ライフサイエンスコーパス: controlled clinical trial

1 Prospective, randomized, multicenter, controlled clinical trial.

2 Randomized, double-blind, placebo-controlled clinical trial.

3 spective, 24-month, dose-ranging, paired-eye controlled clinical trial.

4 s syndrome deserving of a randomized placebo controlled clinical trial.

5 The DCCT was a large multicenter randomized controlled clinical trial.

6 ey have not been validated in a prospective, controlled clinical trial.

7 treatment, through a parallel-group, placebo-controlled clinical trial.

8 Prospective randomized controlled clinical trial.

9 be further explored in a randomised, placebo-controlled clinical trial.

10 tage CHL in a multicenter phase 3 randomized controlled clinical trial.

11 Eighteen-month, multicenter, randomized, controlled clinical trial.

12 cessions (REC), in a prospective randomized, controlled clinical trial.

13 ent has never been subjected to a randomized controlled clinical trial.

14 riodontal pockets, in a double-blind placebo-controlled clinical trial.

15 te cancer mortality should be evaluated in a controlled clinical trial.

16 ed in this randomized, double-blind, placebo-controlled clinical trial.

17 This was a single-blind, randomized controlled clinical trial.

18 Randomized, double-masked, placebo-controlled clinical trial.

19 Design: Randomized, controlled clinical trial.

20 a booster aP vaccine dose in this randomized controlled clinical trial.

21 lticenter, randomized, double-blind, placebo-controlled clinical trial.

22 nd, prospective, non-inferiority, randomised controlled clinical trial.

23 38 Dutch volunteers enrolled in 2 randomized controlled clinical trials.

24 This represents the basis for forthcoming controlled clinical trials.

25 6 randomized, double-masked, sham- and laser-controlled clinical trials.

26 , body mass index, or waist circumference in controlled clinical trials.

27 nts, however, has to be further evaluated in controlled clinical trials.

28 ed in patients with chronic liver disease in controlled clinical trials.

29 esuscitation in HS should be corroborated in controlled clinical trials.

30 ve interventions, which must be evaluated in controlled clinical trials.

31 in depressed patients in randomised placebo-controlled clinical trials.

32 should be investigated in future randomized controlled clinical trials.

33 nalysis of the VISUAL-1 and VISUAL-2 placebo-controlled clinical trials.

34 rigor analogous to multicenter, randomized, controlled clinical trials.

35 low-up after participating in a prospective, controlled, clinical trial.

36 iewed using the evidence base resulting from controlled clinical trials; 2) untoward effects of ICDs

37 apple were included in an open, randomized, controlled clinical trial: 27 patients consumed daily de

38 proved, prospective, double-blinded, placebo-controlled clinical trial, 418 women aged 32-89 years wh

39 In a double-blinded randomized controlled clinical trial, 44 mothers with active caries

40 In a controlled clinical trial, 48 patients (mean age 50 +/-

41 There are few randomized, controlled clinical trials about the effect of non-surgi

42 Few prospective, randomized controlled clinical trials address the diagnosis and man

43 In a randomized double-blinded placebo-controlled clinical trial, adults with grass pollen-indu

44 studies, with six randomised, double-blind, controlled clinical trials, all of which investigated ve

45 onducted a randomized, double-blind, placebo-controlled clinical trial among pregnant women presentin

46 lementation should be tested in a randomized controlled clinical trial and that the analysis should i

47 mpliant, randomized, double-blinded, placebo-controlled clinical trial, and all patients provided inf

48 udies included randomised controlled trials, controlled clinical trials, and cohort studies; their ov

49 Finally, 11 studies (eight RCTs, two controlled clinical trials, and one retrospective study)

50 iteria: randomized controlled trials (RCTs), controlled clinical trials, and prospective clinical stu

51 INE In-Process, Cochrane Central Register of Controlled Clinical Trials, and the Web site www.Clinica

52 ewed as preliminary until data from blinded, controlled clinical trials are available.

53 not the high efficacy reported in randomised controlled clinical trials are materialising in real-wor

54 cute liver failure, multicenter, randomized, controlled clinical trials are needed to confirm that hy

55 Randomized controlled clinical trials are needed to confirm the res

56 However, controlled clinical trials are needed to determine prope

57 More well designed controlled clinical trials are needed which use phytoche

58 wever, long-term, multicentered, randomized, controlled clinical trials are required to know the clin

59 Controlled clinical trials are under way to assess the e

60 lable which require evaluation in randomized controlled clinical trials as adjunct therapies for shor

61 Randomized, double-blind, placebo-controlled clinical trial at 3 US academic medical cente

62 rallel-group, forced dose titration, placebo-controlled clinical trial at 30 sites from May 10, 2011,

63 A prospective randomized controlled clinical trial at 5 centers was conducted.

64 , multicenter, randomized, active comparator-controlled, clinical trial at multiple locations of the

65 us study, a randomized double-blind, placebo-controlled clinical trial, between August 2003 and Novem

66 c reviews (SRs), randomized clinical trials, controlled clinical trials, case series, and case report

67 Randomized, controlled trials (RCTs); controlled clinical trials (CCTs); or comparative observ

68 the PubMed and Cochrane Central Register of Controlled Clinical Trials (CENTRAL) search engines from

69 ed MEDLINE, the Cochrane Central Register of Controlled Clinical Trials, ClinicalTrials.gov, and rele

70 This prospective, randomized, controlled clinical trial compared changes in exercise p

71 lticenter, randomized, double-blind, placebo-controlled clinical trial compared the efficacy of rosig

72 This randomized placebo-controlled clinical trial compared the response to a gin

73 onducted a randomized, double-blind, placebo-controlled clinical trial comparing apixaban, at a dose

74 (PISTE) trial was a multicentre, randomised, controlled clinical trial comparing intravenous thrombol

75 We performed a prospective randomized controlled clinical trial comparing NPWT to standard dry

76 article, the extended data of a randomized, controlled clinical trial comparing two epoetins were ex

77 Randomized controlled clinical trials comparing a strategy of promp

78 y cases, do not have support from randomised controlled clinical trials comparing bariatric surgery w

79 Randomized controlled clinical trials comparing DES and BMS for tre

80 Fifty-five randomized controlled clinical trials comparing regenerative therap

81 Controlled clinical trials conduct the research that com

82 In a randomized, double-blind, placebo-controlled clinical trial conducted as a pilot study, 52

83 domized, double-blind, double-dummy, placebo-controlled clinical trial conducted at 10 university cli

84 ts (FISH) study, a randomized, double-blind, controlled clinical trial conducted at 15 North American

85 Multicenter prospective, double-masked, controlled clinical trial conducted at 80 clinical sites

86 ata from a randomized, double-blind, placebo-controlled clinical trial conducted at the Christian Med

87 lel-group, randomized, double-blind, placebo-controlled clinical trial conducted between September 1,

88 Randomized, double-blind, placebo-controlled clinical trial conducted from 2008 to 2013 in

89 YNDIET study is a 6-mo randomized, parallel, controlled clinical trial conducted in 122 overweight an

90 TICIPANTS: Randomized, double-blind, placebo-controlled clinical trial conducted in 5 academic medica

91 reated with placebo in 12 randomized placebo-controlled clinical trials conducted mostly in outpatien

92 Phase 1-2, randomized, double-blind, placebo-controlled, clinical trial conducted from 2008 to 2012.

93 trials, quasi-randomized controlled trials, controlled clinical trials, controlled before-after stud

94 trials, quasi-randomized controlled trials, controlled clinical trials, controlled before-and-after

95 trials, quasi-randomized controlled trials, controlled clinical trials, controlled before-and-after

96 Our phase III randomized placebo-controlled clinical trial demonstrated that naproxen at

97 e cost-effectiveness study with a randomized controlled clinical trial design that has been performed

98 he mechanisms of action of novel agents, and controlled clinical trials documenting their efficacy an

99 This retrospective analysis of five placebo-controlled clinical trials does not support a decreased

100 , participant- and surgeon-masked randomized controlled clinical trial (EudraCT No.

101 This randomized controlled clinical trial evaluated the effects of repea

102 xtension study of a multicenter, randomized, controlled clinical trial evaluating the effect and long

103 s performed to identify all blinded, placebo-controlled clinical trials evaluating acute selective NS

104 of psychodynamic psychotherapies, randomized controlled clinical trials evaluating such psychotherapi

105 There is a major lack of randomized controlled clinical trials evaluating the efficacy of pr

106 Methods A systematic review of randomized controlled clinical trials evaluating weight loss interv

107 No randomized controlled clinical trials exist to definitively support

108 However, randomized, controlled, clinical trials failed to demonstrate benefi

109 derscoring the need for drug development and controlled clinical trials focused on improved treatment

110 mized, double-blind, 14- to 15-week, placebo-controlled clinical trial, followed by a 1-year open-lab

111 dence, from case reports to large randomized controlled clinical trials, for the possible adverse eff

112 -stratified multicentre, randomised, placebo-controlled clinical trial from Nov 16, 2010, to Sept 12,

113 A number of controlled clinical trials have been performed to show i

114 Numerous studies including controlled clinical trials have demonstrated that anti-T

115 Controlled clinical trials have identified a limited num

116 To date, randomized, controlled clinical trials have not reproduced the effic

117 roup, multicenter, double-blind, randomized, controlled clinical trial in 150 adults after gastrointe

118 trial is a randomized, double-blind, placebo-controlled clinical trial in 160 patients with severe, n

119 pated in a randomized, double-blind, placebo-controlled clinical trial in 2011 and 2012 on the safety

120 In this phase 1 placebo-controlled clinical trial in 73 healthy male subjects, e

121 ospective, double-blind, randomized, placebo-controlled clinical trial in an ambulatory care and home

122 dy was a pragmatic, single-centre randomised controlled clinical trial in community-dwelling individu

123 In this Phase I randomised controlled clinical trial in HIV-1 negative volunteers w

124 hase 1b, double-blinded, randomised, placebo-controlled clinical trial in Kampala, Uganda to examine

125 -center, randomized, double-blinded, placebo-controlled clinical trial in patients undergoing emergen

126 The first randomized controlled clinical trial in refractory adult and childh

127 ulticenter randomized, double-blind, placebo-controlled clinical trial in Tasmania and Victoria, Aust

128 Multicenter, randomized controlled clinical trial in which 37 nursing homes were

129 lticenter, randomized, double-blind, placebo-controlled clinical trial in which asymptomatic, persist

130 a lack of long-term data and data outside of controlled clinical trials in carotid artery stenting.

131 herapies have been shown to be of benefit in controlled clinical trials in humans.

132 have been reported to reduce cocaine use in controlled clinical trials in outpatient settings.

133 be considered when designing future placebo-controlled clinical trials in patients with active UC.

134 We recommend controlled clinical trials in patients with ICUAW that c

135 Results of the first randomized, controlled clinical trials in this population suggest a

136 ycline (SDD) regimen (double-masked, placebo-controlled clinical trial) in postmenopausal (PM) women

137 Basic research, as well as controlled clinical trials, in this realm offers promisi

138 Sixteen controlled clinical trials, including more than 3000 chi

139 hrough population-based studies and in large controlled clinical trials; inflammatory marker levels a

140 Randomized, controlled trials; controlled clinical trials; interrupted time series; and

141 Randomized, double-blind, placebo-controlled clinical trials investigating the efficacy of

142 lticenter, double-blind, randomized, placebo-controlled clinical trial involving 114 North American e

143 A randomized, double-blind, sham-controlled clinical trial involving 239 participants who

144 pe 2 diabetes in a double-blind, randomized, controlled clinical trial involving 4360 patients.

145 d be required to mount a randomized, placebo-controlled clinical trial involving premanifest HD indiv

146 ruvada) has demonstrated efficacy in placebo-controlled clinical trials involving men who have sex wi

147 xtends beyond the skin and that a randomized controlled clinical trial is needed to confirm these fin

148 A randomized controlled clinical trial is the best way to minimize bi

149 The randomized controlled clinical trial is the gold standard scientifi

150 The aim of this randomized, controlled clinical trial is to determine whether ridge

151 Further evaluation in a randomized controlled clinical trial is warranted to test for effic

152 st evidence from population-level randomized controlled clinical trials is lacking.

153 A single controlled clinical trial may be unlikely to show cases

154 A controlled clinical trial may be warranted.

155 reduce cocaine use in double-blind, placebo-controlled clinical trials, namely baclofen, modafinil,

156 In this randomized, double-blind, placebo-controlled clinical trial, nesiritide had no impact on r

157 Controlled clinical trials now underway will help elucid

158 he largest randomized, double-blind, placebo controlled clinical trial, now underway, designed to eva

159 The trial was registered with Controlled Clinical Trials (number ISRCTN76894700).

160 Medline was searched to identify RCTs, controlled clinical trials, observational studies, case

161 DESIGN, SETTING, AND PATIENTS: Controlled clinical trial of 153 older adults with Alzhe

162 ) study, a randomized, double-blind, placebo-controlled clinical trial of 3069 community-dwelling par

163 DESIGN, SETTING, AND PATIENTS: Controlled clinical trial of 951 adults 65 years or olde

164 We conducted a randomized, controlled clinical trial of a peer mentoring interventi

165 r herpesviruses in this disease is through a controlled clinical trial of an efficacious antiviral dr

166 d as neonates in a double-blind, randomized, controlled clinical trial of caffeine versus placebo und

167 This was a double-blind randomized placebo-controlled clinical trial of creatine monohydrate (10 g/

168 No double-blinded, placebo controlled clinical trial of curcumin has been successfu

169 cted a prospective, multicenter, randomized, controlled clinical trial of diabetic patients to invest

170 A randomized placebo-controlled clinical trial of dietary phosphatidylcholine

171 Population-based randomized controlled clinical trial of first graders from 44 schoo

172 NTS: A multicenter, randomized, double-blind controlled clinical trial of high-dose folate, vitamin B

173 lticenter, randomized, double-blind, placebo-controlled clinical trial of hydroxyurea in infants (beg

174 ry chronic hepatitis C enrolled in a placebo-controlled clinical trial of interferon gamma-1b (IFN-ga

175 In 2013 we conducted a randomized, placebo-controlled clinical trial of live attenuated influenza v

176 st intermediate AMD enrolled in a randomized controlled clinical trial of lutein/zeaxanthin and/or om

177 igh-quality phenotype data from a randomized controlled clinical trial of nAMD.

178 ledge, this is the first efficacy randomized controlled clinical trial of panic-focused psychodynamic

179 In this randomized controlled clinical trial of patients with acute iliofem

180 were obtained from subjects during a placebo-controlled clinical trial of peanut OIT.

181 lticenter, randomized, double-blind, placebo-controlled clinical trial of peanut sublingual immunothe

182 This was a randomized controlled clinical trial of subjects with primary DSM-I

183 ospective, randomized, double-blind, placebo-controlled clinical trial of terlipressin was performed.

184 ospective, double-blind, randomized, placebo-controlled clinical trial of the effects of 5 smoking ce

185 ples ascertained through the largest placebo-controlled clinical trial of the monoamine oxidase B inh

186 r, randomized, single-masked, sham-injection controlled clinical trial of the safety, tolerability, a

187 Controlled clinical trials of anti-acid treatments are n

188 Several relatively small randomized controlled clinical trials of anticoagulation as cancer

189 Randomized controlled clinical trials of BT in severe asthma have n

190 y from several sources, including randomized controlled clinical trials of DES versus BMS in carefull

191 Three randomized controlled clinical trials of fasting in humans were ide

192 cancer risk, few large, randomized, placebo-controlled clinical trials of multivitamins with cancer

193 int that should be used in future randomized controlled clinical trials of novel therapies in idiopat

194 6810), two phase 3, double-blind, randomised controlled clinical trials of the HPV-16/18 AS04-adjuvan

195 ase pathogenesis and knowledge provided from controlled clinical trials of these new therapeutic agen

196 Three new controlled clinical trials of thiazolidinediones offer n

197 Randomized controlled clinical trials offer the best evidence for c

198 blind, household-cluster-randomized, placebo-controlled clinical trial on Flores island, Indonesia, a

199 randomized, crossover, double-blind, placebo-controlled clinical trial on human immunodeficiency viru

200 o treat mast cell mediator-related symptoms, controlled clinical trials on how they improve quality o

201 Results from many meta-analyses and well controlled clinical trials on the effects of a variety o

202 d studies were randomized controlled trials, controlled clinical trials, or cohort studies with 10 or

203 ESIGN, SETTING, AND PARTICIPANTS: Randomized controlled clinical trial performed at an urban academic

204 level of evidence of treatments based on the controlled clinical trials performed with each compound

205 This randomized, double-blind, prospective controlled clinical trial (phase 2B) was designed to inv

206 rechallenge, additional data are needed from controlled clinical trials, prospective registries, and

207 th blood pressure (BP) levels and randomized controlled clinical trials providing evidence of stroke

208 This randomized controlled clinical trial (RCT) called for 120 participa

209 stematically reviewed to identify randomized controlled clinical trials (RCTs) in chronic heart failu

210 ual patient data meta-analysis of randomized controlled clinical trials (RCTs) to evaluate whether ba

211 Randomized controlled clinical trials (RCTs), prospective cohort st

212 hest level of evidence comes from randomized controlled clinical trials (RCTs).

213 s phase 2, randomised, double-blind, placebo-controlled clinical trial recruited patients aged 18-65

214 ycINFO (1974-October 2005), and the Cochrane Controlled Clinical Trials Register Database (1966-Octob

215 tiple electronic databases (Medline, EMBASE, Controlled Clinical Trials Register Database, and the Co

216 Randomized controlled clinical trials remain the best method for mi

217 ICIPANTS: Multicenter, double-blind, placebo-controlled clinical trial (Renal Optimization Strategies

218 ncludes a review of split-mouth, randomized, controlled clinical trial results that specifically trac

219 polyneuropathy, according to recent placebo-controlled clinical trial results.

220 In the same patients, however, these placebo-controlled clinical trials revealed a little-understood

221 long-term follow-up of a randomized, placebo-controlled, clinical trial (SHEP) of patients aged 60 ye

222 Results of recent randomized controlled clinical trials suggest that most patients wi

223 A recent controlled clinical trial suggested a role for amantadin

224 is a large body of evidence from randomized controlled clinical trials supporting the cardiovascular

225 as a prospective, single-blinded, randomized controlled clinical trial testing the hypothesis that he

226 k Trial), a randomized, double-blind, active-controlled clinical trial that enrolled hypertensive ind

227 I) 53 is a randomized, double-blind, placebo-controlled clinical trial that evaluated the safety of s

228 he ICTUS trial was a multicenter, randomized controlled clinical trial that included 1,200 patients w

229 Eight searches were performed seeking controlled clinical trials that addressed the ability of

230 review was conducted to identify randomised controlled clinical trials that assessed the use of poly

231 , prospective, retrospective, and randomized controlled clinical trials that evaluated implant stabil

232 ive search strategies to identify randomized controlled clinical trials that evaluated the effects of

233 Randomized controlled clinical trials that evaluated the efficacy o

234 ed and inconsistent evidence from randomized controlled clinical trials that greater PAC involvement

235 Prospective, randomized, controlled clinical trials that reported isoniazid acety

236 tudy was a randomized, double-blind, placebo-controlled, clinical trial that accrued subjects from fi

237 les from a randomized, double-blind, placebo-controlled clinical trial (the Vitamin D Antenatal Asthm

238 eing evaluated prospectively in a randomized controlled clinical trial, the AREDS2.

239 In this randomized, controlled clinical trial, the questionnaires Oral Impac

240 We did a randomised controlled clinical trial to assess the efficacy and saf

241 ok a large randomized, double-blind, placebo-controlled clinical trial to compare placebo with 10 mic

242 We conducted a randomized, double-blind, controlled clinical trial to determine whether hyperbari

243 METHODS AND We performed a randomized controlled clinical trial to evaluate the effect of high

244 y (AREDS) is the only large-scale randomized controlled clinical trial to show a 25% beneficial effec

245 orm management of Legionnaires' disease, and controlled clinical trials to ascertain the optimum anti

246 The objective was to combine evidence from controlled clinical trials to assess the effect of n-3 L

247 sed of several histological types, rendering controlled clinical trials to establish the best treatme

248 nge will be to design prospective randomized controlled clinical trials to provide the evidence neces

249 66-March 2005), Cochrane Central Register of Controlled Clinical Trials (to 4th quarter 2004), PsychI

250 f patients who would have been excluded from controlled clinical trials undergoes carotid artery sten

251 Data from a randomized double-blind placebo-controlled clinical trial undertaken in healthy young ad

252 Among nine controlled clinical trials using niacin, mostly combined

253 A prospective, randomized, fellow-eye-controlled clinical trial was conducted at the Byers Eye

254 A randomized, double-blind, placebo-controlled clinical trial was conducted between May 7, 2

255 is 12-week double-blind, randomized, placebo-controlled clinical trial was conducted from February 1,

256 A 6-month randomized and placebo-controlled clinical trial was conducted in 171 postmenop

257 A 12-week, randomized, double-blind, placebo-controlled clinical trial was conducted in 50 unpaid tre

258 This randomized, double-blind, placebo-controlled clinical trial was conducted in 54 women with

259 A single-blind randomized controlled clinical trial was conducted in southern Mala

260 lend.A prospective, double-blind, randomized controlled clinical trial was conducted in which childre

261 A randomized controlled clinical trial was conducted to compare the e

262 A controlled clinical trial was conducted to determine the

263 pective, randomized, placebo, and positively controlled clinical trial was designed to evaluate the c

264 A controlled clinical trial was done in young adult volunt

265 No human controlled clinical trial was identified that addressed

266 le neutralizing antibody response, a placebo-controlled clinical trial was performed in 48 healthy ad

267 A randomized, double-blind, placebo-controlled clinical trial was performed in 70 women with

268 A randomized "two armed" controlled clinical trial was performed.

269 ackground: The aim of the present randomized controlled clinical trial was to assess the bucco-lingua

270 The objective of this randomized controlled clinical trial was to assess the efficacy of

271 The purpose of this multicenter randomly controlled clinical trial was to compare two acellular d

272 The primary aim of this randomized, controlled clinical trial was to determine the efficacy

273 e purpose of this single-masked, randomized, controlled clinical trial was to evaluate the effects of

274 A double-blind, placebo-controlled, clinical trial was conducted.

275 KEEPS, a randomized, double-blinded, placebo-controlled clinical trial, was conducted at nine US acad

276 In this randomized, crossover, placebo-controlled clinical trial, we characterized the effects

277 In a double-blind, randomized, controlled clinical trial, we compared the efficacy, tol

278 In this double-blind, placebo-controlled clinical trial, we enrolled a cohort of patie

279 In this double-blind, randomized, placebo-controlled clinical trial, we evaluated systemic and muc

280 hich was a randomized, double-blind, placebo-controlled clinical trial, we explored the effectiveness

281 In this randomised, double-blind, placebo-controlled clinical trial, we recruited patients from 78

282 For this phase 2, randomised, placebo-controlled, clinical trial, we enrolled patients with re

283 spective, randomized, double-masked, placebo-controlled clinical trials were conducted at 39 ophthalm

284 No controlled clinical trials were identified.

285 Prospective human controlled clinical trials were included that compared s

286 Two independent prospective randomized controlled clinical trials were performed for treatment

287 This was a controlled clinical trial where patients with an elevate

288 Future placebo-controlled clinical trials will be required to establish

289 However, long-term, multicenter randomized, controlled clinical trials will be required to know thei

290 of preliminary studies, ongoing randomized, controlled clinical trials will potentially provide defi

291 We conducted a 24-week randomized, controlled clinical trial with 166 patients assigned to

292 conducted a randomized double-blind placebo-controlled clinical trial with 208 opioid-dependent pati

293 Randomized controlled clinical trial with 4-week follow-up that inc

294 Randomized, blinded, placebo-controlled clinical trial with a 12-week treatment perio

295 Double-blind, randomized, placebo-controlled clinical trial with a 12-week treatment phase

296 Other long-term randomized controlled clinical trials with a large sample size and

297 Uncontrolled and controlled clinical trials with different compounds and

298 Prospective controlled clinical trials with immunomodulatory therapy

299 manuals and found efficacious in at least 2 controlled clinical trials with random assignment that i

300 Dual review for controlled clinical trials with the patient as the unit