tissues and found tha
90 th systems striving to serve the poor should continually evaluate and seek to improve equity, even wi
94 lained by Red Queen dynamics: Organisms must continually evolve to maintain fitness relative to inter
95 nt cells competes against variants that have continually evolved and adapted to host immune pressure.
97 ted diversity of the strains involved in the continually evolving HIV-1 pandemic.IMPORTANCE Very litt
98 ompounds and modes of action to out-maneuver continually evolving resistance pathways, especially aga
101 tation approaches for fragment libraries are continually evolving, and the lack of up-to-date guidanc
107 s, alms1-deficient beta-cells were unable to continually expand as a result of decreased proliferatio
110 lligent data mining of recently released and continually expanding large-scale tomato functional geno
113 while our knowledge of the genetic causes is continually expanding, our understanding into how these
114 tics Institute (EMBL-EBI, www.ebi.ac.uk) are continually expanding: total disk capacity increases sig
122 nsformation optics material prescription has continually forced researchers to make simplifying appro
126 e been implicated in pattern separation, are continually generated in the dentate gyrus in the adult
127 ue properties and their association with the continually generated olfactory sensory neurons, OEG hav
128 rthermore, DGCs are unusual in that they are continually generated throughout life, with aberrant int
130 o apply this knowledge to data sets that are continually growing in a field that is rapidly changing.
131 ce for increased usability and support for a continually growing list of organisms, maintain CHOPCHOP
132 Portals database and associated projects are continually growing, and we invite new partners and coll
134 s always on the horizon, it is imperative to continually identify new treatments, comprising both adv
135 tors (GABAARs) containing beta3 subunits are continually implicated in autism spectrum disorders (ASD
136 assessing and modifying practice patterns to continually improve safety, efficacy, and efficiency.
137 tage-sensing fluorescence proteins have been continually improved and as a result have provided a wea
138 dysfunction, technological innovations have continually improved these penile implants since that ti
139 ncing single DNA molecules with nanopores is continually improving, but de novo genome sequencing and
140 Computational object-vision models, although continually improving, do not yet reach human performanc
141 ggest that the hypothalamus might reorganize continually in adulthood to integrate the metabolic stat
144 s suggested that these elements are produced continually, in sites such as core-collapse supernovae.
146 sed steadily in DMADDM-containing groups and continually increased in control group, and the biofilm
148 for coping with natural challenges, such as continually increasing osmolarity, it results in a trade
152 ises a single stem cell pool, in which cells continually interconvert between As and syncytial states
153 of innovative technologies, new threats are continually introduced to the workplace (eg, indium comp
154 Although STAT6 is imported to the nucleus continually, it accumulates in the nucleus following tyr
157 ical imaging continues to improve, capturing continually longer-term, richer, and more complex data,
158 ndicates that clonogenic growth potential is continually maintained, but the determinants of self-ren
159 ese results provide evidence that people are continually managing their self-concepts, seeking to ass
160 egation in aneuploid human tumour cells that continually mis-segregate whole chromosomes and display
161 ion knowledge is available and data sets are continually modified with the inflow of new information.
162 ites needs to have built-in functionality to continually monitor and diagnose their own health states
163 n Automated Carbon Efflux System was used to continually monitor soil CO2 efflux from December 2010 t
164 d by a network of tissue-resident cells that continually monitor the external environment, and in hea
165 primary immune effector cells in the brain, continually monitor the tissue parenchyma for pathologic
166 vidual risk stratification, patients must be continually monitored and thus carry the burden of this
168 ar organisms grow, positional information is continually needed to regulate the pattern in which cell
169 ation to the body, spatial computations were continually needed to transform map coordinates into geo
170 ration of the pulsed reactors, ureolysis was continually observed, suggesting that the balance betwee
172 n of genes either constitutively (i.e., in a continually "ON" state) or conditionally (i.e., in respo
173 anogenic pathway (fmc values) dynamics for a continually operated mesophilic bioreactor and highlight
175 model finds that TIP-susceptible HIV strains continually outcompete TIP-resistant HIV mutants at both
177 heir gaze steady on a given location, humans continually perform microscopic eye movements, including
178 the tiny movements humans and other species continually perform, even when attending to a single poi
179 ression of the histone deacetylase HDAC7 but continually phosphorylated and exported this transcripti
182 field of tumor drug delivery research, while continually presenting new and innovative approaches, in
184 le within the upper ocean, where alkanes are continually produced and subsequently consumed within da
189 e programmed to limit bacterial growth while continually producing and releasing cytotoxic agents in
193 plain the observations; one in which T cells continually re-assess fate decisions on the basis of mul
195 tes a time window during which each cell can continually read its environment and adjusts its fate.
196 es sense of the multitude of stimuli that it continually receives in natural conditions is a challeng
198 flora and inhaled environmental microbes may continually recruit microbicidal macrophages through TLR
200 -responsive window during which cells can be continually recruited into the otic domain and uncover S
201 e indicates that novel viruses are likely to continually reemerge, presenting threats to humans.
202 n large part because these systems have been continually refined and their use focused on questions w
203 er is initially produced in low yield, it is continually reformed via decomposition of the beta hydro
206 th cases, it can be argued that the organism continually rehearses possible future actions, so it can
207 zation, the depression narrows, deepens, and continually rejects the visible spectrum of light until
208 e show that, after light activation, ATR can continually release and rebind to any receptor remaining
211 y replaced during an animal's life, and must continually renew components of their various organelles
212 ral distinct cell types that are rapidly and continually renewed by intestinal stem cells that reside
213 se that stereocilia F-actin cores are either continually renewed every 24-48 h via a treadmill or are
217 are non-unique, and damaged biomolecules are continually repaired or regenerated, kinetic models are
218 e lymphocytes have a finite lifespan and are continually replaced by input from generative organs.
220 throughout adult life, with old cells being continually replaced by the progeny of stem cell divisio
221 munohistochemistry to chart organogenesis of continually replacing cichlid teeth and discovered an ep
226 ivo, suggesting that CD4+ effector cells are continually required for optimal IFN-gamma production by
227 e (CDK) and Dbf4-dependent kinase (DDK), are continually required throughout the S-phase for all repl
229 plasmic reticulum (ER)-resident proteins are continually retrieved from the Golgi and returned to the
230 corporation into clinical practice should be continually revised as more information becomes availabl
231 ged over the 6-yr study period, the use of a continually revised intra-abdominal hypertension/abdomin
234 y, started in 1987, is unique as the longest continually running investigation of the effects of elev
235 Instead, T(FH) cells remained motile and continually scanned the surface of many GC B cells, form
237 y and specificity of diagnostic systems, one continually searches for alternative DNA hybridization m
239 lects the initial flow stimulus, or fish may continually sense flow during the burst to determine whe
244 ithin 20 years after diagnosis has decreased continually since the mid-1980s and is expected to furth
245 of its guidelines program in 1993, ASCO has continually sought ways to produce a greater number of g
250 e olfactory bulb, where ongoing neurogenesis continually supplies new inhibitory granule cells into e
254 tumors, and that p53 activation needs to be continually sustained, as reversion from senescence occu
258 estinal myeloid-derived cells are stimulated continually through PRRs; metallothionein expression was
259 mmalian adult gastric epithelium self-renews continually through the activity of stem cells located i
260 y mechanisms counteract the effects of aging continually throughout life, or whether they act during
261 ment of subgingival plaque, which is exposed continually to an array of host proteases in the inflamm
262 ncing act that requires oncologists to adapt continually to different factors: their individual relat
267 es to the layout of the maze forced subjects continually to relearn their favored routes, thereby exp
270 hite-crowned sparrows, new neurons are added continually to the song nucleus HVC (proper name) and pr
271 come, ventromedial prefrontal cortex (vmPFC) continually tracked the learned value of the available o
273 t the inhibitory NK cell receptor KIR2DL1 is continually trafficked into the synapse, and remains sur
275 g) and their wild-type (WT) littermates were continually treated with GC (prednisolone 5 mg/kg/day vi
276 n optimal versican content and PCM volume by continually trimming versican in hyaluronan-versican agg
278 biology have revealed that these organelles continually undergo fusion and fission while functioning
281 F-centric web repository Factorbook and will continually update this repository as more ENCODE data a
288 ss the potential and challenges of producing continually updated infectious disease risk maps using d
290 However, to realize this possibility, a continually updated road map of files in the TCGA is req
291 o access the results of a systematically and continually updated standardized alignment as well as ge
293 ome-scale data for bacteria are compiled and continually updated, thereby enabling comparative analys
296 ce of scientific and treatment advances, and continually walk a fine line between providing palliatio
298 e organs are in close proximity and interact continually, we have described recent design considerati
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