ライフサイエンスコーパス: contractile force

1 to inhibit phosphatase activity and increase contractile force.

2 ouple action potentials to the generation of contractile force.

3 ely disturb production and/or propagation of contractile force.

4 l fluid dynamics simulations to estimate the contractile force.

5 y FtsZ, FtsA, and ZipA is used to exerting a contractile force.

6 val of existing cardiomyocytes that generate contractile force.

7 evice support demonstrated a 37% increase in contractile force.

8 verting free energy from ATP hydrolysis into contractile force.

9 ial myocardium was used to assess myocardial contractile force.

10 s of rise of light chain phosphorylation and contractile force.

11 ation, reduced Ca2+ entry, and inhibition of contractile force.

12 insufficient generation of myosin-dependent contractile force.

13 ain cardiomyopathies associated with altered contractile force.

14 where they formed functional NMJs, restored contractile force.

15 esult in profound muscle fatigue and loss of contractile force.

16 n many patients by a reduction in myocardial contractile force.

17 nd purse-string actomyosin networks generate contractile force.

18 eatures, including decreased muscle mass and contractile force.

19 in vivo cardiac morphogenesis independent of contractile forces.

20 3D hydrogel-based matrices against cellular contractile forces.

21 ent in the lung have the ability to generate contractile forces.

22 cells into elastic fibrils and subjected to contractile forces.

23 ng the expression of key genes that activate contractile forces.

24 epend little on adhesion bonds and mostly on contractile forces.

25 were deformed inward by acto-myosin mediated contractile forces.

26 an age-related increase in mass (12%) and in contractile force (30%) in adult slow twitch soleus musc

27 -activated kinase pathway that amplifies the contractile force, a phenomenon known as Ca(2+) sensitiz

28 caspase 1 also attenuated the depression in contractile force after I/R (from 35% of control to 75.8

29 llular Ca(2+) handling and calcium-activated contractile force after the onset of endotoxemia.

30 also predicts that the cell exerts stronger contractile forces against a stiffer external environmen

31 velocity of action potential propagation and contractile force amplitude compared to patches containi

32 uscle, beta-adrenergic stimulation increases contractile force and accelerates relaxation.

33 Contractile force and arrhythmias were recorded in human

34 alpha-toxin-permeabilized strips at pCa 6.7, contractile force and CPI-17 phosphorylation were propor

35 -mediated pressure overload by enhancing its contractile force and developing hypertrophy without dil

36 Positive correlation between contractile force and GCaMP6-reported calcium responses

37 ac myocytes Ca(2+) is a crucial regulator of contractile force and in this review we compare and cont

38 ament reorganization, accompanied by reduced contractile force and increased stiffness of cells.

39 nuclear disintegration requires actin-myosin contractile force and lamin proteolysis, making apoptosi

40 y with SNP suppressed an increase in Ca(2+), contractile force and phosphorylation of MLC, CPI-17, MY

41 mature length and is required for efficient contractile force and proper heart function during devel

42 In contrast, ROCK2 regulates contractile force and Rac1 activity at the leading edge

43 rt the theory and yield values of fibroblast contractile force and stiffness roughly an order of magn

44 splayed strong punctate centers of uropodial contractile force and strong directional motion on stiff

45 on stick-slip adhesion and the generation of contractile force and suggests new experiments to test t

46 the dominant negative Cdc42 mutant inhibited contractile force and the increase in actin polymerizati

47 Through modulation of vascular contractile force and vascular compliance dVSMCs regulat

48 Contractile force and velocity of cardiac muscle were de

49 terations in contraction properties (such as contractile force and Young's modulus).

50 eractions, which in turn elicit differential contractile forces and adhesions to determine the prefer

51 mechanical circuit that integrates adhesion, contractile forces and biochemical signaling to drive th

52 lation and later decoupling between cellular contractile forces and changes in tissue morphology.

53 ow ingression is sensitive to the balance of contractile forces and cortical tension.

54 TPH composites, which resists the fibroblast contractile forces and may, therefore, be able to reduce

55 mpressive struts that resist both actomyosin contractile forces and their own polymerization forces t

56 eric structure, cell and matrix deformation, contractile force, and electrical conduction.

57 MYPT1 membrane association, RhoA activation, contractile force, and regulatory light chain phosphoryl

58 tractile force, the axon generates 0.6 nN of contractile force, and that the net overall tension gene

59 ed by actin polymerization, myosin dependent contractile forces, and force transmission between the c

60 scle, i.e. transient and drastic increase in contractile force appeared within the decreasing force p

61 Contractile forces are essential for many developmental

62 proaches have provided new insights into how contractile forces are generated and coordinated between

63 ing cytokinesis or eukaryotic cell crawling, contractile forces are generated inside the cell to cons

64 Contractile forces are implicated in cell polarity and a

65 Here, we investigate how contractile forces are integrated across the tissue.

66 Contractile forces are the end effectors of cell migrati

67 exes and the actinmyosin cytoskeleton, whose contractile forces are transmitted through transcellular

68 This further implicates spatially regulated contractile force as a determinant of epithelial cell pl

69 supported patients and demonstrated improved contractile force at 1-Hz stimulation, with reversal of

70 tained by the generation and organization of contractile forces at the cell and tissue levels.

71 ytokinesis failure resulting from defects in contractile forces at the cleavage furrow.

72 he magnetic bead; and 4), derive the myocyte contractile force base on the maximal displacement of ce

73 ures that anchor thin filaments and transmit contractile force between cardiac myocytes.

74 l linkage systems that connect and transduce contractile forces between muscle fibers and the extrace

75 Tendons transmit contractile forces between musculoskeletal tissues.

76 this transmission is mediated by coupling of contractile forces between neighboring cells.

77 ograde flow is primarily generated by myosin contractile forces, but when myosin is inhibited, leadin

78 tion of IGF1 and CT1 significantly increased contractile force by 14% to 22%.

79 Ca2+ desensitization of contractile force by 8-Br-cGMP was attenuated by 50% in

80 ascade in the heart, functioning to modulate contractile force by altering the rate of calcium re-seq

81 mechanism(s) for the Ca2+ desensitization of contractile force by cGMP.

82 activation of P2Y6 enhanced ATP-mediated BSM contractile force by up to 45%, indicating synergistic i

83 Activating cellular contractile forces by calf serum and disrupting F-actin

84 ely constant force inward, the peak of local contractile forces by CUs scales with rigidity.

85 ximal velocity but a 27% decrease in maximal contractile force compared with nonfailing myocardium.

86 ht chain (MLC) phosphorylation, a marker for contractile force, concomitant with protein kinase C (PK

87 ile force that is opposed by decreased wound contractile forces contributing to the enlarging ear wou

88 reas CHC depletion in vivo induced a loss of contractile force due to the detachment of sarcomeres fr

89 that traction-mediated protrusive forces or contractile forces due to myosin II are sufficient to in

90 leads to accelerated loss of muscle mass and contractile force during aging.

91 ciated kinase (Rok) is important to generate contractile force during apical constriction.

92 hibit an increased capability of maintaining contractile force during repetitive stimulation in the p

93 utant muscles generate significantly smaller contractile forces during a single twitch and during tet

94 -therapy studies by regulating the amount of contractile force effectively transmitted at the junctio

95 p1-/- mice generated greater agonist-induced contractile force, even after removal of the epithelium.

96 Active contractile forces exerted by eukaryotic cells play sign

97 operties, the major drivers of which are the contractile forces exerted by platelets against the fibr

98 Contractile forces exerted on the surrounding extracellu

99 m data available in the literature, the mean contractile force (Fc) generated by individual dermal fi

100 We propose that laterally opposed contractile forces first enhance contact growth and stab

101 Cells actively produce contractile forces for a variety of processes including

102 us types of actomyosin bundles that generate contractile forces for biological processes, such as cyt

103 mechanism of locomotion maximized the use of contractile forces for overcoming friction of the suppor

104 lopment and enhance local integrin-dependent contractile forces for pulling neighboring cells apart.

105 nvolved in generating a coherent cytoplasmic contractile force from one side of the cell to the other

106 Thus, calculations of contractile force from the drag force are incomplete.

107 al constructs typically calculate an average contractile force from the gross deformation of a macros

108 in eukaryotic cells have been attributed to contractile forces from the actomyosin ring and the acto

109 resulted in a reduction in the overall peak contractile force generated by dermal fibroblasts.

110 Contractile forces generated by chemically skinned singl

111 Contractile forces generated by the actin-myosin cytoske

112 Contractile forces generated by the actomyosin cytoskele

113 movement and cytokinesis are facilitated by contractile forces generated by the molecular motor, non

114 essential to maintain animal cell shape, and contractile forces generated within it by nonmuscle myos

115 oblast differentiation resulted in decreased contractile force generation and attenuated 488-FN incor

116 C phosphorylation abrogated EGF-induced cell contractile force generation and motility.

117 suggest that cell spreading, alignment, and contractile force generation are directly influenced by

118 ofibroblasts and is a primary contributor to contractile force generation by these differentiated cel

119 (IL-17A), but not IL-17F or IL-22, enhanced contractile force generation of airway smooth muscle thr

120 olling actomyosin assembly and intracellular contractile force generation, a function of equal physio

121 eletal protein expression levels and reduced contractile force generation, as well as a decrease in f

122 re responsible for electrical conduction and contractile force generation, while the other cell types

123 +) sensitivity with no effect on the maximal contractile force generation.

124 e for a major part of EGF-induced fibroblast contractile force generation.

125 phosphorylation, followed by a reduction of contractile force having a latency period of about 15 s.

126 As a consequence, contractile force in aged Sod1(-/-) muscles is greatly d

127 these peptide antioxidants potently improved contractile force in an ex vivo heart model.

128 cellular calcium is central to regulation of contractile force in cardiac muscle.

129 Potential roles for contractile force in cell motility include cell-body tra

130 bipoles are likely to produce an unbalanced contractile force in cells and in actin-myosin gels and

131 ERK) activation, myosin phosphorylation, and contractile force in dSMCs.

132 tracellular Ca2+ concentration ([Ca2+]i) and contractile force in intact ventricular muscle from SHHF

133 c glycosides are used clinically to increase contractile force in patients with cardiac disorders.

134 transients declined in parallel with tetanic contractile force in single intact fibres.

135 intracellular free calcium concentration and contractile force in trabeculae revealed a doubling of C

136 nerated 23% of the total bethanechol-induced contractile force in vitro compared to unoperated contro

137 Class II myosins generate contractile forces in cells by polymerizing into bipolar

138 lamentous actin (F-actin) arrays to generate contractile forces in muscle and nonmuscle cells.

139 and growth-cone pauses arises because strong contractile forces in the rear of the growth cone pull m

140 and find that although microtubules modulate contractile forces in vitro, their interactions are not

141 ustained reactive intracellular cytoskeleton contractile force increase in different adherent mechano

142 after contraction, combined with their high contractile forces, indicates that clots may be stiffene

143 19-induced MYPT1 Thr-853 phosphorylation and contractile force, indicating that NO/cGMP/cGKI signalin

144 nous p63RhoGEF in mouse portal vein inhibits contractile force induced by endothelin-1 to a greater e

145 hy and fluid shear stress alter the cellular contractile forces, influence the genetic expression of

146 Enhancement of contractile force (inotropy) occurs in skeletal muscle f

147 artner dystroglycan distribute intracellular contractile forces into the surrounding extracellular ma

148 Nonmuscle myosin II produces contractile forces involved in driving actin network tra

149 Myosin-based cell contractile force is considered to be a critical process

150 Generation of contractile force is correlated with the expression of a

151 a simplified mechanism for the generation of contractile forces is sufficient to explain periodic lam

152 ere observed during interventions increasing contractile force; isoproterenol or norepinephrine (3.2

153 le, we report a novel single cardiac myocyte contractile force measurement technique based on moving

154 [Ca2+]i and contractile force measurements in trabeculae revealed th

155 imaging (Ca(2+) and membrane potential), and contractile force measurements in ventricular myocytes a

156 Contractile force-mediated remodeling of ECM fibers has

157 lated anteriorly, suggesting that asymmetric contractile forces might produce different-sized daughte

158 To test these hypotheses, we studied contractile force, mitochondrial function, and mitochond

159 blique extraocular muscle at 2 weeks of age: contractile force, muscle mass, total myofiber area, myo

160 As well as producing active contractile force, muscles are also passively elastic, w

161 tream of Rho activation, which generates the contractile force necessary to drive disassembly of epit

162 keleton is generally accepted to produce the contractile forces necessary for cellular processes such

163 l sarcomere, whereas the transduction of the contractile force normally associated with the Z-disc is

164 al platelets can generate an average maximum contractile force of 29 nN and form adhesions stronger t

165 factor (IGF) have been shown to increase the contractile force of adult heart and skeletal muscles, r

166 d stress-fiber formation while measuring the contractile force of an individual cell.

167 gels pull on and deform their surface with a contractile force of approximately 1 microN, or approxim

168 tood as an acute process that depends on the contractile force of cells.

169 er factors were injected into the orbit, the contractile force of dissected muscles was measured in v

170 The effect of NO on the contractile force of lateral rectus muscle is greater th

171 Anapoe, a detergent molecule, increases the contractile force of muscle fibers and binds specificall

172 In agreement with previous studies, the contractile force of muscles in wild-type (NCAM(+/+)) mi

173 ts from G159D-CTnC is expected to weaken the contractile force of the myocardium, whereas the lack of

174 approximately threefold increase in maximum contractile force of the treated muscle at 2 wk compared

175 , for a given amount of InsP3 generated, the contractile force of the uterine artery was significantl

176 We conclude that contractile forces of a fibroblast are transmitted to th

177 ed by energy from Ca(2+) binding to generate contractile forces of approximately 10 nN.

178 key GPCR that regulates human heart rate and contractile forces of cardiomyocytes, was determined rec

179 e-dependent growth suggests a model in which contractile forces of the ring shape the septum cell wal

180 semble into bipolar filaments that produce a contractile force on the actin cytoskeleton.

181 ric bipole that generates equal and opposite contractile forces on actin.

182 , cells experience intracellular tensile and contractile forces on microscopic scales.

183 e hypothesis that myofibroblasts exert tonic contractile forces on the cardiomyocytes and affect elec

184 At longer times, fibroblasts exert contractile forces on the dermal tissue, the resulting t

185 e actin bundles infused with myosin to exert contractile forces on the extracellular environment.

186 on which myosin motors can attach and exert contractile forces on the nodes, the attachment being co

187 Cells exert contractile forces on their matrix and the matrix elasti

188 rocess whereby activated platelets transduce contractile forces onto the fibrin network of a thrombus

189 As the mice grow older, the contractile force per cross-sectional area further decre

190 pidly moving cells that generate substantial contractile force perpendicular to their direction of lo

191 We propose that local, periodic contractile forces polarize vertex resolution to drive D

192 patient slow fibres produced only 63% of the contractile force produced in control slow fibres and ha

193 n injury in old age and has implications for contractile force production and the rapid execution of

194 ly 25% smaller cross-sectional area, and had contractile force reduced by half or more.

195 the uniaxial stretch and the strength of the contractile forces regulate a gradual transition between

196 SMC contractile force requires cyclic interactions between S

197 ound microbubbles and the actin cytoskeleton contractile force responses, we determine that TB-ATC el

198 tissue, tension wood, which exerts a strong contractile force resulting in negative gravitropism of

199 ospasm, we observed significant increases in contractile force, RhoA activation, regulatory light cha

200 007"), significantly reduced agonist-induced contractile force, RLC(20), and myosin light chain phosp

201 Contractile force, tension, and calcium responsiveness w

202 Lmod2-null cardiomyocytes produce less contractile force than wild type when plated on micropil

203 Actomyosin networks generate contractile force that changes cell and tissue shape.

204 ll as total fibronectin, which generates the contractile force that promotes MF differentiation.

205 rsurface of the RPE may impart a substantial contractile force that tears this already-strained tissu

206 The adherent cells generated contractile forces that deform the substrate.

207 ons to the substrate and myosin II-dependent contractile forces that drive cells toward one another.

208 logically plausible rules describing (a) the contractile forces that endothelial cells exert on the E

209 The murine ECTs produced consistent contractile forces that followed the Frank-Starling law

210 ppression of RhoA by integrins may alleviate contractile forces that would otherwise impede protrusio

211 rear of the growth cone generates 2.0 nN of contractile force, the axon generates 0.6 nN of contract

212 uired for the production of actomyosin-based contractile forces, the regulation of the structure and

213 norhabditis elegans requires transmission of contractile force through a series of mechanical linkage

214 suggests these buckles are evidence of high contractile forces throughout the cytoplasm, and that th

215 igh-density state and generates a sufficient contractile force to achieve division.

216 rine, zinterol, and norepinephrine increased contractile force to approximately the same extent, hast

217 structurally organized while generating the contractile force to divide one cell into two.

218 on is enriched in myosin II, which generates contractile force to support junctional tension.

219 ents and identify sites at which cells apply contractile force to the matrix as they divide.

220 ng enables the cells to polarize and develop contractile forces to break free from the tumor spheroid

221 to fibrin deposited in the matrix and exert contractile forces to cause a narrowing of the lumen.

222 rs embedded within the actin cortex generate contractile forces to modulate cell shape in essential b

223 Contractile force transduction by myosin II derives from

224 proteins; this finding implicates defects in contractile-force transmission as one mechanism underlyi

225 organelle, the spasmoneme, generates higher contractile force under increased stall resistances.

226 tic acid (RGD)-containing synthetic peptide, contractile force was depressed significantly by, 28% at

227 Both perfusion pressure and contractile force were measured in prostaglandin F(2alph

228 lls followed a common trend whereby size and contractile forces were negatively correlated with cell

229 imicking DIs) have been shown to reduce mean contractile force when applied to airway smooth muscle (

230 within collagen gels generated less maximum contractile force when stimulated with endothelin-1, sph

231 oteolytic fragments of denatured collagen on contractile force, whereas experiments with function-blo

232 Epithelial cells transmit contractile force with adherens junctions to mediate mor

233 A normal heart increases its contractile force with increasing heart rate.

234 ce exhibited the typical biphasic decline in contractile force with repetitive stimuli of hind-limb m

235 examined was the correlation of whole-muscle contractile force with the degree of evoked eye displace

236 phorylation at 20-kDa myosin light chain and contractile force, with a nanomolar concentration requir

237 bout that point in the cell, suggesting that contractile forces within the cell act on the entire cyt