ライフサイエンスコーパス: contractile ring

1 join these nodes, which condense to form the contractile ring.

2 at protein layer, generated by an actomyosin contractile ring.

3 the nodes pull nodes together into a single contractile ring.

4 stress fibers and the cytokinetic actomyosin contractile ring.

5 first phase relies on the assembly of a wide contractile ring.

6 lane and allow efficient constriction of the contractile ring.

7 cleavage can continue in the absence of the contractile ring.

8 mbly and constriction of an actomyosin-based contractile ring.

9 ature into the precursors of the cytokinetic contractile ring.

10 s is mediated by a cortical actomyosin-based contractile ring.

11 dles of linear antiparallel filaments in the contractile ring.

12 polarizing actin cables, and the cytokinetic contractile ring.

13 e actin filaments to condense nodes into the contractile ring.

14 d is required for myosin enrichment into the contractile ring.

15 venting DNA breaks or constrictions from the contractile ring.

16 generation of actin filaments that form the contractile ring.

17 s pulls the nodes together to form a compact contractile ring.

18 embly and contraction of an actomyosin-based contractile ring.

19 PIP2 promote cytokinesis in the absence of a contractile ring.

20 divides by assembling actin filaments into a contractile ring.

21 s accomplished by constriction of a cortical contractile ring.

22 proteins that condense into the cytokinetic contractile ring.

23 eavage furrow formed by the actomyosin-based contractile ring.

24 uired for localization and activation of the contractile ring.

25 ediated by ingression of an actomyosin-based contractile ring.

26 ing and are not required for assembly of the contractile ring.

27 -dependent assembly of the cytokinetic actin contractile ring.

28 ed models of the dynamics of the cytokinetic contractile ring.

29 nesis and is localized on the midbody of the contractile ring.

30 specification signal for positioning of the contractile ring.

31 th the assembly and disassembly of the actin contractile ring.

32 o a delay in mitotic exit or assembly of the contractile ring.

33 n septin recruitment to the furrow canal and contractile ring.

34 lated proteins occur at late anaphase at the contractile ring.

35 nt signal that specifies the position of the contractile ring.

36 lymerize actin filaments for the cytokinetic contractile ring.

37 supergroups lack myosin II of the actomyosin contractile ring.

38 t the cell cycle and are constituents of the contractile ring.

39 ins in the functional units of a cytokinetic contractile ring.

40 suggest act as inhibitors of F-actin at the contractile ring.

41 f recruiting other proteins to stabilize the contractile ring.

42 bers outside the plasma membrane, not by the contractile ring.

43 uently captured by the ingressing polar body contractile ring.

44 yosin-V (Myo51) that are also present in the contractile ring.

45 to cytoplasmic puncta, actin cables, and the contractile ring.

46 idual filaments throughout the cell, and the contractile ring.

47 to understand how these proteins function at contractile rings.

48 ds to the formation of misplaced or multiple contractile rings.

49 quired for appropriate constriction of these contractile rings.

50 o, which allows cells to assemble functional contractile rings.

51 ved dynamin-related proteins that form outer contractile rings.

52 reas decreasing actin favors formin-mediated contractile rings.

53 many eukaryotes requires an actomyosin-based contractile ring [1].

54 sition and triggers the assembly of a medial contractile ring [5, 9-11].

55 alizes to and assists in the assembly of the contractile ring, a conserved eukaryotic actomyosin stru

56 proteins that contribute to the cytokinetic contractile ring accumulate during interphase in nodes-p

57 In contrast to cells that use a contractile ring, actin was not concentrated in the furr

58 ound that targeted secretion, in contrast to contractile ring activation, requires cyclin degradation

59 The contractile ring also contains a potential filament cros

60 have revealed that cytokinesis in cells with contractile rings (amoebas, fungi, and animals) depends

61 nisms that position the furrow, assemble the contractile ring, anchor the ring to the plasma membrane

62 ow invagination requires an actomyosin-based contractile ring and addition of new membrane.

63 anaphase B, but are not concentrated in the contractile ring and are not required for assembly of th

64 sis requires cooperative interaction between contractile ring and central spindle components, but how

65 Forces from the actomyosin contractile ring and cortex do contribute to the cell sh

66 rgets the septins, but not myosin II, to the contractile ring and does not require either for its own

67 calization of Hof1p from septin rings to the contractile ring and for Hof1p-triggered contractile rin

68 ut not NMII-A (MYH9), is localized in the MK contractile ring and implicated in mitosis/endomitosis t

69 determines myosin II localization to the MK contractile ring and is responsible for the specific rol

70 protein, Nod1, colocalizes with Gef2 in the contractile ring and its precursor cortical nodes.

71 ast, cytokinesis nodes are precursors of the contractile ring and mark the future cleavage site.

72 und that p27 and citron-K colocalized at the contractile ring and mid-body during telophase and cytok

73 In contrast, the contractile ring and midbody required for cytokinesis, t

74 e for actin patches but is important for the contractile ring and possibly actin cables.

75 ain protein, add structural integrity to the contractile ring and prevent it from fragmenting during

76 quired for the localization of the myosin II contractile ring and subsequent formation of a cleavage

77 unexpected signaling interaction between the contractile ring and the adjacent cells.

78 ngly, Cyk3p localizes both to the actomyosin contractile ring and the division septum, promoting ring

79 rt because of a role in adhesion between the contractile ring and the plasma membrane.

80 2, which in turn induces the assembly of the contractile ring and triggers the ingression of the clea

81 ut it is not known how SpTm localizes to the contractile ring and whether SpTm plays a direct role in

82 Proteins concentrated up to 100 times in contractile rings and 7500 times in spindle pole bodies

83 and Myo52p (class V myosins that function at contractile rings and actin cables, respectively).

84 longation of actin filaments for cytokinetic contractile rings and other cellular structures.

85 icle cells, resulted in over-constriction of contractile rings and ring canals.

86 e developed a method to measure the sizes of contractile rings and ring canals.

87 of non-muscle actomyosin structures, such as contractile rings and stress fibers, are poorly understo

88 uss the model's implication for mechanics of contractile rings and stress fibers.

89 sufficient to induce assembly of functional contractile rings and that cell rounding facilitates fur

90 ein that organizes and stabilizes actomyosin contractile rings and was previously thought to function

91 t of the cleavage plane, the assembly of the contractile ring, and the ingression of the cleavage fur

92 ications between the central spindle and the contractile ring are critical for the spatial and tempor

93 ontrol the formation and constriction of the contractile ring are incompletely understood.

94 nisms by which myosin II is recruited to the contractile ring are not fully understood.

95 at nodes, protein assembly precursors to the contractile ring, are discrete structural units with sto

96 They are released from the contractile ring as it disassembles and then associate w

97 Contractile rings assemble normally in blt1 cells, but t

98 Unlike mitotic contractile rings, polar body contractile rings assemble over one spindle pole so that

99 test the popular model that the cytokinetic contractile ring assembles from a single myosin II proge

100 ion of the cytokinesis furrow, such that the contractile ring assembles in an equatorial zone between

101 The actomyosin contractile ring assembles through the condensation of a

102 cdc12 truncations were severely defective in contractile ring assembly and constriction, although cor

103 ne triphosphatase (GTPase) RhoA orchestrates contractile ring assembly and constriction.

104 The GTPase RhoA promotes contractile ring assembly and furrow ingression during c

105 , with Myo2 and Myo51 taking the lead during contractile ring assembly and Myp2 making the greatest c

106 asses normal cell-cycle controls and induces contractile ring assembly and sometimes even ring contra

107 e, we report that the myosin-V Myo51 affects contractile ring assembly and stability during fission y

108 dlin oligomerization during anaphase induces contractile ring assembly at the membrane.

109 ese evolutionarily diverse formins can drive contractile ring assembly by a generally similar mechani

110 animal cell cytokinesis, the spindle directs contractile ring assembly by activating RhoA in a narrow

111 , in which the deletion of Fim1p rescues the contractile ring assembly defects caused by mutation of

112 refore, SpTm makes multiple contributions to contractile ring assembly during and after actin polymer

113 for both endocytic actin patch kinetics and contractile ring assembly during cytokinesis.

114 ructure) actively influences the position of contractile ring assembly during early mitosis.

115 To investigate the mechanism of contractile ring assembly in animal cells, we directly c

116 g actomyosin interactions, which facilitates contractile ring assembly in the fission yeast system.

117 on of formin Cdc12 is required for efficient contractile ring assembly in vivo.The fission yeast cyto

118 the fission yeast Schizosaccharomyces pombe, contractile ring assembly initiates at the onset of mito

119 ghts into the mechanism by which the site of contractile ring assembly is specified.

120 on, rearrangement of microtubule structures, contractile ring assembly, ring ingression, and completi

121 nd concentrating the factors responsible for contractile ring assembly, whereas KIF4A is required for

122 n a three-dimensional computational model of contractile ring assembly, with semiflexible actin filam

123 GAP domain, ultimately promoting actomyosin contractile ring assembly.

124 torial cortex in spermatocytes, critical for contractile ring assembly.

125 es important steps and molecular players for contractile ring assembly.

126 gle tropomyosin isoform SpTm is required for contractile ring assembly.

127 m the Plo1 kinase to control a final step in contractile ring assembly.

128 s that may explain the role of this motor in contractile ring assembly.

129 egulated to ensure spatiotemporal control of contractile ring assembly.

130 us helps to direct the medial positioning of contractile-ring assembly and subsequent cell division.

131 els have emerged to explain the mechanism of contractile-ring assembly during cytokinesis in the fiss

132 ntractile-ring closure, but does not inhibit contractile-ring assembly, localization of a chromosomal

133 Mid1 specifies the division site and induces contractile-ring assembly.

134 ablished role in formation of the actomyosin contractile ring at mitotic exit, through the local acti

135 eins that play key roles in anchorage of the contractile ring at the cell equator during cytokinesis

136 heet-like equatorial band into a ribbon-like contractile ring at the furrow tip.

137 with adhesion of the plasma membrane to the contractile ring at the furrow.

138 ity is required to condense the nodes into a contractile ring, based on slower or absent node condens

139 o not have a constriction, arguing against a contractile ring-based nuclear expulsion mechanism.

140 le so that the spindle must move through the contractile ring before cytokinesis.

141 The failure to properly position the contractile ring between the segregated chromosomes can

142 and amoebas depends on the constriction of a contractile ring built from a common set of conserved pr

143 rces for cytokinesis are not produced by the contractile ring but are driven by the assembly of cell

144 can assemble nodes and actin filaments into contractile rings but complete assembly later than norma

145 yosin, is the major source of tension in the contractile ring, but how Myo2 is anchored and regulated

146 coalescence of components on one side of the contractile ring, but is insensitive to a 10-fold reduct

147 ns of Rng3p can concentrate independently in contractile rings, but only full-length Rng3p supports c

148 12p, and other proteins, and condense into a contractile ring by movements that depend on actin and m

149 We did not observe assembly of contractile rings by extension of a leading cable from a

150 urrows, demonstrating that components of the contractile ring can be localized by stable microtubules

151 indle and overlying membrane out through the contractile ring center.

152 reveal a novel role for Aim44p in regulating contractile ring closure through effects on Hof1p.

153 the contractile ring and for Hof1p-triggered contractile ring closure, rescues the cytokinesis defect

154 Deletion of AIM44 results in defects in contractile ring closure.

155 -II is required throughout cytokinesis until contractile ring closure.

156 oth septins and type II myosins and promotes contractile ring closure.

157 Deletion of MDM10 inhibits contractile-ring closure, but does not inhibit contracti

158 Sticky (Sti), the Drosophila ortholog of the contractile ring component Citron kinase (CIT-K), intera

159 As an early, abundant contractile ring component with multiple binding partner

160 ecting and regulating a molecular network of contractile ring components and microtubule-associated p

161 h-avidity membrane binding, stabilization of contractile ring components at the medial cortex, and th

162 al organization of Schizosaccharomyces pombe contractile ring components relative to the plasma membr

163 nesis failure due to disruption of two other contractile ring components, the Rho effectors diaphanou

164 Contractile rings constrict to a greater degree, resulti

165 These slowly assembled contractile rings constricted at a normal rate but with

166 vitro motility rate, which ensures effective contractile ring constriction and function.

167 ac activity was proposed to be inhibitory to contractile ring constriction and thus specifically inac

168 nship between centralspindlin and the CPC in contractile ring constriction during cytokinesis.

169 ns in parallel with RhoA activation to drive contractile ring constriction during cytokinesis.

170 ng vertebrate cytokinesis it is thought that contractile ring constriction is driven by nonmuscle myo

171 of germline cyst formation demonstrates that contractile ring constriction proceeds to a defined end

172 pport the canonical "purse-string" model for contractile ring constriction, but also suggest that the

173 n is only required during assembly and early contractile ring constriction.

174 laments and to exert tension on actin during contractile ring constriction.

175 tion at this site promotes the initiation of contractile ring constriction.

176 the cleavage furrow relatively evenly during contractile-ring constriction, but the rim of the cleava

177 Defects arise as the contractile ring constricts and disassembles, resulting

178 The contractile ring contains three filament systems: actin,

179 uring cytokinesis, closure of the actomyosin contractile ring (CR) is coupled to the formation of a m

180 mbly of an F-actin- and myosin-II-containing contractile ring (CR) is required for cytokinesis in euk

181 and constricting an actin- and myosin-based contractile ring (CR) that is physically linked to the p

182 We find that Clp1/Flp1 is tethered at the contractile ring (CR) through its association with anill

183 the components and spatial regulation of the contractile ring (CR), the precise ultrastructure of act

184 CPC activity for proper accumulation at the contractile ring (CR).

185 mbly and constriction of an actomyosin-based contractile ring (CR).

186 a late cytokinesis failure associated with a contractile ring defect.

187 Gef2 localization to cortical nodes and the contractile ring depends on its last 145 residues, and t

188 -based midbody or from the outside in by the contractile ring-derived midbody ring, it is assumed tha

189 activity to block cytokinesis progress after contractile ring disassembly.

190 phase specify the location of the actomyosin contractile ring during cytokinesis, but the detailed me

191 conserved force-generating components of the contractile ring during cytokinesis.

192 specifically in assembly of the actin-based contractile ring during cytokinesis.

193 xtracellular matrix with the dynamics of the contractile ring during cytokinesis.

194 ion of formin activity and the mechanisms of contractile ring dynamics and assembly.

195 understanding of the molecular mechanisms of contractile ring dynamics in the model organism Schizosa

196 ch is necessary for proper RhoA activity and contractile ring dynamics.

197 ts activators accumulate in patches near the contractile ring early in anaphase B, but are not concen

198 g recruitment of a critical component of the contractile ring, filamentous actin (F-actin).

199 FtsZ, a cytoskeletal GTPase, forms a contractile ring for cell division in bacteria and chlor

200 In all organisms that use a contractile ring for cell division, the process of cytok

201 c bundling by SpAin1 is important for proper contractile ring formation and constriction.

202 II (Myo2p) and tropomyosin are essential for contractile ring formation and cytokinesis in fission ye

203 directional cortical transport contribute to contractile ring formation during cytokinesis.

204 p is required for both the normal process of contractile ring formation from precursor nodes and an a

205 Contractile ring formation has been well characterized i

206 owever, whether and how the SIN functions in contractile ring formation has remained unclear.

207 limited G-actin and to assemble F-actin for contractile ring formation in dividing cells.

208 f cytokinesis, but the involvement of Rho in contractile ring formation is disputed.

209 Contractile ring formation is mediated by RhoA activatio

210 Furthermore, their careful analysis of contractile ring formation may help bridge two existing

211 the search-capture-pull and release model of contractile ring formation predicted that nodes clump wh

212 ECT2 prevent this translocation and disrupt contractile ring formation, indicating that active Rho i

213 mbly at the division site is predominant for contractile ring formation.

214 lethal with mutations that cause defects in contractile ring formation.

215 , indicating that active Rho is required for contractile ring formation.

216 ponents necessary for specifying the site of contractile ring formation.

217 gulators of division-plane specification and contractile-ring formation during cytokinesis, but how t

218 provide strong support for the SCPR model of contractile-ring formation in cytokinesis.

219 the small GTPase RhoA is a key regulator of contractile-ring formation.

220 Unlike mitosis, where an actomyosin contractile ring forms between the sets of segregating c

221 wing the chromosome movements of anaphase, a contractile ring forms in the cortex midway between the

222 sets of segregating chromosomes, the meiotic contractile ring forms on the cortex adjacent to one spi

223 mutant cells at late stages of division, the contractile ring frequently detaches from the cortex and

224 ay be two parallel mechanisms to prevent the contractile rings from being completely closed, physical

225 quirement for cleavage furrow maturation and contractile ring function during cytokinesis.

226 e rings, but only full-length Rng3p supports contractile ring function in vivo.

227 e cell wall with the plasma membrane and for contractile ring function, as proposed for the equivalen

228 mal Myo2p in vitro motility rates and normal contractile ring function.

229 l map provides a framework for understanding contractile ring function.

230 In addition, Gef2 also regulates contractile-ring function late in cytokinesis and may ne

231 ring cytokinesis, constriction of a cortical contractile ring generates a furrow that partitions one

232 The fission yeast contractile ring has been proposed to assemble by Search

233 The functions of the actin-myosin-based contractile ring in cytokinesis remain to be elucidated.

234 expansion and concatenation also formed the contractile ring in dividing cells.

235 ate in the formation and constriction of the contractile ring in fission yeast.

236 cortical nodes that generate the cytokinetic contractile ring in fission yeast.

237 lin-like protein mid1p helps to position the contractile ring in the cell middle.

238 We conclude that orderly assembly of the contractile ring in wild-type cells depends on Mid1p to

239 of a membrane-tethered version of FtsZ into contractile rings in lipid tubules, in vitro dynamic pat

240 ls the organization of cytokinesis nodes and contractile rings in live fission yeast cells.

241 organizing the structural components of the contractile ring including filamentous actin (F-actin),

242 essential role in recruiting proteins to the contractile ring, including Pxl1 and Fic1.

243 s that contain all maternal DNA, because the contractile ring ingressed past the spindle midpoint.

244 cofilins condensed nodes, precursors of the contractile ring, into clumps rather than rings.

245 The contractile ring is a complex molecular apparatus which

246 Assembly of a cytokinetic contractile ring is a form of cell polarization in which

247 The actomyosin contractile ring is a network of cross-linked actin fila

248 Cell division facilitated by a contractile ring is an almost universal feature across a

249 How the constriction of a contractile ring is arrested and how an arrested contrac

250 eavage-furrow tip adjacent to the actomyosin contractile ring is believed to be the predominant site

251 The contractile ring is essential for cytokinesis in most fu

252 ted from the furrow region, where the myosin contractile ring is subsequently formed.

253 ractile ring is arrested and how an arrested contractile ring is transformed into a ring canal is unk

254 The contractile-ring localization of Nod1 and Gef2 also depe

255 where the Nod1/Gef2 complex plays a role in contractile-ring maintenance and affects the septation i

256 ime-lapse imaging of C. elegans meiosis, the contractile ring moved downward along the length of the

257 ing Aip1 are viable and assemble cytokinetic contractile rings normally, but rings in these Deltaaip1

258 Cells with only Myo2 assemble contractile rings normally.

259 Chemical disruption of the contractile ring of actin and myosin immediately vegetal

260 Animals and fungi assemble a contractile ring of actin filaments and the motor protei

261 myosin-II (Myo2) to assemble and constrict a contractile ring of actin filaments.

262 intercellular bridges, are derived from the contractile rings of incomplete cytokinesis (IC) in most

263 Contractile rings play critical roles in a number of bio

264 Unlike mitotic contractile rings, polar body contractile rings assemble

265 ivisions and driven by the constriction of a contractile ring positioned and controlled solely by the

266 Here, we show that the contractile ring possesses an intrinsic symmetry-breakin

267 ing in vitro reconstitution of fission yeast contractile ring precursor nodes containing formins and

268 in nodes that accumulate myosin-II and other contractile ring proteins during mitosis.

269 formation to anaphase onset by concentrating contractile ring proteins on the equatorial cortex in a

270 strands containing actin filaments and other contractile ring proteins.

271 nesis in animal cells is that the actomyosin contractile ring provides the primary force to divide th

272 Without Blt1p, contractile rings recruited and retained less Sid2p/Mob1

273 tion with myosin light chain 2 (MLC2) in the contractile ring region of mitotic cells during cytokine

274 factor Gef2p, and kinesin Klp8p emerge from contractile ring remnants.

275 chosen, the local assembly of the actomyosin contractile ring remodels the plasma membrane.

276 itosis, cytoskeletal actin forms part of the contractile ring, rendering a round shape to podocytes.

277 As does Rgf3, Art1 concentrates to the contractile ring starting at early anaphase and spreads

278 tubulin-like FtsZ protein polymerizes into a contractile ring structure required for cytokinesis in m

279 ust process impervious to discontinuities in contractile ring structure.

280 ans, ring channels are a specialized form of contractile ring that are maintained at a constant diame

281 Myosin II is an essential component of the contractile ring that divides the cell during cytokinesi

282 s is driven by constriction of an actomyosin contractile ring that is controlled by Rho-family small

283 karyotes, cytokinesis requires an actomyosin contractile ring that is crucial for cell constriction a

284 Anillin is a conserved component of the contractile ring that is essential for cytokinesis, and

285 ha-Actinin ain1 deletion cells form a normal contractile ring through nodes in the absence of the spo

286 around the cell equator and assembled into a contractile ring through stochastic motions, after a mes

287 t regulatory logics for the anchorage of the contractile ring through the anillin/Mid1 family protein

288 alizes with Myo1p, the type II myosin of the contractile ring, throughout most of the cell cycle.

289 a growing shell, a cell-cycle engine, and a contractile ring to enforce cytokinesis.

290 division during which the animal cell uses a contractile ring to pinch itself in half.

291 n nodes from early interphase through to the contractile ring until cell separation.

292 vivo formation of actin cables or the actin contractile ring were identified.

293 is general node organization persists in the contractile ring where nodes move bidirectionally during

294 the type 2 node markers incorporate into the contractile ring, whereas type 1 nodes with Cdr1p and Cd

295 The contractile ring, which is predicted to provide only a t

296 s of animal cells requires the assembly of a contractile ring, which promotes daughter cell splitting

297 sulting in a net pulling of the nodes into a contractile ring, while cross-linking interactions help

298 s requires the constriction of an actomyosin contractile ring, whose architecture and mechanism remai

299 Although both proteins localize to the contractile ring, with Cdc15 preceding Imp2, only cdc15

300 In Escherichia coli, a contractile ring (Z-ring) is formed at midcell before cy