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1 ignificantly phosphorylated during the acute contractile response.
2 a constant level to ensure constancy of the contractile response.
3 st or antagonist in a P2Y6 receptor-mediated contractile response.
4 ment fully revives the diminished beta(1)-AR contractile response.
5 desensitization, permitting agonist-induced contractile response.
6 ty and, surprisingly, restore the beta(1)-AR contractile response.
7 ndent activation of AC and induce a positive contractile response.
8 d the beta(2)-AR but not beta(1)-AR-mediated contractile response.
9 ure overload hypertrophy and beta-adrenergic contractile response.
10 M) and GSK-269962 (50 nM) both abrogated the contractile response.
11 n are associated with the LY379196-sensitive contractile response.
12 A nor soluble guanylate cyclase altered this contractile response.
13 d by activated mast cells that may promote a contractile response.
14 yometrial activation, allowing for a maximal contractile response.
15 yometrial activation, allowing for a maximal contractile response.
16 NA interference significantly attenuated the contractile response.
17 this compound caused, at least in part, the contractile response.
18 23/Ser24 clusters to the endothelin-mediated contractile response.
19 changes contribute to age-related changes in contractile responses.
20 activity (23%) and impaired beta-adrenergic contractile responses.
21 microM) caused a complete restoration of the contractile responses.
22 t express PARs and the mechanisms leading to contractile responses.
23 whereby mast cells may modulate HASM-driven contractile responses.
24 tein levels resulting in higher 5-HT-induced contractile responses.
26 of protein kinase, blocked the increases in contractile response and Ca2+ currents to ISO in WT and
27 f cyclooxygenase-derived prostanoids in this contractile response and determined whether there were a
28 elated with a prevention of the hyperdynamic contractile response and enhanced myocardial protection,
29 re in Pkd2(+/-) mice exhibits an exaggerated contractile response and increased sensitivity to PE.
30 proteins responsible for alpha 1-AR-mediated contractile response and inositol phosphate accumulation
31 odeled (32% longer and 18% wider), but their contractile response and intracellular calcium kinetics
32 s Ca(2+) release at baseline, as well as the contractile response and the incidence of arrhythmias in
33 fic IKK2-deficient mice had decreased aortic contractile responses, and reduced hypertensive response
36 nally considered cardiodepressant mediators, contractile responses are complex and bimodal, with an e
38 M by 27%) and anal (LM by 36% and CM by 36%) contractile responses as well as the anal relaxation res
40 with isoproterenol resulted only in a modest contractile response but caused significant mortality in
41 from alpha(1)3.2-null arteries showed normal contractile responses, but reduced relaxation in respons
43 PKA-) and DBL(PKA-) mice displayed a blunted contractile response compared to wild-type and TnI(PKA-)
47 gnificantly attenuated both phasic and tonic contractile responses elicited by phenylephrine, angiote
48 e decreased (efficacy as measured by maximum contractile response, Emax: 3.0 +/- 0.3 vs. 4.7 +/- 0.2
51 nhibition of PI3K enhances forskolin-induced contractile response in a betaARK-ct sensitive manner.
54 ignificantly suppressed tetrodotoxin-induced contractile response in mouse colon, which suggests that
55 AT1b receptor is a major mediator for Ang II contractile response in mouse vessels, such as abdominal
56 results suggest that alpha 1-ARs mediate the contractile response in rat aorta by coupling to both Gq
60 rs after lipopolysaccharide, despite reduced contractile responses in aortic rings and the lack of ef
62 s leukotriene (LT)D4 receptor expression and contractile responses in cultured human airway smooth mu
65 ae infection can directly alter the vascular contractile responses in porcine coronary arteries, prov
67 roglitazone decreases norepinephrine-induced contractile responses in the rat tail artery, an effect
68 rophic signals and the regulation of myocyte contractile responses in the setting of heart failure.
69 OVA failed to elicit histamine release or contractile responses in trachea isolated from sensitize
70 sine attenuates the myocardial metabolic and contractile responses induced by ss-adrenergic stimulati
74 lation with isoproterenol but attenuated the contractile response (maximal cell shortening, 15.5 +/-
75 ontractile activity, maximum agonist-induced contractile response (measured as total force generation
76 panel of beta2-AR ligands revealed that the contractile response mediated by most beta2-AR agonists,
77 n and myosin light chain), regulators of the contractile response (myosin light chain kinase, myosin
78 pendent on H(2)O(2), whereas beta-adrenergic contractile responses occur independently of H(2)O(2) si
79 of PKG KT 5823 (1 micromol/L); the positive contractile response of 1 micromol/L SNAP persisted, des
81 hrine release simultaneously with the evoked contractile response of a mesenteric artery from a healt
83 that disrupts the final 51 aa increases the contractile response of cultured cardiac cells to cholin
84 fects of cardiopulmonary bypass (CPB) on the contractile response of human peripheral microvasculatur
86 (all after topical 2.5% phenylephrine), and contractile response of isolated CM strips, obtained <1
92 er or stimulation chamber decreased the oral contractile response of the LM and CM (by about 30-40 %)
93 arginine (L-NA; 100 microM) reduced the oral contractile response of the LM and CM by 50%, the anal c
94 e response of the LM and CM by 50%, the anal contractile response of the LM by 30%, and the anal rela
98 , airway responsiveness was monitored by the contractile response of tracheal smooth muscle to electr
99 effect of insulin to attenuate the Ca2+ and contractile response of vascular smooth muscle to a numb
102 hyperresponsive to vasopressin; in contrast, contractile responses of collaterals to endothelin are a
106 in coronary artery disease, we compared the contractile responses of leukotriene C4 (LTC4) and leuko
108 dine attenuated the graded carbachol-induced contractile responses of mouse bronchial rings and calci
109 ty of tasks and to illustrate the individual contractile responses of MUs whose collective action det
112 drenergic receptor kinase 1 in mediating the contractile responses of the heart to beta-adrenergic st
113 thonium (300 microM) almost blocked the oral contractile responses of the LM and CM but had no affect
114 ctile responses, and the anal relaxation and contractile responses of the LM and CM produced by L-NA
118 atively important mechanisms involved in the contractile responses of vascular tissues to pH change a
120 We conclude that the higher 5-HT-induced contractile response results from a higher density of 5-
122 ut significant, increase in the component of contractile responses sensitive to Rho-kinase antagonism
123 ding of the functional effects of non-linear contractile responses, slow muscle relaxation, and neuro
124 acellular calcium during metaphase induced a contractile response, suggesting that calcium transients
125 enhancement of vasopressin-mediated Ca2+ and contractile responses suggests increases in vasopressin
126 ch P3 regenerative cells are shown to lack a contractile response that is seen in other fibroblast cu
127 onditions but after CP-Rep elicited a potent contractile response that was inhibited in the presence
128 e sensitivity in that pD2 (-logEC50) for the contractile response to 5-HT was 7.19 +/- 0.15 and 6.62
131 ppression of alpha1C, as well as that of the contractile response to acetylcholine, by 24 hours of tr
133 n mutants F31, F118 or F31/118 inhibited the contractile response to ACh stimulation but did not inhi
134 ed that PLCepsilon(-/-) mice had a decreased contractile response to acute isoproterenol administrati
135 s from HFD-fed mice also displayed a reduced contractile response to adrenergic stimulation when comp
137 effects of ACE and chymase inhibitors on the contractile response to angiotensin I (Ang I) in human r
138 d with nontransgenic control mice, while the contractile response to angiotensin II receptor stimulat
139 xamethonium had no significant effect on the contractile response to any agonist, indicating that the
140 itive G(i) proteins in addition to G(s), the contractile response to beta(1)-AR stimulation by norepi
142 led that in titin M-line-deficient mice, the contractile response to beta-adrenergic agonists and ext
143 e an age-associated diminution in myocardial contractile response to beta-adrenergic receptor (beta-A
145 myocardium is characterized by an attenuated contractile response to beta-adrenergic receptor (betaAR
147 LPS depresses cardiac contractility and the contractile response to beta-adrenergic stimulation by a
148 unction in LVH rats and markedly blunted the contractile response to beta-adrenergic stimulation.
149 ction), the force-frequency response and the contractile response to beta-adrenergic stimulation.
152 ; (2) as a special case, the lack of cardiac contractile response to beta2AR agonists in TG4 mice is
153 of GRK2 led to a G(i)-dependent decrease of contractile response to betaAR stimulation in cultured m
154 Furthermore, the in vivo left ventricular contractile response to betaAR stimulation was restored
157 0.005-mg/kg dose of endotoxin decreased the contractile response to cholecystokinin octapeptide for
159 nitric oxide synthase reversed the decreased contractile response to cholecystokinin octapeptide.
161 In a separate group of experiments, the contractile response to cumulative concentrations of the
162 cedure that removed the endothelium, and the contractile response to cumulative doses of endothelin-1
163 We studied the effect of allopurinol on the contractile response to dobutamine and exercise in 7 chr
164 Both radionuclide perfusion tracers and contractile response to dobutamine have been used to ide
165 tional tissue after MI demonstrates a larger contractile response to dobutamine than normal myocardiu
168 r endotoxin administration and decreased the contractile response to electrical field stimulation for
169 adder TLR4 and MyD88 expression and enhanced contractile response to electrical field stimulation.
170 onist dexmedetomidine completely blocked the contractile response to electrical stimulation in vas de
173 ic GMP-dependent protein kinase (PKG) in the contractile response to exogenous NO in rat ventricular
174 nd inhibited C3a-induced potentiation of the contractile response to field stimulation of perfused ra
175 and prostaglandin E(2) abrogated the potent contractile response to hypoxia and restored the wild-ty
177 phorylation is the principal mediator of the contractile response to increased beta-agonist stimulati
180 However, there were no differences in the contractile response to isoproterenol between myocytes f
183 etaARK1 (3 to 5-fold) have a blunted in vivo contractile response to isoproterenol when compared with
186 o test the hypothesis that modulation of the contractile response to muscarinic receptor activation c
188 sulin (50 mU/l) significantly attenuated the contractile response to NE in lean rats (14.7 +/- 3.3%;
189 nges in gene expression promoted an enhanced contractile response to oxytocin in pregnant human myome
194 r relaxation (acetylcholine) and an enhanced contractile response to vasoactive agents (phenylephrine
195 tion, these animals exhibit hypertrophic and contractile responses to 10-day infusion of angiotensin
196 orylation of RyR2 in both the heart rate and contractile responses to acute catecholaminergic stimula
197 gnaling molecule central to adaptive cardiac contractile responses to acute stress, which appears to
198 transgenic than TnIDD22,23 (P<0.02), whereas contractile responses to afterload were similar between
199 femoral, and mesenteric arteries had reduced contractile responses to agonists and depolarization in
202 reatment fully rescued the ICa, [Ca2+]i, and contractile responses to beta2AR agonists in both WT and
204 d that TGF-beta pre-treatment enhanced acute contractile responses to bradykinin (BK) in isolated rat
205 ce) exhibited blunted heart rate and cardiac contractile responses to catecholamines (isoproterenol).
206 STZ in WT mice increased bladder weight and contractile responses to CCh and to electrical field sti
208 However, the age-associated diminutions in contractile responses to either beta1-AR or beta2-AR sti
209 of aging coronary arteries is their enhanced contractile responses to endothelial vasoconstricting fa
212 s in which Ser16 is phosphorylated, inhibits contractile responses to high extracellular KCl and to s
214 gallbladder stasis by decreasing gallbladder contractile responses to hormonal and neural stimuli.
215 croscopic measurement of afferent arteriolar contractile responses to increasing bath concentrations
218 kade heightened arteriolar and large venular contractile responses to norepinephrine, a nonselective
221 ar reactivity, as demonstrated by diminished contractile responses to phenylephrine and enhanced rela
222 hiPSC-CMs, mattress hiPSC-CMs display robust contractile responses to positive inotropic agents, such
223 This model was compared with metabolic and contractile responses to repeated activation using value
225 n altered Starling relationship, and blunted contractile responses to the beta-adrenergic agonist dob
226 ic left ventricular function, and attenuated contractile responses to the beta-adrenergic agonist, is
227 ly a 20% decrease in RLC phosphorylation and contractile responses to the muscarinic agonist carbacho
230 ce and gp91(phox) knock-out mice had similar contractile responses to U46619 and hypoxia and similar
231 mg) doses of estradiol inhibited the maximal contractile responses to U46619 compared with arteries f
232 ion, both LNA and methylene blue potentiated contractile responses to U46619 of arteries from animals
233 elium, associated with significantly reduced contractile responses to UTP and enhanced endothelium-de
235 and carotid arteries, whereas a decrease in contractile response was found in mesenteric arteries.
236 beta-AR) agonist isoproterenol (ISO)-induced contractile response was measured in isolated hearts.
238 h inducible SRF overexpression, the in vitro contractile response was significantly increased in all
239 the G(i) coupling negating the G(s)-mediated contractile response, we determined whether the heart fa
240 melittin-stimulated release of AA and their contractile response were attenuated in inflamed cells.
242 ed an increase in the IAS tone; these tissue contractile responses were confirmed by single-cell cont
244 inhibition of RLC phosphorylation and aorta contractile responses, whereas a 90% decrease profoundly
245 e had no effect on RLC phosphorylation or on contractile responses, whereas an 80% decrease resulted
246 CR4 sustained normal vascular reactivity and contractile responses, whereas CXCR4 deficiency favored
248 onstrated a quantitatively normal myocardial contractile response without development of wall motion
249 m) markedly enhanced the beta(2)-AR-mediated contractile response, without altering base-line contrac
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