ライフサイエンスコーパス: controlled-release

1 l diffusion rates to give systems capable of controlled release.

2 n for correlating structure with function in controlled release.

3 iety of applications ranging from sensors to controlled release.

4 design of surface coatings in the context of controlled release.

5 st line drug gemcitabine after heat mediated controlled release.

6 lly find analogous uses in encapsulation and controlled release.

7 ntial to ensure high quality and efficacy in controlled release.

8 ycol/poly(-caprolactone), allowing diffusion-controlled release.

9 es, proteins, small RNA molecules, and their controlled release.

10 priate therapeutic drug concentration with a controlled release.

11 (416 to 1001) and three journals (Journal of Controlled Release, Advanced Drug Delivery Reviews, and

12 ly improved its stability and contributed to controlled release after consumption by modifying vitami

13 ition, we describe the use of macrophages as controlled release agents upon stimulation by physical a

14 al stimulus, allows for new opportunities in controlled release and delivery applications.

15 art nanosystems used in biosensing, imaging, controlled release and other applications.

16 irmed the suitability of MSPs as support for controlled release and protection of bioactive molecules

17 viding the possibility of a spatiotemporally controlled release and protection of bound biomolecules.

18 dil is a feasible option for a non-invasive, controlled release and pulmonary preferential treatment

19 Signaling pathways that rely on the controlled release and/or accumulation of calcium ions a

20 s and hence present unique opportunities for controlled-release and tissue-engineering applications.

21 n a range of areas, including microfluidics, controlled release, and tertiary oil recovery.

22 ping single-administration vaccines based on controlled-release antigen delivery systems.

23 lot results indicate that locally delivered, controlled-release antimicrobial treatment may improve t

24 able peptide hydrogel system may be used for controlled release applications as a carrier for therape

25 th different drugs has been investigated for controlled release applications.

26 r new molecular capture, interim storage, or controlled release applications.

27 onstrate their utility for encapsulation and controlled release applications.

28 H, which suggests possible encapsulation and controlled release applications.

29 ial as materials for nanoscale transport and controlled release applications.

30 is establishes a technical advantage for the controlled-release approach.

31 Finally, novel approaches to controlled release are described, including devices that

32 in, where physiological mechanisms impacting controlled release are incorporated to capture observed

33 vesicles for site-specific drug delivery and controlled release at pathological sites.

34 s used as gates, the opening mechanisms, and controlled release behavior are detailed.

35 solid-shelled microcapsules having precisely controlled release behavior is described.

36 hesized that combining i.LN vaccination with controlled release biomaterials permitting sustained dos

37 ne based-approach comprised of two synthetic controlled-release biomaterials, poly(lactide-co-glycoli

38 d code, to receive lacosamide monotherapy or controlled-release carbamazepine (carbamazepine-CR) twic

39 of two doses of phentermine plus topiramate controlled-release combination as an adjunct to diet and

40 sing, good colonic absorption and a reliable controlled release (CR) technology are necessary.

41 n with an extended-release formulation (HCTZ-controlled release [CR]) was added.

42 eveloping new generations of site-selective, controlled-release delivery nanodevices.

43 ype mesoporous silica nanosphere-based (MSN) controlled-release delivery system has been synthesized

44 rectomy, with subcutaneous implantation of a controlled-release deoxycorticosterone acetate pellet, a

45 ncepts in the development of injectable PLGA controlled-release depots for peptides and proteins, and

46 An important poorly understood phenomenon in controlled-release depots involves the strong interactio

47 unlike the diffusion based unloading of most controlled release devices for small molecules.

48 implications of our results to the design of controlled-release devices is discussed.

49 cial development in the area of this complex controlled release dosage form.

50 technical challenges when developing an oral controlled release dosage form.

51 ars, there have been significant advances in controlled release dosage forms used for contraception.

52 PLGA microspheres are widely studied for controlled release drug delivery applications, and many

53 pment and translation of clinically-relevant controlled release drug delivery systems.

54 , extravascular drug delivery, and polymeric controlled-release drug codelivery design.

55 elivery routes, less-frequent dosing through controlled-release drug delivery and improved drug targe

56 Controlled-release drug delivery systems have many appli

57 ry systems with retained lactase in milk and controlled release during in vitro digestion.

58 and negatively charged drugs, as well as the controlled release effect.

59 n with directly adding CaO2 due to the OH(-) controlled-release effect of OCRMs.

60 Controlled release experiments showed an initial burst f

61 vedilol and metoprolol succinate (metoprolol controlled release/extended release [CR/XL]) on hemodyna

62 Controlled-release fertilizers (CRFs) can change the rel

63 and simulations techniques used for coated, controlled-release fertilizers.

64 The controlled release FGF2 additive reduces the frequency o

65 lating complex multidrug administration from controlled release films for localized delivery remains

66 an historical overview of drug delivery and controlled release followed by highlights of four emergi

67 bic and hydrophilic drugs and are capable of controlled release for a prolonged period of time.

68 a frontline chemo drug, into PLGA MPP, with controlled release for at least 4 days and negligible bu

69 ability against harsh conditions and provide controlled release for food/pharmaceutical applications.

70 tainers can act as inert packaging with slow/controlled release for virtually any type of encapsulati

71 illustrates an effective platform to produce controlled release formulation of anti-cancer drugs, and

72 biocompatible, biodegradable, and non-toxic controlled release formulation of ATRA for effective HCC

73 erates healing of cutaneous wounds only as a controlled release formulation.

74 An oral once-a-day osmotic controlled-release formulation of methylphenidate produc

75 drug delivery systems have produced numerous controlled release formulations helping patients improve

76 In conclusion, our data suggest that controlled release formulations of IL-2, TGF-beta and ra

77 In particular, this review focuses on (1) controlled release formulations that deliver natural sol

78 yl cellulose film coatings in pharmaceutical controlled release formulations.

79 solution standard and for two novel topical controlled-release formulations in which the DEET active

80 the factors that contribute to the slow and controlled release from each class of particle, as well

81 stematic study to optimize encapsulation and controlled release from the polymer without compromising

82 in an indigenously prepared, biodegradable, controlled-release gel as an adjunct to scaling and root

83 in an indigenously prepared, biodegradable, controlled-release gel, as an adjunct to scaling and roo

84 The field of controlled release has contributed significantly to fema

85 Light-controlled release has gained popularity in recent years

86 device design that gives rise to the desired controlled release has yet to be defined.

87 ersity of chemical modifications, stability, controlled release, however limited drug loading capacit

88 e encapsulated by various wall materials for controlled release in food and digestion systems.

89 tages, providing an improved opportunity for controlled release in higher-stage patients.

90 es in the endoplasmic reticulum (followed by controlled release in the Golgi) are unclear.

91 s and synthetic polymers for the purposes of controlled release in tissue engineering.

92 h microsphere formulations exhibited erosion-controlled release in vitro, indicated by similar polyme

93 potential for facile production of low-cost controlled-release injectable depots for leuprolide and

94 rated into a methylcellulose vehicle for its controlled release into intrabony defect (IBD) sites as

95 adsorbed 1 microg TGF-beta1, suggesting that controlled release is effective at 10-fold less drug dos

96 The optimal controlled release is found from the interplay of electr

97 The Journal of Controlled Release (JCR) has played a pivotal role in th

98 he time of the first issue of the Journal of Controlled Release (JCR), polymeric drugs, polymer-drug

99 nd showcases the importance of tailoring the controlled release kinetics of the formulation to the ho

100 eutics to the target site with sustained and controlled release kinetics.

101 size selective separation and purification, controlled-release materials, sensors and catalysts, sca

102 lymers (SELPs) have been effectively used as controlled release matrices for the delivery of viruses

103 nthesized material prior to application as a controlled release matrix.

104 A novel electrochemically controlled release method for nitric oxide (NO) (based o

105 examined the in-vivo efficacy of a nebulised controlled-release microparticle formulation of heparin

106 Release testing of parental controlled release microspheres is an essential step in

107 vivo correlations (IVIVCs) for biodegradable controlled release microspheres.

108 We examined whether a controlled-release mitochondrial protonophore (CRMP) tha

109 A controlled-release mitochondrial protonophore reverses h

110 elease oral formulation of DNP, called CRMP (controlled-release mitochondrial protonophore), that pro

111 unable molecular sieves, gated membranes and controlled-release nanocontainers.

112 erapeutics that can be self-assembled into a controlled release nanoparticle with abilities to delive

113 sponse of tumor cells to XRT, we developed a controlled-release nanoparticle drug delivery system usi

114 is to resolve component spectra, temperature-controlled release of 3-NBS through vesicle membranes co

115 readily encapsulated in nanoparticles, with controlled release of 89% of drug into media over three

116 d-supported catalytic system enabled locally controlled release of a fluorescent dye into the brain o

117 gical order-order transitions to achieve the controlled release of a model payload (e.g., silica nano

118 ed drug delivery platforms for sustained and controlled release of a plethora of therapeutic agents.

119 ated via temperature change, followed by the controlled release of affinity-captured targets back int

120 here delivery system has been fabricated for controlled release of alendronate (AL).

121 Thus, a novel new methodology for controlled release of amino-containing drugs, peptides,

122 y system (PR-AuNPs-MSN) for the photoinduced controlled release of an anticancer drug, paclitaxel, in

123 neficial for many applications requiring the controlled release of an oxidizing species, e.g., microf

124 The controlled release of anti-PD1 and CpG ODN by CpG DNA-ba

125 e-5'-triphosphate (ATP) as a trigger for the controlled release of anticancer drugs.

126 in polymer, and d) provide improved in vitro controlled release of antigenic TT.

127 In this paper, the controlled release of aroma compounds from cyclodextrins

128 and that beta-CD polymers could perform the controlled release of aroma compounds.

129 delivery vehicle, it was discovered that the controlled release of autoantigen was important for the

130 late the production of lactose-free food and controlled release of beta-galactosidase into lactose-in

131 iterion to corrective therapy was the steady controlled release of beta-glu and its diffusion through

132 self-healable materials, mesophases for the controlled release of bioactive compounds, or dynamic fu

133 ple for the general temporally and spatially controlled release of bioactive molecules, pharmacophore

134 These NPs undergo controlled release of both drugs over a period of 48-72

135 to verify that laser irradiation facilitated controlled release of both hydrophobic and hydrophilic d

136 ivery system (BA-MSN) for glucose-responsive controlled release of both insulin and cyclic adenosine

137 nts in the Plasmodium life cycle rely on the controlled release of Ca(2)(+) from intracellular stores

138 In vitro controlled release of cAMP was studied at two pH conditi

139 This system facilitates easily controlled release of cargoes to achieve multi-functiona

140 es (and hydrogels) for targeted delivery and controlled release of cargoes.

141 tissue destruction, we hypothesized that the controlled release of CCL22 could also recruit Tregs to

142 erous cells has been targeted herein for the controlled release of chemotherapeutics at the tumour si

143 Controlled release of chromatin from the nuclei of infla

144 al properties and smooth surfaces and showed controlled release of CHX over a long time.

145 to target mitochondria of cells, resulted in controlled release of cisplatin from Platin-M locally in

146 The nanoparticles also provide controlled release of cisplatin in effective concentrati

147 hat, when placed into a meniscal defect, the controlled release of collagenase and PDGF-AB increases

148 s work shows one of the first examples of pH-controlled release of corrosion-inhibiting ions from an

149 Local controlled release of corticosteroids may reduce the rat

150 environment and thus offers a mechanism for controlled release of CPT.

151 uronal network capable of restoring feedback-controlled release of DA in the nigrostriatal system.

152 ene delivery through improved protection and controlled release of DNA cargo.

153 lerated and we successfully demonstrated the controlled release of dopamine over a period of four wee

154 Controlled release of DOX molecules from GIANs is achiev

155 ystems have been developed which can provide controlled release of drug for potentially long periods

156 mplexes have received much attention for the controlled release of drugs due to the remarkable abilit

157 s an important role in the encapsulation and controlled release of drugs from PLGA microparticles.

158 retention of vaginal gels and modulating the controlled release of drugs from the gel matrix.

159 Herein we focus on reviewing advances in controlled release of drugs from tissue engineering plat

160 et system (TMUPS), using coated pellets, for controlled release of drugs is an effective therapeutic

161 found widespread use in applications such as controlled release of drugs, cosmetics, inks, pigments o

162 articles (NPs) for differential delivery and controlled release of drugs.

163 Controlled release of E325 was achieved by separately ad

164 The controlled release of each protein allowed them to be de

165 to their unique properties and potential for controlled release of encapsulated drugs and structure-s

166 a gene delivery system for the prolonged and controlled release of EPO.

167 ubic (fcc) FePt nanoparticles (NPs) show the controlled release of Fe in low pH solution.

168 ulation systems can positively influence the controlled release of food ingredients in food and nutri

169 cle based transfection approach functions by controlled release of gene regulatory elements from a 6

170 cell proliferation and viability, while the controlled release of GLN from the PLGA-GLN pellet resul

171 A field study involving the controlled release of groundwater containing dissolved C

172 Controlled release of growth factors, cytokines, and sma

173 these results suggest that coacervate-based controlled release of HB-EGF may serve as a new therapy

174 mouse excisional full-thickness wound model, controlled release of HB-EGF within the wound significan

175 her molecular machines driven by ATP is that controlled release of hydrolysis products is essential f

176 demonstrates targeted delivery, imaging, and controlled release of hydrophobic agents.

177 tractive candidate for the encapsulation and controlled release of hydrophobic nutraceuticals and bio

178 Both nanoparticle formulations provided controlled release of I3C and DIM in PBS medium.

179 Targeted delivery and controlled release of inactive platinum (Pt) prodrugs ma

180 ocarrier-based degradable hydrogels provided controlled release of lactic acid for several hours; how

181 degradable hydrogels were developed for the controlled release of lactic acid in the vagina of BV-in

182 copies of lactic acid per molecule provided controlled release of lactic acid with a maximum release

183 uncharacterized proteases might promote the controlled release of membrane-anchored regulatory prote

184 erve as a transmembrane delivery vehicle for controlled release of membrane-impermeable proteins in l

185 Synaptic transmission requires the controlled release of neurotransmitter from synaptic ves

186 is critical in the retention and maturation-controlled release of neutrophils from the marrow, while

187 Folding occurs upon controlled release of newly synthesized proteins from th

188 Stent-based controlled release of NO donor significantly reduces in-

189 s, including decreased leaching of NO donor, controlled release of NO, and maintenance of ultra-low f

190 To summarize, with increased solubility and controlled release of olive leaf phenolic compounds thro

191 Controlled release of oxygen from small organic molecule

192 timely activation of each device to perform controlled release of pesticides in air.

193 ntially is highly useful in the delivery and controlled release of pharmaceutical agents.

194 e results are likely of use in signaling the controlled release of pharmaceutical payloads.

195 We hypothesized that controlled release of PHCCC from degradable nanoparticle

196 design of reagents and polymers that provide controlled release of phenols in environments that are l

197 merase II (Pol II) to promoters, through the controlled release of promoter-proximally paused Pol II

198 extensively studied to achieve localized and controlled release of protein drugs.

199 (PLGA) has most often been employed for the controlled release of protein formulations because of it

200 the main contributor for the observed highly controlled release of proteins that are otherwise rapidl

201 folds often use synthetic polymers to enable controlled release of proteins, but most synthetic deliv

202 Controlled release of repressor binding led to rapid res

203 of many metazoan genes is regulated through controlled release of RNA polymerase II (Pol II) that ha

204 he unique protecting role of surface sulfur, controlled release of S(2-) from Tu, and formation of NC

205 nto account when formulating, more precisely controlled release of SC injected biopharmaceuticals cou

206 gh comparisons between model predictions and controlled release of several drugs from various-sized m

207 drug-eluting stents (DES), which impart the controlled release of sirolimus or paclitaxel from durab

208 re may also contribute to the spatiotemporal controlled release of some of its components, which part

209 These results suggest that controlled release of STX and similar compounds can prov

210 Synaptic communication requires the controlled release of synaptic vesicles from presynaptic

211 Microencapsulation and controlled release of the biocontrol agent Pantoea agglo

212 t, the prototype contact lenses demonstrated controlled release of the molecules studied, with zero-o

213 cated protein subunits to trigger the highly controlled release of the nascent RNA transcript.

214 inflammatory M1 macrophages concomitant with controlled release of the payload of anti-inflammatory d

215 The controlled release of the probe molecules was investigat

216 h, revealing their ability to participate in controlled release of their constituent nanostructures,

217 IR) has great potential for spatiotemporally controlled release of therapeutic agents, it has been ha

218 anoparticles (NPs) capable of targeting, and controlled release of therapeutic and diagnostic agents.

219 ding stable platforms for imaging agents and controlled release of therapeutic monolayer payloads.

220 Polymer microspheres for controlled release of therapeutic protein from within an

221 nanoconstructs to reach their potential for controlled release of therapeutics and biological cleara

222 l to trigger plant immunity and suggest that controlled release of these molecules upon infection may

223 Controlled release of this unusual C1 product may suppor

224 m through the simultaneous encapsulation and controlled release of two synergistic anticancer drugs u

225 future, local administration and sustained, controlled release of VEGF(165) may decrease amputations

226 Inter-subunit chemical switches modulate the controlled release of virus particles in the unusual hig

227 novel delivery systems for encapsulation and controlled release of volatile allyl isothiocyanate (AIT

228 drogels were employed for immobilization and controlled released of beta-galactosidase.

229 The formulation provided controlled releases of the encapsulated therapeutic comp

230 ch issues of low bioavailability and limited controlled release opportunities are well known and have

231 tions of 3DOM materials, namely sorption and controlled release, optical and electrochemical sensors,

232 protease activity or mechanical forces, with controlled release or activation.

233 We developed a controlled-release oral formulation of DNP, called CRMP

234 nd 2) this depot platform enabled long-term, controlled release over 4weeks (92-272mug/mL of MK2i).

235 ive encapsulation and enable sustained, dose-controlled release over 72 h under conditions mimicking

236 -inhibitor-polymer conjugate formulated into controlled-release particles that maximizes efficacy and

237 C (prednisolone 5 mg/kg/day via subcutaneous controlled-release pellet) or placebo for 14, 28, or 42

238 ubcutaneous substitution of E(2) by means of controlled-release pellets caused a strong increase in t

239 Controlled-release pellets containing equimolar amounts

240 Controlled-release phentermine/topiramate (PHEN/TPM CR),

241 d the OCRMs with triple functions for oxygen controlled-release, phosphorus removal and less impact o

242 port that stabilization of FGF2 levels using controlled release PLGA microspheres improves expression

243 We synthesized a bioconjugate composed of controlled release polymer nanoparticles and aptamers an

244 e therapeutic targeting of drug encapsulated controlled release polymer particles in a cell- or tissu

245 These newer generations of targeted and controlled release polymeric NPs are now engineered to n

246 )-poly(ethylene glycol) (PEG)-functionalized controlled release polymers.

247 crease or decrease of KCNQ5 channel activity controlled release probability through alterations in re

248 As a result of this controlled release process, the length of DNA available

249 indings have implications for all manners of controlled release processes, especially for site-specif

250 For the controlled release Procet 8 formulation, we calculated a

251 optimal formulation based on siRNA loading, controlled release profile, and mRNA knockdown.

252 rable drug delivery systems enable on-demand controlled release profiles that may enhance therapeutic

253 ficiently deliver multiple therapeutics with controlled release properties and increased tumor deposi

254 y of the suture for surgical repair with the controlled release properties of a biodegradable polymer

255 ts were enrolled in the MERIT-HF (Metoprolol Controlled-Release Randomized Intervention Trial in Hear

256 d in an intact form from the scaffold with a controlled release rate and transfect cells in vitro.

257 We achieved controlled release rates of multiple antiretrovirals ran

258 l fiber-optic fluorescence sensor based on a controlled-release reagent for the determination of lith

259 used to connect alcohol-bearing molecules to controlled-release reagents, the linkage described in th

260 the mesoporous silica shell that allowed the controlled release, resulting in a NIR-responsive DNA-ga

261 Analysis of beta-galactosidase activity and controlled release reveals that chitosan-grafted hydroge

262 This review highlights the important role of controlled release science in development of reliable me

263 s been an important field for the Journal of Controlled Release since the early 2000s.

264 Next, we discuss the use of controlled release strategies to tune the balance betwee

265 Accordingly, we developed a controlled release system capable of generating a steady

266 This local controlled release system is capable of shifting the bal

267 Here we used a customized, controlled release system of biodegradable polymeric mic

268 We developed a controlled release system to deliver recombinant periost

269 velopment as a therapeutic requires a robust controlled release system.

270 Controlled release systems and nanoparticles are being i

271 Controlled release systems are an effective means for lo

272 Unfortunately, unlike controlled release systems for drugs, single-administrat

273 Here, we provide an overview of controlled release systems for local delivery and we rev

274 which was accomplished by local placement of controlled release systems that sustain a gradient of th

275 ied in the fields of nanomaterial syntheses, controlled release systems, and drug delivery.

276 Controlled-release systems capable of responding to exte

277 le delivery and discusses efforts to develop controlled-release systems for delivery of biopharmaceut

278 Thus, the inability to stabilize proteins in controlled-release systems represents a major obstacle i

279 Although hydrogels are widely used in controlled-release systems, obtaining extended, uniform

280 Controlled release technologies are often used to supply

281 New controlled release technologies will be needed to contin

282 nsdermal drug delivery (TDD) is a successful controlled release technology.

283 With controlled-release technology, it is now possible to ach

284 Mathematical models of controlled release that span the in vitro to in vivo tra

285 monstrate the potential of these systems for controlled release, the release of Nile Red as a "model

286 Since the early days of the Journal of Controlled Release, there has been considerable interest

287 onporous hybrids drive substrate capture and controlled release through chemical reactivity.

288 gels in biomedical applications ranging from controlled release to cell encapsulation.

289 iramate (7.5/46), or 15 mg phentermine/92 mg controlled-release topiramate (15/92)] to complete a tot

290 treatment [placebo, 7.5 mg phentermine/46 mg controlled-release topiramate (7.5/46), or 15 mg phenter

291 icient polymer photodegradation and remotely controlled release using near-IR laser light at an unpre

292 ucing synthetic formulation that consists of controlled release vehicles for IL-2, TGF-beta and rapam

293 is work, to ultimately develop site-specific controlled release vehicles for NO, the NO donor S-nitro

294 ilities for their application as temperature-controlled release vessels.

295 her evidence for an ion pairing mechanism of controlled release was provided through the measurement

296 evice for dry reagent storage and subsequent controlled release, we tested this device with the malar

297 ion (i.e., fractional uptake of enzyme), and controlled release were studied as a function of pH and

298 nd prospects of recombinant polymers used in controlled release will be reviewed.

299 Light-activatable drugs offer the promise of controlled release with exquisite temporal and spatial r

300 sembling peptide nanofibers (NFs) to provide controlled release within the myocardium.