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1 has long been known that neuronal axons are contractile.
2 his study characterizes protein dynamics and contractile abnormalities in the ischemic and remote myo
3 s, skeletal muscle atrophy, muscle weakness, contractile abnormalities, the loss of functional motor
4 herin adhesion-dependent, substrate-parallel contractile actin belt at the apex that governs anaphase
5 he cytoskeletal architecture is dominated by contractile actin bundles attached at their ends to larg
8 h and mouse in vivo, resulted in the loss of contractile actin filaments and perturbed epithelial pac
9 S-injected rats exhibited impaired intrinsic contractile activity and associated inflammatory changes
10 ading to limited contribution to the heart's contractile activity and increased arrhythmogenic risks.
11 the volume, intensity, frequency and mode of contractile activity and is most evident when contrastin
12 lts from the decline in calcium oscillations/contractile activity and mitofusin 1 (Mfn1), because (i)
13 ns regulate mitochondrial ATP production and contractile activity and thus play a pivotal role in mat
14 ns regulate mitochondrial ATP production and contractile activity and thus play a pivotal role in mat
15 is involves contrasting how different muscle contractile activity patterns regulate the underlying mo
17 d media distinctly enhanced CM spreading and contractile activity, which was shown by pathway inhibit
19 at endothelial cell-cell junctions links the contractile acto-myosin cytoskeletons of adjacent cells,
20 oss was associated with abnormal basolateral contractile actomyosin and Enabled (Ena) accumulation.
25 together but also couple cell membranes to a contractile actomyosin network, which limits the expansi
30 metrium precontracted by a broad spectrum of contractile agonists, and that targeting TAS2Rs is an at
31 N-deficient hearts, and maximally stimulated contractile and calcium kinetic parameters were similar
32 ote resident fibroblast differentiation into contractile and extracellular matrix-producing myofibrob
33 homeostasis, they nonetheless develop fatal contractile and metabolic dysfunction as a consequence o
35 red antibiotic free, with retained organized contractile and mitochondrial morphology, transcriptiona
40 e concluded that the cooperative work of the contractile and the elastic elements within a myofibril
42 osensor assessment, e.g. membrane voltage or contractile apparatus Ca(2+) ion responses (force resolu
43 nism of some DCM-associated mutations in the contractile apparatus has been studied in vitro and in t
44 proteins into sarcomeres and coupling of the contractile apparatus to the sarcoplasmic reticulum (SR)
46 sion, modification, titin isoform shift, and contractile behavior of cardiomyocytes in heart tissue o
49 c protein expression and phosphorylation and contractile behaviour in single membrane-permeabilized c
52 ral arteries from HA fetuses showed a higher contractile capacity but a diminished response to catech
57 and organization in vivo and in specialized contractile cells, such as smooth muscle and myoepitheli
58 optical flow data one can identify distinct contractile centers and distinguish active cell contract
59 brium can explain how cells maintain stable, contractile connections to discrete points within ECM du
61 ation-free and efficient characterization of contractile cycles, an important characteristics of card
62 uggests that the subcellular organization of contractile cytoskeletal networks plays a key role in fo
64 studied in vitro and in transgenic mice, the contractile defect in human heart muscle has not been st
66 ices to study drug responses, as well as the contractile development of human stem cell-derived lamin
68 e had unaltered NDPK-C expression but showed contractile dysfunction and exacerbated cardiac remodeli
73 ights significantly improve understanding of contractile dysfunction at a level of noninvasive interr
75 e, a reduction in Ca transient amplitude and contractile dysfunction can by caused by Ca leak through
78 l histone doses (30 mg/kg), left ventricular contractile dysfunction was the prominent abnormality wi
79 provide a framework to study development of contractile dysfunction with disease and evaluate the ma
80 at total loss of Ryr2 leads to cardiomyocyte contractile dysfunction, arrhythmia, and reduced heart r
81 onded to chronic catecholamine toxicity with contractile dysfunction, cardiomyocyte hypertrophy, card
82 nd insulin resistance (IR), as well as major contractile dysfunction, which was associated with alter
90 These electrochemical muscles can deliver a contractile energy conversion efficiency of 5.4%, which
91 ile state and that a significant part of the contractile energy is not transferred to cell anchorage
92 ng with a computational approach to identify contractile events, we discovered that differences in co
93 l RhoA activation initiates the formation of contractile F-actin structures that surround emigrating
95 ve coalescence of NMY-2 filaments into large contractile foci and for long-range coordinated contract
96 velocity of action potential propagation and contractile force amplitude compared to patches containi
97 ac myocytes Ca(2+) is a crucial regulator of contractile force and in this review we compare and cont
99 hibit an increased capability of maintaining contractile force during repetitive stimulation in the p
100 re responsible for electrical conduction and contractile force generation, while the other cell types
101 approximately threefold increase in maximum contractile force of the treated muscle at 2 wk compared
102 ce exhibited the typical biphasic decline in contractile force with repetitive stimuli of hind-limb m
105 mechanical circuit that integrates adhesion, contractile forces and biochemical signaling to drive th
110 operties, the major drivers of which are the contractile forces exerted by platelets against the fibr
111 us types of actomyosin bundles that generate contractile forces for biological processes, such as cyt
112 lopment and enhance local integrin-dependent contractile forces for pulling neighboring cells apart.
113 in eukaryotic cells have been attributed to contractile forces from the actomyosin ring and the acto
114 essential to maintain animal cell shape, and contractile forces generated within it by nonmuscle myos
115 rocess whereby activated platelets transduce contractile forces onto the fibrin network of a thrombus
116 the uniaxial stretch and the strength of the contractile forces regulate a gradual transition between
117 ng enables the cells to polarize and develop contractile forces to break free from the tumor spheroid
118 lls followed a common trend whereby size and contractile forces were negatively correlated with cell
120 ex, stroke volume index, global and regional contractile function (myocardial strain), coronary arter
121 l resting SR Ca(2+) leak resulted in reduced contractile function and muscle fiber atrophy for longer
122 ue by combining experimental measurements of contractile function and pressure generation with a prev
124 streptozotocin (STZ) treatment, and bladder contractile function and TLR4 pathway expression were ev
126 peptide 1 (GLP-1) therapies improve cardiac contractile function at rest and in response to adrenerg
127 pharmacological agent that augments cardiac contractile function by enhancing myofilament Ca(2+) sen
129 thods to preserve cardiac cell viability and contractile function following ischemia are limited in t
130 th gata1 MO rescued trabeculation to restore contractile function in association with upregulation of
131 regression of acute individual measures with contractile function in corresponding areas at day 21 de
132 mulation impairs beta-adrenergically induced contractile function in isolated cardiomyocytes and Lang
134 ve of human engineered cardiac tissue (hECT) contractile function measurements under matched experime
135 tes glomerular filtration rate (GFR) and the contractile function of glomerular mesangial cells (MCs)
137 the downstream consequences of the earliest contractile function on cardiac differentiation and morp
138 that TRPC6 may regulate GFR by modulating MC contractile function through multiple Ca(2+) signaling p
139 s (KATP channels) in cardiac myocytes adjust contractile function to compensate for the level of avai
140 IS200D were protected, recovering 88+/-8% of contractile function versus 35+/-15% in littermate contr
143 Left ventricular structure, diastolic and contractile function, and ventricular-arterial coupling
144 s, acting to regulate cardiac metabolism and contractile function, as well as promoting anticontracti
153 rone receptor (PR), inhibits proinflammatory/contractile gene expression during pregnancy are incompl
159 how that the ring is vulnerable to intrinsic contractile instabilities, and protection from these ins
162 ngle platelets and aggregates use actomyosin contractile machinery and integrin-mediated adhesion to
167 in THP-1 cells and reduced the expression of contractile markers in co-cultured human aortic smooth m
168 The actomyosin cell cortex is an active contractile material for driving cell- and tissue morpho
169 of human fetal cardiac muscle structure and contractile maturation can provide a framework to study
170 ated into CMs (hiPSC-CMs) that model cardiac contractile mechanical output more robustly when micropa
171 ng of a model parameter space shows that the contractile mechanism of motility supports robust cell t
172 output necessary for heart function through contractile mechanisms that involve shortening of sarcom
173 orter-4 (GluT4) is critical for insulin- and contractile-mediated glucose uptake in skeletal muscle.
175 smooth myocytes later co-opted the striated contractile module repeatedly - for example, in vertebra
176 ne are extremely important in homeostasis of contractile muscles as a results of their role as buffer
177 desmin intermediate filaments interlink the contractile myofibrillar apparatus with mitochondria, nu
178 that the RhoA pathway was essential for the contractile myofibroblastic phenotype present in early c
179 ue to Rho kinase (ROCK) controlled excessive contractile myosin-II activity and not to elevated F-act
180 sses: the R-type PTLBs, which are related to contractile Myoviridae phage tails, and the F-type PTLBs
181 minated by biaxial deformations are robustly contractile over a wide range of connectivities, while n
182 n in the adult heart significantly increased contractile parameters and calcium kinetics, associated
183 ingle micropatterned hiPSC-CMs and determine contractile parameters that can be used to elucidate mec
186 specific Nox4 transgenic mice exhibit a hypo-contractile phenotype in response to phenylephrine that
187 between cholinergic neuroplasticity and ASM contractile phenotypes that operates uniquely in early l
189 Pase Rab35 as an essential component of this contractile process, which functions as a membrane ratch
191 ity of this new reporter rat, we studied the contractile properties and valvular functions of mesente
192 Ca(2+) cycling, the electrophysiological and contractile properties of cardiomyocytes, cardiac fibros
194 similar to human muscle in its single-fiber contractile properties, but exhibits a much higher fract
198 ctivator (cyclin D1, E1, and IGF1) and fetal contractile protein (ssTNI, betaMHC) mRNA was increased
199 e recruitment and localization of anillin, a contractile protein and a crucial regulator of cytokines
200 ches such as isolated myofibril and isolated contractile protein biomechanical assays allow study of
201 myofibrils from 3 TTNtv mutants, and 3 with contractile protein mutations (TNNI3 K36Q, TNNC1 G159D a
203 ance of muscle function requires assembly of contractile proteins into highly organized sarcomeres.
204 ction depends on the precise organization of contractile proteins into sarcomeres and coupling of the
205 aberrant expression of muscle structural and contractile proteins, mimicking the hallmarks of the hum
209 show that APC-dependent RNAs are enriched in contractile protrusions, via detyrosinated microtubules,
210 a2 AR, contributing to impairment of cardiac contractile reserve before cardiac structural and functi
212 ced exercise capability and impaired cardiac contractile reserve in response to adrenergic stimulatio
214 f cyclooxygenase-derived prostanoids in this contractile response and determined whether there were a
215 s from HFD-fed mice also displayed a reduced contractile response to adrenergic stimulation when comp
218 ty of tasks and to illustrate the individual contractile responses of MUs whose collective action det
219 d that TGF-beta pre-treatment enhanced acute contractile responses to bradykinin (BK) in isolated rat
220 This model was compared with metabolic and contractile responses to repeated activation using value
221 ed an increase in the IAS tone; these tissue contractile responses were confirmed by single-cell cont
222 CR4 sustained normal vascular reactivity and contractile responses, whereas CXCR4 deficiency favored
223 and constricting an actin- and myosin-based contractile ring (CR) that is physically linked to the p
224 the components and spatial regulation of the contractile ring (CR), the precise ultrastructure of act
230 ion of the cytokinesis furrow, such that the contractile ring assembles in an equatorial zone between
231 on of formin Cdc12 is required for efficient contractile ring assembly in vivo.The fission yeast cyto
232 al organization of Schizosaccharomyces pombe contractile ring components relative to the plasma membr
233 nesis failure due to disruption of two other contractile ring components, the Rho effectors diaphanou
234 ac activity was proposed to be inhibitory to contractile ring constriction and thus specifically inac
235 pport the canonical "purse-string" model for contractile ring constriction, but also suggest that the
239 sets of segregating chromosomes, the meiotic contractile ring forms on the cortex adjacent to one spi
244 organizing the structural components of the contractile ring including filamentous actin (F-actin),
245 s that contain all maternal DNA, because the contractile ring ingressed past the spindle midpoint.
247 ing in vitro reconstitution of fission yeast contractile ring precursor nodes containing formins and
248 tubulin-like FtsZ protein polymerizes into a contractile ring structure required for cytokinesis in m
249 s is driven by constriction of an actomyosin contractile ring that is controlled by Rho-family small
251 nisms that position the furrow, assemble the contractile ring, anchor the ring to the plasma membrane
252 yosin, is the major source of tension in the contractile ring, but how Myo2 is anchored and regulated
253 s of animal cells requires the assembly of a contractile ring, which promotes daughter cell splitting
254 o not have a constriction, arguing against a contractile ring-based nuclear expulsion mechanism.
263 have revealed that cytokinesis in cells with contractile rings (amoebas, fungi, and animals) depends
267 hincter muscle cells, with the light-induced contractile signal apparently spreading through gap junc
269 ate in plaques because fully differentiated, contractile SMCs reprogramme into a 'synthetic' migrator
270 ptimal readout to properly characterize cell contractile state and that a significant part of the con
271 mote insulin resistance and impair lymphatic contractile status by reducing glucose uptake, altering
273 tivation of NM myosin II is regulated during contractile stimulation of airway SM tissues by RhoA-med
274 e evaluated the function of NM myosin during contractile stimulation of canine tracheal SM tissues.
277 tional assay that provides insights into the contractile strength of muscle fibers as well as the len
279 ike stiffness matrix, mutant cells exhibited contractile stress fibre accumulation, increased focal a
280 uce elasticity, while increasing the overall contractile stress generated by the platelet-fibrin mesh
281 llective migration, shows that intracellular contractile stress, isolated cell speed, and adhesion al
282 quirements for production and dissipation of contractile stress: Asymmetric filament compliance, spat
283 actomyosin interactions are able to generate contractile stresses during ring constriction, although
285 non-invasive, electronic readouts of tissue contractile stresses inside cell incubator environments.
288 cterial toxins that disrupt the stability of contractile structures in endothelial cells promote the
293 Whereas muscle is often viewed as a strictly contractile tissue, these findings reveal that different
294 imensional multicellular in vitro or in vivo contractile tissues, such as cardiac "organoids," engine
295 the assembly and organization of the central contractile unit of striated muscle and also as a mechan
296 hat each bicellular border is an independent contractile unit, with actin cables anchored end-on to c
297 way by which Epac increases STOC activity in contractile vascular smooth muscle and show that a criti
298 mmuno-localization and is capable to resolve contractile waves and their synchronization within matur
299 ative role in the development of atrophy and contractile weakness of the diaphragm in critically ill
300 l patients displayed significant atrophy and contractile weakness, but lacked impaired mitochondrial
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