ライフサイエンスコーパス: contractile protein

1 um ATPase2a expression, but no difference in contractile protein.

2 icularly by a significant down-regulation of contractile proteins.

3 oxidation pathways and altered expression of contractile proteins.

4 lts from increased gene expression of muscle-contractile proteins.

5 e expression of cardiac-specific isoforms of contractile proteins.

6 minimal effects on the expression of muscle contractile proteins.

7 nor did a change in Ca2+ sensitivity of the contractile proteins.

8 established as residing at loci encoding the contractile proteins.

9 n of various cytoplasmic proteins, including contractile proteins.

10 ed with altered expression of genes encoding contractile proteins.

11 ls into allosteric conformational changes of contractile proteins.

12 PAGE and Western immunoblot analysis of the contractile proteins.

13 to primitive cardiac myocytes that expressed contractile proteins.

14 own of GAS5 increased, the expression of SMC contractile proteins.

15 factor signaling and increased expression of contractile proteins.

16 eading to the dephosphorylation of important contractile proteins.

17 ic contractility and decreased expression of contractile proteins.

18 cells (PASMC), resulting in the induction of contractile proteins.

19 proliferation and reduced expression of SMC contractile proteins.

20 ulting from structural rearrangements of the contractile proteins.

21 s a critical regulator of other membrane and contractile proteins.

22 ype characterized by increased expression of contractile proteins.

23 (kip1), but failed to increase expression of contractile proteins.

24 pe and regulating the expression of critical contractile proteins.

25 suggests a slower actomyosin turnover by the contractile proteins.

26 reducing the expression of these proadhesive/contractile proteins.

27 rdin-regulated genes encoding SMC-restricted contractile proteins.

28 and acts as a transcriptional suppressor of contractile proteins.

29 ctin, actin-bundling proteins, and, finally, contractile proteins.

30 cues and slows cytokinesis progression while contractile proteins accumulate and correct shape asymme

31 l gene expression during differentiation and contractile protein accumulation are becoming well under

32 d striated muscle-specific markers including contractile proteins, acetylcholine receptor subtypes, a

33 odel for the interaction of cMyBP-C with the contractile proteins actin and myosin and the regulatory

34 In addition to the contractile proteins actin and myosin, contractile filam

35 ssion of alpha-smooth muscle actin and other contractile proteins, along with inhibition of genes res

36 Transcription of the contractile protein alpha-smooth muscle actin (alpha-SMA

37 Expression of the contractile protein alpha-smooth muscle actin was high i

38 tter, as well as increased expression of the contractile proteins alpha-smooth muscle actin, myosin l

39 ze, protein synthesis, and expression of the contractile proteins alpha-smooth muscle actin, myosin l

40 ncreased abundance of the mRNAs encoding the contractile proteins, alpha-myosin heavy chain and cardi

41 e recruitment and localization of anillin, a contractile protein and a crucial regulator of cytokines

42 th factor receptor-1 expression, and reduced contractile protein and basic fibroblast growth factor c

43 e important for activating the expression of contractile protein and other muscle-specific genes.

44 ris muscles, and Northern analyses of muscle contractile protein and oxidative enzyme mRNA expression

45 n of genes encoding skeletal muscle-specific contractile proteins and calcium channels.

46 e propose that PGI2-mediated upregulation of contractile proteins and connexin 43 is a critical step

47 propose that PGI(2)-mediated upregulation of contractile proteins and connexin 43 is a critical step

48 Myofibroblasts have increased expression of contractile proteins and display augmented contractility

49 MC overexpressed several SRF-MYOCD-regulated contractile proteins and exhibited a hypercontractile ph

50 l muscle fiber cross-section area, levels of contractile proteins and force production in isometric c

51 have shown it to be a disease of sarcomeric contractile proteins and have highlighted its genetic he

52 udying the structure and function of cardiac contractile proteins and how differences in these transl

53 nd, conceivably, mutations in genes encoding contractile proteins and ion channels.

54 ysical and biochemical properties of mutated contractile proteins and may help to improve clinical di

55 selective transcription of genes coding for contractile proteins and metabolic enzymes in these musc

56 er mutant mice show misexpression of cardiac contractile proteins and profound sarcomere disarray.

57 MuRF1 is controlling the degradation of only contractile proteins and suggest a role for MuRF1 in the

58 igh levels in medial SMCs that are producing contractile proteins and that they would be downregulate

59 to investigate the functional properties of contractile proteins and that Tmod1 functions are critic

60 r (IP) upregulated the expression of several contractile proteins and the gap junction protein connex

61 r (IP) upregulated the expression of several contractile proteins and the gap junction protein connex

62 ese differences, we examined the profiles of contractile proteins and their messages in mesenteric ly

63 tected changes in the stoichiometry of other contractile proteins and/or sarcomere architecture.

64 osin heavy chain (MHC), the principal muscle contractile protein, and mixed muscle protein (MMP) in s

65 lar matrix constituents, membrane receptors, contractile proteins, and associated signaling molecules

66 ctivation, increased Ca2+ sensitivity of the contractile proteins, and increased intracellular pH, bu

67 tal muscle development, expression of muscle contractile proteins, and myofibril assembly.

68 genes encoding many signaling molecules and contractile proteins are associated with cardiomyopathy;

69 contractile apparatus reveals that although contractile proteins are expressed, the sheath cells app

70 uantitative changes in muscle fibre size and contractile proteins are not the dominating factors unde

71 iomyocyte-specific transcription factors and contractile proteins, as well as stimulated cellular con

72 scle atrophy and preferential loss of muscle contractile proteins associated with reduced muscle func

73 In this study, we identify spectrin, a contractile protein at the cytoskeleton-membrane interfa

74 ches such as isolated myofibril and isolated contractile protein biomechanical assays allow study of

75 inesis, mechanical perturbation also directs contractile proteins but without apparently disrupting c

76 or units activate genes for slow isoforms of contractile proteins, but it remains unclear if there is

77 Acute endotoxemia caused contractile protein calcium insensitivity, oxygen wastag

78 the gene (TNNT2) encoding the thin-filament contractile protein cardiac troponin T are responsible f

79 argue for significant qualitative changes in contractile proteins causing the severely impaired resid

80 In the heart, contractile protein changes correlating with functional

81 ocardial caspase 3 activation and troponin-I contractile protein cleavage were studied in the non-inf

82 +/-) SMCs also had reduced expression of SMC contractile proteins compared with WT SMCs.

83 labeling of early and late-expressed muscle contractile proteins confirms the myotome mediolateral g

84 ne transfer to mouse pial arteries increased contractile protein content and diminished CBF responses

85 abnormalities in skeletal muscle histology, contractile protein content and enzymology contribute to

86 In contrast, silencing SRF normalized contractile protein content and reversed a hypercontract

87 characterized by expression of SMC-specific contractile proteins ("contractile phenotype").

88 Mutations in several contractile proteins contribute to DCM, but definitive e

89 The electrical properties of contractile proteins contribute to muscle structure and

90 h are apposed to CNS capillaries and contain contractile proteins, could initiate such signalling.

91 vo caspase inhibition can prevent myocardial contractile protein degradation, improve myocardial func

92 Quantitative analyses of contractile proteins demonstrated elevated expressions i

93 es were functionally competent and expressed contractile proteins, desmin, connexin43, and N-cadherin

94 ardiac sarcomere, but mutations in the known contractile protein disease genes are not found in up to

95 s involved in increasing Ca2+ sensitivity of contractile proteins during endothelin stimulation may b

96 Mechanical tuning of contractile protein dynamics provides robustness to the

97 energic receptor signaling, cytoskeletal and contractile proteins, energy metabolism, extracellular m

98 myosin heavy chain (alpha-MyHC) is the major contractile protein expressed in the myocardium of adult

99 Differentiation of lung fibroblasts into contractile protein-expressing myofibroblasts by transfo

100 VSMC) phenotype, which manifest as a loss of contractile protein expression and increased proliferati

101 w-level Raf activity in these cells augments contractile protein expression and myocyte fusion.

102 n SMCs increases proliferation and decreases contractile protein expression and suggest that the incr

103 how that rapamycin activates Akt and induces contractile protein expression in human VSMC in an insul

104 n, decreased SMC proliferation and increased contractile protein expression in the Tsc2(+/-) SMCs to

105 +)-independent force generation and elevated contractile protein expression likely contribute to thes

106 Changes in contractile protein expression were regulated primarily

107 s myogenin expression, but causes a delay in contractile protein expression.

108 utant mice caused a dramatic decrease in SMC contractile protein expression.

109 ferentiation, whereas Akt1 appears to oppose contractile protein expression.

110 Akt2, but not Akt1, is sufficient to induce contractile protein expression.

111 Other major regulatory/contractile proteins for Ca(2+) sensitization are expres

112 d translational repression of genes encoding contractile proteins found in the heart and vasculature.

113 Enhancement as well as impairment of contractile protein function is observed, suggesting tha

114 tile function is related to an alteration in contractile protein function is presently unknown.

115 Drawing on observations of mutant contractile protein function, together with mouse models

116 hypertrophy may be due, in part, to altered contractile protein function.

117 triated myocyte-selective transcription of a contractile protein gene encoding cardiac troponin T (cT

118 ream of XNkx2.5 and at or above the level of contractile protein gene expression.

119 scle phenotype and not in the maintenance of contractile protein gene expression.

120 l phenotypic modulation linked to changes in contractile protein gene expression.

121 Correct regulation of troponin and myosin contractile protein gene isoforms is a critical determin

122 these results suggest that the repression of contractile protein gene transcription by IL-1beta may b

123 editary, and mutations in cardiac sarcomeric contractile protein genes have been reported with autoso

124 Linkage analysis to selected sarcomeric contractile protein genes identified cardiac troponin I

125 t they would be downregulated along with the contractile protein genes in neointimal SMCs.

126 ght ratio and up-regulation of embryonic and contractile protein genes including atrial natriuretic f

127 y (HCM) is caused by mutations in at least 8 contractile protein genes, most commonly beta myosin hea

128 ucts related to the myocyte cytoskeleton and contractile proteins have been identified.

129 While mutations in other contractile proteins have been studied widely by others,

130 ltiple isoforms of the major force-producing contractile protein in cardiac and skeletal muscles.

131 y light chain (RLC) of myosin, but not other contractile proteins in "chemically skinned" fibers, we

132 ch regulate the turnover and accumulation of contractile proteins in cultured neonatal cardiac myocyt

133 activated kinase that mediates expression of contractile proteins in differentiating myoblasts, but M

134 acetylglucosamine (O-GlcNAc) modification of contractile proteins in human heart using SDS-PAGE and t

135 ts a significant mechanical role for the non-contractile proteins in muscle, namely that of equilibra

136 obese adipocytes decreased the expression of contractile proteins in myotubes, consequently inducing

137 ata, which characterizes the function of the contractile proteins in response to calcium that is inde

138 lating MF organization and the metabolism of contractile proteins in the cardiac myocyte.

139 creased expression of smooth muscle-specific contractile proteins in the gastrointestinal tract, impa

140 sts an increased proteolysis of the two main contractile proteins in the rested and fasted state, whi

141 and internal strain related to activation of contractile proteins, in mechanically ventilated, deeply

142 be caused by mutations in any one of several contractile proteins, including beta cardiac myosin heav

143 It has been linked to many cardiac contractile proteins, including four point mutations in

144 Furthermore, contractile protein induction was dependent on the conce

145 Furthermore, contractile protein induction was dependent on the conce

146 n the sarcoplasmic reticulum, and disrupting contractile protein interactions.

147 ance of muscle function requires assembly of contractile proteins into highly organized sarcomeres.

148 The assembly of contractile proteins into organized sarcomeric units is

149 ction depends on the precise organization of contractile proteins into sarcomeres and coupling of the

150 myocyte enhancer factor 2 and genes encoding contractile proteins is decreased in Set7 knockdown myoc

151 ith the idea that the intrinsic speed of the contractile proteins is faster in atrial than in ventric

152 The expression of skeletal muscle contractile proteins is tightly regulated during embryon

153 As actin is a major contractile protein, it was important to determine wheth

154 This highly conserved contractile protein likely drives cell-sheet movements t

155 The abundant expression of muscular and contractile proteins may have affected body weight and r

156 aberrant expression of muscle structural and contractile proteins, mimicking the hallmarks of the hum

157 neously, IL-1beta attenuated the increase in contractile protein mRNAs (skeletal alpha-actin and beta

158 myofibrils from 3 TTNtv mutants, and 3 with contractile protein mutations (TNNI3 K36Q, TNNC1 G159D a

159 We found that the three contractile protein mutations but not the TTNtv mutation

160 y increased expression of genes encoding the contractile proteins MyHC beta and MyHC alpha, followed

161 Multiple isoforms of the contractile protein myosin are present in mammalian skel

162 lation of the regulatory light chains of the contractile protein myosin IIa (MLC).

163 inding of the phosphorylated integrin to the contractile protein myosin in order to mediate transmiss

164 We demonstrate that the contractile proteins myosin II and cortexillin I redistr

165 significant changes in several cytoskeletal/contractile proteins (myosin light chain MLY2, myosin he

166 The concentrations of contractile proteins, myosin heavy chain isoform, and MA

167 hey partially reverse changes in fetal-adult/contractile protein, natriuretic peptide, SR-Ca(2+)-ATPa

168 ial for expression of the full complement of contractile proteins necessary for optimal force develop

169 une response to cardiac myosin (CM), a major contractile protein of cardiac muscle, is elicited in re

170 ell response to cardiac myosin (CM), a major contractile protein of the heart, and that pretransplant

171 that myosin genes not only encode the major contractile proteins of muscle, but act more broadly to

172 are caused by mutations in genes that encode contractile proteins of skeletal myofibers.

173 C) and up-regulation of betaMHC, the primary contractile proteins of the heart.

174 nce, the continual process of replacement of contractile proteins of the myofilament lattice with new

175 of the synthesis, assembly, and turnover of contractile proteins of the sarcomere.

176 Other proteins included cytoskeletal/contractile proteins (paxillin, vimentin, elongation fac

177 on induced a transition toward a slow muscle contractile protein phenotype, slower shortening velocit

178 s of TnC and its interactions with the other contractile proteins play a crucial role in modulating t

179 to unstretched controls, the turnover of the contractile protein pool was suppressed 50% to 100% in s

180 MFs did not alter the turnover of the total contractile protein pool, the cytoplasmic protein pool,

181 tin was regulated in parallel with the total contractile protein pool.

182 of engineered proteins to the heart, cardiac contractile protein profiles can be effectively remodele

183 which could account for spindle-independent contractile protein recruitment.

184 ntinued for four weeks, preserves myocardial contractile proteins, reduces systolic dysfunction, and

185 ene, in addition to encoding a major cardiac contractile protein, regulates cardiac growth and gene e

186 hanisms by which subtle genetic variation in contractile proteins remodel the human heart remains an

187 unofluorescence microscopy of structural and contractile proteins revealed the formation of a complex

188 ras(-/-) mice exhibited higher levels of the contractile proteins ROCK II, phosphorylated-MYPT(1) and

189 nase bound to detergent-washed smooth muscle contractile proteins similar to recombinant full-length

190 ression of ACTA2, the gene encoding the cyto-contractile protein smooth muscle alpha-actin.

191 hat restrict transcription of genes encoding contractile proteins specifically to either slow- or fas

192 ctivator (cyclin D1, E1, and IGF1) and fetal contractile protein (ssTNI, betaMHC) mRNA was increased

193 gene transfer, without detectable changes in contractile protein stoichiometry or sarcomere architect

194 se studies point to defects in ion channels, contractile proteins, structural proteins, and signaling

195 lcium homeostasis and possibly alteration in contractile protein structure.

196 reas the myofibrillar fraction had important contractile proteins, such as actin, tropomyosin, myosin

197 Moreover, other contractile proteins, such as alpha-actin and tropomyosi

198 upstream of myocardin and smooth muscle cell contractile protein synthesis.

199 These data indicate that MRP is a novel contractile protein that co-integrates with myosin into

200 TnT is a muscle contractile protein that, in association with the thin f

201 stem, an inducible expression of an abundant contractile protein, the atrial isoform of essential myo

202 decreases contractility at the level of the contractile proteins; therefore, we asked whether antiox

203 ay interact directly with the aforementioned contractile proteins through its 10-kDa domain.

204 nce for a mechanosensory system that directs contractile proteins to regulate cell shape during mitos

205 c AMP-dependent protein kinase (PKA) targets contractile proteins, troponin-I (TnI) and myosin bindin

206 Conversely, contractile protein turnover was suppressed in cells tre

207 s the short axis of the MFs suppressed total contractile protein turnover, the turnover of MHC and ac

208 n parallel with the MFs modestly accelerated contractile protein turnover.

209 presses expression of multiple smooth muscle contractile proteins, useful markers of differentiation.

210 for reactions of ATP, ADP and P(i) with the contractile proteins varied with IS, thus suggesting tha

211 A modest loss of contractile proteins was observed and linked to an early

212 rdiomyocytes; sarcomeric organization of the contractile proteins was observed.

213 Contractile proteins were unchanged with either modes of

214 in heavy chain (SM-MHC) gene encodes a major contractile protein whose expression exclusively marks t

215 rved were associated with phosphorylation of contractile proteins with results showing that quantitat