ライフサイエンスコーパス: convoluted tubule

1 ria, and morphological changes in the distal convoluted tubule.

2 enhanced WNK pathway activity in the distal convoluted tubule.

3 n of Bowman's space and the initial proximal convoluted tubule.

4 imal tubule, thick ascending limb, or distal convoluted tubule.

5 or salt reabsorption in the mammalian distal convoluted tubule.

6 timulate transport in the TAL and the distal convoluted tubule.

7 e, whereas it is transcellular in the distal convoluted tubule.

8 protein produced predominantly in the distal convoluted tubule.

9 ng limb of the loop of Henle, and the distal convoluted tubule.

10 in mDCT15 cells, a model of the mouse distal convoluted tubule.

11 in with predominant expression in the distal convoluted tubule.

12 trate must pass before reaching the proximal convoluted tubule.

13 e sites in vivo, predominantly in the distal convoluted tubule.

14 thick ascending limb, but also by the distal convoluted tubule.

15 ricted to the epithelium of the renal distal convoluted tubules.

16 d tubular atrophy particularly in the distal convoluted tubules.

17 with a putative cell of origin in the distal convoluted tubules.

18 basement membrane thickening in the proximal convoluted tubules.

19 RNA was markedly increased in renal proximal convoluted tubules.

20 aquaporin-2, and pendrin showed that distal convoluted tubule and connecting segment cells, A-type i

21 n calcium entry into the cells of the distal convoluted tubule and connecting segment of the nephron,

22 MK K(+) channel did not change in the distal convoluted tubule and decreased slightly in the cortical

23 s not impair calcium transport in the distal convoluted tubule and indicates that thiazides should be

24 mediator of salt reabsorption in the distal convoluted tubule and is a key determinant of the blood

25 transcript was detected only in the proximal convoluted tubule and proximal straight tubule.

26 f the nephron, comprising part of the distal convoluted tubule and the connecting tubule, and regulat

27 r apical sodium transporters in the proximal convoluted tubule and the distal convoluted tubule of th

28 (+)-2Cl(-) cotransporter NKCC2 in the distal convoluted tubule and the thick ascending limb of Henle'

29 t, with their functional roles in the distal convoluted tubule and thick ascending limb, respectively

30 ts in proximal tubule, loop of Henle, distal convoluted tubule, and cortical and medullary collecting

31 nding limb of Henle's loop and/or the distal convoluted tubule, and these disorders generate the grea

32 l cells in the thick ascending limbs, distal convoluted tubules, and collecting ducts of mice.

33 -sensitive Na-Cl cotransporter of the distal convoluted tubule appears to be the chief molecular targ

34 kidney, recent evidence points to the distal convoluted tubule as a possible site of mineralocorticoi

35 nating in widespread destruction of proximal convoluted tubules at the glomerulotubular junction.

36 y for normal salt reabsorption in the distal convoluted tubule because of the need for K(+) recycling

37 d absorption are sharply reduced in proximal convoluted tubules, blood pressure is reduced and there

38 e SPAK mainly activates NCC along the distal convoluted tubule, but the kinases may compensate for ea

39 ve Na+-Cl- cotransporter (NCC) of the distal convoluted tubule cause Gitelman's syndrome, an inherite

40 esults of siRNA transfection in mouse distal convoluted tubule cells and those of unilateral ureteral

41 expression model and in native murine distal convoluted tubule cells in culture.

42 In Cav1-/- mice, distal convoluted tubule cells were completely devoid of Cav1 a

43 h localized to the apical membrane of distal convoluted tubule cells, T58M Ncc localized primarily to

44 chief apical sodium entry pathway of distal convoluted tubule cells, we prepared an affinity-purifie

45 chemistry showed TSC labeling only in distal convoluted tubule cells.

46 in the extracellular matrix surrounding the convoluted tubules, collecting ducts and loops of Henle

47 nd basolateral Rhcg expression in the distal convoluted tubule, connecting segment, and initial colle

48 The importance of the kidney distal convoluted tubule (DCT) and cortical collecting duct (CC

49 t-absorptive pathway in the mammalian distal convoluted tubule (DCT) and is the site of action of one

50 at WNK3 is expressed in the nephron's distal convoluted tubule (DCT) and stimulates NCC activity.

51 Na(+) transport in the renal distal convoluted tubule (DCT) by the thiazide-sensitive NaCl c

52 In kidney distal convoluted tubule (DCT) cells, stimulation of Na+/K(+)-A

53 NaCl cotransporter (NCC) of the renal distal convoluted tubule (DCT) controls ion homeostasis and art

54 , CD8(+) T cells directly contact the distal convoluted tubule (DCT) in the kidneys of DOCA-salt mice

55 m-chloride cotransporter (NCC) in the distal convoluted tubule (DCT) is solely responsible.

56 The mammalian distal convoluted tubule (DCT) makes an important contribution

57 transcellular Ca(2+) transport in the distal convoluted tubule (DCT) of the kidney.

58 The distal convoluted tubule (DCT) plays a critical role in renal s

59 Thiazide diuretic drugs act in the distal convoluted tubule (DCT) to inhibit a Na+Cl- cotransporte

60 ates Mg(2+) reabsorption in the renal distal convoluted tubule (DCT) via engagement of its receptor o

61 In the distal convoluted tubule (DCT), potassium imbalance causes WNK

62 showed that Pcbd1 is expressed in the distal convoluted tubule (DCT), where Pcbd1 transcript levels a

63 lciuria and marked hyperplasia of the distal convoluted tubule (DCT), whereas the opposite is true in

64 in the apical plasma membrane of CON distal convoluted tubule (DCT).

65 ucial for calcium reabsorption in the distal convoluted tubule (DCT).

66 e major NaCl transport protein in the distal convoluted tubule (DCT).

67 Ca(2+) reabsorption via TRPV5 in the distal convoluted tubule (DCT).

68 of the thick ascending limb (TAL) and distal convoluted tubule (DCT).

69 or alpha-Klotho (KL) localizes to the distal convoluted tubule (DCT).

70 Following microinjection into distal convoluted tubules (DCTs) 46.1 +/- 6.1 % (n = 8) of the

71 ascending limb of Henle (TAL) and in distal convoluted tubules (DCTs): Ksp-cre;Pth1r(fl/fl) Mutant m

72 l nephron structures (podocytes and proximal convoluted tubules) despite the presence of activated No

73 atest accumulation of renox mRNA in proximal convoluted tubule epithelial cells.

74 ion and a decrease in the mass of the distal convoluted tubule, exclusive to DCT1.

75 infection, epithelial cells of the proximal convoluted tubules frequently contained abnormal mitocho

76 rved between the development of the granular convoluted tubules (GCT) of the SMG in these mice and SM

77 conducting primary filtrate to the proximal convoluted tubule has been Bowman's space (BS) (1).

78 The distal convoluted tubule has been proposed to sense plasma [K(+

79 3 probes gave intense labeling of the distal convoluted tubule in pig kidney but (unexpectedly) no de

80 We conclude that the distal convoluted tubule is an important site of action of the

81 that potassium reabsorption in the proximal convoluted tubule is passive in nature and depends partl

82 ression in kidney was restricted to proximal convoluted tubules; little or no expression was observed

83 important transporters in the renal proximal convoluted tubule, namely Na-H exchanger 3, Na-K ATPase,

84 he proximal convoluted tubule and the distal convoluted tubule of the kidney, respectively.

85 ing active Ca(2+) reabsorption in the distal convoluted tubule of the kidney.

86 dullary potassium channel in the late distal convoluted tubule of WNK1(+/FHHt) mice, which could cont

87 a strong decrease in NCC labeling in distal convoluted tubules of aldosterone-escape rats with no ch

88 hy (OCT) revealed that cells lining proximal convoluted tubules of living donor kidneys (LDKs) procur

89 Kidney expresses RALDH2 in the proximal convoluted tubules of the cortex but not in the distal c

90 protein primarily in the proximal and distal convoluted tubules of the cortex but not in the glomerul

91 ne of transporting epithelia in the proximal convoluted tubules of the kidney and the small intestine

92 lication and gene expression in the proximal convoluted tubules of the kidney by causing interstitial

93 lial cells of the mammary glands; (e) distal convoluted tubules of the kidney; (f) epidermal keratino

94 hate co-transporter NaPi-IIa in the proximal convoluted tubules of the outer renal cortex, assessed b

95 fect on lithium reabsorption in the proximal convoluted tubule or loop of Henle.

96 rgeting the thick ascending limb, the distal convoluted tubule or the collecting system.

97 Segments of superficial proximal convoluted tubules or cysts, isolated by upstream and do

98 tubules of the cortex but not in the distal convoluted tubules or glomeruli.

99 The proximal convoluted tubule (PCT) and the medullary thick ascendin

100 The proximal convoluted tubule (PCT) reabsorbs most of the filtered b

101 t potassium reabsorption in the rat proximal convoluted tubule (PCT).

102 Following microinjection into proximal convoluted tubules (PCTs), 18.5 +/- 2.9 % (mean +/- s.e.

103 6) M angiotensin II to the lumen of proximal convoluted tubules perfused in vivo had no effect on the

104 The transport of organic anions in proximal convoluted tubules plays an essential role in the active

105 agnesium (Mg(2+)) reabsorption in the distal convoluted tubule represents the final step before Mg(2+

106 ption in the thick ascending limb and distal convoluted tubule, respectively.

107 K-2Cl cotransporter [NKCC2]), and the distal convoluted tubule (the thiazide-sensitive Na-Cl cotransp

108 Henle, the intercalated cells of the distal convoluted tubule, the connecting segment, and all inter

109 tive region of the nephron, i.e., the distal convoluted tubule, the connecting tubule, and the cortic

110 Henle, the Na-Cl cotransporter of the distal convoluted tubule, the epithelial Na+ channel of the col

111 rption across the S2 segment of the proximal convoluted tubule, transepithelial potential differences

112 region and caused an increase in late distal convoluted tubule volume.

113 tential difference (PD) at the late proximal convoluted tubule was +2.1 +/- 0.3 mV (lumen positive) a

114 hile fractional reabsorption in the proximal convoluted tubule was enhanced.

115 ium concentration ratio at the late proximal convoluted tubule was raised in the low-K+ animals (1.50

116 Fractional water reabsorption in proximal convoluted tubules was enhanced in potassium-depleted ra

117 use TRPV5 and Klotho coexpress in the distal convoluted tubule, we investigated whether Klotho regula

118 tion studies showed that developing proximal convoluted tubules were the most severely hypoxic nephro

119 the dissociation can be traced to the distal convoluted tubule, where calcium and sodium transport ar

120 P receptor is highly expressed in the distal convoluted tubule, where it may have a distinct effect o

121 uitous kinase isoform of WNK1, in the distal convoluted tubule, which in turn, stimulates the activit

122 try revealed normal morphology of the distal convoluted tubule with reduced NCC expression.

123 by reduced levels of TRPV5 protein in distal convoluted tubules, with a concomitant increase in TRPV5