ライフサイエンスコーパス: contusion

1 e than 24 hours, subdural hematoma, or brain contusion).

2 1-28 days following a moderate thoracic (T9) contusion.

3 nical management and pathophysiology of lung contusion.

4 athogenesis of sterile injury following lung contusion.

5 omote neurological recovery from spinal cord contusion.

6 reduced regardless of the distance from the contusion.

7 injury models: transection, compression, or contusion.

8 motor cortex and brainstem after spinal cord contusion.

9 ired only in the area immediately around the contusion.

10 e acute inflammatory response following lung contusion.

11 s injected into wild-type mice prior to lung contusion.

12 ate in the pathogenesis of brain edema after contusion.

13 tic and injured cells at 48 h after cortical contusion.

14 n cell survival and apoptosis after cortical contusion.

15 patients, especially patients with pulmonary contusion.

16 axis of the cord at 1, 2, 3 and 4 days after contusion.

17 d controls only in structures ipsilateral to contusion.

18 her in patients and wild-type mice with lung contusion.

19 mice received a moderate midthoracic spinal contusion.

20 atients who underwent surgery for a cerebral contusion.

21 for proinflammatory cytokines following lung contusion.

22 ute inflammatory response and injury in lung contusion.

23 driver of acute inflammation following lung contusion.

24 n central neuropathic pain after spinal cord contusion.

25 67 in newly born rats or after a spinal cord contusion.

26 tmortem lung samples from patients with lung contusion.

27 (DTI) to identify axonal injury distant from contusions.

28 nt injuries and 27 (22.0%) had isolated bone contusions.

29 ents were documented in the cases with these contusions.

30 ions by 2 h after either left or right sided contusions.

31 nd functional recovery in rats with thoracic contusions.

32 cic (T9) spinal cord 1 week after a moderate contusion (10 gm, 12.5 mm, NYU impactor).

33 f CBF in the cortex contralateral to a focal contusion, 24 h after the event.

34 ral degeneration and apoptosis and a smaller contusion 3 days post-injury than wild type littermates.

35 respiratory distress syndrome (8%, 3 of 40), contusion (3%, 1 of 40), and unknown (3%, 1 of 40).

36 ebral disk edema, and one patient had a cord contusion, a ligamentous injury, and an intervertebral d

37 Nine days after contusion, a Vitrogen matrix +/-one million MSC was inje

38 at infiltrate the brain after nerve crush or contusion actually protect neurons from injury.

39 g cardiopulmonary disorders (e.g., pulmonary contusion, acute respiratory distress syndrome, atelecta

40 g cardiopulmonary disorders (e.g., pulmonary contusion, acute respiratory distress syndrome, atelecta

41 By contrast, blunt contusion affected progression of a subsequent local GAS

42 rison of the temporal outcome patterns among contusion and compression injuries in rats and other spe

43 cans enables accurate identification of lung contusion and differentiation of contusion from other ca

44 I in two different injury mouse models-focal contusion and diffuse concussive injury.

45 1ra levels very similar to those produced by contusion and glutamate.

46 man trials if they elicit benefits in severe contusion and larger animal models and pass the test of

47 nearly all neurons subacutely after cortical contusion and persists for at least 2 weeks thereafter.

48 n with attenuated brain edema after cerebral contusion and to reduce brain edema after focal cerebral

49 Long-Evans rats received unilateral cortical contusion and were tested in the Morris Water Task (MWT)

50 ncrease at the lesion site after right-sided contusions and 22% and 32% increases in the contralatera

51 tentionally injured women had a total of 434 contusions and abrasions, 89 lacerations, and 41 fractur

52 tracranial abnormalities such as haematomas, contusions and cerebral oedema.

53 Any additional contusions and internal derangements were documented in

54 aring was seen at CT in 38 (95%) of the lung contusions and none of the cases of atelectasis, lacerat

55 Sixty percent of the patients had pulmonary contusion, and 59% were cigarette smokers.

56 torsion, hematoma, spermatic cord injury or contusion, and epididymal, scrotal, and urethral injurie

57 per respiratory tract infection, soft tissue contusion, and no obvious portal of entry.

58 matomas, one pneumocephalus, one hemorrhagic contusion, and one subarachnoid hemorrhage.

59 pulmonary embolism, myocarditis, myocardial contusion, and renal failure, can be associated with an

60 e most prevalent diagnoses were lacerations, contusions, and fractures.

61 Rodent models of cortical contusion are being used effectively to clarify the mole

62 These contusions are almost always associated with a far perip

63 The anti-CD11d mAb treatment reduced contusion areas as well as overall contusion volume comp

64 Adolescents may have the same pattern of contusions as adults but may maintain an intact ACL owin

65 were subjected to a standardized weight drop contusion at T-8 (10 gm x 2.5 cm) and NBQX (15 nmol) or

66 were subjected to a standardized weight-drop contusion at T8 (10 gm x 2.5 cm).

67 After a spinal cord contusion at T9 in adults, the area of alpha1beta1 integ

68 Following contusion at the T8 spinal level (made using the Infinit

69 giopoietin-1 mimetic following a spinal cord contusion at thoracic level 9 in mice rescued epicentre

70 hilar interneurons 8-13 weeks after cortical contusion brain injury in transgenic mice that express e

71 orm in microvessels surrounding the cortical contusion by 24 h post-injury.

72 Ocular contusion can produce severe lesions, which if not treat

73 in the management of patients with cerebral contusion (CC) following severe traumatic brain injury (

74 ral activation pathways, lung injury in lung contusion demonstrated increased p38 mitogen-activated p

75 This model of mild contusion did not provide a focus for initiation or seed

76 of contrast extravasation and laceration or contusion extending into the hepatic vein(s), inferior v

77 ors, was infused into rats after spinal cord contusion for 28 days.

78 e acetylcysteine group, and aortic aneurysm, contusion, forearm fracture, and worsening IPF in the pl

79 Seven of the 366 patients had cervical cord contusions, four patients had ligamentous injuries, thre

80 ion of lung contusion and differentiation of contusion from other causes of lung opacification in chi

81 Female adult C57Bl/6 mice with a spinal cord contusion had progressively more ADAM8 (CD156) immunosta

82 Five patients with bone contusions had an intact ACL at MR imaging.

83 us, 28% of the 18 patients with typical bone contusions had intact ACLs.

84 After contusion, HO-1 was induced in both gray and white matte

85 cellular protein function and the structural contusion implies a model in which newly synthesized, in

86 NRP/GRP) into a midthoracic injury 9 d after contusion improved bladder and motor function, diminishe

87 neuroprotective after a thoracic spinal cord contusion in adult rats.

88 Ocular contusion in childhood may not be reported by children.

89 ibutes to secondary damage after spinal cord contusion in mice and suggest that LPA1 antagonism might

90 ed 10-20 years) were reviewed to detect bone contusions in the posterolateral tibial plateau or the l

91 Specifically, contusion increased emm1 GAS dissemination locally to dr

92 Lung contusion induced profound global hypoxia rapidly.

93 linically-relevant rodent models of cervical contusion-induced neuropathic pain that result in chroni

94 role of the classical complement pathway in contusion-induced SCI, male C1q knock-out (KO) and wild-

95 the lesion epicenter of subchronic (10 days) contusion-injured rats.

96 rats received either sham or T9 spinal cord contusion injuries and were implanted with blank or test

97 reactive lymphocytes after SCI, we performed contusion injuries in the thoracic spinal cord of transg

98 ats with thoracic spinal cord transection or contusion injuries induce significant descending cortico

99 57Bl/6 and 129X1/SvJ mice received identical contusion injuries to the mid-thoracic spinal cord and w

100 Contusion injury (25 mm) to spinal cord T10 was produced

101 , we subjected one group of rats to cortical contusion injury (CCI) and another to transient middle c

102 ificantly reduced brain edema after cortical contusion injury (CCI) in rat 5h post-injury.

103 als were prepared with a unilateral cortical contusion injury (CCI).

104 s (OEC) into the lesion cavity 6 weeks after contusion injury (NYU impactor device, 25 mm height sett

105 Following spinal cord contusion injury (SCI) in the rat, certain supraspinal p

106 Spinal cord contusion injury (SCI) is known to induce pain-related b

107 as designed to determine effects of cortical contusion injury and d-AMPH on CMRglu in cortical and su

108 ury pathology in adult rats following spinal contusion injury and LV-ChABC treatment, with reduced ca

109 37tg) and wild-type (WT) mice to spinal cord contusion injury and then treated them with recombinant

110 gue-Dawley rats received a moderate thoracic contusion injury and were divided into three groups: ope

111 Female rats received a contusion injury at T8/9.

112 tissue of ablating reactive astrocytes after contusion injury generated by controlled cortical impact

113 We report that, after spinal cord contusion injury in adult female mice, the biosynthesis

114 or, promotes recovery after traumatic spinal contusion injury in mice, a benefit achieved in part by

115 n-4 (AQP4) water channels after experimental contusion injury in mice, a clinically relevant animal m

116 TBI was induced by cortical contusion injury in Sprague-Dawley rats.

117 hange in bacterial morphology observed after contusion injury in the muscle model.

118 ents 9 months after moderate thoracic spinal contusion injury in the rat.

119 n alphaB-crystallin for the first week after contusion injury leads to sustained improvement in locom

120 ng either spinal cord dorsal column crush or contusion injury models, miR-155 deletion improves indic

121 sthetized and subjected to a 0.5-mm cortical contusion injury of the somatosensory cortex.

122 s with a thoracic spinal cord transection or contusion injury result in substantial corticospinal and

123 Contusion injury resulted in large lesions, with no sign

124 y relevant rat model of thoracic spinal cord contusion injury to examine the effect of varying the de

125 Unilateral contusion injury to the sensorimotor cortex causes, amon

126 Rats received a contusion injury to the spinal cord followed by treatmen

127 T-cell migration and activation after spinal contusion injury were characterized using B10.PL (wild-t

128 the lesion 12 weeks after mouse spinal cord contusion injury were fully remyelinated.

129 background (BUB) received a mild-moderate T9 contusion injury with the Infinite Horizon impactor.

130 Finally, in a model of spinal contusion injury, miR-155 deletion improves locomotor fu

131 ces neurological recovery from a spinal cord contusion injury, showing its potential clinical impact.

132 Using a new model of mild contusion injury, we set out to determine the effect of

133 ions in astrocyte hypertrophy after cortical contusion injury.

134 Sprague Dawley rats underwent T9 spinal cord contusion injury.

135 Sprague Dawley rats underwent T9 spinal cord contusion injury.

136 or 42 days following midthoracic (T9) spinal contusion injury.

137 male Sprague Dawley rats underwent T9 spinal contusion injury.

138 ion of apoptosis in rat brain after cortical contusion injury.

139 ared normal uninjured tissue with that after contusion injury.

140 ured spinal cords after a moderate, thoracic contusion injury.

141 the rat spinal cord following a standardized contusion injury.

142 rns of adjacent spinal gray matter following contusion injury.

143 or increased pain in a mouse model of spinal contusion injury.

144 s of spinal cord demyelination and traumatic contusion injury.

145 ion was initiated 3 months after spinal cord contusion injury.

146 hs of treatment between 4 and 6 months after contusion injury.

147 nd facet fractures, vertebral body and facet contusions, intervertebral disk herniations, ligamentum

148 Contusions involving the posterior lip of the medial tib

149 Management of severe pulmonary contusion is a challenge for clinicians.

150 Lung contusion is a major risk factor for the development of

151 Lung contusion is a major risk factor for the development of

152 Unilateral cerebral contusion is associated with an early (30 min) increase

153 Early recovery from incomplete spinal cord contusion is improved by prolonged stimulation of the hi

154 in NE release following unilateral cerebral contusion is protective and that this may act to stabili

155 ocytes was characterized throughout a spinal contusion lesion in Sprague-Dawley and Lewis rats by usi

156 riptional expression patterns in midcervical contusion lesion sites between 1 and 90 d postinjury of

157 to pulmonary hypertension, greater pulmonary contusion lesion size, and stiffer lungs in this porcine

158 are reduced in spinal cord tissue following contusion lesion.

159 ocomotor function is associated with smaller contusion lesions and decreased accumulation of inflamma

160 l analysis showed a large extent of cortical contusion lesions, including both the sensory and motor

161 survive following 50 and 12.5-mm weight drop contusion lesions, respectively, albeit with a reduced i

162 ale rats had unilateral somatosensory cortex contusions made with a 5 mm diameter impact piston.

163 resence of blunt traumatic injury, pulmonary contusion, massive transfusion, and flail chest injury (

164 We used a contusion model (N.Y.U. Impactor) to initiate the early

165 A mild focal cortical contusion model in adult mouse sensory-motor cortex was

166 Using a contusion model of SCI, we found that intravenous delive

167 Thus, we used a spinal contusion model to examine the spatiotemporal expression

168 employed an adaptation of the focal cortical contusion model.

169 al cell counts in the cortex adjacent to the contusion (n = 11).

170 se lesion in midbrain (n = 6), temporal lobe contusion (n = 2), posterior cerebral artery (n = 3), an

171 In chronic rat spinal contusion, NgR1 decoy treatment from 4 to 6 months after

172 l-computer interface in rats with a cervical contusion of the spinal cord, we synchronized intraspina

173 es were occult fracture (P<.01), bone marrow contusion of the vertebral body (P=.01), muscle strain (

174 ns for knee trauma was conducted to identify contusions of the posterior lip of the medial tibial pla

175 The effect of contusion on emm1 iGAS infection was assessed in three m

176 njury, we set out to determine the effect of contusion on iGAS bacterial burden, phenotype, and host

177 One or more brain contusions on MRI, and >/=4 foci of hemorrhagic axonal i

178 ent study, the effect of mid-thoracic spinal contusions on the rat estrous cycle was examined.

179 Following spinal cord contusion or exposure to elevated glutamate, concentrati

180 neuronal loss in the hippocampus and minimal contusion or infarction at the impact site.

181 d diaphragm, sternal fracture, and pulmonary contusion or laceration seen on radiographs.

182 reference for ligament and disk injuries and contusion or occult fracture) for traumatic injuries.

183 nical factors, such as compression, stretch, contusion or transection.

184 ring brain adjacent to evacuated hemorrhagic contusions or underlying evacuated subdural hematomas wa

185 In brain tissue adjacent to cerebral contusions or underlying subdural hematomas, even brief

186 21) in experimental spinal cord hemisection, contusion, or transection on locomotor recovery measured

187 s underwent polytrauma (femur fractures/lung contusion, P), hemorrhage (mean arterial pressure 25-30

188 Female rats with moderate spinal cord contusion participated in treadmill training, swim train

189 Spinal contusion pathology in rats and mice is distinct.

190 located 4.5, 13.5, and 22.5 mm away from the contusion (PC(4.5), PC(13.5), and PC(22.5), respectively

191 Skin-related events included abrasions, contusions, pressure ulcers and lacerations.

192 teral cerebellum after right- and left-sided contusions, respectively.

193 After pulmonary contusion, resuscitation with diaspirin cross-linked hem

194 Adult male Sprague-Dawley rats underwent contusion SCI at the T9 thoracic level.

195 gest that AQP4 plays a protective role after contusion SCI by facilitating the clearance of excess wa

196 PDGFRalpha), Olig2+, and P0+ cells following contusion SCI in mice.

197 cterized 2 rat models of unilateral cervical contusion SCI that behaviorally result in chronic persis

198 ns in adult rats 1 month after sham surgery, contusion SCI, and SCI treated with a selective inhibito

199 r mice following unilateral midcervical (C4) contusion SCI, numbers of GLT1-expressing astrocytes in

200 mpared with wild-type (WT) littermates after contusion SCI.

201 microdialysis sampling immediately following contusion SCI.

202 In nontransgenic animals, crush or contusion SCIs routinely exhibit regions of degenerated

203 Rats with bilateral contusions showed increased levels of edema on days 1, 3

204 Unilateral sensorimotor cortical contusion significantly decreased ipsilateral hippocampa

205 ury site or (2) a PNG that bridged a chronic contusion site with a second, more distal injury site.

206 ve into a highly relevant, chronic, cervical contusion site with ChABC treatment of the glial scar an

207 nd hypothalamic regions, and surrounding the contusion site.

208 Animals were sacrificed and contusion size and GDNF protein expression measured.

209 hough combining it with l-arginine decreased contusion size, it did not enhance behavioral recovery.

210 Contusion spinal cord injury (SCI) at T8 produces respir

211 MMP-9 increased rapidly after a moderate contusion spinal cord injury, reaching a maximum at 24 h

212 al cord by microdialysis in association with contusion spinal cord injury.

213 parameters in 21 TBI patients with cerebral contusions studied during the acute phase (3.1 +/- 2.1 [

214 Other CT characteristics of lung contusion such as location, shape, and confluence were a

215 l is one of the most commonly used models of contusion TBI.

216 Lung contusions tended to be posterior (60%), crescentic (50%

217 rginine post-CCI had a significantly smaller contusion than injured rats who did not receive any trea

218 tly because even relatively mild spinal cord contusions that produce only minor permanent locomotor d

219 After the contusion, the area of alpha6beta1-stained blood vessels

220 By 6 days post-contusion, the hypometabolism partially reversed in all

221 tions: 13 of these patients had typical bone contusions; the other two had no bone abnormalities but

222 ness cartilage loss, which supports the bone contusion theory of SC formation.

223 Contusion to soft tissue had no effect on bacterial burd

224 tradiol filled implants, prior to a moderate contusion to the spinal cord.

225 tal conditions such as sprains, strains, and contusions, topical NSAIDs are associated with greater p

226 that a major portion of SCI patients suffer contusion trauma to cervical spinal cord.

227 conditions, including multiple sclerosis and contusion-type spinal cord injury.

228 d brain function recovery and lessened brain contusion volume after trauma.

229 Contusion volume and hippocampal survival were assessed

230 Contusion volume and neuron density in the CA1 and CA3 r

231 t reduced contusion areas as well as overall contusion volume compared to vehicle treated animals.

232 osttraumatic hypoxia significantly increased contusion volume compared with traumatic brain injury-no

233 enon improves neurologic outcome and reduces contusion volume following traumatic brain injury in mic

234 omplicated by secondary ischemia, increasing contusion volume from 1 to 30.6 mm3 in the animals that

235 L-arginine treatment reduced the contusion volume from a median value of 5.28 mm3 to 0.63

236 Contusion volume was larger in hypothermic vs. normother

237 For example, overall contusion volume was reduced from 2.7+/-0.5 mm(3) (mean+

238 Contusion volume was significantly (p < 0.05) reduced in

239 n treatment significantly (p < 0.05) reduced contusion volume when xenon was given 15 minutes after i

240 utcome score, 2) histological measurement of contusion volume, and 3) analysis of locomotor function

241 rapid rewarming (15 mins) failed to decrease contusion volume, those animals undergoing a slow rewarm

242 Bcl-2 transgenic mice had smaller contusion volumes and increased numbers of surviving neu

243 led 3 days after traumatic brain injury, and contusion volumes were quantitatively assessed.

244 demonstrated significantly (p <.03) reduced contusion volumes, compared with hypoxic normothermic ra

245 The specific medial tibial contusion was demonstrated in 25 of 215 (12%) knee MR ex

246 A new model of mild contusion was developed using a weight drop device and c

247 Nonlethal closed-chest unilateral lung contusion was induced in a hypoxia reporter mouse model

248 Cortical contusion was induced in male Wistar rats with a pneumat

249 Unilateral lung contusion was induced in toll-like receptor 3 (-/-), TIR

250 olar lavage and serum samples following lung contusion was measured.

251 The extent of lung injury following lung contusion was significantly reduced in conditional knock

252 bpV(phen) treatments started 4 h after contusion were fully effective.

253 Lateral compartment contusions were noted in 24 (96%) cases.

254 omputed tomographic (CT) features of 40 lung contusions were reviewed for the presence of subpleural

255 t risk factors for later seizures were brain contusion with subdural hematoma, skull fracture, loss o

256 All animals underwent spinal cord contusion with the NYU-Impactor by a 12.5-mm weight drop