ライフサイエンスコーパス: convergent

1 x renders its linear halogen-bond donors non-convergent.

2 fishery, documented here, appears strikingly convergent.

3 accomplished utilizing a stereoselective and convergent [2 + 2] glycosylation strategy inclusive of a

4 Herein, we describe the convergent [3+3] synthesis of the hexasaccharide repeati

5 The transformation provides convergent access to alpha-benzyl-alpha,alpha-difluoroke

6 Non-oxidative, regioselective, and convergent access to densely functionalized oxazoles is

7 ovo lipogenesis, and this occurs through the convergent activation of the mechanistic target of rapam

8 ABSTRACT: Convergent activity in neural circuits can generate chan

9 mong mangroves is common, the possibility of convergent adaptation in their genomes is quite intrigui

10 es to the unrelated Chlamydiales, suggesting convergent adaptation to an obligate intracellular lifes

11 Our study thus shows that convergent adaptation to the same environment can involv

12 n gradients, as this spontaneously generates convergent alignments.

13 at spontaneously generate tandem rather than convergent alignments.

14 soil bacterial potential function is highly convergent along the latitudinal gradient and there were

15 Here, we provide convergent anatomical and physiological evidence that ax

16 ed thought was additionally varied between a convergent and a divergent thinking task.

17 The first one is convergent and based on the LDA-induced 4,4'-dimerizatio

18 Internal consistency reliability, convergent and discriminant validity were found to be go

19 There was good convergent and discriminant validity, with significant a

20 selection as the primary force to shape the convergent and divergent changes between Chinese domesti

21 Here, we review recent research on convergent and divergent evolution in pitcher plant trap

22 s encountered at higher generations, in both convergent and divergent protocols because of the multis

23 Taken together, our findings reveal convergent and divergent roles for FUS, TAF15 and TDP-43

24 A convergent and flexible strategy for the stereoselective

25 This convergent and modular assembly of intact cyclotryptamin

26 This total synthesis is highly convergent and modular, thus offering opportunities to s

27 xplanation may be an unusually high level of convergent and parallel evolution (homoplasy).

28 spiracid-3 is revised based upon an original convergent and stereoselective total synthesis of the na

29 A convergent and stereoselective total synthesis of the pr

30 e starting building block for the divergent, convergent, and double-stage convergent-divergent iterat

31 Our convergent approach couples two achiral fragments of sim

32 Key transformation in this convergent approach involves Ph3P-I2-mediated formation

33 The transformation constitutes a unique, convergent approach to the asymmetric synthesis of valua

34 The convergent approach unites two highly complex fragments

35 lithromycin, have been synthesized using our convergent approach.

36 th native and pooled range records predicted convergent areas.

37 final forms, thus providing rapid and highly convergent assembly at the challenging quaternary stereo

38 thetic route to macrolide antibiotics by the convergent assembly of simple chemical building blocks,

39 Analogues WN-2-WN-7 are prepared through convergent assembly of the chromane-containing fragment

40 t proportional, variant electrode area), to "convergent" at long time where its response now tends to

41 e preferential filopodial activity along the convergent axis observed in many tissues.

42 s of this behavior, we use position averaged convergent beam electron diffraction in scanning transmi

43 We use convergent-beam electron diffraction to quantify grating

44 Our study demonstrates convergent biology amongst variants representing differe

45 iosynthesis of cahuitamycin C proceeds via a convergent biosynthetic pathway, with one of the steps a

46 ed the repeated evolution of the complex and convergent C4 trait.

47 We have shown that convergent caffeine production, surprisingly, has evolve

48 o the evolutionary history of genes underlie convergent changes at the cellular process level across

49 Patients receiving l-methylfolate exhibited convergent changes in ventromedial prefrontal physiology

50 A convergent chemoenzymatic approach for sequential instal

51 g activity for both neocortex and the model: convergent clusters comprised of fan-in triangle motifs,

52 l development and nutrient transport display convergent co-option by placental and mammary gland cell

53 test-retest reliability) and validity (i.e., convergent, concurrent, and predictive validity) in Kore

54 iance compared with the separate, tandem and convergent configurations, and this higher covariance is

55 This method enables convergent construction of type II polyketide ring syste

56 gio- and diastereoselective processes enable convergent construction of type II polyketide substructu

57 ings, we report here a sequence wherein: (1) convergent cortical downstates lead thalamic downstates;

58 of the claustrum suggests an integration of convergent cortical inputs, gated by GABAergic circuits.

59 lel occurrence of a suite of morphologically convergent craniodental characteristics in three herbivo

60 Convergent cross mapping (CCM) is a non-linear approach

61 as examined using cross-wavelet analyses and convergent cross mapping (CCM).

62 direct cause and effect relationships using convergent cross mapping reveal that accretion rates are

63 Here, we use convergent cross mapping, a robust test for causality th

64 ical salience of the events that provide the convergent cross-modal inputs.

65 Convergent CTCF insulator sites flanking the HLA-A gene

66 Recently, we reported a convergent cyclopropanation-Cope approach to the core of

67 vious reports, these initial results provide convergent data for a role of regular sugar-sweetened be

68 inter-rater reliability, construct validity (convergent, discriminant, and known group), predictive v

69 lectual disability (ID) patients that showed convergent disruptive effects on AMPAR recycling and glu

70 the divergent, convergent, and double-stage convergent-divergent iterative methods for the synthesis

71 oss of bitterness phenotypes associated with convergent domestication of wild cucurbits.

72 elanogaster Altogether, our work unveils the convergent emergence of a Drosophila-like dosage compens

73 As convergent end point, redox dysregulation has successful

74 This work establishes a convergent entry to the pleuromutilins and provides a fo

75 Here we report convergent evidence for decreased mu-opioid receptor (MO

76 For example, increasing convergent evidence from a range of methodologies sugges

77 Using convergent evidence from animal and human transcriptomic

78 There is now considerable convergent evidence from multiple methodologies and clin

79 These data provide convergent evidence of the importance of the hippocampus

80 Convergent evidence suggests that schizophrenia is a dis

81 This provides convergent evidence that declarative memory decisions ca

82 to be one of the most remarkable examples of convergent evolution across the plant kingdom.

83 40 The pitcher trap is a striking example of convergent evolution across unrelated carnivorous plant

84 Rv2813-2814c, and Rv2815-2816c as targets of convergent evolution among transmissible strains.

85 elatively low levels of diversity as well as convergent evolution at multiple loci dispersed across t

86 a parallel mutation, potentially indicating convergent evolution at the base pair level.

87 Additional examples of convergent evolution between birds and mammals are the l

88 arches and phylogenetic analyses demonstrate convergent evolution between effectors from divergent pa

89 also present, ruling out the possibility of convergent evolution between hagfish and gnathostomes.

90 vasive that they are unlikely to result from convergent evolution but argue instead that early verteb

91 specificity as GalB, providing an example of convergent evolution for catalytic conversion of a commo

92 ancestral polymer or arose multiple times by convergent evolution from monomeric actin-like proteins.

93 transcriptional states prompts the idea that convergent evolution generates phenotypically similar ce

94 However, convergent evolution has clearly occurred in the island

95 tent covary with rrn copy number, suggesting convergent evolution in response to resource availabilit

96 Auanema species display convergent evolution in some features with parasitic nem

97 argeting sequence, and this motif emerged by convergent evolution in toothed whales, the only other m

98 Convergent evolution is a process that has occurred thro

99 notypes and lineages, and, most notably, the convergent evolution observed in recent years.

100 y modulation and provide a mechanism for the convergent evolution of bleat-like calls in mammals.

101 nse response of their host plants, including convergent evolution of complex pathways for production

102 multiple origins, critical genes underlying convergent evolution of different weedy types can be fou

103 Convergent evolution of end wall types was demonstrated

104 impairs tumor growth but later leads to the convergent evolution of fast-growing clones with mitotic

105 Furthermore, we show evidence of convergent evolution of G gene sequence duplication and

106 this study, we identified genetic markers in convergent evolution of M. tuberculosis toward enhanced

107 called 'superclade' is an artefact linked to convergent evolution of morphological characters associa

108 milar molecular tools have been used for the convergent evolution of placentation in independently ev

109 together with phylogenetic analysis, suggest convergent evolution of plant and fungal STSs, and also

110 Our results provide an example of the convergent evolution of plant specialized metabolism.

111 To what extent is the convergent evolution of protein function attributable to

112 We hypothesize that convergent evolution of protein sequence and temporal ge

113 g events for PUF3 orthologs, independent but convergent evolution of PUF4/5 binding specificity and t

114 We propose a mechanism for the convergent evolution of secondary walls in which the dep

115 Our data provide evidence for convergent evolution of skull and thus brain shrinkage a

116 Convergent evolution of tetrodotoxin (TTX) resistance, a

117 and phylogenetic analyses of OsONS1 suggest convergent evolution of the alpha-onocerin pathways.

118 The frequent occurrence of convergent evolution of these complex functional novelti

119 Convergent evolution of this loss of function was observ

120 Convergent evolution provides a type of natural replicat

121 des remain largely unknown, but its repeated convergent evolution raises the question of whether it m

122 specifically designed for low diversity and convergent evolution regimes.

123 Gene duplication and convergent evolution within a genome provide obvious bio

124 ghlight research that reveals to what extent convergent evolution, and its inherent predictability, m

125 internationally dispersed clones, linked by convergent evolution, is surprising for an environmental

126 Convergent evolution, the acquisition of morphologically

127 Thus, our data indicate that through convergent evolution, the parasite has acquired a protei

128 workshop demonstrated an interesting case of convergent evolution, where organizations that were very

129 om morphological characters, in part because convergent evolution, which confounds phylogenetic recon

130 y distinct, indicating multiple instances of convergent evolution.

131 nt vertebrate taxa that has evolved based on convergent evolution.

132 d range of photosynthetic eukaryotes through convergent evolution.

133 similar dynamic properties, possibly through convergent evolution.

134 Pancrustacea or an extraordinary example of convergent evolution.

135 to the bacterial one and must have arisen by convergent evolution.

136 ta exemplify functional, but not structural, convergent evolution.

137 and cognitive continuity with radiation and convergent evolution.

138 sis that this phenomenon is a consequence of convergent evolution.

139 atal spiny projection neurons (SPNs) receive convergent excitatory synaptic inputs from the cortex an

140 splayed heightened aggression accompanied by convergent expression changes in specific genes associat

141 Both phenotypes represent convergent extension (CE) defects, arising from impaired

142 Convergent extension (CE) is a fundamental morphogenetic

143 Oriented cell division (OCD) and convergent extension (CE) shape developing renal tubules

144 solution of multicellular rosettes can drive convergent extension (CE) type cell rearrangements durin

145 in vertebrates and invertebrates, including convergent extension (CE).

146 cell interactions and planar polarity during convergent extension in the Drosophila embryo.

147 Convergent extension movements during vertebrate gastrul

148 complex and involves cellular events such as convergent extension, apical constriction and interkinet

149 that include cell elongation, intercalation, convergent extension, proliferation, and differentiation

150 Here, we show that Akt activation is a convergent feature of acquired EGFR tyrosine kinase inhi

151 te centrifugal cholinergic input with highly convergent feedforward sensory input.

152 These convergent findings from mouse and hiPSC SZ models provi

153 Convergent findings indicate that cortical gamma-aminobu

154 There were convergent findings on a measure of clinical post-trauma

155 These convergent findings support CNIH3 involvement in the pat

156 r factor of activated T cells c1 (NFATc1) is convergent for normal bone homeostasis.

157 ccharyl bromide as glycosylation donors in a convergent fragment coupling strategy.

158 The evolution of a convergent fragment-coupling strategy for the enantiosel

159 n import and how these elements may permit a convergent function of this highly variable class of tar

160 and of the evidence in the field to date, a convergent functional evidence score prioritizing biomar

161 We then used a Convergent Functional Genomics (CFG) approach to priorit

162 Third, we used a convergent functional genomics (CFG) approach to priorit

163 wo clinical instruments in the form of apps, Convergent Functional Information for Suicidality (CFI-S

164 c measures as apps (for suicide risk (CFI-S, Convergent Functional Information for Suicidality) and f

165 l contingency in forming new cell types with convergent functionality.

166 nderlying functional hypothesis is that this convergent funneling of the full blend of pectinases con

167 es, we find that Y-linked genes have evolved convergent gene functions associated with testis express

168 evisiae Differences in PAS placement between convergent genes lead to starkly different antisense tra

169 The convergent genetic changes, contributing physical and mo

170 , we identified ENC1 and UNC5C as genes with convergent genetic, epigenetic, and transcriptomic evide

171 Convergent genetic, pharmacological and neuroimaging evi

172 in IP3-mediated Ca(2+) signaling represent a convergent hub function shared across the spectrum of au

173 Convergent IC local circuit (processing) neurons have en

174 fter optimization, all tools provided highly convergent identification and reliable quantification pe

175 accessed via application of our strategy for convergent imidazolone synthesis from a common thioester

176 Convergent increases in hemoglobin-oxygen affinity were

177 tes ( approximately 60 spikes s(-1) ) during convergent inhibition from spontaneously active Purkinje

178 ll spiking when the coherence (synchrony) of convergent inhibition is increased.

179 tly in several mammalian species, suggesting convergent innovation of Nup-mediated transcription regu

180 Retinal ganglion cells (RGCs) receive convergent input from bipolar cell types with different

181 Convergent input from different presynaptic partners sha

182 lateral HVC, and each HVC location receives convergent input from each afferent nucleus in parallel.

183 Unexpectedly, these neurons receive convergent input from OA neurons and P1 neurons, a popul

184 source of movement-related activity-provide convergent input onto some of the same auditory cortical

185 shaw cells receive, at least in the neonate, convergent inputs from sensory afferents (likely Ia) and

186 ural circuits may switch dynamically between convergent inputs is through temporal organization refle

187 pecificity could be readily accomplished via convergent intramolecular coevolution with only modest a

188 The convergent lens has a plano-concave geometry, in contras

189 tain parts of the landscape that are low and convergent, likely through influences on plant-available

190 pothesis, Laland and colleagues rely on four convergent lines of evidence drawn from behavioral and n

191 cific lncRNAs and that CAT7/cat7l represents convergent lncRNAs that independently evolved to tune PR

192 iness in both species, providing evidence of convergent local adaptation despite 140 million years of

193 th neurons that responded to both defined as convergent (local reflex processors).

194 cessible via traditional linear methods in a convergent manner to better understand solubility and co

195 an be used to install functional groups in a convergent manner, which would otherwise be challenging

196 ylbenzene, forming two novel dendrimers in a convergent manner.

197 tradiol and catecholamines, we observed that convergent MAPKs signalling pathways facilitate P-UAEC p

198 ed onto its respective EF-P through entirely convergent means.

199 C. elegans longevity pathways, as part of a convergent mechanism focused on the nucleolus.

200 Our findings further imply a convergent mechanism of inhibition of TLR signaling by T

201 via gene mutation or altered expression as a convergent mechanism regulating susceptibility to epilep

202 tein antigenic variants is an evolutionarily convergent mechanism used by bacterial pathogens to esca

203 mors in vivo Overall, our results illustrate convergent mechanisms of PI3Kalpha and CDK4/6 blockade o

204 to the probabilistic modeling parameters, B) convergent metabolic states are solutions to the determi

205 Dominant variants at the hotspots arose via convergent microevolution, appear to be immune-escape va

206 a conserved molecular mechanism can control convergent morphogenesis through different cell behaviou

207 ident at closely spaced promoters supporting convergent mRNA transcription.

208 teasome core particle (CP) is blocked by the convergent N termini of alpha-subunits.

209 Next, we demonstrate convergent NeanderScore-related findings in the brain (m

210 These data reveal convergent neurobiological characteristics of PTHS mouse

211 Together, our data pinpoint convergent neurobiological features in PTHS mouse models

212 se (P<0.05 versus short CI), particularly on convergent neurons (P<0.05), as well as neurons receivin

213 In control and MI, convergent neurons represented the largest subpopulation

214 afferent neural signals, and remodelling of convergent neurons, represents a 'neural signature' of i

215 These convergent neurophysiological and behavioural effects un

216 erived neurotrophic factor (BDNF) are highly convergent on brain function.

217 ression data showed that candidate genes are convergent on eight shared modules with specific layer e

218 of angiosperms) have distinct anatomies but convergent optical properties; they all produce angle-de

219 volution of protein function attributable to convergent or parallel changes at the amino acid level?

220 tigen-experienced repertoire showed signs of convergent paired light-chain genetic signatures, includ

221 for future research focused on establishing convergent pathogenic mechanisms relevant to the potenti

222 the pif3, pif4 or pif5 mutations, suggesting convergent pathways.

223 In contrast, we found convergent patterns of gene retention and loss among the

224 Through a convergent pharmacophore approach, we synthesized alpha-

225 the frequency and predictability with which convergent phenotypes arise via the same or multiple pat

226 rtaining the proximate mechanisms underlying convergent phenotypes, less is known about the frequency

227 aptation to a new environment often leads to convergent phenotypic changes whose underlying genetic m

228 results suggest that CRMP-2 in the NAc is a convergent point that receives inputs from two signaling

229 vor the efficient funneling of pectinases at convergent points within the cell.

230 For convergent promoters, stochastic simulations indicate th

231 uclei and cortex underlies classic models of convergent Purkinje influence on cerebellar output.

232 , dual model for insect wing origins and the convergent reduction of notal fusion in more derived cla

233 at during the completion of DNA replication, convergent replication forks form a palindrome-like stru

234 A concise and convergent route for the stereoselective total synthesis

235 A convergent route to eravacycline (1) has been developed

236 A convergent route to the C1-C15 subunit of sorangicin A i

237 Genetic comparisons among three temporally convergent samples revealed that they were homozygous an

238 n, we report its total synthesis by a highly convergent Ser ligation approach and this strategy allow

239 quencies, the T2D-PLN was able to identify a convergent set of biological pathways that were perturbe

240 high levels during viral infection and have convergent signaling through STAT1.

241 Furthermore, the convergent signalling of MAPKs involved in catecholoestr

242 aits with social insects, which demonstrates convergent social evolution of these taxa prior to agric

243 The syntheses were achieved through convergent strategies employing enantioselective constru

244 In conclusion, mangrove genomes employ a convergent strategy of TE load reduction by suppressing

245 Compound 2 was synthesized with a convergent strategy to construct a central phenylene cor

246 11 stereogenic centers, was achieved using a convergent strategy with the longest linear sequence of

247 ss in total synthesis, designed with a novel convergent strategy, not only overcame the supply issue

248 eading and tuber-forming morphotypes through convergent subgenome parallel selection of paralogous ge

249 e in both arrangements, may be the result of convergent substitution and be favoured in response to s

250 Convergent substitutions at the same amino acid residue

251 These results provide convergent support for the hypothesis that dysregulation

252 Our findings provide convergent support for the hypothesis that retrospective

253 nsitive lamin-A and retinoids underscore the convergent synergy of insoluble and soluble cues in diff

254 Our convergent synthesis enabled both the confirmation of th

255 ion of the communesin core, provide a highly convergent synthesis of (-)-communesin F.

256 The convergent synthesis of bicyclo[2.2.2]diazaoctane struct

257 ide in transglycosylation, enabling a highly convergent synthesis of core-fucosylated, complex CD52 g

258 cosaminidase (ENGase) catalysis to allow the convergent synthesis of glycosyl amino acids bearing M6P

259 embly of intact cyclotryptamine subunits for convergent synthesis of highly complex bis- and tris-dia

260 ment of an efficient, high yielding six-step convergent synthesis of the semisynthetic alkaloid (-)-p

261 A highly convergent synthesis was developed, employing 4-methoxy-

262 Herein we describe a flexible and convergent synthetic route to prepare advanced precoliba

263 To this end, we first designed a convergent synthetic route toward the diminutive analogu

264 Reported herein is a short and convergent synthetic route towards some small-molecule S

265 delicate and divergent, unlike the prominent convergent tecto-ION terminals in Neognathae.

266 planation for the observed departure and the convergent temperature response of R using a global data

267 Convergent temporal trends were sought via independent e

268 The development of an asymmetric and highly convergent three-component synthesis of the functionaliz

269 ess rigid interclavicle-clavicle structures, convergent to the avian furculum, and they retain should

270 d glenohumeral joints, is different from and convergent to the shoulder mobility at the pivotal clavi

271 age preparation of analogues, a flexible and convergent total synthesis of (+/-)-aureothin is present

272 A convergent total synthesis of (-)-nahuoic acid Ci(Bii) (

273 The result is a highly convergent total synthesis of chivosazole F through the

274 Convergent traits that have evolved across pitcher plant

275 regions and quantified from human cells how convergent transcription contributes to R-loop generatio

276 transcription, divergent transcription, and convergent transcription.

277 Our results suggest convergent transcriptional regulatory hubs in diseases a

278 an integrative genomic approach to identify convergent transcriptomic pathways in emphysema and IPF.

279 esenting a new carbon framework derived from convergent (truncated red cluster and exogenous hbn clus

280 a modular synthesis of pleuromutilins by the convergent union of an enimide with a bifunctional iodoe

281 e made via high-yielding sequences and their convergent union was efficient, the critical C4-C5 bond

282 We carried out a convergent validation process using coverage of three he

283 lass correlation coefficient=0.66 vs. 0.61); convergent validity (r with comprehensive measure=0.79);

284 The scale displayed reasonable convergent validity and statistically significant variab

285 by intraclass correlation coefficient (ICC); convergent validity by correlation with the CES-D; concu

286 The measures resulted in very similar convergent validity characteristics (correlation coeffic

287 quantitative analyses (eg, discriminant and convergent validity correlations, known-groups analyses)

288 The convergent validity of the Arabic CAM-ICU was explored b

289 Convergent validity was established based on substantial

290 Convergent validity was supported by moderate-to-strong

291 Construct convergent validity with the ESMO-MCBS did not increase

292 correlation with a comprehensive measure for convergent validity, with perceived stress level and sle

293 te correlation between the measures suggests convergent validity.

294 ssion Inventory-Second Edition) to establish convergent validity.

295 labelled NTS neurons, indicating that highly convergent viscerosensory signals reach the CeA.

296 enophilia is either evolutionarily shared or convergent with bonobos and not unique to our species as

297 nsume cambium, wood and bark-is ecologically convergent with Early Cretaceous bark-beetle borings 120

298 Our findings are convergent with human studies of the Val(158)Met polymor

299 egration, have been viewed as evolutionarily convergent with mushroom bodies.

300 rchosaur that is unexpectedly and remarkably convergent with the "dome-headed" pachycephalosaur dinos