ライフサイエンスコーパス: convergent extension

1 ndergoing the morphogenetic movement called 'convergent extension'.

2 beta4GalT1 morphants, indicative of abnormal convergent extension.

3 tion, a pre-requisite for its involvement in convergent extension.

4 he components of the fly PCP pathway control convergent extension.

5 scussed in light of recent models on PCP and convergent extension.

6 lecular and tissue interactions required for convergent extension.

7 ants, solidly implicating a role of NF-AT in convergent extension.

8 t result in convergent thickening instead of convergent extension.

9 ll movements such as those that occur during convergent extension.

10 al plate, a morphogenetic process defined as convergent extension.

11 inhibition of NF-AT signaling blocks neural convergent extension.

12 er form of tubulin, inhibits lamellipodia or convergent extension.

13 the microtubule cytoskeleton, is crucial for convergent extension.

14 rogates the ability of nocodazole to inhibit convergent extension.

15 cteristic of cellular intercalation known as convergent extension.

16 the actin cytoskeleton during the process of convergent extension.

17 ns and cell-cell contact, thereby inhibiting convergent extension.

18 d and widened axial tissues due to defective convergent extension.

19 in can induce both active cell migration and convergent extension.

20 e integrated to control cell motility during convergent extension.

21 in and loss of pk1 function cause defects in convergent extension.

22 ected migration of cranial motor neurons and convergent extension.

23 terior notochordal and neural regions during convergent extension.

24 also regulates the morphogenetic process of convergent extension.

25 ervation of control mechanisms in vertebrate convergent extension.

26 nypek potentiates Wnt11 signaling, mediating convergent extension.

27 naling plays an important role in vertebrate convergent extension.

28 f intercalating dorsal mesoderm cells during convergent extension.

29 th inhibition of either neural or mesodermal convergent extension.

30 s in the inhibition of the cell movements of convergent extension.

31 lticellular rosette formation, and defective convergent extension.

32 and cell division contribute little to their convergent extension.

33 to the essential cell behaviours that drive convergent extension.

34 dden behind an opaque epithelium) underlying convergent extension.

35 ity and polarized cell rearrangements during convergent extension.

36 e for this transcription factor primarily in convergent extension.

37 the PCP pathway-regulated process of embryo convergent extension.

38 oupled to apical polarity proteins regulates convergent extension.

39 onsistent with the mediolateral component of convergent extension.

40 we find that we need only two conditions for convergent extension.

41 show that WGEF is involved in Wnt-regulated convergent extension.

42 r polarized cellular rearrangements known as convergent extension.

43 istent with a cell-autonomous disturbance of convergent extension.

44 avior changes, notably during the process of convergent-extension.

45 mus (stbm) participates in the regulation of convergent extension, a critical morphogenetic process r

46 r overexpression in Xenopus embryos disrupts convergent extension, a hallmark feature of Wnt/PCP comp

47 ion, mesodermal and ectodermal cells undergo convergent extension, a process characterised by promine

48 the anterior-posterior body axis depends on convergent extension, a process that involves polarized

49 t Xbra, a transcription factor necessary for convergent extension, actively inhibits cell migration,

50 ew morphogenic cell behaviors driving neural convergent extension and also define roles for signals f

51 ble-mutant embryos have dramatically reduced convergent extension and are completely cyclopic.

52 inhibition of Xdsh signaling disrupted both convergent extension and blastopore closure, mesendoderm

53 distinct from this pathway's earlier role in convergent extension and intercalation.

54 at polarized cell behaviour is essential for convergent extension and is controlled by vertebrate Dis

55 This process is known as convergent extension and it is so powerful in remodellin

56 ectin with antisense morpholinos blocks both convergent extension and mediolateral protrusive behavio

57 8, causes embryonic lethality and defects in convergent extension and morphogenesis of extra-embryoni

58 ition to uncovering novel roles of TRIM28 in convergent extension and morphogenesis of extra-embryoni

59 pus homologue of PTK7 is required for neural convergent extension and neural tube closure.

60 ropose a model explaining the role of blf in convergent extension and neurulation.

61 mesoderm and this results in the failure of convergent extension and somitogenesis in this tissue.

62 eral cell intercalation behaviors that drive convergent extension and the elongation of the frog dors

63 ho kinase, but not jun N-terminal kinase, in convergent extension and the onset of neural tube closur

64 nservation between Dvl function in mammalian convergent extension and the PCP pathway in fly.

65 l polarity (PCP) signaling cascade in neural convergent extension and tube closure.

66 ermination, cell migration, planar polarity, convergent extension, and immunity.

67 crucial regulator of cell morphology during convergent extension, and microtubules limit its activit

68 complex and involves cellular events such as convergent extension, apical constriction and interkinet

69 While many of the cell behaviors involved in convergent extension are known, the molecular interactio

70 n in axial elongation, and a role for neural convergent extension as an equalizing force to produce a

71 tions as a switch to keep cell migration and convergent extension as mutually exclusive behaviors dur

72 do not mediolaterally elongate during their convergent extension as the mesodermal cells do, we pred

73 f the central axis of the vertebrate embryo (convergent extension) as well as morphogenesis of organs

74 tropic differential adhesion can account for convergent extension, as observed during embryonic devel

75 e "neural deep cell explants" undergo active convergent extension autonomously, implying that these c

76 Convergent extension behaviour is critical for the forma

77 w simultaneous assessment of the progress of convergent extension, blastopore closure and archenteron

78 r fuzzy (fy) affected not only PCP-dependent convergent extension but also elicited embryonic phenoty

79 t5a (pipetail) genes, which are required for convergent extension but not cell fate specification.

80 ired for both neural tube closure and neural convergent extension, but the connection between these t

81 ctivated RhoA and rescued the suppression of convergent extension by dominant-negative Wnt-11, wherea

82 planar cell polarity (PCP) proteins control convergent extension by exploiting an evolutionarily anc

83 Dishevelled from the cell membrane disrupts convergent extension by preventing Rho/Rac activation an

84 stocoel roof, while trunk mesoderm undergoes convergent extension (C&E).

85 hypothesis that Zic3 is necessary for proper convergent extension (C-E) morphogenesis.

86 ollows a morphogenetic program that includes convergent extension (C/E), followed by anterior-posteri

87 uring development, the PCP pathway regulates convergent extension (CE) and uniform orientation of sen

88 the cellular mechanisms underlying mammalian convergent extension (CE) are unknown.

89 Both phenotypes represent convergent extension (CE) defects, arising from impaired

90 mbryos injected with ofd1 MOs also displayed convergent extension (CE) defects, which were enhanced b

91 involves two distinct morphogenetic events--convergent extension (CE) driven by mediolateral cell in

92 Convergent extension (CE) is a conserved morphogenetic m

93 Convergent extension (CE) is a fundamental morphogenetic

94 In Xenopus, Wnt-regulated convergent extension (CE) is readily affected by Dvl mut

95 Convergent extension (CE) is the narrowing and lengtheni

96 Convergent extension (CE) movements and epithelial-mesen

97 gulation of beta-catenin and coordination of convergent extension (CE) movements is Dishevelled (Dvl)

98 Forces generated within the embryo during convergent extension (CE) must overcome mechanical resis

99 Oriented cell division (OCD) and convergent extension (CE) shape developing renal tubules

100 solution of multicellular rosettes can drive convergent extension (CE) type cell rearrangements durin

101 axis elongation without additional growth is convergent extension (CE), whereby a tissue undergoes si

102 in vertebrates and invertebrates, including convergent extension (CE).

103 CP, planar polarization is also required for convergent extension (CE); a polarized cellular movement

104 In convergent-extension (CE), a planar-polarized epithelial

105 ty (PCP) pathway is the primary regulator of convergent extension cell movements during vertebrate de

106 noncanonical Wnt11/Wnt5 pathway to regulate convergent extension cell movements, but is unlikely to

107 ated down-regulation of Xenopus Amer2 blocks convergent extension cell movements, suggesting that the

108 g plays a direct role in the coordination of convergent extension cell movements.

109 quired for nocodazole-mediated inhibition of convergent extension; constitutively active XLfc recapit

110 ng and narrowing of a field of cells, termed convergent extension, contributes to a variety of morpho

111 Furthermore, Xdsh mutations that inhibit convergent extension correspond to mutations in Drosophi

112 We analyzed the relationships between the convergent extension defect, the expression of hedgehog

113 ant and overexpression phenotype represent a convergent extension defect.

114 netrance; and Fz2(-/-);Fz7(-/-) mice exhibit convergent extension defects and mid-gestational lethali

115 PTK7 silencing results in the PCP-dependent convergent extension defects in the zebrafish.

116 iliary bundles in the bpck inner ear and the convergent extension defects in zebrafish morphants are

117 on of MOs against ift80 and BBS genes led to convergent-extension defects.

118 Surprisingly, the axis of convergent extension depends on the specific tissues tha

119 The collective movements of convergent extension drive both global reorganization of

120 s undergoes cell rearrangements that lead to convergent extension during early somite stages, and tha

121 airing RPTPpsi activity also interferes with convergent extension during gastrulation.

122 ) (kny), and kny;tri, which are defective in convergent extension during gastrulation.

123 ed cell division, cellular polarization, and convergent extension during gastrulation.

124 is spatially enriched in tissues undergoing convergent extension during gastrulation.

125 l-polarity (PCP) pathway in flies, regulates convergent extension during vertebrate gastrulation.

126 naling polarizes mesodermal cells undergoing convergent extension during Xenopus laevis gastrulation.

127 By contrast, midline convergent extension fails completely in Vangl2 Cfl1 dou

128 fore provides a specific tool for uncoupling convergent extension from other processes of neurulation

129 While many genes required for convergent extension have been identified, little is kno

130 ntation of protrusive activity during neural convergent extension in any system.

131 issues reveals a primary role for mesodermal convergent extension in axial elongation, and a role for

132 the midline neural plate, revealed defective convergent extension in both axial mesoderm and neuroepi

133 further demonstrate that Xstbm can regulate convergent extension in both dorsal mesoderm and neural

134 of embryonic phenotypes after inhibition of convergent extension in different tissues reveals a prim

135 During convergent extension in Drosophila melanogaster, the spa

136 During convergent extension in Drosophila, polarized cell movem

137 um mobilization occurred in cells undergoing convergent extension in explants of gastrulating Xenopus

138 n X. laevis and further our understanding of convergent extension in general.

139 lin is essential for the process of directed convergent extension in presumptive notochord at gastrul

140 These analyses reveal an unexpected role for convergent extension in shaping wing veins.

141 al adhesion reproduce the hallmark stages of convergent extension in the correct sequence, with rando

142 modulate multiple signaling events, inhibits convergent extension in the dorsal mesoderm and in the p

143 cell interactions and planar polarity during convergent extension in the Drosophila embryo.

144 The underlying defect involves a failure of convergent extension in the midline of the early neural

145 non-canonical Wnt signaling is important for convergent extension in the mouse notochord and neural p

146 ls a more selective function, affecting only convergent extension in the neural ectoderm.

147 the following morphogenetic mechanisms: (1) convergent extension in the neural plate (NP); (2) cell

148 g, the Loop-tail mutation that disrupts both convergent extension in the neuroepithelium and PCP in t

149 In order to evaluate the role of convergent extension in this defect, we vitally labelled

150 signaling is a common mechanism controlling convergent extension in two very different tissues in th

151 in the control of cell intercalation during convergent extension in vertebrates.

152 them towhat is known about the regulation of convergent extension in vertebrates.

153 that these cells contribute force for neural convergent extension in vivo.

154 signaling antagonists also inhibited neural convergent extension in whole embryos.

155 mportant step in the investigation of neural convergent extension in X. laevis and further our unders

156 f the active cell motility underlying neural convergent extension in X. laevis are the first high-res

157 identifies XNF-ATc3 as a regulator of neural convergent extension in Xenopus and adds to a short list

158 Expression of mNkd disrupted convergent extension in Xenopus, consistent with a role

159 This implicates a defect of convergent-extension in the COUP-TFI(-/-) duct.

160 ecreases in height and width as it undergoes convergent extension, increasing in length with the axis

161 Elongation of the head-to-tail body axis by convergent extension is a conserved developmental proces

162 ption of Xdsh signaling, we demonstrate that convergent extension is crucial to tube closure.

163 Convergent extension is the primary driving force elonga

164 tity of the GEF involved in Wnt-PCP-mediated convergent extension is unknown.

165 the proliferative chondrocytes result from a convergent extension-like process that is regulated inde

166 We find that convergent-extension, mitotic cell division, and daughte

167 Convergent extension movement defects in knypek are asso

168 depletion of XProfilin2 specifically affects convergent extension movement independent of mesodermal

169 ury, not, goosecoid, and papc indicated that convergent extension movement was defective in Dhrs3 mor

170 nd explants, FoxD3 induced mesodermal genes, convergent extension movements and differentiation of ax

171 Gain-of-function of Pk1 also inhibits convergent extension movements and enhances the slb phen

172 arity in Drosophila epithelia, and activates convergent extension movements and intracellular Ca(2+)

173 In vertebrates, the PCP pathway regulates convergent extension movements and neural tube closure,

174 er, these data demonstrate that PCP-mediated convergent extension movements are crucial to proper ver

175 5-hydroxytryptamine receptors inhibits both convergent extension movements associated with dorsal me

176 g pathway have been shown to be required for convergent extension movements but the relationship betw

177 ty, PCP) pathway regulates cell polarity and convergent extension movements during axis formation in

178 eceptor for Wnt5a and mediates Wnt5a-induced convergent extension movements during embryogenesis in m

179 the planar cell polarity pathway to regulate convergent extension movements during gastrulation and n

180 es, PCP genes have a vital role in polarized convergent extension movements during gastrulation and n

181 main, specifically affects cell polarity and convergent extension movements during gastrulation, inde

182 , beta4GalT1, and its requirement for proper convergent extension movements during gastrulation.

183 ity is required for cells to undergo correct convergent extension movements during gastrulation.

184 in show that RhoA activity does not regulate convergent extension movements during sea urchin gastrul

185 Convergent extension movements during vertebrate gastrul

186 is closely associated with the generation of convergent extension movements during Xenopus gastrulati

187 Xdd1 blocked convergent extension movements in ectodermal explants st

188 hibited chordomesodermal cell elongation and convergent extension movements in planar dorsal marginal

189 h RhoA activity has been reported to control convergent extension movements in vertebrate embryos, ex

190 Jun NH(2)-terminal kinases (JNKs) regulate convergent extension movements in Xenopus embryos throug

191 ediate CamKII function downstream of Dvl1 in convergent extension movements in Xenopus gastrulation.

192 , we reveal the presence of three domains of convergent extension movements in zebrafish gastrula.

193 boundaries, moving progressively forward as convergent extension movements lengthen the tubule.

194 During Xenopus development, convergent extension movements mediated by cell intercal

195 Concomitantly, convergent extension movements narrow germ layers mediol

196 Xenopus Dishevelled (Xdsh) function disrupts convergent extension movements of cells during gastrulat

197 gous to the PCP pathway acts to regulate the convergent extension movements of gastrulation [3-7].

198 in early Xenopus embryos in controlling the convergent extension movements of gastrulation.

199 Xenopus C-cadherin is regulated during convergent extension movements of gastrulation.

200 This intercalation event differs from the convergent extension movements of the mesoderm described

201 planar signals from the organizer can induce convergent extension movements of the posterior neural t

202 terior neural fold closure without affecting convergent extension movements or mesoderm cell fate spe

203 ssion of activated Daam1 can rescue impaired convergent extension movements resulting from deregulate

204 l rearrangements, filopodial extensions, and convergent extension movements to elongate and shape the

205 al tissues has a crucial role in driving the convergent extension movements underlying vertebrate gas

206 rpholino oligonucleotides leads to defective convergent extension movements, enhances the silberblick

207 topore closure in Xenopus but did not affect convergent extension movements, tissue separation or neu

208 t of WNT signalling that plays a role during convergent extension movements, which we show here are a

209 ontribute to defective cell migration during convergent extension movements.

210 n absolute requirement for beta4GalT1 during convergent extension movements.

211 ed phenotype results from enhanced defective convergent extension movements.

212 nalog of the planar polarity pathway governs convergent extension movements.

213 stablish polarized cell behaviors underlying convergent extension movements.

214 like overexpression of Xbra-En(R), inhibits convergent extension movements.

215 vities of the GTPases Rho and Rac to control convergent extension movements.

216 rospective neural plate ectoderm, undergoing convergent-extension movements characteristic of neuroec

217 is altered in cells of the gut which undergo convergent-extension movements during the formation of t

218 been interpreted to result from epiboly and convergent-extension movements that drive body elongatio

219 eliminated from endoderm cells during their convergent-extension movements.

220 sociated beta-catenin levels as they undergo convergent-extension movements.

221 during epithelial-mesenchymal conversion and convergent-extension movements.

222 that the APP morphant embryos have defective convergent-extension movements.

223 Unlike other convergent extension mutants, blf morphants display a sp

224 t midgestation and defects characteristic of convergent extension mutants, including a shortened body

225 ected embryos, similar to that seen in known convergent extension mutants.

226 In Xenopus, convergent extension occurs in the dorsal mesoderm and p

227 forms through simultaneous invagination and convergent extension of a monolayer epithelial plate.

228 l motility could drive both invagination and convergent extension of a monolayer epithelium.

229 pment by analyzing how RhoA and Rac1 control convergent extension of axial mesoderm during Xenopus ga

230 underlying normal cell intercalation during convergent extension of both mesodermal and neural and t

231 ve cell migration of prechordal mesoderm and convergent extension of chordamesoderm.

232 opus gastrulation, cell intercalation drives convergent extension of dorsal tissues.

233 Overexpression of Xstbm inhibits convergent extension of mesodermal and neural tissues, a

234 at cellular resolution in the mouse embryo: convergent extension of the axial midline; and posterior

235 ired for establishing epithelial PCP and for convergent extension of the cochlear duct of Mus musculu

236 lopmental processes such as regionalization, convergent extension of the cochlear duct, cell fate spe

237 (tri) and knypek (kny) mutants with affected convergent extension of the embryonic axis during gastru

238 , mediolateral intercalation, involution and convergent extension of the marginal zone do not occur.

239 Convergent extension of the mesoderm is the major drivin

240 is similar to that previously described for convergent extension of the mesodermal cells.

241 a finite amount of medial progress and that convergent extension of the midline is necessary to redu

242 htening, apical constriction at hingepoints, convergent extension of the midline, and pushing by the

243 aracterize the cellular mechanism underlying convergent extension of the neural ectoderm in the Xenop

244 to drive the mediolateral intercalation and convergent extension of the neural plate in Xenopus.

245 Arg also regulated convergent extension of the trunk mesoderm by influencin

246 erning of morphogenic cell behaviors driving convergent extension of the Xenopus neural plate in the

247 patterning the cell motilities that underlie convergent extension of the Xenopus neural plate.

248 rect the elongation of the appendage and the convergent-extension of the roof-cell population.

249 iolateral cell intercalation, involution and convergent extension, or differentiation of posterior no

250 differs from the beta-catenin-dependent and convergent extension pathways.

251 Additionally, nlk strongly enhances convergent/extension phenotypes associated with wnt11/si

252 ion require Xdsh function; and (2) what role convergent extension plays in the closure of the neural

253 uring Drosophila germband extension (GBE), a convergent-extension process elongating the body axis.

254 blished during early morphogenetic stages by convergent extension processes and maintained by polariz

255 During gastrulation in these frogs, convergent extension produces longitudinal tissue growth

256 that include cell elongation, intercalation, convergent extension, proliferation, and differentiation

257 Convergent extension relies on the same intracellular mo

258 een Wnt-secreting and receiving cells during convergent-extension remain elusive.

259 indings identify a cell-autonomous defect of convergent extension, requiring PCP signalling via RhoA-

260 re of cells lacking Xdsh function to undergo convergent extension results from defects in cell polari

261 For modeling convergent extension, simulations include anisotropic di

262 reas depletion of WGEF led to suppression of convergent extension that could be rescued by RhoA or Rh

263 (PCP) signaling plays a primary role in the convergent extension that drives neural tube closure and

264 necessary for the oriented cell division and convergent extension that establishes and maintains the

265 nypek locus impair gastrulation movements of convergent extension that narrow embryonic body and elon

266 Convergent extension, the simultaneous narrowing and len

267 Although microtubules are required for convergent extension, this applies only to initial stage

268 s around the tubule circumference, producing convergent-extension tissue movements.

269 ebrates is elongated in embryonic stages by "convergent extension" tissue movements.

270 ments, we visualized calcium dynamics during convergent extension using a calcium-sensitive fluoresce

271 onstruct and implement a stochastic model of convergent extension, using a minimal set of assumptions

272 the force contribution of the deep cells to convergent extension, we explanted single layers of neur

273 Consistent with a function in neural convergent extension, we show that XNF-ATc3 is expressed

274 xamine the cytoskeleton more directly during convergent extension, we visualized actin and microtubul

275 ks the PDZ-binding region of Xstbm, inhibits convergent extension when expressed alone but rescues th

276 shed the calcium dynamics and also inhibited convergent extension without affecting cell fate.