ライフサイエンスコーパス: contractile response

1 ignificantly phosphorylated during the acute contractile response.

2 a constant level to ensure constancy of the contractile response.

3 st or antagonist in a P2Y6 receptor-mediated contractile response.

4 ment fully revives the diminished beta(1)-AR contractile response.

5 desensitization, permitting agonist-induced contractile response.

6 ty and, surprisingly, restore the beta(1)-AR contractile response.

7 ndent activation of AC and induce a positive contractile response.

8 d the beta(2)-AR but not beta(1)-AR-mediated contractile response.

9 ure overload hypertrophy and beta-adrenergic contractile response.

10 M) and GSK-269962 (50 nM) both abrogated the contractile response.

11 n are associated with the LY379196-sensitive contractile response.

12 A nor soluble guanylate cyclase altered this contractile response.

13 d by activated mast cells that may promote a contractile response.

14 yometrial activation, allowing for a maximal contractile response.

15 yometrial activation, allowing for a maximal contractile response.

16 NA interference significantly attenuated the contractile response.

17 this compound caused, at least in part, the contractile response.

18 23/Ser24 clusters to the endothelin-mediated contractile response.

19 changes contribute to age-related changes in contractile responses.

20 activity (23%) and impaired beta-adrenergic contractile responses.

21 microM) caused a complete restoration of the contractile responses.

22 t express PARs and the mechanisms leading to contractile responses.

23 whereby mast cells may modulate HASM-driven contractile responses.

24 tein levels resulting in higher 5-HT-induced contractile responses.

25 )-AR-mediated negative modulation on myocyte contractile response and [Ca(2+)](i) regulation.

26 of protein kinase, blocked the increases in contractile response and Ca2+ currents to ISO in WT and

27 f cyclooxygenase-derived prostanoids in this contractile response and determined whether there were a

28 elated with a prevention of the hyperdynamic contractile response and enhanced myocardial protection,

29 re in Pkd2(+/-) mice exhibits an exaggerated contractile response and increased sensitivity to PE.

30 proteins responsible for alpha 1-AR-mediated contractile response and inositol phosphate accumulation

31 odeled (32% longer and 18% wider), but their contractile response and intracellular calcium kinetics

32 s Ca(2+) release at baseline, as well as the contractile response and the incidence of arrhythmias in

33 fic IKK2-deficient mice had decreased aortic contractile responses, and reduced hypertensive response

34 The oral contractile responses, and the anal relaxation and contr

35 Both oxygen sensing and the contractile response are thought to be intrinsic to pulm

36 nally considered cardiodepressant mediators, contractile responses are complex and bimodal, with an e

37 OA-NO(2) significantly inhibits Ang II contractile response as compared to oleic acid (OA) in m

38 M by 27%) and anal (LM by 36% and CM by 36%) contractile responses as well as the anal relaxation res

39 ed decreases in both KCl- and u46619-induced contractile responses at both time points.

40 with isoproterenol resulted only in a modest contractile response but caused significant mortality in

41 from alpha(1)3.2-null arteries showed normal contractile responses, but reduced relaxation in respons

42 The altered contractile responses coincided with a down-regulation o

43 PKA-) and DBL(PKA-) mice displayed a blunted contractile response compared to wild-type and TnI(PKA-)

44 Maximum contractile response decreased significantly in the RESU

45 Basal contractile activity and maximum contractile response did not change significantly in the

46 tration needed to produce 50% of the maximal contractile response (EC50).

47 gnificantly attenuated both phasic and tonic contractile responses elicited by phenylephrine, angiote

48 e decreased (efficacy as measured by maximum contractile response, Emax: 3.0 +/- 0.3 vs. 4.7 +/- 0.2

49 of the frequency causing 50% of the maximal contractile response (ES50).

50 To evaluate neurally mediated contractile responses, frequency-response curves to elec

51 nhibition of PI3K enhances forskolin-induced contractile response in a betaARK-ct sensitive manner.

52 nfusion was associated with a more robust LV contractile response in AC(VI) mice (P < 0.05).

53 on attenuates the adrenergic-induced cardiac contractile response in animal hearts.

54 ignificantly suppressed tetrodotoxin-induced contractile response in mouse colon, which suggests that

55 AT1b receptor is a major mediator for Ang II contractile response in mouse vessels, such as abdominal

56 results suggest that alpha 1-ARs mediate the contractile response in rat aorta by coupling to both Gq

57 on segments produced up to a 10-fold greater contractile response in Smn deficient tissues.

58 g by fenoterol restores the blunted beta2-AR contractile response in the failing heart.

59 f beta2-AR/G(s) by ligands restores beta2-AR contractile response in the failing heart.

60 rs after lipopolysaccharide, despite reduced contractile responses in aortic rings and the lack of ef

61 ufficient for robust RLC phosphorylation and contractile responses in bladder smooth muscle.

62 s leukotriene (LT)D4 receptor expression and contractile responses in cultured human airway smooth mu

63 ced PKA phosphorylation of phospholamban and contractile responses in myocytes.

64 R, PKA phosphorylation of phospholamban, and contractile responses in PGE2-pretreated myocytes.

65 ae infection can directly alter the vascular contractile responses in porcine coronary arteries, prov

66 ssociated with recovery of betaAR-stimulated contractile responses in rescued cardiomyocytes.

67 roglitazone decreases norepinephrine-induced contractile responses in the rat tail artery, an effect

68 rophic signals and the regulation of myocyte contractile responses in the setting of heart failure.

69 OVA failed to elicit histamine release or contractile responses in trachea isolated from sensitize

70 sine attenuates the myocardial metabolic and contractile responses induced by ss-adrenergic stimulati

71 The "rescued" contractile response is completely reversed by a beta(1)

72 The contractile response is variable and depends on actomyos

73 Despite a similar contractile response, M/MtCK-/- hearts increased [ADP] b

74 lation with isoproterenol but attenuated the contractile response (maximal cell shortening, 15.5 +/-

75 ontractile activity, maximum agonist-induced contractile response (measured as total force generation

76 panel of beta2-AR ligands revealed that the contractile response mediated by most beta2-AR agonists,

77 n and myosin light chain), regulators of the contractile response (myosin light chain kinase, myosin

78 pendent on H(2)O(2), whereas beta-adrenergic contractile responses occur independently of H(2)O(2) si

79 of PKG KT 5823 (1 micromol/L); the positive contractile response of 1 micromol/L SNAP persisted, des

80 The negative contractile response of 100 micromol/L SNAP was complete

81 hrine release simultaneously with the evoked contractile response of a mesenteric artery from a healt

82 By studying the contractile response of cells to dynamic stiffness condi

83 that disrupts the final 51 aa increases the contractile response of cultured cardiac cells to cholin

84 fects of cardiopulmonary bypass (CPB) on the contractile response of human peripheral microvasculatur

85 The contractile response of isolated afferent arterioles to

86 (all after topical 2.5% phenylephrine), and contractile response of isolated CM strips, obtained <1

87 The post-CPB contractile response of peripheral arterioles to ET-1 wa

88 The Ca2+-activated contractile response of permeabilized bronchial smooth m

89 Functionally, the contractile response of pressurized thoracodorsal resist

90 isoproterenol (ISO) resulted in an impaired contractile response of TG hearts.

91 The anal contractile response of the CM was unaffected by L-NA.

92 er or stimulation chamber decreased the oral contractile response of the LM and CM (by about 30-40 %)

93 arginine (L-NA; 100 microM) reduced the oral contractile response of the LM and CM by 50%, the anal c

94 e response of the LM and CM by 50%, the anal contractile response of the LM by 30%, and the anal rela

95 ceptor subtypes, is then able to enhance the contractile response of the myometrium.

96 A substantial component of the contractile response of the vas deferens to sympathetic

97 alcium entry via VDCCs serves to enhance the contractile response of these cells.

98 , airway responsiveness was monitored by the contractile response of tracheal smooth muscle to electr

99 effect of insulin to attenuate the Ca2+ and contractile response of vascular smooth muscle to a numb

100 ndothelium-derived NO and thereby reduce the contractile response of vascular smooth muscle.

101 The enhanced contractile responses of airways from the SO2-exposed ne

102 hyperresponsive to vasopressin; in contrast, contractile responses of collaterals to endothelin are a

103 Contractile responses of coronary arteries to cumulative

104 The maximal contractile responses of femoral arterial rings to the s

105 asthma exacerbations by directly modulating contractile responses of HASM.

106 in coronary artery disease, we compared the contractile responses of leukotriene C4 (LTC4) and leuko

107 l of key regulatory proteins is required for contractile responses of mature VSM.

108 dine attenuated the graded carbachol-induced contractile responses of mouse bronchial rings and calci

109 ty of tasks and to illustrate the individual contractile responses of MUs whose collective action det

110 Contractile responses of normal LV rings were measured i

111 Contractile responses of the carotid artery were enhance

112 drenergic receptor kinase 1 in mediating the contractile responses of the heart to beta-adrenergic st

113 thonium (300 microM) almost blocked the oral contractile responses of the LM and CM but had no affect

114 ctile responses, and the anal relaxation and contractile responses of the LM and CM produced by L-NA

115 microM) in the recording chamber reduced the contractile responses of the LM and CM.

116 The contractile responses of the renal arterial rings to tra

117 In addition, contractile responses of TSM to methacholine (MCh) were

118 atively important mechanisms involved in the contractile responses of vascular tissues to pH change a

119 embrane (ERM) formation, a proliferative and contractile response on the retinal surface.

120 We conclude that the higher 5-HT-induced contractile response results from a higher density of 5-

121 During recovery the contractile response returned to 51% of control, indicat

122 ut significant, increase in the component of contractile responses sensitive to Rho-kinase antagonism

123 ding of the functional effects of non-linear contractile responses, slow muscle relaxation, and neuro

124 acellular calcium during metaphase induced a contractile response, suggesting that calcium transients

125 enhancement of vasopressin-mediated Ca2+ and contractile responses suggests increases in vasopressin

126 ch P3 regenerative cells are shown to lack a contractile response that is seen in other fibroblast cu

127 onditions but after CP-Rep elicited a potent contractile response that was inhibited in the presence

128 e sensitivity in that pD2 (-logEC50) for the contractile response to 5-HT was 7.19 +/- 0.15 and 6.62

129 A contractile response to a nonselective beta-AR agonist,

130 of alpha(1C) protein and mRNA as well as the contractile response to acetylcholine and KCl.

131 ppression of alpha1C, as well as that of the contractile response to acetylcholine, by 24 hours of tr

132 lonic circular smooth muscle cells and their contractile response to acetylcholine.

133 n mutants F31, F118 or F31/118 inhibited the contractile response to ACh stimulation but did not inhi

134 ed that PLCepsilon(-/-) mice had a decreased contractile response to acute isoproterenol administrati

135 s from HFD-fed mice also displayed a reduced contractile response to adrenergic stimulation when comp

136 al access to the myofilaments and to restore contractile response to adrenergic stimulation.

137 effects of ACE and chymase inhibitors on the contractile response to angiotensin I (Ang I) in human r

138 d with nontransgenic control mice, while the contractile response to angiotensin II receptor stimulat

139 xamethonium had no significant effect on the contractile response to any agonist, indicating that the

140 itive G(i) proteins in addition to G(s), the contractile response to beta(1)-AR stimulation by norepi

141 Although the contractile response to beta(2)-R* in TG4 cells was abol

142 led that in titin M-line-deficient mice, the contractile response to beta-adrenergic agonists and ext

143 e an age-associated diminution in myocardial contractile response to beta-adrenergic receptor (beta-A

144 The mechanisms underlying the blunted contractile response to beta-adrenergic receptor (beta-A

145 myocardium is characterized by an attenuated contractile response to beta-adrenergic receptor (betaAR

146 This blunts the local contractile response to beta-adrenergic stimulation and

147 LPS depresses cardiac contractility and the contractile response to beta-adrenergic stimulation by a

148 unction in LVH rats and markedly blunted the contractile response to beta-adrenergic stimulation.

149 ction), the force-frequency response and the contractile response to beta-adrenergic stimulation.

150 each residue plays a role in regulating the contractile response to beta-agonist stimulation.

151 Myocardial contractile response to beta1- and beta2-adrenergic rece

152 ; (2) as a special case, the lack of cardiac contractile response to beta2AR agonists in TG4 mice is

153 of GRK2 led to a G(i)-dependent decrease of contractile response to betaAR stimulation in cultured m

154 Furthermore, the in vivo left ventricular contractile response to betaAR stimulation was restored

155 A marked age-associated depression in contractile response to both beta-AR subtype stimulation

156 The contractile response to capsaicin was not affected by th

157 0.005-mg/kg dose of endotoxin decreased the contractile response to cholecystokinin octapeptide for

158 Endotoxin abolished the contractile response to cholecystokinin octapeptide in g

159 nitric oxide synthase reversed the decreased contractile response to cholecystokinin octapeptide.

160 p/dtmax in response to BK, indicating a poor contractile response to CSAR activation.

161 In a separate group of experiments, the contractile response to cumulative concentrations of the

162 cedure that removed the endothelium, and the contractile response to cumulative doses of endothelin-1

163 We studied the effect of allopurinol on the contractile response to dobutamine and exercise in 7 chr

164 Both radionuclide perfusion tracers and contractile response to dobutamine have been used to ide

165 tional tissue after MI demonstrates a larger contractile response to dobutamine than normal myocardiu

166 The quantitative myocardial contractile response to dobutamine was similar in patien

167 The contractile response to each agonist was suppressed sign

168 r endotoxin administration and decreased the contractile response to electrical field stimulation for

169 adder TLR4 and MyD88 expression and enhanced contractile response to electrical field stimulation.

170 onist dexmedetomidine completely blocked the contractile response to electrical stimulation in vas de

171 The contractile response to ET-1 is through activation of ET

172 In vitro contractile response to ET-1 was assessed by videomicros

173 ic GMP-dependent protein kinase (PKG) in the contractile response to exogenous NO in rat ventricular

174 nd inhibited C3a-induced potentiation of the contractile response to field stimulation of perfused ra

175 and prostaglandin E(2) abrogated the potent contractile response to hypoxia and restored the wild-ty

176 e, caused both the oxidation current and the contractile response to increase.

177 phorylation is the principal mediator of the contractile response to increased beta-agonist stimulati

178 elaxation in Gsalpha at baseline but not the contractile response to ISO in Gsalpha myocytes.

179 We studied the contractile response to isoprenaline (10 nm) in isolated

180 However, there were no differences in the contractile response to isoproterenol between myocytes f

181 In addition, the contractile response to isoproterenol was blunted in bot

182 LPS attenuation of the contractile response to isoproterenol was restored compl

183 etaARK1 (3 to 5-fold) have a blunted in vivo contractile response to isoproterenol when compared with

184 The contractile response to LPS required TLR4 signaling and

185 ethoctramine, and tropicamide to inhibit the contractile response to muscarine.

186 o test the hypothesis that modulation of the contractile response to muscarinic receptor activation c

187 Inflammation suppresses the phasic contractile response to muscarinic receptor activation i

188 sulin (50 mU/l) significantly attenuated the contractile response to NE in lean rats (14.7 +/- 3.3%;

189 nges in gene expression promoted an enhanced contractile response to oxytocin in pregnant human myome

190 al contractions (P < 0.05) and an attenuated contractile response to oxytocin.

191 Contractile response to phenylephrine (PE; 10(-10) to 10

192 to lipopolysaccharide in vitro decreased the contractile response to phenylephrine.

193 In vivo contractile response to the beta1AR agonist dobutamine,

194 r relaxation (acetylcholine) and an enhanced contractile response to vasoactive agents (phenylephrine

195 tion, these animals exhibit hypertrophic and contractile responses to 10-day infusion of angiotensin

196 orylation of RyR2 in both the heart rate and contractile responses to acute catecholaminergic stimula

197 gnaling molecule central to adaptive cardiac contractile responses to acute stress, which appears to

198 transgenic than TnIDD22,23 (P<0.02), whereas contractile responses to afterload were similar between

199 femoral, and mesenteric arteries had reduced contractile responses to agonists and depolarization in

200 Additionally, contractile responses to alpha-adrenergic agonists were

201 s in determining the airway inflammatory and contractile responses to antigen in a mouse model.

202 reatment fully rescued the ICa, [Ca2+]i, and contractile responses to beta2AR agonists in both WT and

203 In this study, the contractile responses to both beta1-AR and beta2-AR stim

204 d that TGF-beta pre-treatment enhanced acute contractile responses to bradykinin (BK) in isolated rat

205 ce) exhibited blunted heart rate and cardiac contractile responses to catecholamines (isoproterenol).

206 STZ in WT mice increased bladder weight and contractile responses to CCh and to electrical field sti

207 We found increased contractile responses to EFS in infected animals compare

208 However, the age-associated diminutions in contractile responses to either beta1-AR or beta2-AR sti

209 of aging coronary arteries is their enhanced contractile responses to endothelial vasoconstricting fa

210 The contractile responses to exogenous noradrenaline (NA; 0.

211 VSM contractile responses to G-protein-coupled receptor stim

212 s in which Ser16 is phosphorylated, inhibits contractile responses to high extracellular KCl and to s

213 Contractile responses to high molar KCl and u46619 level

214 gallbladder stasis by decreasing gallbladder contractile responses to hormonal and neural stimuli.

215 croscopic measurement of afferent arteriolar contractile responses to increasing bath concentrations

216 No difference in isolated vascular contractile responses to KCI (125 mM), phenylephrine, or

217 These findings indicate that contractile responses to NE in human LUT tissues are med

218 kade heightened arteriolar and large venular contractile responses to norepinephrine, a nonselective

219 However, phenylephrine infusion enhanced contractile responses to parasympathetic stimulation.

220 Cultured vessels also showed contractile responses to pharmacological agents and cont

221 ar reactivity, as demonstrated by diminished contractile responses to phenylephrine and enhanced rela

222 hiPSC-CMs, mattress hiPSC-CMs display robust contractile responses to positive inotropic agents, such

223 This model was compared with metabolic and contractile responses to repeated activation using value

224 ymphatic muscle would exhibit rate-sensitive contractile responses to stretch.

225 n altered Starling relationship, and blunted contractile responses to the beta-adrenergic agonist dob

226 ic left ventricular function, and attenuated contractile responses to the beta-adrenergic agonist, is

227 ly a 20% decrease in RLC phosphorylation and contractile responses to the muscarinic agonist carbacho

228 Contractile responses to these drugs were assessed in me

229 The integrated contractile responses to these regulatory mechanisms dep

230 ce and gp91(phox) knock-out mice had similar contractile responses to U46619 and hypoxia and similar

231 mg) doses of estradiol inhibited the maximal contractile responses to U46619 compared with arteries f

232 ion, both LNA and methylene blue potentiated contractile responses to U46619 of arteries from animals

233 elium, associated with significantly reduced contractile responses to UTP and enhanced endothelium-de

234 Contractile responses to vasopressin (100 mmol/L) were e

235 and carotid arteries, whereas a decrease in contractile response was found in mesenteric arteries.

236 beta-AR) agonist isoproterenol (ISO)-induced contractile response was measured in isolated hearts.

237 The enhanced contractile response was prevented by the CaCC blockers

238 h inducible SRF overexpression, the in vitro contractile response was significantly increased in all

239 the G(i) coupling negating the G(s)-mediated contractile response, we determined whether the heart fa

240 melittin-stimulated release of AA and their contractile response were attenuated in inflamed cells.

241 These enhanced contractile responses were also observed in MIP/Mtmr14(-

242 ed an increase in the IAS tone; these tissue contractile responses were confirmed by single-cell cont

243 In contrast, enhanced contractile responses were not observed in response to a

244 inhibition of RLC phosphorylation and aorta contractile responses, whereas a 90% decrease profoundly

245 e had no effect on RLC phosphorylation or on contractile responses, whereas an 80% decrease resulted

246 CR4 sustained normal vascular reactivity and contractile responses, whereas CXCR4 deficiency favored

247 a1 versus beta2) to the overall reduction in contractile response with aging is unknown.

248 onstrated a quantitatively normal myocardial contractile response without development of wall motion

249 m) markedly enhanced the beta(2)-AR-mediated contractile response, without altering base-line contrac