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1 IU/kg pump prime, and 10,000 KIU/kg per hour continuous infusion).
2 ng for 10 minutes, followed by 0.5 mg/kg/min continuous infusion).
3 concurrent fluorouracil (200 mg/m(2) per day continuous infusion).
4 in 3 days and persisted throughout 7 days of continuous infusion.
5 700, 850, and 1,000 mg/m(2)/d for 4 days via continuous infusion.
6 ected daily but causes severe bone loss with continuous infusion.
7 with FU/LV; FU was administered by bolus or continuous infusion.
8 cause undesirable side effects and require a continuous infusion.
9 No DLT occurred with 24-hour continuous infusion.
10 d two-compartment (biexponential) model with continuous infusion.
11 nge of 2-7 mmol/kg either as a bolus or as a continuous infusion.
12 administered through intrathecal boluses or continuous infusion.
13 efore resuscitation, and 1.5 mL.kg-1.hr-1 by continuous infusion.
14 ay courses of 2-CDA (8.9 mg/m(2)/d) given by continuous infusion.
15 n with paclitaxel, administered as a 96-hour continuous infusion.
16 zodiazepines and opioids, via both bolus and continuous infusion.
17 assigned to intravenous exenatide or placebo continuous infusion.
18 g i.v. bolus injections, as well as by 5-day continuous infusions.
19 nd prefer to administer these medications as continuous infusions.
20 termittent sedative dosing prior to starting continuous infusions.
22 caine (n = 7) bolus (1.5 mg/kg), followed by continuous infusion (100 mg/h for patients >70 kg or 70
23 itial bolus (4 mg/m(2)) and subsequent 4-day continuous infusion (12.5, 15.0, 17.5, or 20.0 mg/m(2)/w
29 l 400 mg/m(2), followed by 2400 mg/m(2) 46-h continuous infusion), administered every 2 weeks for a t
30 by means of either a bolus every 12 hours or continuous infusion and at either a low dose (equivalent
31 the same amount of antibody administered by continuous infusion and by split administrations, compar
32 o 10 mg/kg, FU 600 to 800 mg/m(2) (120 hours continuous infusion), and hydroxyurea from 500 to 1,000
34 (2) by either a 1-hour infusion (Arm A) or a continuous infusion (Arm B) for 3, 5, or 7 days before a
36 udy groups received morphine (boluses and/or continuous infusion) as rescue medication on the guidanc
37 xed-onium chlorofumarate 24a following a 1 h continuous infusion at 10-20 microg/kg/min (95-100% bloc
39 domly assigned to receive levosimendan (in a continuous infusion at a dose of 0.025 to 0.2 mug per ki
41 ver a 10-minute period; this was followed by continuous infusion at a rate of 1 mug/kg/h until imagin
43 ur O6-BG infusion at 120 mg/m2 followed by a continuous infusion at an initial dose of 30 mg/m2/d for
44 aline when given as an intravenous bolus and continuous infusion attenuates water content of small bo
45 m(2) daily and fluorouracil (FU) 400 mg/m(2) continuous infusion (CI) daily for the final 10 days of
46 ed to determine the feasibility of combining continuous-infusion (CI) paclitaxel with concurrent radi
48 unorubicin 90 mg/m(2) per day for 3 days and continuous-infusion cytarabine 100 mg/m(2) per day for 7
49 s 4 to 6), and cytarabine 1.5 g/m(2) IV as a continuous infusion daily for 3 or 4 days (days 4 to 7).
50 g regimen consisted of cisplatin (25 mg/m(2) continuous infusion daily for 4 days), fludarabine (30 m
51 mg/m(2)), day 0; 5-FU (1,000 mg/m(2)/d), by continuous infusion days 0 to 2; and VCR (1.5 mg/m(2)),
53 monthly, and high-dose pulses of in-patient continuous infusion decrescendo IL-2 (54 MIU/m(2)) over
56 was to define the maximum-tolerated dose of continuous-infusion doxorubicin administered with standa
58 al-beam radiation with concurrent fixed-dose continuous-infusion doxorubicin followed by surgical res
63 ol amino acid solution was administered as a continuous infusion during burn intensive care unit stay
64 gimen by adding fludarabine to dose-adjusted continuous-infusion etoposide, prednisone, vincristine,
65 Paclitaxel was administered as a 120-hour continuous infusion every 3 weeks during the course of r
66 el feature, UCN-01 is administered as a 72-h continuous infusion every 4 weeks (in second and subsequ
68 dition of weekly oxaliplatin to preoperative continuous infusion fluorouracil (FU) and external-beam
69 terial floxuridine combined with intravenous continuous-infusion fluorouracil (chemotherapy arm, 53 p
70 e-to-one ratio to epirubicin, cisplatin, and continuous-infusion fluorouracil (ECF), irinotecan plus
71 oxicity and possibly enhanced activity makes continuous-infusion fluorouracil (FU) an attractive alte
72 included cisplatin 20 mg/m(2) for 4 days and continuous-infusion fluorouracil 1,000 mg/m(2)/d for 4 d
73 reated with blinatumomab in cycles of 4-week continuous infusion followed by a 2-week treatment-free
74 ered on cardiopulmonary bypass followed by a continuous infusion for >/=12 hours and </=5 days after
76 120 mg/m2 of O6-BG over 1 hour followed by a continuous infusion for 2 days at escalating doses presu
77 inistering the antagonists as a subcutaneous continuous infusion for 2 weeks compared to a single bol
78 ients received 1.5 g/m(2) per day cytarabine continuous infusion for 3 days and laromustine 600 mg/m(
79 nder the curve of 6.5, followed by TOPO as a continuous infusion for 3 days; the starting dose of TOP
80 d 11 h), and bleomycin (25 units per day, by continuous infusion for 5 days on days 10-14; two cycles
81 ight patients received cladribine 12 mg/m(2) continuous infusion for 5 days with melphalan 180 mg/m(2
82 mg/m2, weekly; arm E, 5-FU 750 mg/m2/d IV by continuous infusion for 5 days, then 750 mg/m2 weekly, a
83 9-AC 35 microg/m(2)/h was administered by continuous infusion for 72 hours every 2 weeks via ambul
84 vopiridol (50 mg/m(2)/d) was administered by continuous infusion for 72 hours every 2 weeks, and resp
86 patients at a dose of 0.1 mg/kg as a 24-hour continuous infusion for a total of 7 days each cycle.
88 infusion) or ciclosporin (2 mg/kg per day by continuous infusion for up to 7 days, followed by twice-
89 was performed every 8 hrs in lumens without continuous infusions for the duration of catheter placem
90 stases were treated with weekly oxaliplatin, continuous infusion FU 200 mg/m2 intravenously, and RT.
91 , the addition of oxaliplatin to intravenous continuous infusion FU and RT for patients with locally
93 15) was developed to compare the efficacy of continuous-infusion FU (CIFU) plus levamisole to FU/LV p
94 25 g of human serum albumin every 8 hrs with continuous infusion furosemide, or dual placebo, targete
97 ents with pneumonia who received extended or continuous infusion had lower mortality than those recei
98 of 200 mg/day in four divided doses or as a continuous infusion in a dose of 240 mg/day (10 mg/hr) f
99 s, and arginine butyrate was administered by continuous infusion in an intrapatient dose escalation,
101 administration of beta-lactam antibiotics by continuous infusion in critically ill patients with seve
102 ed ara-C doses of 1 to 2 gm/m(2)/d, given by continuous infusion in IA, and over 2 to 4 hours in FA a
103 armacokinetics of a 96-hour intravenous (IV) continuous infusion in patients with advanced cancer.
104 h-dose (100 U/kg bolus followed by age-based continuous infusion in randomized children) vs low-dose
105 e., approximately EC(95)]) administered as a continuous infusion in vitro provides virtually complete
107 stered through either intrathecal boluses or continuous infusion induced a dose-dependent downregulat
108 ively, were given sedation or analgesia as a continuous infusion, intermittent doses, or both (p<0.00
109 and 194 eligible patients were randomized to continuous infusion intravenous IL-2 (9 million units/m(
111 hat received intravenous bolus followed by a continuous infusion, lung water content was significantl
112 linical data suggest that administration via continuous infusion may result in enhanced antitumor act
113 ulmonary arterial hypertension (PAH) require continuous infusions, multiple inhalations, or oral admi
115 tumors, (2) evaluate the safety of extending continuous-infusion O6-BG at the optimal dose with intra
117 sing a conventional dosing of 16 g/2 g/24 hr continuous infusion, obese patients were more likely tha
118 ficantly greater risk of nephrotoxicity than continuous infusion (odds ratio = 8.204; p </= 0.001).
119 icrog/kg bolus i.v. over 2 min followed by a continuous infusion of 0.1 microg/kg per min) and a high
122 d either to 3 mg/kg Bbeta15-42 followed by a continuous infusion of 1 mg/kg/hr for 5 hours (pFX06; n
123 icrog/kg bolus i.v. over 2 min followed by a continuous infusion of 1 microg/kg per min), significant
125 njection of 2 nmol ghrelin was followed by a continuous infusion of 12 nmol ghrelin via a primed 200-
126 180 microg/kg boluses 10 min apart and as a continuous infusion of 2 microg/kg per min) during percu
127 400 mg/m(2) intravenously on day 1 and then continuous infusion of 2,400 mg/m(2) over the next 46 ho
128 o 180-microg/kg boluses 10 minutes apart and continuous infusion of 2.0 microg/kg per minute), starte
129 e randomly allocated 1:1 either to receive a continuous infusion of 200 mg of hydrocortisone for 5 da
134 mg/mL per min per day for 4 days, etoposide continuous infusion of 338 mg/m(2) per day for 4 days, a
136 s (control), or injured animals treated with continuous infusion of 7-nitroindazole, a specific neuro
137 Ten men and eight women received a primed-continuous infusion of [1,1,2,3,3-(2)H(5)]glycerol and c
138 of age) were studied during 8.5 h of primed continuous infusion of [1,2-(1)(3)C]leucine with intermi
139 infusion of [1,1,2,3,3-(2)H(5)]glycerol and continuous infusion of [1-(13)C]palmitate to measure gly
141 nts with Parkinson's disease, long-acting or continuous infusion of a dopaminergic drug reduces the r
142 aising intragastric pH on the first day as a continuous infusion of a histamine-2-receptor antagonist
143 and LHA from groups of male rats treated by continuous infusion of aCSF or lactate into the caudal f
145 hBNP-054 or vehicle in 6 dogs that received continuous infusion of ANG II to induce hypertension.
147 at 6 months of age, followed 1 week later by continuous infusion of angiotensin II (1 microg/kg per m
148 one site of mouse aorta (elastase model) or continuous infusion of angiotensin II in hyperlipidemic
150 kg of anti-rat NPCT antibody was followed by continuous infusion of anti-NPCT (16 mug per hour) via a
152 d melphalan regimen consisted of carboplatin continuous infusion of area under the plasma concentrati
153 ponse of lymphocytes in leukemic patients to continuous infusion of blinatumomab helps to better unde
154 all patients of a phase 2 study responded to continuous infusion of blinatumomab in a strikingly simi
155 s lower among patients receiving extended or continuous infusion of carbapenems or piperacillin/tazob
156 randomized studies suggests that extended or continuous infusion of carbapenems or piperacillin/tazob
158 induction chemotherapy including 4 cycles of continuous infusion of combinations of dexamethasone, vi
159 ntravenously to male adult rats, followed by continuous infusion of curcumin (0.24 micromol/day) for
161 ved for a 2-h period before the AH by primed continuous infusion of di-deuterated 6,6[2H2]glucose (1.
162 2,100 mg/m2/d on days 1 and 2, and a 72-hour continuous infusion of doxorubicin 75 mg/m2 and vincrist
165 d) or intermittent air (IA; control) and (2) continuous infusion of either 50% dextrose or saline (co
167 randomly allocated at H6 to receive a 42-hr continuous infusion of either hydrocortisone at 200 mg/d
169 e randomly assigned 77 patients to receive a continuous infusion of esmolol titrated to maintain hear
170 nderwent partial pancreatectomy, followed by continuous infusion of EXE or saline (SAL) for 14 weeks.
174 were fluid overloaded, and were receiving a continuous infusion of furosemide (> or =6 mg/kg/day).
179 oncentrate complex (hPCC; 2.5 mL/kg, n = 2), continuous infusion of hPCC (1.0 mL/h, n = 1) or continu
180 inuous infusion of hPCC (1.0 mL/h, n = 1) or continuous infusion of human recombinant factor VIIa (1
182 creases in lung and brain water content with continuous infusion of hypertonic saline may have therap
183 GFR was measured simultaneously using a continuous infusion of I-iothalamate and external radioa
187 Isoproterenol testing was performed with continuous infusion of isoproterenol (45 mug/min) for 3
188 Desensitization was then induced by a 2-hour continuous infusion of isoproterenol, and venodilatation
192 ol intravenously as boluses before and after continuous infusion of L748337 (a specific beta3 antagon
197 estigate the effect of an acute injection or continuous infusion of LPS on experimentally induced hyp
199 atic transection CRPS model is reversed by a continuous infusion of MP (3 mg/kg/day over 21 days), an
200 with an ED(50) of 1.2 mg/kg/day for a 14-day continuous infusion of MP, and a maximum inhibitory effe
201 7) We suggest that patients receiving a continuous infusion of neuromuscular-blocking agent rece
202 neuromuscular blockade in patients receiving continuous infusion of neuromuscular-blocking agents.
203 od, fetuses were given a bolus followed by a continuous infusion of Nomega-nitro-L-arginine methyl es
204 this hypothesis, rats were made tolerant by continuous infusion of NTG for 3 days (10 microgram kg(-
206 connected to osmotic pumps that delivered a continuous infusion of patients' or control cerebrospina
208 he kinase suppressor of ras-1 (KSR1) gene by continuous infusion of phosphorothioate antisense oligon
210 electively stimulated VEGFR-1 and VEGFR-2 by continuous infusion of receptor-specific ligands or sele
211 after subtotal nephrectomy, rats received a continuous infusion of recombinant HGF, neutralization o
212 after subtotal nephrectomy, rats received a continuous infusion of recombinant HGF, neutralization o
216 ith a subcutaneous minipump that delivered a continuous infusion of secreted products from the model
217 tion interruption (defined as cessation of a continuous infusion of sedation agent) were identified.
218 echanically ventilated patients prescribed a continuous infusion of sedative medication while in the
219 th dextran sulphate sodium (DSS) followed by continuous infusion of soy lipid-based PN solution throu
220 p (n = 91) received a weight-based bolus and continuous infusion of T4 according to the organ procure
223 aneous implantation of a morphine pellet and continuous infusion of the delta-opioid receptor antagon
224 cardiotoxicity can be prevented in adults by continuous infusion of the drug, but mechanisms of cardi
226 16 open-chest dogs: 8 controls and 8 given a continuous infusion of the GPI tirofiban, starting 45 mi
227 In mice where hyperalgesia subsided after continuous infusion of the highest morphine dose (i.e.,
228 ature osmotic pumps, we now demonstrate that continuous infusion of these cytokines for 7 days had a
230 s, pulmonary hypertension was induced by the continuous infusion of U46619, a thromboxane A2 analog.
231 Pulmonary hypertension was produced by the continuous infusion of U46619, a thromboxane A2 mimetic.
233 l; group 2, vancomycin twice daily; group 3, continuous infusion of vancomycin; and group 4, linezoli
234 In addition, six sham animals (not injured, continuous infusion of vehicle) were used to obtain refe
235 c oxide synthase group was administered with continuous infusion of ZK 234238 started 1 hr postinjury
236 h sessions, participants received bolus plus continuous infusions of 2-FA, were scanned for 1 h after
237 ein turnover were determined by using primed continuous infusions of [(2)H(5)]phenylalanine and [1-(1
238 inhibitor may be an alternative to high-dose continuous infusions of a histamine-2-receptor antagonis
239 abbits underwent intrathecal cannulation and continuous infusions of either 300 microg/ml recombinant
240 d 2002, 222 patients were treated with 4-day continuous infusions of fluorouracil (1,000 mg/m2/d) and
241 ted at rest and after exercise during primed continuous infusions of l-[ring-(2)H5]phenylalanine and
243 f patients with delirium (CAM-ICU+) received continuous infusions of midazolam (59% vs. 32%, p < .05)
244 assured, and all patients were sedated using continuous infusions of midazolam and/or fentanyl; no ch
245 el and eyelid closure for patients receiving continuous infusions of neuromuscular-blocking agents.
246 en the analyses were adjusted for the use of continuous infusions of opioids and/or sedatives and ven
247 ho were receiving mechanical ventilation and continuous infusions of sedative drugs in a medical inte
249 oprotection, and biomechanics under acute or continuous infusions of the apelinergic agonists ELA or
251 ach on day 1 plus fluorouracil 750 mg/m(2)/d continuous infusion on days 1 to 5 every 3 weeks (DCF) o
252 ) on day 1 plus fluorouracil 1,000 mg/m(2)/d continuous infusion on days 1 to 5 every 4 weeks (CF).
253 , and 3), cytarabine (100 mg/m(2) per day by continuous infusion on days 1-7), and GO (6 mg/m(2) on d
254 ne reduced 25% plus interleukin-2 by 24-hour continuous infusion (on days 5 to 8, 17 to 20, and 26 to
255 ified, the schedule was changed to a 24-hour continuous infusion once weekly (starting dose, 300 mg/m
256 m(2) bolus followed by 2,400 mg/m(2) 46-hour continuous infusion, once every 2 weeks) or gemcitabine
257 A second group of rats were treated with continuous infusion only for 48 hrs of either 7.5% hyper
258 y was administered by bolus as compared with continuous infusion or at a high dose as compared with a
262 every 21 days, ifosfamide 9 g/m2 over 3 days continuous infusion, or ifosfamide 3 g/m2 per day in 3 h
263 , patients can be treated with higher doses, continuous infusions, or the addition of a thiazide diur
265 /m(2) in combination with mesna 5000 mg/m(2) continuous infusion over 24 h, days 1 and 2; one dose of
266 ssitated the administration of BR96-Dox as a continuous infusion over 24 hours and use of antiemetics
267 cated that the higher dose of 10 mg given as continuous infusion over 24 hours had the most favorable
269 (2), LV 400 mg/m(2), and FU 1,400 mg/m(2) by continuous infusion over 48 hours, with the same FUDR do
272 nts, median z score = -0.70 SD, P =.006; for continuous-infusion patients, median z score = -0.765, P
274 he authors used [(11)C]raclopride bolus-plus-continuous-infusion positron emission tomography (PET) t
275 odilatation has been shown to decline during continuous infusion, possibly suggestive of an internali
277 use of either intermittent bolus sedation or continuous infusion sedation targeting specific titratio
278 using either intermittent bolus sedation or continuous infusion sedation with daily interruptions or
280 that it provides long-term cardioprotection; continuous infusions should be eliminated from pediatric
281 g intravenous bolus along with a 10 mg/kg/hr continuous infusion starting just before reperfusion and
282 nine (O6-BG) administered intravenously as a continuous infusion that suppresses O6-alkylguanine-DNA
285 the clinical evidence base for prolonged or continuous infusion therapy is insufficiently strong to
287 agent such as alteplase is an alternative to continuous-infusion thrombolytic regimens and minimizes
288 diation (fluorouracil 225 mg/m(2) per day by continuous infusion throughout radiotherapy, and 45.0 Gy
289 hypothesis, IFN-gamma was administered as a continuous infusion to Fancc-/- and wild-type (WT) mice
290 human clinical trials comparing prolonged or continuous infusion to intermittent injection have faile
291 rmittent bolus administration or propofol by continuous infusion to maintain a Ramsay score of 2-3.
292 uscular blockers, which were administered as continuous infusions to 146 (7%) of these neonates.
293 double-blind, randomized controlled trial of continuous infusion versus intermittent bolus dosing of
294 by intermittent intraperitoneal injection or continuous infusion via an implanted infusion pump.
295 njury from the intraparenchymal catheter and continuous infusion was confined primarily to a narrow z
297 is phase I study of relapsed/refractory NHL, continuous infusion with CD19-targeted immunotherapy bli
298 adolescent rats on postnatal days 30-47 via continuous infusion with implanted osmotic minipumps, us
299 ase II dose of G3139 is 7 mg/kg/d as a 7-day continuous infusion, with cyclophosphamide 500 mg/m2/d a
300 (112 mug/d; n = 2) dosing of blinatumomab by continuous infusion, with dexamethasone prophylaxis, in
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