ライフサイエンスコーパス: contractile function

1 es in energy production, and improvements in contractile function.

2 sulting in subsequent improvement of cardiac contractile function.

3 al stress throughout life to maintain proper contractile function.

4 ons of NO exert purely inhibitory effects on contractile function.

5 in modulations of myocardial energetics and contractile function.

6 iling heart to revive the myocardium and its contractile function.

7 pathways important for energy metabolism and contractile function.

8 LM, and correlates with impaired post-anoxia contractile function.

9 roduction then inhibits all other aspects of contractile function.

10 , maintaining ventricular wall thickness and contractile function.

11 tes sarcomere assembly, and promotes cardiac contractile function.

12 e and lipid metabolism, energy transfer, and contractile function.

13 ascular load than IPAH and leads to worse RV contractile function.

14 ee of pathological remodeling, and preserves contractile function.

15 acellular cAMP but minimally affects cardiac contractile function.

16 d cytoskeletal dynamics in the regulation of contractile function.

17 soforms that is essential for tuning cardiac contractile function.

18 g to balance myocardial substrate supply and contractile function.

19 ophy, left ventricular dilation, and reduced contractile function.

20 umption was proportionate to the increase in contractile function.

21 ncreasing SERCA activity results in enhanced contractile function.

22 essential for normal cardiac respiratory and contractile function.

23 (LDH) release and infarct size and improved contractile function.

24 y effects of genetic manipulation on cardiac contractile function.

25 mide does not limit left ventricular chamber contractile function.

26 of genetic and extrinsic factors to maintain contractile function.

27 cription, signaling, growth, metabolism, and contractile function.

28 (d) improved myocyte calcium transients and contractile function.

29 AP-targeted PKA in control of heart rate and contractile function.

30 remodeling, as well as greater depression of contractile function.

31 ceptor signalling and the impacts on cardiac contractile function.

32 erobic metabolism, which collectively impair contractile function.

33 P mice reflects impaired ventricular myocyte contractile function.

34 anoids, thereby restoring ENS cell types and contractile function.

35 l-D-glucosamine (GlcNAc) may regulate muscle contractile function.

36 r perfusion, reduced apoptosis, and improved contractile function.

37 heir potential role in regulating myocardial contractile function.

38 significantly improving muscle histology and contractile function.

39 ltered PKD activity in disease may impact on contractile function.

40 than 3 months of age despite preservation of contractile function.

41 dose-dependent effects on basal and dynamic contractile function.

42 ations in intracellular calcium handling and contractile function.

43 ing produced cardiac hypertrophy and reduced contractile function.

44 e expense of an attenuated level of regional contractile function.

45 accompanied by time-dependent restoration of contractile function.

46 e apoptosis and thereby preserves myocardial contractile function.

47 es may also partly contribute to the altered contractile function.

48 een associated with abnormalities in cardiac contractile function.

49 ropometric measurements and left ventricular contractile function.

50 nner consistent with impaired relaxation and contractile function.

51 stress modulates trabeculation to influence contractile function.

52 comere shortening and reduced in vivo atrial contractile function.

53 rgy in the form of ATP to support persistent contractile function.

54 ly significant parasympathetic control of LV contractile function.

55 in the heart directly correlate with cardiac contractile function.

56 ormationally sensitive regions that underlie contractile function.

57 nergetics to cardiac myocyte and whole-heart contractile function.

58 y role in the regulation of normal PVAT anti-contractile function.

59 role of oxygen in the regulation of cardiac contractile function.

60 han wild-type mice but unexpectedly enhanced contractile function.

61 is preferentially required for Rho-mediated contractile functions.

62 etrimental effects on cardiac electrical and contractile functions.

63 ses revealed improvement in left ventricular contractile function 2 weeks after transplant (hCPC vers

64 ed (1) improved remodeling, hypertrophy, and contractile function; (2) less apoptosis; and (3) dimini

65 r dilation and preserved regional and global contractile function after myocardial infarction compare

66 rdiomyocytes offers the potential to restore contractile function after myocardial injury.

67 by an absence of muscle pathology, restored contractile function and a reduction in serum creatine k

68 MRI revealed preservation of contractile function and an improved ejection fraction 1

69 h in turn resulted in marked increases in BZ contractile function and ATP turnover rate.

70 ct heart can improve myofilament and in vivo contractile function and attenuate maladaptive remodelin

71 , VEGF-B167 markedly preserved diastolic and contractile function and attenuated ventricular chamber

72 develop cardiac dilation and showed improved contractile function and blunted adverse remodeling.

73 nvestigate protein localization and evaluate contractile function and Ca(2+) transients, compared wit

74 haq mice had marked abnormalities of myocyte contractile function and calcium transients.

75 Surprisingly, however, cardiac contractile function and cardiac compliance were unimpro

76 onclude that neuronostatin regulates cardiac contractile function and cardiomyocyte survival.

77 ha-actinin associated with severely impaired contractile function and cardiomyopathy in vivo.

78 This perturbation has been shown to impair contractile function and cause muscle fatigue in dystrop

79 ink in the myocyte, influencing both cardiac contractile function and cell metabolism and survival an

80 myocyte architecture, calcium handling, and contractile function and compared our results vs. severa

81 not significantly alter postischemic cardiac contractile function and coronary flow.

82 and NO generation with increased recovery of contractile function and decreased infarction in the pos

83 SCS significantly improved cardiac contractile function and decreased ventricular arrhythmi

84 Contractile function and dynamic force-length measuremen

85 PDPN receptor CLEC-2, PDPN endowed FRCs with contractile function and exerted tension within the reti

86 ects that these roles may have on myocardial contractile function and HF development.

87 MIF depresses human myocardial contractile function and impairs mitochondrial respirati

88 for ROS-induced SrcFK activity in normal VSM contractile function and in vascular remodelling in card

89 Specialized contractile function and increased mitochondrial number

90 usion injury, evidenced by lower recovery of contractile function and increased necrosis and apoptosi

91 s with type 2 diabetes mellitus (DM2) affect contractile function and insulin action in cardiomyocyte

92 Contractile function and insulin action were analyzed in

93 oxide synthase (iNOS) expression on regional contractile function and left ventricular (LV) remodelin

94 c reticulum Ca2+ handling, included improved contractile function and left ventricular remodeling.

95 l resting SR Ca(2+) leak resulted in reduced contractile function and muscle fiber atrophy for longer

96 nt (3E10Fv-MTM1) in Mtm1delta4 mice improved contractile function and muscle pathology.

97 baseline (pH 7.4) indicated similar cellular contractile function and myofilament calcium sensitivity

98 with diminished IGF contents but with normal contractile function and no apparent endoplasmic reticul

99 he main contributor to depressed ventricular contractile function and occurrence of arrhythmia in hea

100 g complete SERCA inhibition eventually limit contractile function and precipitate LV pump failure.

101 ue by combining experimental measurements of contractile function and pressure generation with a prev

102 on (MI) is associated with depressed cardiac contractile function and progression to heart failure.

103 al cardiomyocyte hypertrophy, maintenance of contractile function and progression towards inherited o

104 Preservation of contractile function and protection against adverse chan

105 uced injury, active I-1 expression augmented contractile function and recovery.

106 fer revealed improved systolic and diastolic contractile function and reductions in left ventricular

107 d play different roles in regulating cardiac contractile function and remodeling in response to injur

108 rare variant in MYH11, R247C, alters myosin contractile function and SMC phenotype, leading to incre

109 The contractile function and the CSA of LV cardiomyocytes is

110 Ventricular contractile function and the VCS fate map remained uncha

111 streptozotocin (STZ) treatment, and bladder contractile function and TLR4 pathway expression were ev

112 The preserved contractile function and translocation responses to PHE

113 ating peptide preserved the left ventricular contractile function and was accompanied by increased le

114 of nitric oxide (NO) in regulating lymphatic contractile function and, consequently, lymph flow has b

115 h wild type, suggesting a greater reserve of contractile function and/or recruitment of compensatory

116 Myofibroblasts develop contractile functions and secrete the extracellular matr

117 6a3(+/d16) mice displayed compromised muscle contractile functions and thereby provide an essential p

118 VEGF reduces apoptosis, preserves myocardial contractile function, and delays the onset of failure in

119 ained, can induce changes in cell structure, contractile function, and gene expression.

120 more left ventricle (LV) dilation, worse LV contractile function, and higher LV end-diastolic pressu

121 ransforming growth factor betabeta1, reduced contractile function, and inhibited mRNA expression of a

122 ATP is required for normal cardiac contractile function, and it has long been hypothesized

123 tenuates adverse LV remodeling, preserves LV contractile function, and reduces mortality.

124 requires a constant flux of ATP to maintain contractile function, and there is increasing evidence t

125 Omecamtiv mecarbil increased atrial contractile function, and there were no clinically relev

126 components including left ventricular size, contractile function, and VA coupling.

127 of ejection fraction (EF)-ventricular size, contractile function, and ventricular-arterial (VA) inte

128 Left ventricular structure, diastolic and contractile function, and ventricular-arterial coupling

129 o determine whether vascular SM and pericyte contractile functions, and not merely their presence, ar

130 Causes of impaired contractile function are not fully understood and may in

131 observation that myosin II organization and contractile function are optimally matched to the load c

132 Remarkably, their LV size and contractile function are preserved.

133 r mechanisms by which vascular smooth muscle contractile functions are regulated are not completely e

134 ter TAC resulted in a significant decline in contractile function as compared with animals in which C

135 HF myocardium exhibited impaired contractile function as evidenced by reduced maximal for

136 s, acting to regulate cardiac metabolism and contractile function, as well as promoting anticontracti

137 lt heart elicited significant enhancement of contractile function, associated with preferential phosp

138 It also led to significantly increased contractile function at baseline and during adrenergic s

139 peptide 1 (GLP-1) therapies improve cardiac contractile function at rest and in response to adrenerg

140 ormation and improved cardiac remodeling and contractile function at the chronic stage.

141 uce CEPT1, which remodels the SR to preserve contractile function at the expense of insulin sensitivi

142 of mutations in cMyBPC that lead to abnormal contractile function at the myofilament level, thereby c

143 t rate, aortic function or mesenteric artery contractile function, at either 3 or 6 months of age.

144 nsfer in the failing heart not only improves contractile function but also directly restores electric

145 RB3 were generated and they exhibited normal contractile function but altered cardiac signal transduc

146 n A and angiopoietin-2 reduced cardiomyocyte contractile function, but only activin A reduced the exp

147 pharmacological agent that augments cardiac contractile function by enhancing myofilament Ca(2+) sen

148 While catecholamines could normalize contractile function by increasing I(Ca) and SR Ca(2+) c

149 Failure to induce critical genes involved in contractile function, calcium handling and energy metabo

150 he proximal C-terminal domain causes reduced contractile function, cardiac hypertrophy, and heart fai

151 myofibers and have impaired skeletal muscle contractile function compared to their wild type control

152 lts align with the hypothesis that defective contractile function contributes to the pathogenesis of

153 Assessment of cardiac contractile function, coronary arterial flow reserve, is

154 Neither hypertrophic severity nor contractile function correlated with familial or genetic

155 igh-fat diet, with the result that [ATP] and contractile function decreased significantly.

156 Diminished contractile function develops in response to low dose ph

157 elimb grip strength, ex vivo measurements of contractile function) did not improve.

158 tes cTnI at Ser-150 in vivo to alter cardiac contractile function directly at the level of the myofil

159 so it is unclear whether these cells improve contractile function directly through addition of new fo

160 TP-generating processes may therefore affect contractile function directly.

161 osporin A (CsA) is known to preserve cardiac contractile function during endotoxemia, but the mechani

162 stigate the effects of cardiomyocyte Nox2 on contractile function during increased Ang II activation.

163 ntraction, and, ultimately, left ventricular contractile function during infarct repair.

164 nd most significantly increased intact heart contractile function (echocardiography) compared to vehi

165 lation (eg, protein disulfide isomerase A3), contractile function (eg, filamin-C), and serine/threoni

166 citation-contraction coupling, modulation of contractile function, energy supply-demand balance (incl

167 nsion, atherosclerosis, depressed myocardial contractile function, fatty acid metabolism, hypertrophi

168 All measures of systolic contractile function fell during HD and HDF, with partia

169 12-hour controlled mechanical ventilation on contractile function, fiber dimension, cytokine producti

170 thods to preserve cardiac cell viability and contractile function following ischemia are limited in t

171 oponin I cleavage in rat hearts and improved contractile function following ischemia-reperfusion.

172 baseline mitochondrial function and cardiac contractile function following pressure overload hypertr

173 the cardiomyocyte would be unable to recover contractile function following the simulated conditions

174 othelin-1 is critical for maintaining normal contractile function, for controlling superoxide and Mmp

175 occur within the heart with age to maintain contractile function from the maladaptive responses asso

176 is function of the right ventricle show that contractile function improvement precedes right ventricu

177 It normalized the contractile function in 2 patients.

178 t of agonist-induced PKCbetaII activation on contractile function in adult cardiac myocytes.

179 hereby enhancing angiogenesis and preserving contractile function in an animal AMI model.

180 th gata1 MO rescued trabeculation to restore contractile function in association with upregulation of

181 alogues significantly increased intact heart contractile function in calsequestrin-overexpressing mic

182 We sought to evaluate contractile function in cardiomyocytes following electri

183 regression of acute individual measures with contractile function in corresponding areas at day 21 de

184 Thus, short-term Akt activation improves contractile function in failing hearts.

185 y by short-term Akt activation might improve contractile function in failing hearts.

186 thermia (33.0 degrees C) on left ventricular contractile function in healthy pigs and compared them w

187 e a novel therapeutic strategy for improving contractile function in heart failure.

188 paired CK-related energy metabolism improves contractile function in HF.

189 Regional myocardial blood flow and contractile function in ischemic myocardium are well mat

190 mulation impairs beta-adrenergically induced contractile function in isolated cardiomyocytes and Lang

191 aphy, and 40% reduction in right ventricular contractile function in isolated perfused hearts.

192 The E2-treatment led to impaired contractile function in male CMs only, which was charact

193 between humans and mice, and that E2 impairs contractile function in male CMs only.

194 ct of restoring sarcolemmal nNOSmu on muscle contractile function in mdx mice.

195 ochondrial gene regulatory derangements, and contractile function in MHC-PPARalpha mice.

196 In conclusion, EMEPO improved contractile function in myocytes experiencing an imbalan

197 We hypothesized that EMEPO would improve contractile function in myocytes with altered nitroso-re

198 ugh CK ex vivo and in vivo but did not alter contractile function in normal mice.

199 Remarkably, in the context of well preserved contractile function in perfused hearts, we observed dec

200 ce suggests an abnormal vascular reactivity, contractile function in Pkd mutant vessels has not been

201 one had little effect on the acceleration of contractile function in response to dobutamine.

202 ed hearts indicated exacerbated postischemic contractile function in Sestrin2 KO hearts compared with

203 receptor gamma axis in endothelial cells and contractile function in smooth muscle cells.

204 phosphorylation is a key aspect of impaired contractile function in the diseased myocardium.

205 re consequences for the energetic support of contractile function in the heart and is implicated in t

206 y loss of myocytes, remodeling, and impaired contractile function in the heart.

207 eversing concentric remodeling and improving contractile function in the hearts of patients with diab

208 egeneration that stabilizes bioenergetic and contractile function in the infarct zone and border zone

209 Acute Ang II treatment also enhanced contractile function in transgenic hearts in vivo and tr

210 Quantification of cardiomyocyte contractile function in vivo opens many possibilities fo

211 , and is essential for maintenance of normal contractile function in vivo.

212 rs that may have specialized trafficking and contractile functions in cytoskeletal compartments that

213 hy and showed ventricular dilation, impaired contractile function, increased myocyte length and accum

214 phy, indicating that Akt activation improves contractile function independently of its growth-promoti

215 25 in vivo resulted in a significant loss of contractile function, injection of an antisense oligonuc

216 se provides further evidence that proper SMC contractile function is critical for maintaining the int

217 the diabetic lipoprotein particle; decreased contractile function is not related to cardiac lipid acc

218 LAS, as a marker for longitudinal contractile function, is an independent parameter for ou

219 LA contractile function (LA negative peak strain), conduit

220 However, right ventricular contractile function may improve following CRT independe

221 ve of human engineered cardiac tissue (hECT) contractile function measurements under matched experime

222 In addition to contractile function measurements, dynamic features of R

223 , cardiomyocyte hypertrophy, and enhanced LA contractile function (median active emptying fraction 16

224 In addition to contractile function, muscle provides a metabolic buffer

225 ex, stroke volume index, global and regional contractile function (myocardial strain), coronary arter

226 er mutations in the kinase that controls SMC contractile function (myosin light chain kinase [MYLK])

227 stolic calcium, consistent with the observed contractile function observed in experimental PV measure

228 pothesized that diminished LA compliance and contractile function occur early during the development

229 profound implications for understanding the contractile function of actomyosin, as needed in therape

230 anner, with significant implications for the contractile function of actomyosin.

231 maturation, but its specific effects on the contractile function of aneural engineered muscle remain

232 vivo, neural agrin can directly promote the contractile function of aneural engineered muscle via me

233 Contractile function of cardiac cells is driven by the s

234 intracellular calcium, [Ca2+]i, regulate the contractile function of cardiac muscle cells.

235 Moreover, MRTF-A improves contractile function of chronic hibernating myocardium o

236 tructural organization, vascularization, and contractile function of fully differentiated vs. undiffe

237 tes glomerular filtration rate (GFR) and the contractile function of glomerular mesangial cells (MCs)

238 CPB decreases myogenic contractile function of human peripheral arterioles in r

239 ty has emerged as a novel therapy to restore contractile function of injured failing myocardium.

240 Contractile function of intact extensor digitorum longus

241 Contractile function of isolated myocytes was depressed

242 fractional shortening in vivo and preserved contractile function of isolated perfused hearts.

243 TRPC1 plays an important role in controlling contractile function of MC.

244 GATA-6 deregulates CPI-17 expression and the contractile function of smooth muscle.

245 ave been identified in genes that govern the contractile function of the cardiomyocytes.

246 BVR and HO-2 levels, myocyte apoptosis, and contractile function of the heart can be modulated by sm

247 showed a normal survival rate and unaltered contractile function of the heart monitored by serial ec

248 ndan improves neuromechanical efficiency and contractile function of the human diaphragm.

249 ted to promote calcium handling and increase contractile function of the intact heart independently o

250 type-specific expression of Cxs for optimal contractile function of the mammary myoepithelium.

251 ment patterns are not reliable indicators of contractile function of the SO muscle.

252 the downstream consequences of the earliest contractile function on cardiac differentiation and morp

253 all amounts of myotubularin, showed impaired contractile function only in EDL muscles.

254 idant exposure that do not result in loss of contractile function or gross oxidative stress.

255 alone had no effect on left ventricular (LV) contractile function or on isoprenaline- or preload-indu

256 myofibril organization, and skeletal muscle contractile function owing to compensatory upregulation

257 t of energy significantly impaired postshock contractile function (p < .05), whereas the change of en

258 the failing heart improved left ventricular contractile function (P<0.01), suppressed cardiac altern

259 was associated with reduced left ventricular contractile function (P=0.026) and relaxation (P=0.041).

260 diac regeneration and contributes to loss of contractile function, pathological remodelling and susce

261 s essential throughout vSMC life to maintain contractile function, prevent vSMC reprogramming, and pr

262 The LV contractile function, regional myocardial wall complianc

263 rt, yet their functional roles in modulating contractile function remain incompletely understood.

264 d yet the role of this isoform in modulating contractile function remains controversial.

265 tionship between cardiomyocyte shape and the contractile function remains unclear.

266 Myocardial contractile function significantly improved after resver

267 p(-/-) mice manifested a severe reduction of contractile function, signs of heart failure, and increa

268 Besides hampering contractile function, smoking may have immediate benefic

269 ocardium can improve myofilament and in vivo contractile function, suggesting that cMyBPC gene therap

270 ties in cell signaling, gene expression, and contractile function that are not clearly understood.

271 : cardiac size (end-diastolic volume [EDV]); contractile function (the end-systolic pressure volume r

272 To improve contractile function, the myocardium undergoes hypertrop

273 itin kinase region emerges as a regulator of contractile function through effects on calcium handling

274 that TRPC6 may regulate GFR by modulating MC contractile function through multiple Ca(2+) signaling p

275 modulates cardiomyocyte SR Ca(2+) uptake and contractile function through redox-regulated changes in

276 s (KATP channels) in cardiac myocytes adjust contractile function to compensate for the level of avai

277 vel approach to preserving or even restoring contractile function to infarcted hearts.

278 iable and display normal SR Ca2+ release and contractile function under basal conditions.

279 reconcile observed cellular and organ level contractile function using a cardiac multiscale model.

280 We tested the hypothesis that contractile function using speckle-tracking echocardiogr

281 IS200D were protected, recovering 88+/-8% of contractile function versus 35+/-15% in littermate contr

282 in the central region of Tm modifies cardiac contractile function via its effect on the overlapping e

283 Although OB fetal hearts exhibited a normal contractile function vs. CON fetal hearts during basal p

284 splantation and to compare regional MBF with contractile function (wall motion) and microvascular den

285 Contractile function was also equally impaired in Cont a

286 Contractile function was also preserved in colon ascende

287 /kg intraperitoneally), and left ventricular contractile function was assessed 5 days later using bot

288 Decreased contractile function was associated with attenuated TGF-

289 Small artery contractile function was examined in vitro with wire myo

290 Also, the oxygen cost of the contractile function was increased by 63% and 46% in hea

291 abbreviation of systolic ejection, although contractile function was largely preserved.

292 re housed in hypoxia for 3 wk before in vivo contractile function was measured using cine MRI.

293 Contractile function was rescued by replacing oleate wit

294 Cardiac remodeling and contractile function were assessed extensively at the wh

295 These effects of ANP and BNP on contractile function were examined further by using an i

296 Metabolic fate of the lipoprotein TAG and contractile function were examined.

297 for all of the cardiomyocytes that recovered contractile function, whereas the absence of Mb(III) ban

298 mphatic vasculature, NO production depresses contractile function, which influences lymph flow needed

299 Determining whether the increase in contractile function will translate into improved clinic

300 engraftment of adult myofibers with enhanced contractile function without the formation of teratomas.