ライフサイエンスコーパス: controlled trial

1 e using an independently designed randomized controlled trial.

2 ndomly assigned in a double-blinded, placebo-controlled trial.

3 intakes of </=600 mg/d in a 12-mo randomized controlled trial.

4 multicenter stepped wedge cluster randomized controlled trial.

5 sing data from an expertise-based randomised controlled trial.

6 orders has not been assessed in a randomised controlled trial.

7 center, randomized (1:1 allocation), placebo-controlled trial.

8 Randomized, single-masked, controlled trial.

9 Quasi-randomized controlled trial.

10 egistered, randomised, double-blind, placebo-controlled trial.

11 ctive, single-center, nonblinded, randomized controlled trial.

12 Prospective randomized controlled trial.

13 s need evidence from age-specific randomized controlled trials.

14 nowledge gaps and impediments for randomized controlled trials.

15 CINAHL and the Cochrane Central Register of Controlled Trials.

16 e favorably with outcomes seen in randomized controlled trials.

17 disease, and most (87%) were non-randomized controlled trials.

18 disorders have shown efficacy in randomised controlled trials.

19 matical modelling studies, and no randomised controlled trials.

20 t patient data meta-analysis from randomized controlled trials.

21 In this randomized controlled trial, 128 young adults (71 male, 57 female)

22 ne, Embase, and Cochrane Central Register of Controlled Trials (1990 to November 2014).

23 the risk of weight regain.In this randomized controlled trial, 61 healthy overweight or obese partici

24 We conducted a randomized controlled trial; 67 patients with severe endometriosis-

25 In this multicentre, randomised controlled trial, 75 adults with type 1 diabetes in the

26 tors.In a multicenter, crossover, randomized controlled trial, 92 men and women with abdominal obesit

27 lticenter, randomized, double-blind, placebo-controlled trial, 96 HT recipients were randomized to un

28 national, multicentre, double-blind, placebo-controlled trial, adult patients (>/=18 years) with rela

29 Based on data from randomized controlled trials, adult patients who undergo autologous

30 lticentre, randomised, double-blind, placebo-controlled trial, adults (>/=18 years) with S aureus bac

31 3, multinational, double-blind, randomised, controlled trial, adults (aged 18 years or older) with p

32 Randomized controlled trials also support an expanded role for neur

33 We did a cluster randomised controlled trial among Royal Marines and Army personnel

34 d 64 meta-analyses, including 540 randomized controlled trials analyzing 137,957 patients.

35 Eighteen studies met one randomized controlled trial and 17 observational studies.

36 rollment criteria for any studied randomized controlled trial and 30% (n = 28) were eligible for only

37 eutic irrigation" or "lavage" AND randomized controlled trial and any derivatives of those terms.

38 affeine for Apnea of Prematurity) randomized controlled trial and assessed at the Royal Women's Hospi

39 ved, 42 met inclusion criteria (5 randomized controlled trials and 37 observational studies), involvi

40 Eligible studies were randomized controlled trials and observational ones.

41 based on a systematic review of randomized, controlled trials and observational studies published th

42 of Science on July 11, 2016, for randomised controlled trials and observational studies that reporte

43 ations on a systematic review of randomized, controlled trials and systematic reviews published throu

44 s study sets the stage for larger randomized controlled trials and testing in other emotional disorde

45 cluded a minimum of 5 oral health randomized controlled trials and used continuous outcomes.

46 EDLINE, Embase, Cochrane Central Register of Controlled Trials, and Ageline databases from inception

47 Web of Science, Cochrane Central Register of Controlled Trials, and ClinicalTrials.gov and manual sea

48 Ovid MEDLINE, Cochrane Central Register of Controlled Trials, and Cochrane Database of Systematic R

49 EDLINE, PubMed, Cochrane Central Register of Controlled Trials, and PsycINFO for studies published in

50 uctured training and the upcoming randomized controlled trials are needed to assess the technique fur

51 Controlled trials are ongoing to validate these conclusi

52 Randomized controlled trials are required to confirm these results.

53 Further data from randomized controlled trials are urgently needed because lepirudin

54 Further studies of randomized controlled trials are warranted to confirm the observed

55 This randomized, double-blind, placebo-controlled trial assessed the effects of tenapanor on se

56 to our knowledge, the first large randomised controlled trial assessing individual psychological inte

57 We undertook a multicenter, randomized, controlled trial at 31 French hospitals (NCT01508468).

58 Double-blinded, placebo-controlled trial at 9 academic medical centers in the Un

59 , we did a double-blind, randomised, placebo-controlled trial based in Doneguebougou and surrounding

60 nce suggests that design flaws of randomized controlled trials can result in over- or underestimation

61 Effects (DARE), Cochrane Central Register of Controlled Trials (CENTRAL) and the Cochrane Database of

62 EMBASE (OVID), Cochrane Central Register of Controlled Trials (CENTRAL), Cochrane Database of System

63 EDLINE, EMBASE, Cochrane Central Register of Controlled trials, CINAHL, and ClinicalTrials.gov.

64 ematic Reviews, Cochrane Central Register of Controlled Trials, CINAHL, Scopus, and ISI Web of Scienc

65 February 2016), Cochrane Central Register of Controlled Trials, Cochrane Database of Systematic Revie

66 November 2016), Cochrane Central Register of Controlled Trials, Cochrane Database of Systematic Revie

67 This randomized controlled trial compared the antischizontocidal efficac

68 TIME was a randomized, double-blind, placebo-controlled trial comparing 150 million bone marrow monon

69 s being investigated in a phase 3 randomised controlled trial comparing lorlatinib to crizotinib.

70 igate 3-year survival following a randomized controlled trial comparing minimally invasive with open

71 Databases were searched for randomized controlled trials comparing administration of high-flow

72 searched electronic databases for randomized controlled trials comparing AL to non-ACTs that reported

73 screened titles and abstracts for randomized controlled trials comparing bowel protocols to control (

74 review and identified more recent randomized controlled trials comparing dose-escalated external beam

75 eviewers independently identified randomized controlled trials comparing dynamic assessment of fluid

76 om inception to Aug 15, 2017, for randomised controlled trials comparing the use of atraumatic needle

77 The lack of randomized controlled trials comparing various routes and formulati

78 aspirin therapy (n=21 722) from 4 randomized controlled trials comparing VKAs and NOACs (n=71 681) in

79 6 were randomized and 2 were not randomized controlled trials comprising a total of 661 patients-the

80 randomized, double-blind, multisite placebo-controlled trial conducted in human subjects demonstrate

81 a) was a randomized, double-blinded, placebo-controlled trial conducted in malaria-endemic Uganda, co

82 INTERPRETATION: This is the largest controlled trial conducted in SPS patients and demonstra

83 months of age were pooled from 5 randomized controlled trials conducted in Europe and the United Sta

84 ia were enrolled in this randomized, placebo-controlled trial consisting of an initial 12- to 16-week

85 included, 14 (including 1 cluster randomized controlled trial [cRCT]) used live attenuated influenza

86 Selected publications included randomized controlled trial data and observational studies describi

87 Cohort study using randomized controlled trial data.

88 In this nonblinded, randomized controlled trial, de novo SOTR received standard teachin

89 ing a threat-attention task and a randomized controlled trial design to evaluate potential complement

90 A parallel-group randomised controlled trial design was used.

91 he intervention arm of the RHIVA2 randomised controlled trial done in Hackney, London (UK), a borough

92 isted of a randomised, double-blind, placebo-controlled trial done over 18 months.

93 ual patient included data from 17 randomised controlled trials done in 14 low-income and middle-incom

94 We identified 13 randomised controlled trials done in 739 adults with type 1 hepator

95 is double-blind, parallel-group, randomised, controlled trial, eligible patients had COPD, post-bronc

96 We searched Cochrane Central Register of Controlled Trials, Embase, and MEDLINE for reports publi

97 s (Medline, the Cochrane Central Register of Controlled Trials, Embase, CINAHL) and internet sources

98 HODS AND Randomized, double-blinded, placebo-controlled trial enrolled 31 patients with recurrent Can

99 Methods In the MAP.3 randomized, placebo-controlled trial evaluating exemestane, participants com

100 alized Register were searched for randomized controlled trials evaluating the efficacy of smoking ces

101 he Cochrane Library databases for randomized controlled trials evaluating use of probiotics and CDI i

102 This randomized controlled trial examined the efficacy of a novel gaze-c

103 edge, this is the first cookstove randomized controlled trial examining prenatal BP.

104 and focuses on recently published randomized controlled trials exploring the efficacy of oral toleran

105 ulticentre, double-blind, randomised placebo-controlled trial for which patients were recruited at 60

106 chINFO, and the Cochrane Central Register of Controlled Trials for articles published between 1947 an

107 nts receiving AIT and efficacy in randomised controlled trials for drug development could be enhanced

108 tic, parallel-group, multicentre, randomised controlled trials for our study (PROSPECT [PROlapse Surg

109 NE, EMBASE, and Cochrane CENTRAL Register of Controlled Trials for studies including published data o

110 Randomized, placebo-controlled trial from July 2014 to May 2016.

111 PubMed and the Cochrane Central Register of Controlled Trials from December 2006 through December 20

112 s based on a systematic review of randomized controlled trials from February 2014 to December 2016 pl

113 Randomized controlled trials from MEDLINE, EMBASE, CENTRAL, clinica

114 EMBASE, and the Cochrane Central Register of Controlled Trials (from database inception to November 2

115 rhosis, but no adequately powered randomised controlled trials have been done.

116 Randomized controlled trials have demonstrated that the newest late

117 ts from large cohort studies and randomized, controlled trials have provided conflicting messages abo

118 Recently, 3 randomized controlled trials have published contradictory conclusio

119 There were no randomized controlled trials identified.

120 rived from a previously published randomised controlled trial (IMPACT).

121 multicentre, open-label, phase 3 randomised controlled trial (IMvigor211) at 217 academic medical ce

122 We did a cluster-randomised, controlled trial in 12 hospitals in Guangxi, China.

123 The program was implemented as a randomized controlled trial in 121 villages, 60 of which received t

124 We did this randomised controlled trial in 18 SSSs in England.

125 a phase 2, randomized, double-blind, placebo-controlled trial in 27 centers across North America to d

126 We did a community-based, cluster-randomised controlled trial in a rural area of North Central Provin

127 This randomized controlled trial in acute laparoscopic appendectomy recr

128 The START trial was a randomised controlled trial in ART-naive HIV-positive patients with

129 for radical cure, we undertook a randomized controlled trial in Ethiopia.

130 We conducted a randomized, placebo-controlled trial in Niger to evaluate the efficacy of a

131 We performed a prospective, randomized, controlled trial in nondiabetic DIOS patients with hepat

132 ouble-blind, multicentre, randomised placebo-controlled trial in previously untreated adult patients

133 We conducted a 3-arm, multicentre randomised controlled trial in primary- and secondary-care United K

134 agmatic, multicentre, open-label, randomised controlled trial in seven HIV clinics at academic and no

135 A randomized controlled trial in Togo assigned microenterprise owners

136 We did a cluster-randomised controlled trial in two adjoining districts of Jharkhand

137 We did a two-arm randomised controlled trial in women aged 70-85 years to compare a

138 report two double-blind, randomised, placebo-controlled trials in adults with chronic non-cancer pain

139 bility of information gained from randomized controlled trials in critically ill patients by assessin

140 thors present a meta-analysis of all placebo-controlled trials in patients with acute exacerbations o

141 Surgery: Pragmatic Evaluation and randomised Controlled Trials]) in 35 centres (a mix of secondary an

142 This randomized, placebo-controlled trial included 4- to 6-month-old infants who

143 The randomized controlled trial included 533 women who were randomly as

144 This multicentre randomised controlled trial included patients with advanced or meta

145 is 6-week, randomized, double-blind, placebo-controlled trial included patients with schizophrenia, s

146 2 or 3 randomized and placebo or comparator-controlled trials (integrated parent trials) and the fir

147 This double-blind, randomized, controlled trial investigates the effects of rifaximin o

148 HF-ACTION (Heart Failure: A Controlled Trial Investigating Outcomes of Exercise Trai

149 AST) was a randomized, double-blind, placebo-controlled trial involving 201 patients with stage 3, 4,

150 onducted a randomized, double-blind, placebo-controlled trial involving 30,449 adults with atheroscle

151 lticenter, randomized, double-blind, placebo-controlled trial involving patients in whom perioperativ

152 A randomised controlled trial is needed.

153 ve [TCRI]) and a double-blinded, randomized, controlled trial (MAKI), using adjusted multivariable re

154 e-assignment randomized trial (or randomized controlled trial) may be inadequate.

155 The Cochrane Central Register of Controlled Trials, MEDLINE (through PubMed), EMBASE, Sco

156 e search on the Cochrane Central Register of Controlled Trials, MEDLINE, and Embase, and pooled indiv

157 sional societies supplemented by randomized, controlled trials; meta-analyses; and systematic reviews

158 ospective, double-blind, randomized, placebo-controlled trial (methylphenidate versus placebo) was co

159 We did this single-blind, randomised controlled trial (OASIS) at 26 UK universities.

160 We performed a multicenter randomized controlled trial of 53 children (age, 5-16 y) with FC ac

161 allel design, placebo-controlled, randomized controlled trial of 78 postmenopausal osteopenic women s

162 ur knowledge, this is the largest randomised controlled trial of a psychological intervention for a m

163 e-blind, randomized, parallel-group, placebo-controlled trial of a single ketamine infusion (saline,

164 e the feasibility of conducting a randomised controlled trial of a specialist physiotherapy intervent

165 atic, multicentre, parallel-group randomised controlled trial of adults with bullous pemphigoid (thre

166 We conducted a randomized controlled trial of AF screening using an AliveCor Kardi

167 onducted a randomized, double-blind, placebo-controlled trial of amitriptyline (1 mg per kilogram of

168 ios; 443 were randomly assigned in a placebo-controlled trial of an ACE inhibitor and a statin with t

169 ealth (SEARCH) study is a cluster-randomised controlled trial of an HIV test-and-treat strategy in 32

170 In a randomized controlled trial of children with FC, PPT was more effec

171 a randomized, 3-month double-masked, placebo-controlled trial of daily 2 g DHA or placebo capsules en

172 women in the Partners PrEP Study, a placebo-controlled trial of daily oral PrEP (either tenofovir mo

173 ents enrolled in a large, randomized placebo-controlled trial of duloxetine collected before and 8 we

174 5 to 12 years participating in a randomized controlled trial of ICSs with longitudinal concomitant a

175 e initiation of a multinational, randomised, controlled trial of intrathecal HPbetaCD.

176 The authors performed a randomized controlled trial of nurse-coordinated referral of patien

177 trial, a pragmatic, multicentre, randomised controlled trial of patients (>/=18 years) admitted to o

178 We performed a randomized controlled trial of patients undergoing cranial and spin

179 alysis of MS-STAT, a 24-month, double-blind, controlled trial of patients with SPMS done at three neu

180 After Stroke trial, a double-blind, placebo-controlled trial of pioglitazone for secondary preventio

181 onducted a randomized, double-blind, placebo-controlled trial of pregabalin in patients with sciatica

182 We studied participants from a randomized controlled trial of primary prevention with statin thera

183 S AND We undertook a double-blind randomised controlled trial of small-quantity lipid-based nutrient

184 We identified 19 relevant randomised controlled trials of 12 antipsychotic drugs that involve

185 ticagrelor) were blinded, randomized placebo-controlled trials of antiplatelet therapy for the preven

186 iosis, and ClinicalTrials.gov for randomised controlled trials of antipsychotics for the acute treatm

187 CENTRAL through July 1, 2016, for randomized controlled trials of CCT in older adults with mild cogni

188 However, randomised controlled trials of diet-related factors have not yet s

189 yses of observational studies and randomized controlled trials of dietary risk factors and the five m

190 The INTERACT studies were randomised controlled trials of early intensive blood pressure (BP)

191 phase III, randomized, double-blind, placebo-controlled trials of IFN-gamma-1b in idiopathic pulmonar

192 Most randomized controlled trials of routine versus selective invasive c

193 ant improvement in systolic BP in randomized controlled trials of self-measured BP versus usual care

194 We identified all randomised controlled trials of systemic therapies in non-small-cel

195 However, no randomized controlled trials of the effect of dairy food on weight

196 RATIONALE: Single-center randomized controlled trials of the Zephyr endobronchial valve (EBV

197 stroke, but large-scale, class 1 randomised controlled trials on treatment effectiveness are scarce.

198 In a double-blind, randomized controlled trial, once-daily inhaled placebo, fluticason

199 CINAHL) and internet sources for randomized controlled trials, ongoing clinical trials, and unpublis

200 s were included if they were a cohort study, controlled trial, or case-control study (including case-

201 quality data due to a shortage of randomised controlled trials (partly because of ethical issues), fe

202 ty, open-label, blinded-endpoint, randomised controlled trial, patients aged 70 years or younger with

203 and Methods In this double-blinded, placebo-controlled trial, patients with HER2-positive early brea

204 le-centre, randomised, double-blind, placebo-controlled trial, patients with moderate Parkinson's dis

205 s were assessed over the 4.9-year randomized controlled trial phase and on mortality outcomes over a

206 atic review The Cochrane Central Register of Controlled Trials, Prospero, Medline (1946-December week

207 Fourteen randomized controlled trials provide the evidence base; earlier pha

208 Assessing surgery in randomized controlled trials raises several challenges.

209 Ideally, a randomized controlled trial (RCT) among US women would provide data

210 This randomized controlled trial (RCT) hypothesized that prolonged enter

211 aging to a randomized, double-blind, placebo-controlled trial (RCT) of antidepressant medication for

212 ODS AND A single-blind, pragmatic randomised controlled trial (RCT) was conducted at eight study site

213 Inclusion criteria were: 1) randomised controlled trial (RCT), quasi-RCT, before-after cohort s

214 All randomized controlled trials (RCT) and observational studies compar

215 The findings of randomised controlled trials (RCT), observational studies, and meta

216 ed through October 2016 including randomized controlled trials (RCTs) and prospective cohort studies

217 While randomized controlled trials (RCTs) are based on strict inclusion/e

218 ta-analysis was conducted on: (1) randomized controlled trials (RCTs) assessing the effects of n-3 PU

219 t systematic review includes five randomized controlled trials (RCTs) conducted to determine the effe

220 We included only randomized controlled trials (RCTs) in which CAG and AMT had been c

221 erweight and obesity.We evaluated randomized controlled trials (RCTs) of isolated soluble fiber suppl

222 e has been a dramatic increase in randomized controlled trials (RCTs) of mindfulness interventions ov

223 tudies were eligible if they were randomised controlled trials (RCTs) or prospective cohort studies i

224 Meta-analyses of randomized controlled trials (RCTs) suggest calcium could have adve

225 Evidence from randomized controlled trials (RCTs) suggests the consumption of kon

226 2017 for guidelines, reviews, and randomized controlled trials (RCTs) that assessed the outcomes glyc

227 We performed a meta-analysis of randomised controlled trials (RCTs) to assess whether intensive BP

228 matic review and meta-analysis of randomized controlled trials (RCTs) was carried out.

229 21 randomized controlled trials (RCTs) with a total of 6302 patients w

230 , based on methodologically sound randomized controlled trials (RCTs), demonstrating superiority to p

231 EMBASE, and PsycINFO to identify randomized controlled trials (RCTs), meta-analyses, and systematic

232 yses of observational studies and randomized controlled trials (RCTs).

233 observational cohort studies and randomised controlled trials (RCTs).

234 This randomized, double-blind, placebo-controlled trial recruited patients aged 18 to 70 years

235 PubMed, Embase, Cochrane Central Register of Controlled Trials, reference lists, conference proceedin

236 d with the International Standard Randomised Controlled Trial registry (ISRCTN07742377), and is now c

237 of PubMed, the Cochrane Central Register of Controlled Trials, SCOPUS, Web of Science, Google Schola

238 n a post hoc analysis of a recent randomized controlled trial, Sedation versus Intubation for Endovas

239 , authors and journals publishing randomized controlled trials should pay attention that status of bl

240 tematic reviews using oral health randomized controlled trials should perform sensitivity analyses ba

241 s aggregate data meta-analysis of randomised controlled trials showed that vitamin D supplementation

242 ations, the primary analysis (all randomized controlled trials) showed that cell therapy reduced the

243 n all four much smaller, randomized, placebo-controlled trials specifically designed to evaluate stat

244 This pilot randomized, controlled trial suggests that DHA + aspirin therapy imp

245 e did this single-blind, phase 2, randomised controlled trial (SUPEREDEN3) at four specialist early i

246 y II was a randomized, double-blind, placebo-controlled trial testing multivitamin use (multivitamin

247 In a randomized, controlled trial that compared liraglutide, a glucagon-l

248 IBIS-I was a randomized controlled trial that investigated the effectiveness of

249 We included only randomised controlled trials that compared fibrinolytic agents as a

250 t articles for English-language, randomized, controlled trials that had at least 6 months of follow-u

251 and relevant subject headings for randomized controlled trials that met eligibility criteria defined

252 nd A, and essential fatty acids.A randomized controlled trial, the Lulun ("egg" in Kichwa) Project, w

253 id a community-level open cluster randomised controlled trial to compare the effects of a cleaner bur

254 leukemia (APL) was a phase III historically controlled trial to determine the survival of patients r

255 We performed a randomized controlled trial to determine whether Doppler endoscopic

256 liminary results, we conducted a randomized, controlled trial to determine whether minocycline reduce

257 our knowledge, this is the first randomised controlled trial to document efficacy of a remyelinating

258 We conducted the first randomized sham-controlled trial to evaluate the IASD in HF with EF >/=4

259 onducted a double-blind, randomized, placebo-controlled trial to investigate whether vitamin D supple

260 We conducted a prospective randomized controlled trial to study the impact of in-hospital guid

261 We will also conduct a randomized controlled trial to test the effectiveness of Family Hea

262 We performed a parallel-arm randomized controlled trial to test whether administration of an ex

263 he need of systematic reviews and randomized controlled trials to address evidence gaps.

264 Evaluation of Drug Efficacy is a randomized controlled trial using a multiarm, multistage, platform

265 We present here a randomized, controlled trial using allogeneic MSC, which are logisti

266 double-blind, placebo-controlled, randomized controlled trials, using commonly available oats sourced

267 A randomized controlled trial validated the 7 g/dL threshold, but pre

268 A randomized controlled trial was conducted through Washington Univer

269 tients screened for a multicenter randomized controlled trial was determined by using 16S rRNA gene s

270 nts and Methods This multicenter, randomized controlled trial was undertaken within eight gynecologic

271 lticenter, double-blind, randomized, placebo-controlled trial, we assessed the efficacy and safety of

272 s phase 2, randomized, double-blind, placebo-controlled trial, we compared subcutaneous tezepelumab a

273 atic, parallel-group, open-label, randomised controlled trial, we enrolled adults (aged >/=18 years)

274 purchases.In this parallel-group randomized controlled trial, we enrolled household shoppers across

275 For this double-blind, randomised, placebo-controlled trial, we enrolled self-referred or physician

276 In this double-blind randomised placebo-controlled trial, we enrolled undiagnosed patients, aged

277 In this randomised, double-blind, placebo-controlled trial, we randomly allocated 172 57 (33%) to

278 In this unmasked randomised controlled trial, we randomly assigned (1:1) HIV-infecte

279 In this multicenter, double-blind, placebo-controlled trial, we randomly assigned 1776 women with s

280 In this cluster randomised controlled trial, we recruited non-pregnant adults aged

281 In this randomised controlled trial, we recruited participants aged 18-65 y

282 In this randomised controlled trial, we recruited patients from 34 general

283 egistered, randomized, double-blind, placebo-controlled trial, we tested the effect of a single dose

284 range: 18-73 y) from the Food4Me randomized controlled trial were included in this analysis.

285 Only 2 randomized controlled trials were designed to examine fracture outc

286 109 randomised controlled trials were eligible for inclusion, 42 (39%)

287 Three randomized controlled trials were identified from 48 potential stud

288 In total, 17 randomized controlled trials were identified, including 18 treatmen

289 a Database, and Cochrane Central Register of Controlled Trials, were searched without language restri

290 was to examine in a prospective, randomized controlled trial whether patient expectancy mediates pla

291 ine, in a multicenter double-blinded placebo-controlled trial, whether maximal hepatic arterial phase

292 A randomized controlled trial will evaluate the impact of this techni

293 We thus performed a randomized placebo-controlled trial with atorvastatin 40 mg/day for 9 weeks

294 did a multicentre, single-blind, randomised, controlled trial with follow-up at 4 months and 12 month

295 AND FINDING: Multicentre, cluster-randomised controlled trial with raters masked to an online compute

296 Twenty-three randomized controlled trials with 2,751 patients were included.

297 nalysis included 167 double-blind randomized controlled trials with 28,102 mainly chronic participant

298 Observational studies or randomized controlled trials with a long-term observation period we

299 DS) subphenotypes in two separate randomized controlled trials with differential response to positive

300 ed by comparing simulated randomised placebo-controlled trials within the out-of-sample LABS-PD cohor