ライフサイエンスコーパス: contractile

1 has long been known that neuronal axons are contractile.

2 his study characterizes protein dynamics and contractile abnormalities in the ischemic and remote myo

3 s, skeletal muscle atrophy, muscle weakness, contractile abnormalities, the loss of functional motor

4 herin adhesion-dependent, substrate-parallel contractile actin belt at the apex that governs anaphase

5 he cytoskeletal architecture is dominated by contractile actin bundles attached at their ends to larg

6 Although the contractile actin cortex involved in bleb-driven motilit

7 The contractile actin cortex may govern the lateral organiza

8 h and mouse in vivo, resulted in the loss of contractile actin filaments and perturbed epithelial pac

9 S-injected rats exhibited impaired intrinsic contractile activity and associated inflammatory changes

10 ading to limited contribution to the heart's contractile activity and increased arrhythmogenic risks.

11 the volume, intensity, frequency and mode of contractile activity and is most evident when contrastin

12 lts from the decline in calcium oscillations/contractile activity and mitofusin 1 (Mfn1), because (i)

13 ns regulate mitochondrial ATP production and contractile activity and thus play a pivotal role in mat

14 ns regulate mitochondrial ATP production and contractile activity and thus play a pivotal role in mat

15 is involves contrasting how different muscle contractile activity patterns regulate the underlying mo

16 ed to carry the effect allele had diminished contractile activity when compared with controls.

17 d media distinctly enhanced CM spreading and contractile activity, which was shown by pathway inhibit

18 ges in skeletal muscle metabolism induced by contractile activity.

19 at endothelial cell-cell junctions links the contractile acto-myosin cytoskeletons of adjacent cells,

20 oss was associated with abnormal basolateral contractile actomyosin and Enabled (Ena) accumulation.

21 Thus, UNC-45a promotes generation of contractile actomyosin bundles through synchronized NM-I

22 Contractile actomyosin bundles, stress fibers, are cruci

23 Stress fibers-contractile actomyosin bundles-are important for cellula

24 generating intracellular pressure, which the contractile actomyosin cortex directs into shape.

25 together but also couple cell membranes to a contractile actomyosin network, which limits the expansi

26 During cytokinesis, a contractile actomyosin ring constricts and divides the c

27 Cytokinesis depends on a contractile actomyosin ring in many eukaryotes [1-3].

28 ically separates dividing cells by forming a contractile actomyosin ring.

29 e, scalability, and single-degree-of-freedom contractile actuation motions.

30 metrium precontracted by a broad spectrum of contractile agonists, and that targeting TAS2Rs is an at

31 N-deficient hearts, and maximally stimulated contractile and calcium kinetic parameters were similar

32 ote resident fibroblast differentiation into contractile and extracellular matrix-producing myofibrob

33 homeostasis, they nonetheless develop fatal contractile and metabolic dysfunction as a consequence o

34 otein expression across muscles of different contractile and metabolic phenotypes.

35 red antibiotic free, with retained organized contractile and mitochondrial morphology, transcriptiona

36 -CMR accompanied by transient alterations in contractile and mitochondrial proteins.

37 uired in addition to the YAP pathway for CAF contractile and proinvasive properties.

38 asing IHVR because, when activated, they are contractile and promote fibrogenesis.

39 Remodeling of contractile and signaling Ca(2+) occurs in pathological

40 e concluded that the cooperative work of the contractile and the elastic elements within a myofibril

41 actin cytoskeleton supports a wide range of contractile and transport processes.

42 osensor assessment, e.g. membrane voltage or contractile apparatus Ca(2+) ion responses (force resolu

43 nism of some DCM-associated mutations in the contractile apparatus has been studied in vitro and in t

44 proteins into sarcomeres and coupling of the contractile apparatus to the sarcoplasmic reticulum (SR)

45 d to potential Ca(2+) desensitization of VSM contractile apparatus.

46 sion, modification, titin isoform shift, and contractile behavior of cardiomyocytes in heart tissue o

47 in stiffness is a principal regulator of the contractile behavior of striated muscle.

48 sponse to selection for repetitive, low-cost contractile behavior.

49 c protein expression and phosphorylation and contractile behaviour in single membrane-permeabilized c

50 at surround the cell and is reminiscent of a contractile belt.

51 One example of contractile bundles is a transverse arc that forms via a

52 ral arteries from HA fetuses showed a higher contractile capacity but a diminished response to catech

53 combinations of muscle atrophy and impaired contractile capacity.

54 ness, owing to persistent impaired voluntary contractile capacity.

55 lation of Myosin-II, which leads to a highly contractile cell interface.

56 Finally, Rab35 represents a common contractile cell-shaping mechanism, as mesoderm invagina

57 and organization in vivo and in specialized contractile cells, such as smooth muscle and myoepitheli

58 optical flow data one can identify distinct contractile centers and distinguish active cell contract

59 brium can explain how cells maintain stable, contractile connections to discrete points within ECM du

60 tablishing normal smooth muscle cytoskeletal-contractile coupling.

61 ation-free and efficient characterization of contractile cycles, an important characteristics of card

62 uggests that the subcellular organization of contractile cytoskeletal networks plays a key role in fo

63 as cytokinesis are driven by the actomyosin contractile cytoskeleton.

64 studied in vitro and in transgenic mice, the contractile defect in human heart muscle has not been st

65 ss of synchronicity of beating in cells with contractile defects.

66 ices to study drug responses, as well as the contractile development of human stem cell-derived lamin

67 We built a minimal model to simulate contractile dynamics in the Caenorhabditis elegans zygot

68 e had unaltered NDPK-C expression but showed contractile dysfunction and exacerbated cardiac remodeli

69 diotoxic PAHs, and the mechanisms underlying contractile dysfunction are not known.

70 eneficial therapeutic strategy to ameliorate contractile dysfunction associated with sepsis.

71 Ca loss that mediate altered Ca handling and contractile dysfunction associated with sepsis.

72 t protein kinase II has a causal role in the contractile dysfunction associated with sepsis.

73 ights significantly improve understanding of contractile dysfunction at a level of noninvasive interr

74 Sepsis is associated with cardiac contractile dysfunction attributed to alterations in Ca

75 e, a reduction in Ca transient amplitude and contractile dysfunction can by caused by Ca leak through

76 and functional disruption of JMCs underlies contractile dysfunction in failing hearts.

77 tribute to lower cAMP levels and the related contractile dysfunction in HF.

78 l histone doses (30 mg/kg), left ventricular contractile dysfunction was the prominent abnormality wi

79 provide a framework to study development of contractile dysfunction with disease and evaluate the ma

80 at total loss of Ryr2 leads to cardiomyocyte contractile dysfunction, arrhythmia, and reduced heart r

81 onded to chronic catecholamine toxicity with contractile dysfunction, cardiomyocyte hypertrophy, card

82 nd insulin resistance (IR), as well as major contractile dysfunction, which was associated with alter

83 egy protecting the heart from arrhythmia and contractile dysfunction.

84 ne cell infiltration, myocardial injury, and contractile dysfunction.

85 dimer formation and attenuated H2O2-induced contractile dysfunction.

86 denced by reduced hypertrophy, fibrosis, and contractile dysfunction.

87 impaired systolic strain indicating a subtle contractile dysfunction.

88 ipitates into cardiac insulin resistance and contractile dysfunction.

89 Healthy PVAT elicits an anti-contractile effect, which was lost in mice deficient in

90 These electrochemical muscles can deliver a contractile energy conversion efficiency of 5.4%, which

91 ile state and that a significant part of the contractile energy is not transferred to cell anchorage

92 ng with a computational approach to identify contractile events, we discovered that differences in co

93 l RhoA activation initiates the formation of contractile F-actin structures that surround emigrating

94 in the assembly and activation of NMII into contractile filaments.

95 ve coalescence of NMY-2 filaments into large contractile foci and for long-range coordinated contract

96 velocity of action potential propagation and contractile force amplitude compared to patches containi

97 ac myocytes Ca(2+) is a crucial regulator of contractile force and in this review we compare and cont

98 ament reorganization, accompanied by reduced contractile force and increased stiffness of cells.

99 hibit an increased capability of maintaining contractile force during repetitive stimulation in the p

100 re responsible for electrical conduction and contractile force generation, while the other cell types

101 approximately threefold increase in maximum contractile force of the treated muscle at 2 wk compared

102 ce exhibited the typical biphasic decline in contractile force with repetitive stimuli of hind-limb m

103 eric structure, cell and matrix deformation, contractile force, and electrical conduction.

104 To test these hypotheses, we studied contractile force, mitochondrial function, and mitochond

105 mechanical circuit that integrates adhesion, contractile forces and biochemical signaling to drive th

106 Contractile forces are the end effectors of cell migrati

107 tained by the generation and organization of contractile forces at the cell and tissue levels.

108 ytokinesis failure resulting from defects in contractile forces at the cleavage furrow.

109 Tendons transmit contractile forces between musculoskeletal tissues.

110 operties, the major drivers of which are the contractile forces exerted by platelets against the fibr

111 us types of actomyosin bundles that generate contractile forces for biological processes, such as cyt

112 lopment and enhance local integrin-dependent contractile forces for pulling neighboring cells apart.

113 in eukaryotic cells have been attributed to contractile forces from the actomyosin ring and the acto

114 essential to maintain animal cell shape, and contractile forces generated within it by nonmuscle myos

115 rocess whereby activated platelets transduce contractile forces onto the fibrin network of a thrombus

116 the uniaxial stretch and the strength of the contractile forces regulate a gradual transition between

117 ng enables the cells to polarize and develop contractile forces to break free from the tumor spheroid

118 lls followed a common trend whereby size and contractile forces were negatively correlated with cell

119 epend little on adhesion bonds and mostly on contractile forces.

120 ex, stroke volume index, global and regional contractile function (myocardial strain), coronary arter

121 l resting SR Ca(2+) leak resulted in reduced contractile function and muscle fiber atrophy for longer

122 ue by combining experimental measurements of contractile function and pressure generation with a prev

123 Preservation of contractile function and protection against adverse chan

124 streptozotocin (STZ) treatment, and bladder contractile function and TLR4 pathway expression were ev

125 HF myocardium exhibited impaired contractile function as evidenced by reduced maximal for

126 peptide 1 (GLP-1) therapies improve cardiac contractile function at rest and in response to adrenerg

127 pharmacological agent that augments cardiac contractile function by enhancing myofilament Ca(2+) sen

128 All measures of systolic contractile function fell during HD and HDF, with partia

129 thods to preserve cardiac cell viability and contractile function following ischemia are limited in t

130 th gata1 MO rescued trabeculation to restore contractile function in association with upregulation of

131 regression of acute individual measures with contractile function in corresponding areas at day 21 de

132 mulation impairs beta-adrenergically induced contractile function in isolated cardiomyocytes and Lang

133 aphy, and 40% reduction in right ventricular contractile function in isolated perfused hearts.

134 ve of human engineered cardiac tissue (hECT) contractile function measurements under matched experime

135 tes glomerular filtration rate (GFR) and the contractile function of glomerular mesangial cells (MCs)

136 ave been identified in genes that govern the contractile function of the cardiomyocytes.

137 the downstream consequences of the earliest contractile function on cardiac differentiation and morp

138 that TRPC6 may regulate GFR by modulating MC contractile function through multiple Ca(2+) signaling p

139 s (KATP channels) in cardiac myocytes adjust contractile function to compensate for the level of avai

140 IS200D were protected, recovering 88+/-8% of contractile function versus 35+/-15% in littermate contr

141 Contractile function was also preserved in colon ascende

142 Cardiac remodeling and contractile function were assessed extensively at the wh

143 Left ventricular structure, diastolic and contractile function, and ventricular-arterial coupling

144 s, acting to regulate cardiac metabolism and contractile function, as well as promoting anticontracti

145 LAS, as a marker for longitudinal contractile function, is an independent parameter for ou

146 , maintaining ventricular wall thickness and contractile function.

147 ceptor signalling and the impacts on cardiac contractile function.

148 anoids, thereby restoring ENS cell types and contractile function.

149 rgy in the form of ATP to support persistent contractile function.

150 y role in the regulation of normal PVAT anti-contractile function.

151 es in energy production, and improvements in contractile function.

152 Myofibroblasts develop contractile functions and secrete the extracellular matr

153 rone receptor (PR), inhibits proinflammatory/contractile gene expression during pregnancy are incompl

154 ns in actin gamma 2 (ACTG2), a smooth muscle contractile gene.

155 of P4-PR suppression of proinflammatory and contractile genes during pregnancy.

156 Contractile impairments were caused by impaired protein

157 We measured steady-state and dynamic contractile indices in detergent-skinned guinea pig (Cav

158 Our work reveals how contractile instabilities that are natural to occur in m

159 how that the ring is vulnerable to intrinsic contractile instabilities, and protection from these ins

160 ack between active RhoA and myosin induces a contractile instability in the cortex.

161 Rab35 compartments are enriched at contractile interfaces of intercalating cells and provid

162 ngle platelets and aggregates use actomyosin contractile machinery and integrin-mediated adhesion to

163 expression, effectors such as the actomyosin contractile machinery drive embryo morphogenesis.

164 The contractile machinery of heart and skeletal muscles has

165 Muscle force is dictated by micrometer-scale contractile machines called sarcomeres.

166 r) expression were reduced while SM-MHC (SMC contractile marker) levels were increased.

167 in THP-1 cells and reduced the expression of contractile markers in co-cultured human aortic smooth m

168 The actomyosin cell cortex is an active contractile material for driving cell- and tissue morpho

169 of human fetal cardiac muscle structure and contractile maturation can provide a framework to study

170 ated into CMs (hiPSC-CMs) that model cardiac contractile mechanical output more robustly when micropa

171 ng of a model parameter space shows that the contractile mechanism of motility supports robust cell t

172 output necessary for heart function through contractile mechanisms that involve shortening of sarcom

173 orter-4 (GluT4) is critical for insulin- and contractile-mediated glucose uptake in skeletal muscle.

174 Injected mouse pre-contractile Mesp1-EYFP+ CPCs improved the survivability

175 smooth myocytes later co-opted the striated contractile module repeatedly - for example, in vertebra

176 ne are extremely important in homeostasis of contractile muscles as a results of their role as buffer

177 desmin intermediate filaments interlink the contractile myofibrillar apparatus with mitochondria, nu

178 that the RhoA pathway was essential for the contractile myofibroblastic phenotype present in early c

179 ue to Rho kinase (ROCK) controlled excessive contractile myosin-II activity and not to elevated F-act

180 sses: the R-type PTLBs, which are related to contractile Myoviridae phage tails, and the F-type PTLBs

181 minated by biaxial deformations are robustly contractile over a wide range of connectivities, while n

182 n in the adult heart significantly increased contractile parameters and calcium kinetics, associated

183 ingle micropatterned hiPSC-CMs and determine contractile parameters that can be used to elucidate mec

184 ts in relaxation (diastole) while preserving contractile performance.

185 been attributed to capillary constriction by contractile pericytes.

186 specific Nox4 transgenic mice exhibit a hypo-contractile phenotype in response to phenylephrine that

187 between cholinergic neuroplasticity and ASM contractile phenotypes that operates uniquely in early l

188 Moreover, highly contractile platelet subpopulations present in healthy c

189 Pase Rab35 as an essential component of this contractile process, which functions as a membrane ratch

190 lance between antagonistic proliferative and contractile programs of gene expression.

191 ity of this new reporter rat, we studied the contractile properties and valvular functions of mesente

192 Ca(2+) cycling, the electrophysiological and contractile properties of cardiomyocytes, cardiac fibros

193 We have examined the contractile properties of human fetal cardiac myofibrils

194 similar to human muscle in its single-fiber contractile properties, but exhibits a much higher fract

195 fibers that possess different metabolic and contractile properties.

196 al myocytes in morphological, electrical and contractile properties.

197 ique morphological, electrophysiological and contractile properties.

198 ctivator (cyclin D1, E1, and IGF1) and fetal contractile protein (ssTNI, betaMHC) mRNA was increased

199 e recruitment and localization of anillin, a contractile protein and a crucial regulator of cytokines

200 ches such as isolated myofibril and isolated contractile protein biomechanical assays allow study of

201 myofibrils from 3 TTNtv mutants, and 3 with contractile protein mutations (TNNI3 K36Q, TNNC1 G159D a

202 We found that the three contractile protein mutations but not the TTNtv mutation

203 ance of muscle function requires assembly of contractile proteins into highly organized sarcomeres.

204 ction depends on the precise organization of contractile proteins into sarcomeres and coupling of the

205 aberrant expression of muscle structural and contractile proteins, mimicking the hallmarks of the hum

206 own of GAS5 increased, the expression of SMC contractile proteins.

207 s a critical regulator of other membrane and contractile proteins.

208 and acts as a transcriptional suppressor of contractile proteins.

209 show that APC-dependent RNAs are enriched in contractile protrusions, via detyrosinated microtubules,

210 a2 AR, contributing to impairment of cardiac contractile reserve before cardiac structural and functi

211 ed adrenergic response and preserved cardiac contractile reserve in HFD-fed mice.

212 ced exercise capability and impaired cardiac contractile reserve in response to adrenergic stimulatio

213 drenergic stimulation despite normal cardiac contractile reserve.

214 f cyclooxygenase-derived prostanoids in this contractile response and determined whether there were a

215 s from HFD-fed mice also displayed a reduced contractile response to adrenergic stimulation when comp

216 p/dtmax in response to BK, indicating a poor contractile response to CSAR activation.

217 al contractions (P < 0.05) and an attenuated contractile response to oxytocin.

218 ty of tasks and to illustrate the individual contractile responses of MUs whose collective action det

219 d that TGF-beta pre-treatment enhanced acute contractile responses to bradykinin (BK) in isolated rat

220 This model was compared with metabolic and contractile responses to repeated activation using value

221 ed an increase in the IAS tone; these tissue contractile responses were confirmed by single-cell cont

222 CR4 sustained normal vascular reactivity and contractile responses, whereas CXCR4 deficiency favored

223 and constricting an actin- and myosin-based contractile ring (CR) that is physically linked to the p

224 the components and spatial regulation of the contractile ring (CR), the precise ultrastructure of act

225 many eukaryotes requires an actomyosin-based contractile ring [1].

226 sition and triggers the assembly of a medial contractile ring [5, 9-11].

227 Forces from the actomyosin contractile ring and cortex do contribute to the cell sh

228 In contrast, the contractile ring and midbody required for cytokinesis, t

229 They are released from the contractile ring as it disassembles and then associate w

230 ion of the cytokinesis furrow, such that the contractile ring assembles in an equatorial zone between

231 on of formin Cdc12 is required for efficient contractile ring assembly in vivo.The fission yeast cyto

232 al organization of Schizosaccharomyces pombe contractile ring components relative to the plasma membr

233 nesis failure due to disruption of two other contractile ring components, the Rho effectors diaphanou

234 ac activity was proposed to be inhibitory to contractile ring constriction and thus specifically inac

235 pport the canonical "purse-string" model for contractile ring constriction, but also suggest that the

236 In all organisms that use a contractile ring for cell division, the process of cytok

237 Contractile ring formation is mediated by RhoA activatio

238 Unlike mitosis, where an actomyosin contractile ring forms between the sets of segregating c

239 sets of segregating chromosomes, the meiotic contractile ring forms on the cortex adjacent to one spi

240 l map provides a framework for understanding contractile ring function.

241 The fission yeast contractile ring has been proposed to assemble by Search

242 expansion and concatenation also formed the contractile ring in dividing cells.

243 ate in the formation and constriction of the contractile ring in fission yeast.

244 organizing the structural components of the contractile ring including filamentous actin (F-actin),

245 s that contain all maternal DNA, because the contractile ring ingressed past the spindle midpoint.

246 The contractile ring is a complex molecular apparatus which

247 ing in vitro reconstitution of fission yeast contractile ring precursor nodes containing formins and

248 tubulin-like FtsZ protein polymerizes into a contractile ring structure required for cytokinesis in m

249 s is driven by constriction of an actomyosin contractile ring that is controlled by Rho-family small

250 In contrast to cells that use a contractile ring, actin was not concentrated in the furr

251 nisms that position the furrow, assemble the contractile ring, anchor the ring to the plasma membrane

252 yosin, is the major source of tension in the contractile ring, but how Myo2 is anchored and regulated

253 s of animal cells requires the assembly of a contractile ring, which promotes daughter cell splitting

254 o not have a constriction, arguing against a contractile ring-based nuclear expulsion mechanism.

255 first phase relies on the assembly of a wide contractile ring.

256 ature into the precursors of the cytokinetic contractile ring.

257 d is required for myosin enrichment into the contractile ring.

258 lymerize actin filaments for the cytokinetic contractile ring.

259 ed models of the dynamics of the cytokinetic contractile ring.

260 supergroups lack myosin II of the actomyosin contractile ring.

261 t the cell cycle and are constituents of the contractile ring.

262 ins in the functional units of a cytokinetic contractile ring.

263 have revealed that cytokinesis in cells with contractile rings (amoebas, fungi, and animals) depends

264 uss the model's implication for mechanics of contractile rings and stress fibers.

265 generation candidate gene that modulates the contractile sarcomeric apparatus.

266 the protein kinase A pathway diminished the contractile sexual dimorphisms previously observed.

267 hincter muscle cells, with the light-induced contractile signal apparently spreading through gap junc

268 g endothelial barrier function, and a normal contractile SMC phenotype.

269 ate in plaques because fully differentiated, contractile SMCs reprogramme into a 'synthetic' migrator

270 ptimal readout to properly characterize cell contractile state and that a significant part of the con

271 mote insulin resistance and impair lymphatic contractile status by reducing glucose uptake, altering

272 ed, apical area oscillations still occur and contractile steps are observed.

273 tivation of NM myosin II is regulated during contractile stimulation of airway SM tissues by RhoA-med

274 e evaluated the function of NM myosin during contractile stimulation of canine tracheal SM tissues.

275 Contractile stimulation of tracheal smooth muscle tissue

276 sembly of membrane adhesome complexes during contractile stimulation.

277 tional assay that provides insights into the contractile strength of muscle fibers as well as the len

278 The recruitment of LIMCH1 into contractile stress fibers revealed its localization comp

279 ike stiffness matrix, mutant cells exhibited contractile stress fibre accumulation, increased focal a

280 uce elasticity, while increasing the overall contractile stress generated by the platelet-fibrin mesh

281 llective migration, shows that intracellular contractile stress, isolated cell speed, and adhesion al

282 quirements for production and dissipation of contractile stress: Asymmetric filament compliance, spat

283 actomyosin interactions are able to generate contractile stresses during ring constriction, although

284 Our measurements suggest that the contractile stresses exerted by the leukocytes and the V

285 non-invasive, electronic readouts of tissue contractile stresses inside cell incubator environments.

286 operties with high conduction velocities and contractile stresses.

287 PLST-1 was enriched in contractile structures and was required for effective co

288 cterial toxins that disrupt the stability of contractile structures in endothelial cells promote the

289 ike myoviruses, has a prolate capsid, a long contractile tail and infects Prochlorococcus sp.

290 that is driven by elastic energy stored in a contractile tail sheath.

291 inase essential for junctional integrity and contractile tension at epithelial ZA.

292 deformations can be tuned from extensile to contractile through cross-linking.

293 Whereas muscle is often viewed as a strictly contractile tissue, these findings reveal that different

294 imensional multicellular in vitro or in vivo contractile tissues, such as cardiac "organoids," engine

295 the assembly and organization of the central contractile unit of striated muscle and also as a mechan

296 hat each bicellular border is an independent contractile unit, with actin cables anchored end-on to c

297 way by which Epac increases STOC activity in contractile vascular smooth muscle and show that a criti

298 mmuno-localization and is capable to resolve contractile waves and their synchronization within matur

299 ative role in the development of atrophy and contractile weakness of the diaphragm in critically ill

300 l patients displayed significant atrophy and contractile weakness, but lacked impaired mitochondrial