ライフサイエンスコーパス: contractility

1 rcomere length (T (req), reflecting required contractility).

2 resence of a DT wall organization capable of contractility.

3 tivity underlie augmented pulmonary vascular contractility.

4 e force production, thereby reducing cardiac contractility.

5 ies the cleavage plane, and regulates furrow contractility.

6 Rab11A serine 177 as a modulator of arterial contractility.

7 is dependent upon and enhanced by actomyosin contractility.

8 ess fiber organization and exhibited reduced contractility.

9 causes cardiac hypertrophy without affecting contractility.

10 tion in the normal state enhances myocardial contractility.

11 cell-cell adhesion together with actomyosin contractility.

12 26a6 in regulation of pHi, excitability, and contractility.

13 esponse to Rho-ROCK signaling and actomyosin contractility.

14 beta-adrenoceptor/cAMP signaling and cardiac contractility.

15 he local stresses and actomyosin anisotropic contractility.

16 n dKD cells are elevated with an increase in contractility.

17 table Rho signaling networks underlying cell contractility.

18 onal N-cadherin bonds downregulate Myosin-II contractility.

19 imilar to effects of these inhibitors on ASM contractility.

20 nsin II receptor is known to promote cardiac contractility.

21 GTPase expression and downstream actomyosin contractility.

22 smooth muscle cells significantly increased contractility.

23 by proinflammatory signals that increase VEC contractility.

24 formations, yielding materials with variable contractility.

25 n, myofibroblast invasion, and myofibroblast contractility.

26 P release requires actomyosin-based cellular contractility.

27 le and directly affects airway smooth muscle contractility.

28 ing a Ca(2+)-dependent mechanism of enhanced contractility.

29 a increasing calcium transient amplitude and contractility.

30 tential, Ca(2+) homeostasis, energetics, and contractility.

31 ociated with impaired intraoperative cardiac contractility.

32 atory role of this protein in cardiac muscle contractility.

33 lls in collective calcium signaling and cell contractility.

34 on and association with junctions to promote contractility.

35 disease states associated with smooth muscle contractility.

36 I (MII) hexameric complex and inhibiting MII contractility.

37 on and provides a means for enhancing muscle contractility.

38 f N-WASP activation, actin dynamics and cell contractility.

39 ce of diastolic calcium release, and ectopic contractility.

40 ssion in cardiomyocytes and impaired cardiac contractility.

41 ization, but also contribute to reduced cell contractility.

42 scoelasticity and associates with actomyosin contractility.

43 odies, and impaired intestinal smooth muscle contractility.

44 nmotor cross-linkers, are thought to promote contractility.

45 of overall calcium handling and heart muscle contractility.

46 ontext of substrate stiffness and actomyosin contractility.

47 o be the major motor driving actomyosin ring contractility.

48 in regulation of vascular smooth-muscle cell contractility.

49 culum Ca content, Ca transient amplitude and contractility.

50 including KV 1.5 and KV 2.1, which regulate contractility.

51 our knowledge, novel model of smooth muscle contractility.

52 heart failure therapeutic, increases cardiac contractility.

53 role of NDPK-C in cardiac cAMP formation and contractility.

54 bstrates, indicating elevated cell monolayer contractility.

55 osomes in hMSC paracrine-mediated effects on contractility.

56 d signaling pathways that consequently alter contractility.

57 such as extremely high versus extremely low contractility.

58 sential for actin cytoskeletal structure and contractility.

59 changes to titin stiffness therefore affect contractility.

60 mbination of hypoxia and a simulated loss of contractility (2% strain) is able to additionally induce

61 mbinations, which represent myosin-dependent contractility, a characteristic viscosity-adhesion lengt

62 cer cells and that reducing endothelial cell contractility abrogates migration of melanoma cells acro

63 ew multiscale mathematical model of arterial contractility accounting for structural and functional c

64 nderlying mechanism, we show that actomyosin contractility activates a RhoA-mDia1 signaling pathway t

65 ncreases anterior wall thickness and cardiac contractility after infarction.

66 ells can generate higher forces than through contractility alone.

67 hronic HF, including preservation of cardiac contractility and a reduction in cardiac fibrotic remode

68 nment is driven by Rho-mediated cytoskeletal contractility and accelerated by propagation of tension

69 NMII mediates contractility and actin-based motility, which are fundam

70 The results show that BS inhibits contractility and actin-myosin ATPase by stabilizing the

71 iated signals in regulating endothelial cell contractility and adherens junction disassembly leading

72 nals act in concert to modulate cytoskeletal contractility and adherens junctions disassembly during

73 levated, and calcineurin inhibitors improved contractility and ameliorated cardiac hypertrophy.

74 h 6-bromoindirubin-3'-oxime improved cardiac contractility and ameliorated intraventricular conductio

75 ll-to-matrix adhesion, and impair actomyosin contractility and amoeboid invasion.

76 g these cell-cell interfaces coordinate cell contractility and apical secretion to facilitate tube fu

77 tand hMSC PS and HC effects on human cardiac contractility and arrhythmogenicity by integrating exper

78 nd paracrine signaling (PS) on human cardiac contractility and arrhythmogenicity remain unresolved.

79 tive hMSC PS and HC effects on human cardiac contractility and arrhythmogenicity, and provides novel

80 Myocardial contractility and blood flow provide essential mechanica

81 state causes significant increase in cardiac contractility and cardiac output.

82 ROCK2 act redundantly to maintain actomyosin contractility and cell proliferation and that their loss

83 Targeting mutant constructs to modulate contractility and compliance in the underlying endoderm,

84 ulated genes, including Cx43, in controlling contractility and conduction.

85 ctive migration depends on a balance between contractility and cytoskeletal rearrangements, adhesion,

86 However, because contractility and F-actin organization are interconnecte

87 angendorff hearts, atropine led to increased contractility and heart rates, respectively.

88 ted cardiomyopathy, characterized by reduced contractility and increased left ventricular diameter.

89 ved in cardiac energy production and cardiac contractility and is distinct from that observed in pati

90 nfer how the presence of a substrate affects contractility and long-range multicellular organization

91 tolic septal thickness were lower whereas LV contractility and LV fractional shortening were higher w

92 lthough minor differences in glomerular tuft contractility and macula densa cell calcium handling wer

93 roles for Kir7.1 in regulation of myometrial contractility and melanocortin signaling.

94 can be explained by a combination of reduced contractility and mildly increased passive myocardial st

95 in mice (Erk5-CKO) leads to dampened cardiac contractility and mitochondrial abnormalities with repre

96 terference with lamc1 function impairs basal contractility and optic cup folding.

97 However, most of receptors able to modify contractility and other intracellular responses signal t

98 C1 G159D and MYH7 E1426K) and measured their contractility and passive stiffness in comparison with d

99 he same neuronal population enhances cardiac contractility and prolongs exercise endurance.

100 ress impairs microdomain formation, limiting contractility and promoting arrhythmias.

101 diated miR-208a gene delivery enhanced heart contractility and relaxation parameters in vivo.

102 l, to be effective in improving both cardiac contractility and relaxation when challenged with high f

103 ish a quantitative link between adhesion and contractility and reveal an unprecedented role of N-cadh

104 ion mice treated with MR-409 showed improved contractility and reversal of sarcolemmal structure.

105 ties: cardiovascular (stimulation of cardiac contractility and suppression of blood pressure) and met

106 type in the heart, where it mediates cardiac contractility and the force of contraction.

107 n II (NMII) is uniquely responsible for cell contractility and thus defines multiple aspects of cell

108 lood count, blood chemistry profile, cardiac contractility and tissue histologies from liver, kidney

109 e findings underscore the importance of cell contractility and tissue stress to multicellular vertex

110 erived growth factor receptor alpha-mediated contractility and traction forces, which are transduced

111 n rats and mice resulted in impaired cardiac contractility and upregulation of G-protein-coupled rece

112 microscopy in both inside-out (I-O intrinsic contractility) and outside-in (O-I external perturbation

113 n of genes related to structure, metabolism, contractility, and electric activity regulation, suggest

114 ganization of protrusion relies on myosin II contractility, and feedback between adhesion and Rac-med

115 keleton linker protein nesprin 3, actomyosin contractility, and integrin-mediated adhesion, consisten

116 h the sarcomere, altering myocyte stiffness, contractility, and mechanosignalling.

117 ignment, improved calcium handling, enhanced contractility, and more physiological action potential k

118 PYR improved survival, increased RV contractility, and reduced RV stiffness, RV hypertrophy,

119 n intracellular calcium transient amplitude, contractility, and rhythm, suggesting that histones dire

120 mproved motor performance, quadriceps muscle contractility, and sciatic nerve conduction velocities.

121 strength, actin polymerization rate, myosin contractility, and the integrity of the putative microtu

122 etween cellular adhesions, actomyosin-driven contractility, and the physical characteristics of the e

123 sion, endothelial dysfunction, smooth muscle contractility, and vascular remodeling.

124 single cells experiencing lateral interface contractility are eliminated from tissues by apoptosis.

125 ones that have an impact on left ventricular contractility are located in the caudal region of the le

126 Cellular changes in contractility are paralleled by modifications in the nuc

127 t the mechanisms by which Paks regulate cell contractility are unclear.

128 utions to the enhancement of in vivo cardiac contractility are unknown.

129 irectional regulation of cortical actomyosin contractility as a key effector of this fundamental proc

130 We define actin polymerization and contractility as target mechanisms for migrastatics, and

131 sphatase complex that antagonizes actomyosin contractility, as proteins safeguarding nuclear integrit

132 ical perturbations of cell proliferation and contractility, as well as computational modeling based o

133 owed a 100-fold improvement in cardiomyocyte contractility assays over paroxetine and a plasma concen

134 Remote myocardium showed decreased contractility at 120 min- and 24 h-CMR accompanied by tr

135 In this study we sought to identify how contractility at adherens junctions influences apoptotic

136 ON state of the thick filament, but inhibits contractility at high intracellular calcium concentratio

137 Omecamtiv mecarbil decreases contractility at high levels of activation by disrupting

138 Omecamtiv mecarbil increases contractility at low levels of activation by stabilizing

139 to reduced fractional shortening and cardiac contractility at the in vivo level.

140 sanoid modulators, vascular permeability and contractility at the inner retinal endothelial barrier.

141 resulting shapes are determined not only by contractility, but also by elastic stress in the periphe

142 ought to be important for supporting cardiac contractility, but is hardly detectable in cultured card

143 Acute cAMP elevation inhibits myometrial contractility, but the mechanisms responsible are not fu

144 sed faster relaxation and not only preserved contractility, but unexpectedly increased it above untre

145 al cultures (HBECs), where it suppresses ASM contractility by binding to and inhibiting the Ca(2+) in

146 Changes in cellular contractility by genetic, pharmacological, and matrix st

147 Blebbistatin reduces contractility by stabilizing the thick filament OFF stat

148 ng approach to directly tune in vivo cardiac contractility by tailoring the ability of the heart to r

149 strating myocardial slice viability, maximum contractility, Ca(2+) handling and structure.

150 hanges in lens elasticity and ciliary muscle contractility can affect how ocular parameters respond t

151 by amplifying local strain cues, active cell contractility can facilitate and accelerate the reorient

152 the model simulations show that active cell contractility can facilitate the formation of strings al

153 e, Weng and Wieschaus report that actomyosin contractility can strengthen junctions to override Snail

154 inant of nuclear shape and that unrestrained contractility causes nuclear dysmorphia, nuclear envelop

155 minimal free-boundary models of actin-myosin contractility consisting of the force-balance and myosin

156 to the increasing vascular load by enhancing contractility ("coupling") to maintain flow.

157 a significant decrease in right ventricular contractility (DeltaESV25: +25.5 mL, P=0.0003; DeltaEes:

158 D continuum model of the embryo with induced contractility demonstrates that contractility gradients,

159 actin coalesces into a tension-bearing, MII-contractility-dependent node-and-cable actin network in

160 Cell contractility, driven by the RhoA GTPase, is a fundament

161 itors, which spontaneously aggregate through contractility-driven cellular pulling.

162 nce, Shyer et al. (2017) show that myosin II contractility drives the smooth dermal mesenchyme into a

163 he presence of E-cadherin decreases cortical contractility during mitosis through a signaling cascade

164 llular activity patterns to control cellular contractility dynamics.

165 s on isolated myosin head structures predict contractility effects but not the prominent relaxation a

166 Comparable to apelin, ELA increased cardiac contractility, ejection fraction, and cardiac output and

167 ise (25 W), SSc-PAH patients did not augment contractility (end-systolic elastance) whereas IPAH did

168 or studying characteristics of smooth muscle contractility even though this experimental arrangement

169 tractile centers and distinguish active cell contractility from passive elastic tissue deformations.

170 Thus, increased interface contractility functions as error correction mechanism el

171 The SF-mediated actomyosin contractility further stabilizes the FA and generates a

172 The process requires cell contractility, generates strains at tissue interfaces, a

173 herin protein complex, hypertension, cardiac contractility, glaucoma, microRNA processing, and suscep

174 Our data argue that apical contractility gradients are important for tissue folding

175 with induced contractility demonstrates that contractility gradients, but not contractility per se, p

176 increased tissue rigidity and cell motility/contractility help mediate tumour progression.

177 myosin and respectively activate or inhibit contractility in demembranated cardiac muscle cells.

178 d explore the physical origins of telescopic contractility in disordered networks using agent-based s

179 he molecular rearrangements that bring about contractility in nonmuscle cells are currently debated.

180 e factor-1alpha underlies increased vascular contractility in pulmonary hypertension.

181 Increased LV contractility in rats anaesthetized with urethane was al

182 ergic receptor signaling and restore myocyte contractility in response to beta adrenergic stimulation

183 The p21-activated kinases (Pak) can regulate contractility in smooth muscle and other cell and tissue

184 the generation of potent cortical actomyosin contractility in the Caenorhabditis elegans zygote.

185 Due to actomyosin contractility in the cell contour, characteristic invagi

186 tractile foci and for long-range coordinated contractility in the cortex.

187 ritical gatekeeper of SR calcium cycling and contractility in the heart.

188 METHODS AND We analyzed contractility in the whole rat heart, adult rat ventricu

189 Weakened cardiac contractility in vivo in alcoholic animals is also assoc

190 reduced intracellular calcium transients and contractility in VSMCs.

191 vels of nonmotor cross-linkers are ideal for contractility; in vivo, intermediate levels of the scaff

192 systolic pressure volume relationship (i.e., contractility) increased with dobutamine after liragluti

193 Blocking contractility increases nuclear circularity in cultured

194 e how the two-way feedback loop between cell contractility (induced by the activity of chemomechanica

195 s was disrupted on soft substrates and after contractility inhibition.

196 We conclude that actomyosin contractility is a major determinant of nuclear shape an

197 work into a bundle facilitated by actomyosin contractility is a physiologically relevant and biophysi

198 is becoming increasingly clear that cardiac contractility is also regulated through structural chang

199 Non-muscle cell contractility is critical for tissues to adopt shape cha

200 Such differential regulation of contractility is essential for morphogenesis as loss of

201 ervations on the behavior of the system when contractility is inhibited are in qualitative agreement

202 While contractility is known to be largely RhoA-dependent, the

203 ility of cAMP agonists to repress myometrial contractility is lost with prolonged exposure.

204 nsduction networks in the regulation of cell contractility is not entirely clear.

205 ey interact to regulate airway smooth muscle contractility is not fully understood.

206 s filament organization and the mechanism of contractility is not well understood.

207 Airway contractility is primarily determined by airway smooth m

208 Cardiac contractility is regulated by changes in intracellular C

209 -cell junction morphology, showing that cell contractility is required to maintain adherens junction

210 contractility we find that endothelial cell contractility is responsive to interactions with metasta

211 When the contractility is sufficiently strong, cells break symmet

212 , intracellular electrophysiology, isometric contractility measurement, reverse-transcription polymer

213 ), after which these agents were removed and contractility measurements performed or myocytes isolate

214 effects include stimulation of smooth muscle contractility, migration, and proliferation, as well as

215 Actomyosin contractility modulates outflow resistance of the aqueou

216 This contractility must rely on a microscopic asymmetry, the

217 lation at Ser(112), however, neither loss of contractility nor increase in YAP phosphorylation is suf

218 say, and develop order parameters to measure contractility of a simulated actin network.

219 nd is important for mechanical stability and contractility of both cardiac and skeletal muscles.

220 The contractility of cardiac papillary muscles was also rest

221 mechanisms, which initially may enhance the contractility of individual myocytes but eventually cont

222 Simulations predicted contractility of isolated healthy and ischemic adult hum

223 rimental data indicates that the anisotropic contractility of planar-polarised actomyosin in the vent

224 ny cell biological processes and is based on contractility of random actin arrays.

225 tein (FHOD) family of formins contributes to contractility of striated muscle and cell motility in se

226 rates the viscous nature of the membrane and contractility of the associated cortex.

227 s that mechanical principles mediated by the contractility of the cells and the nonlinearity of the E

228 elivery of BNP116.I-1c was safe and improved contractility of the left ventricle and atrium in a larg

229 In the absence of FN, contractility of the matrix by CAFs is preserved, but th

230 eduction in E-cadherin concentration and the contractility of the neighbouring cells promote self-org

231 miR-143/145 regulates actin dynamics and the contractility of TM cells, consistent with its regulatio

232 d neuropeptide ArPPLN2h has no effect on the contractility of tube feet or the body wall-associated a

233 FAs, however, were dependent on cytoskeletal contractility on lower substrate stiffness values.

234 e interaction stress to determine the global contractility or extensibility of epithelia.

235 ssible biophysical parameters such as myosin contractility, osmotic pressure, and turnover of actin a

236 trates that contractility gradients, but not contractility per se, promote changes to surface curvatu

237 Actomyosin contractility plays a central role in a wide range of ce

238 atin to inhibit myosin IIa-mediated platelet contractility prevented shrinkage of the fibrin network.

239 ile of the signaling molecule as well as the contractility profile of the cell assembly are inhomogen

240 mediates Ca(2+) entry pathways that regulate contractility, proliferation and migration.

241 the nature of the hMSC paracrine effects on contractility, proteomic analysis of hECT/hMSC condition

242 APC-dependent RNAs become enriched in high-contractility protrusions and, accordingly, their locali

243 blood pressure by inhibiting RhoA-dependent contractility, providing a mechanism for the blood press

244 matrix elasticity, showing that coupling of contractility pulses to environmental deformations modul

245 on of the SRX state - accounting for altered contractility, reduced diastolic relaxation, and increas

246 amellipodia formation mediated by arp2/3 and contractility regulated by myosin light chain kinase (ML

247 inally, substrate stiffness and cytoskeletal contractility regulated whether vinculin and paxillin tu

248 o (n = 8, P < 0.05), indicating that myocyte contractility regulates nuclear MLP.

249 r matrix proteins and myofibroblast and cell contractility-related molecules, were significantly down

250 ological or genetic inhibition of actomyosin contractility restores nuclear architecture and genome i

251 Cortical contractility restricts centrosome movement at a minimal

252 epletion of several regulators of actomyosin contractility resulted in a regression of the membrane p

253 gation negatively feeds back with actomyosin contractility, resulting in central traction peak oscill

254 all-molecule inhibitors targeting actomyosin contractility reveal a temporally specific requirement o

255 etermine the relationship between myometrial contractility (spontaneous and oxytocin-induced), PKA ac

256 e population toward a faster speed and lower contractility state.

257 in the model specific patterns of actomyosin contractility, such as the planar-polarisation of actomy

258 es involved in cardiac energy production and contractility suggests that these changes may represent

259 the absence of cell-cell contact, actomyosin contractility suppresses YAP phosphorylation at Ser(112)

260 onic drosophila axons also actively maintain contractility/tension along the circumferential directio

261 ventricular anterior wall thickness, cardiac contractility, tetrahydrobiopterin, the dimers of nitric

262 Molecular inotropy refers to cardiac contractility that can be modified to affect overall hea

263 neous, self-limiting patterns of subcellular contractility that can explore mechanical cues in the ex

264 the diaphragm and prevents the reduction in contractility that is induced by MV.

265 specifically and precisely modulate cardiac contractility that when combined with gene therapy can b

266 on, Cox-1 null mice displayed normal uterine contractility; therefore, this study sought to determine

267 Sympathetic NE increases heart rate and contractility through activation of beta receptors, wher

268 ink between clustering capacity and cortical contractility through E-cadherin and DDR1 proteins.

269 chain phosphorylation to enhance actomyosin contractility through increasing cytosolic calcium.

270 Conversely, inhibition of contractility through pretreatment with either a RhoA/Ro

271 Matrix stiffness-driven contractility thus tenses the nucleus to favor lamin-A,C

272 on by epicardial lidocaine decreased cardiac contractility to a greater extent in CHF rats than sham

273 h p-Mypt1 inactivation/actinomyosin-mediated contractility to facilitate invasion.

274 ntagonist, C-GAP, is essential for effective contractility to occur.

275 tin stress fiber assembly and inhibited cell contractility to perturb tissue morphogenesis, whereas S

276 the myosin light chain, allowing actomyosin contractility to proceed.

277 Actomyosin contractility underlies force generation in morphogenesi

278 AMP signals is necessary to optimize cardiac contractility upon adrenergic activation.

279 Finally, FGF23 increases cardiac contractility via FGFR4, while known effects of FGF23 on

280 ectrogenic anion secretion and smooth muscle contractility via neural and non-neural cholinergic path

281 Subsequent recovery of regional contractility was associated with edema formation on CMR

282 s and the LPS/PepG-induced impaired systolic contractility was attenuated in comparison with wild-typ

283 r fluorescent resonance energy transfer, and contractility was determined in cardiomyocytes (cell sho

284 Myocardial contractility was followed up by cardiac magnetic resona

285 When actomyosin contractility was inhibited, human MSCs did not exhibit

286 Functionally, PASMC contractility was inversely correlated with HIF-1alpha a

287 Myocardial contractility was inversely determined from personalized

288 so decreased in RA-iPSC-CMs, suggesting that contractility was reduced.

289 f pharmacological inhibitors of cytoskeletal contractility we find that endothelial cell contractilit

290 Changes in LV contractility were only observed when this subpopulation

291 ytes to isoprenaline-induced augmentation of contractility, whereas NDPK-C knockdown decreased cAMP l

292 educed insulin sensitivity and cardiomyocyte contractility, which was rescued by CD36 silencing.

293 AD activity is sensitive to MRTF-SRF-induced contractility, while MRTF-SRF signaling responds to YAP-

294 Inhibition of contractility with 10 mum blebbistatin resulted in an ap

295 f the CSAR evokes little increase in cardiac contractility with an exaggerated peripheral vasoconstri

296 tozotocin caused severe reduction of cardiac contractility with enhancing urinary and cardiac lipid p

297 This interdependency, by balancing contractility with metabolic control, is crucial for cel

298 wounds in a collective fashion by increased contractility with substantial reach.

299 fetime FRET measurements reflect acto-myosin contractility within endothelial cells.

300 13V) enhances Ca(2+) sensitivity and cardiac contractility without causing hypertrophy.