ライフサイエンスコーパス: cooperative

1 nto large-scale primary care physician (PCP) cooperatives.

2 in a developmental pathway and suggests that cooperative action among E3s is a conserved feature from

3 lls, but not in bacteria, and correlate with cooperative action in disaggregation in vitro.

4 TLR2-driven robust Mincle expression and the cooperative action of both receptors.

5 ute myeloid leukemia (AML) is induced by the cooperative action of deregulated genes that perturb sel

6 This allowed cooperative activation of small molecules like molecular

7 ogs, with the former relying more heavily on cooperative activities, predicts that at least with cons

8 to provide insights into their metal-ligand cooperative activities.

9 plant cell wall polysaccharide, requires the cooperative activity of a large repertoire of microbial

10 Here, we demonstrate that cooperative activity of a multimetallic metallopeptide e

11 Our data illustrate cooperative activity of the APC/C(CCS52A1) and APC/C(CCS

12 ements (MREs), providing strong evidence for cooperative activity.

13 etal centres could act as both selective and cooperative adsorbents if guest binding at one site were

14 The electronic basis for the cooperative adsorption demonstrated here could provide a

15 d with high degrees of internal order by the cooperative aggregation of molecular subunits, which end

16 tematic categorisation of cooperativity into cooperative aggregation, intermolecular (allosteric) coo

17 and twist on protein-protein interactions in cooperative AGT complexes formed on lesion-free DNAs tha

18 protect those prepared to adopt increasingly cooperative, altruistic, and other prosocial norms of in

19 The resulting tension between cooperative and competitive interactions was found to ge

20 secondary metabolites with distinct roles in cooperative and competitive microbial interactions.

21 able precision, and identified known and new cooperative and competitive miRNAs supported by literatu

22 The analyses also uncovered potential cooperative and competitive relationships, even among cl

23 e that provides an intricate balance between cooperative and individual activities of the readers.

24 nd benefits of two coevolving costly traits: cooperative and local cohesive tendencies.

25 aped CO2 adsorption isotherms resulting from cooperative and reversible insertion of CO2 into metal-a

26 rgo autocatalysis requires the unprecedented cooperative and sequential actions of two inner membrane

27 ts (<10 mol%), the polymerization process is cooperative and the supramolecular helicity is biased to

28 Both rolling (cooperative) and sliding particle rotations are observed

29 These interactions are cooperative, and binding to the prefusion acceptor t-SNA

30 The nonlinear, cooperative, and stochastic character of the interaction

31 ivities separately, but also exhibited their cooperative antibacterial effects.

32 itation, which yields a remarkable H2 O2 -NO cooperative anticancer effect with minimal adverse effec

33 le, combination of MK-1775 and Ex527 induces cooperative antitumor activity in lung cancer xenograft

34 rt of the Appalachian Landscape Conservation Cooperative (App LCC).

35 erature phosphorescence studies, established cooperative assembly of [Cu4(GS)6] as the dominant speci

36 Our results reveal an ordered and cooperative assembly of ERalpha enhancers requiring func

37 +beta protein classes via de novo design and cooperative assembly strategies.

38 m adenylates, and H4a/Psi3 was necessary for cooperative association of two other hairpins (H5/H4b) i

39 h F-actin by different mechanisms, and their cooperative association with actin filaments affects the

40 Bacterial cooperative associations and dynamics in biofilm microen

41 0.93 to + 3.46, p = 0.008) and International Cooperative Ataxia Rating Scale (MD = +3.8, 95% CI = +1.

42 Spectacular examples of cooperative behavior emerge among a variety of animals a

43 der certain conditions, poor players exhibit cooperative behavior in two types of chicken games (the

44 hat at moderate levels of player sensitivity cooperative behavior increases, but that at high levels

45 describe here a model experimental system of cooperative behavior involving Drosophila larvae.

46 The evolution of cooperative behavior is one of the most important issues

47 ilution effect and is not necessarily due to cooperative behavior of the CTLs.

48 he trap of parochialism and instead engender cooperative behavior with the broader global community.

49 in many natural systems and is the basis for cooperative behavior.

50 in, and that CDI system proteins can mediate cooperative behaviors among 'self' cells, a phenomenon c

51 Chimpanzees engage in some cooperative behaviors in the wild as well, but their mot

52 Cooperative behaviors provide a collective benefit, but

53 associate with their clonemates for certain cooperative behaviors.

54 applications, and beyond the microbial realm.Cooperative behaviour among individuals provides a colle

55 he impact of storytelling on hunter-gatherer cooperative behaviour and the individual-level fitness b

56 Our analysis suggests that cooperative behaviour of cancer cells, analogous to the

57 information about own payoffs leads to less cooperative behaviour.

58 Cooperative behaviours can be damaged by the emergence o

59 use the complex patterns of partner-specific cooperative behaviours seen in nature require greenbeard

60 However, we show here that highly cooperative binding also occurs in the (SSB)65/(SSB)56 b

61 n metal sites, appropriate pore geometry and cooperative binding between guest molecules is responsib

62 Nonetheless, the precise role of cooperative binding in defining cell-type identity is st

63 rentiation of bacterial chromatin depends on cooperative binding of abundant nucleoid-associated prot

64 (ii) Selective and cooperative binding of both an acetato ligand and an ami

65 pervades macromolecular function and drives cooperative binding of ligands to macromolecules.

66 This work sheds light on cooperative binding of TF binding proteins in regulating

67 t a DNA U-turn is induced by progressive and cooperative binding of the two TFAM HMG-box domains and

68 In turn, the simultaneous and cooperative binding of these factors is required to regu

69 Highly cooperative binding requires the 56 amino acid intrinsic

70 emblies is a result of significant levels of cooperative binding that is present in both solvents.

71 , one (Cdc20(M)) through well-characterized, cooperative binding to Mad2 and Mad3/BubR1 (forming the

72 In addition to this hierarchical cooperative binding, discrimination requires a competiti

73 Cooperative binding, whereby an initial binding event fa

74 hancer activation that can be dissected from cooperative binding.

75 Cooperative breeders feature the highest level of social

76 Cooperative breeders pursue one of two alternative socia

77 ng, environments can favour the evolution of cooperative breeding behaviour constitutes a paradox of

78 s an intermediate step between nonsocial and cooperative breeding birds.

79 f the conditions that favor the evolution of cooperative breeding can be confounded if this process i

80 se different social systems, concluding that cooperative breeding emerges when family living is favor

81 , thus helping to resolve the paradox of why cooperative breeding evolves in such different types of

82 essential stepping stone in the evolution of cooperative breeding in the vast majority of species.

83 r data show that the subsequent evolution of cooperative breeding was instead linked to environments

84 ments, followed secondarily by selection for cooperative breeding when environmental conditions deter

85 Cooperative breeding, in which more than a pair of consp

86 Alloparental care, the cooperative care of offspring by group members other tha

87 idative side reaction, while employment of a cooperative catalytic approach through inclusion of a hy

88 For less activated (aliphatic) aldehydes, a cooperative catalytic strategy has been developed via th

89 ndothelial cell density was measureable in 6 cooperative children (10 eyes), showing an average 1% de

90 scopy was performed during a clinic visit in cooperative children in the standard upright position.

91 Cooperative chirality phenomena extensively exist in bio

92 sis, stage, MYCN amplification, and national cooperative clinical group between groups.

93 were uniformly higher than those reported in cooperative clinical trials, suggesting that early death

94 sion to recruit numerous neutrophils forming cooperative clusters.

95 th nonhuman apes point to our early-emerging cooperative-communicative abilities as crucial to the ev

96 can be precisely depicted using the standard cooperative coordinate method (CCM).

97 er are directed by hydrophobic interactions, cooperative delivery strategies can be realized.

98 r the Sprouty2 locus was verified to promote cooperative dimerization designating Sprouty2 as a poten

99 gher-order complex formation and altered the cooperative DNA-binding properties of EBNA1.

100 ferences for attractive partners in multiple cooperative domains (not just mating), which accounts fo

101 Compared to the conventional cooperative/dual photocatalysis (type B), this new class

102 ients for longer and were significantly less cooperative during exposure to boat noise, and while mot

103 -component infusion evidently results from a cooperative effect in which charge is generated on g-C3N

104 linear relationship between the magnitude of cooperative effects and the number of mutant subunits.

105 Dimers harboring two mutations with opposite cooperative effects had different allosteric properties

106 lated electron transfers, and the associated cooperative effects lead to the formation of O(-) radica

107 have suggested that strong, but short-range cooperative effects may occur in H-bond chains.

108 les larger property enhancement owing to the cooperative effects of both the increased cross-link den

109 provided new insights on these distinct but cooperative effects.

110 Molecular solids with cooperative electronic properties based purely on pi ele

111 te of neighboring myosin molecules, adding a cooperative element to the activation process.

112 This singlet-based process, called Cooperative Energy Pooling (CEP), utilizes a sensitizer-

113 ides the basis for further understanding the cooperative engagement and interplay between Cse4p prote

114 Cooperative entropic forces expanded the cluster and pul

115 fy OR enhancers by binding in a functionally cooperative fashion to stereotypically spaced motifs tha

116 icotinic acetylcholine receptor (nAChR) in a cooperative fashion, not seen for classical nicotinic ag

117 and nucleophilic N-methylanilide sites in a cooperative fashion.

118 edated" or "very sedated" for 59%, "calm and cooperative" for 25%, and "unarousable" for 16%.

119 ox1(hi) endothelial organization, suggesting cooperative Foxc2-Nfatc1 patterning of these events.

120 Cooperative functioning of the chiral Lewis acid and ach

121 Cooperative functioning of the Lewis acid and Bronsted b

122 udies focusing on STIM1, define distinct but cooperative functions for STIM1 and STIM2 in modulating

123 eatment of Cancer/Invasive Fungal Infections Cooperative Group and Mycoses Study Group (EORTC/MSG) cr

124 icate that control over membership of such a cooperative group can be regulated.

125 , randomised, multi-arm, open-label, phase 3 cooperative group clinical trial of patients with high-r

126 intergroup study was coordinated by SWOG, a cooperative group member within the National Clinical Tr

127 On the basis of our data, we have designed a cooperative group phase III prospective, randomized tria

128 The NCI's investment in its cancer cooperative group research program has provided exceptio

129 esults for cisplatin-treated children in the cooperative group setting.

130 ) S0518, a phase III study conducted in a US cooperative group system, enrolled patients with advance

131 Here, we describe a multicenter cooperative group that has successfully leveraged the ex

132 st cancer remain largely underrepresented in cooperative group therapeutic trials.

133 This was the first cooperative group trial to evaluate this strategy using

134 an inferior outcome in 2 independent large, cooperative group trials.

135 culated for 1069 patients in US and Canadian cooperative groups with high-risk patients who had ccRCC

136 data from published trials performed through cooperative groups, consortia, and single institutions.

137 years, the number of contacts with Dutch PCP cooperatives has increased to 245 contacts per 1000 citi

138 ed in a case-control study nested within the Cooperative Health Research in the Region of Augsburg (K

139 on subjects are less likely to switch to pro-cooperative heuristics.

140 These compact conformations are amenable to cooperative, high-affinity histone binding.

141 species, a range that is broadened by their cooperative hunting.

142 from a longitudinal cohort study called the Cooperative Huntington Observational Research Trial (COH

143 A new route for the cooperative hydrolysis of GVL by framework Zn-OH and Bro

144 22%, and treatment of self-referrals by PCP cooperatives in emergency care access points is safe and

145 More than half of the PCP cooperatives in the Netherlands have integrated with hos

146 ization, performance, and development of PCP cooperatives in the Netherlands.

147 Therefore, the cooperative induction of DNA replication stress and dama

148 Cooperative inductive, mesomeric, steric, and chelate ef

149 We provide evidence of cooperative insertion of homo-oligomeric complexes and d

150 ent more time than low AQ subjects signaling cooperative intent in games with fixed strategy agents w

151 bstrate, suggesting that WRN recruitment and cooperative interaction with FEN1 during lagging-strand

152 studies, showing a complex interplay between cooperative interactions and dynamics dictated by the ZB

153 The co-cultures showed cooperative interactions and revealed another distinct s

154 ns are enriched in the global network, while cooperative interactions are depleted in the individual

155 suggesting that bilayer perturbation and/or cooperative interactions are important for their translo

156 Our findings reveal that competitive and cooperative interactions between actin binding proteins

157 oscopic investigations, it is suggested that cooperative interactions between CO2 and multiple active

158 hese applications depends on the presence of cooperative interactions between members of the communit

159 Competitive and cooperative interactions between organisms, including ba

160 ies have argued that ParB spreading requires cooperative interactions between ParB dimers including D

161 ce of 'cheating' cells that benefit from the cooperative interactions but do not contribute to them.

162 Despite this, cooperative interactions can be stabilized by spatial se

163 Cooperative interactions enrich microbial communities wi

164 this review, we illustrate the relevance of cooperative interactions in microbial biotechnological p

165 anges in the amide group in combination with cooperative interactions of bound water along the backbo

166 g to nucleosomes at suboptimal sites through cooperative interactions on DNA.

167 Harnessing these cooperative interactions to catalyse reactions in synthe

168 AR1 to regulate cocaine effects is linked to cooperative interactions with D2 autoreceptors and assoc

169 tolerant temperament than wolves, promoting cooperative interactions with humans and conspecifics.

170 ng evidence supports the importance of their cooperative interactions, microRNA (miRNA)-binding sites

171 an increased driving force for formation of cooperative interactions.

172 can take into account what others can see in cooperative interactions.

173 By virtue of the cooperative interplay among the selective hydrogenation

174 These results suggest that the cooperative interplay between molecular electronic struc

175 smon-induced hot electrons and exploit their cooperative interplay in a single metal-semiconductor de

176 combination process and find it to be highly cooperative, involving multiple phases.

177 ns because only polycations are able to form cooperative ion pairs with dinonylnaphthalenesulfonate a

178 interactions, which govern phenomena such as cooperative Lamb shifts, superradiant decay rates, Van d

179 To decipher the mechanisms of cooperative ligand binding it is necessary to define at

180 This cooperative lipid extraction mechanism for membrane perf

181 using a pair or team of microrobots, and the cooperative manipulation of multiple micro-objects.

182 roughput microassembly of micro-objects, and cooperative manipulation using multiple microrobots.

183 phycobiliproteins refold and reassemble in a cooperative manner from their unfolded polypeptide subun

184 een different supercoiled states in a highly cooperative manner.

185 A mechanistic proposal implicating a P-N cooperative mechanism for catalysis that incorporates th

186 ing from periplasm to cell surface through a cooperative mechanism involving the beta-barrel assembly

187 ic process by considering both competing and cooperative mechanisms and identifying functional module

188 Our results delineate multiple cooperative mechanisms in miRNA-mediated silencing and f

189 n 3.0-muM-OM-treated fibers, indicating that cooperative mechanisms linked to LDA were altered by the

190 inducing an ordering effect that led to more cooperative membrane melting.

191 a unique metabolic interaction to accomplish cooperative mineralization of organic compounds to CH4 a

192 Cs, we identified allosteric determinants of cooperative miRNA-mediated silencing that are required f

193 implicates a non-canonical seedless site in cooperative miRNA-mediated silencing.

194 ion both as a distinct modification and as a cooperative modification with Ub, using the cellular res

195 We showed that the predicted cooperative movements are essential to accommodate inter

196 accordance with the relative attenuation of cooperative movements with varying distance from the hin

197 transitions, highlighting the importance of cooperative multiscale processes.

198 This study investigated how the cooperative network of bacteria and fungi differ between

199 Thus, OX40 and ICOS act in a cooperative, nonredundant manner to maximize and prolong

200 3), prior taxane use ( P = .02), and Eastern Cooperative Oncology Group >/= 1 ( P = .01).

201 ease (per RECIST version 1.1) and an Eastern Cooperative Oncology Group (ECOG) performance status 0 o

202 previous local brain therapy, and an Eastern Cooperative Oncology Group (ECOG) performance status of

203 ophageal junction adenocarcinoma, an Eastern Cooperative Oncology Group (ECOG) performance status of

204 Patients had to have an Eastern Cooperative Oncology Group (ECOG) score of 0-2 and a doc

205 nction, and good performance status (Eastern Cooperative Oncology Group [ECOG] performance status 0-1

206 weeks of IV induction as part of the Eastern Cooperative Oncology Group high-dose IFN regimen is not

207 or second-line treatment; and had an Eastern Cooperative Oncology Group performance score of 0-2.

208 higher scores indicate worse pain), Eastern Cooperative Oncology Group performance status (range, 0-

209 sample for biomarker assessment, and Eastern Cooperative Oncology Group performance status 0 or 1, am

210 th unresectable, nonsarcomatoid MPM (Eastern Cooperative Oncology Group performance status 0 to 1), s

211 eria included age 18 years or older, Eastern Cooperative Oncology Group performance status 0-1, metas

212 ve treatment, symptomatic dysphagia, Eastern Cooperative Oncology Group performance status 0-2, and a

213 nit increase [1.02-1.20]; p=0.0188), Eastern Cooperative Oncology Group performance status 3-4 (2.92

214 patients (aged >/=18 years) with an Eastern Cooperative Oncology Group performance status of 0 or 1

215 nts were aged 18 years or older with Eastern Cooperative Oncology Group performance status of 0 or 1

216 nd were older than 18 years, with an Eastern Cooperative Oncology Group performance status of 0 or 1,

217 had adequate end-organ function, an Eastern Cooperative Oncology Group performance status of 0 or 1,

218 se, failure of standard therapy, and Eastern Cooperative Oncology Group performance status of 0 or 1.

219 Criteria in Solid Tumors, and had an Eastern Cooperative Oncology Group performance status of 0 or 1.

220 ts had untreated clear cell mRCC and Eastern Cooperative Oncology Group performance status of 0 to 2

221 and Methods Patients with mCRPC and Eastern Cooperative Oncology Group performance status of 0 to 2

222 status, any hormone receptor status, Eastern Cooperative Oncology Group performance status of 0-1, an

223 d curative therapy was available, an Eastern Cooperative Oncology Group performance status of 0-1, an

224 Patients were asymptomatic, with Eastern Cooperative Oncology Group performance status of 0-2, an

225 imited-stage small-cell lung cancer, Eastern Cooperative Oncology Group performance status of 0-2, an

226 unrevealing, and the patient had an Eastern Cooperative Oncology Group performance status of 0.

227 hey were at least aged 18 years, had Eastern Cooperative Oncology Group performance status of 1 or le

228 were aged 18 years or older, had an Eastern Cooperative Oncology Group performance status of 1 or le

229 =5 cm below the left costal margin), Eastern Cooperative Oncology Group performance status of 2 or le

230 proven CD30-positive tumours, had an Eastern Cooperative Oncology Group performance status of 2 or le

231 , 127 patients with stage III NSCLC (Eastern Cooperative Oncology Group performance status, 0 to 1) r

232 ex, including lactate dehydrogenase, Eastern Cooperative Oncology Group performance status, age, and

233 d stratified by geographical region, Eastern Cooperative Oncology Group performance status, macrovasc

234 eatment for metastatic melanoma, and Eastern Cooperative Oncology Group performance status.

235 tion Criteria In Solid Tumors v1.1), Eastern Cooperative Oncology Group performance statuses of 0 or

236 dose interferon (IFN) as part of the Eastern Cooperative Oncology Group regimen compared with observa

237 presence of visceral metastases, and Eastern Cooperative Oncology Group score.

238 ocality, distribution, infiltration, Eastern Cooperative Oncology Group status, AFP level, and PVT ex

239 d matched (for sex, cT and cN stage, Eastern Cooperative Oncology Group status, Charlson comorbidity

240 Network, including patients from the Eastern Cooperative Oncology Group-American College of Radiology

241 This coupling induces cooperative opening and closing of the channels.

242 with iron oxide minerals through a series of cooperative or competitive processes: solution complexat

243 f expectations, particularly about receiving cooperative or generous behavior from others.

244 Here, we show that rather than being cooperative or independent, ATP hydrolysis on the two pr

245 successful strategies depend not only on how cooperative others were in the past but also on the resp

246 We first show that females have a choice of cooperative partners.

247 oth downstream of ATOH7 and in parallel, but cooperative, pathways that involve regulation of Brn3b e

248 further emphasising the important role this cooperative phenomena may play in the RecA-facilitated h

249 t with H2O liquid, reflects a complex set of cooperative phenomena, including H/D exchange across the

250 y revealed that thermotaxis is controlled by cooperative PKC-2-mediated signaling in both AFD sensory

251 of gating and establish whether gating is a cooperative process involving the concerted action of re

252 reover we show that pb10 binding is a highly cooperative process, which favours immediate rebinding o

253 the molecular level that can participate in cooperative processes.

254 rial populations whose growth depends on the cooperative production of public goods are usually threa

255 s suggest that explaining the maintenance of cooperative public goods behaviors in certain natural sy

256 he thermodynamic balance of the metal ligand cooperative reactions, changing the energetics of the pr

257 While interest in cooperative reactivity of transition metals and Lewis ac

258 twork analysis revealed that competitive and cooperative reciprocal interactions are enriched in the

259 ress episodes, which exposes three different cooperative regimes according to the relationship betwee

260 velopment, implicating Myst2 and Niam in the cooperative regulation of this process and suggesting a

261 Here, we report cooperative regulatory functions of miR858 and its MYB83

262 s, the basis for enantioselectivity, and the cooperative relationship of the aldehyde, alkyne, and li

263 udy data from SWOG, an NCI-sponsored network cooperative research group.

264 ablished a network of publicly funded cancer cooperative research groups to systematically evaluate n

265 Experimental modeling has defined a cooperative role of activated eosinophils, mast cells, a

266 ther, these findings reveal differential and cooperative roles of SOM and PV inhibitory neurons in or

267 data demonstrate functionally distinct, but cooperative, roles for each kinase in preserving genome

268 on state in which atropisomerism occurs by a cooperative rotation of the Ar-CO and Ar-Ar' bonds depen

269 active conformation at the paired negatively cooperative site - a "half-site" behavior.

270 Sustained cooperative social interactions are key to successful ou

271 ynamics and gut microbiota of a group-living cooperative species of primate, the red-bellied lemur (E

272 shows that the combination of a conventional cooperative spin transition and ligand-driven magnetic c

273 AP1-UCH, BAP1-ULD, and ASXH domains formed a cooperative stable ternary complex required for deubiqui

274 xtended conformations are stabilized through cooperative steric, electrostatic, and hydrogen-bonding

275 Humans routinely use conditionally cooperative strategies when interacting in repeated soci

276 operties naturally lead to a unique class of cooperative strategies, which contains the classical Win

277 We propose several properties that a robust cooperative strategy for a repeated multiplayer dilemma

278 Switching can also proceed in a cooperative (strong anion then weak acid) or stepwise ma

279 icated that the two subunits tend to undergo cooperative structural changes, both on local (extracell

280 ent and lone-pair interactions, give rise to cooperative structural-ordering processes, by which ultr

281 uch as the US Department of Veterans Affairs Cooperative Studies Program have also enhanced their dat

282 outcome measure was the Alzheimer's Disease Cooperative Study Group Activities of Daily Living Scale

283 of Health's Statewide Planning and Research Cooperative System and census population estimates.

284 the New York Statewide Planning and Research Cooperative System and Nationwide Inpatient Sample.

285 The New York Statewide Planning and Research Cooperative System inpatient database was queried for pa

286 Registry and Statewide Planning and Research Cooperative System were queried for stage I to III colon

287 ts was observed to effect the all-or-nothing cooperative templation of an S6-symmetric host stereoiso

288 ound ATP and calcium is highly concerted and cooperative, the phosphorylation of Asp351 causes areorg

289 , demonstrating that these C2 domains may be cooperative to mediate FTIP1 function during the floral

290 Perturbation of the cooperative Tpz1-Poz1-Rap1 assembly through mutation of

291 These results reveal a cooperative transcriptional activation mechanism of AEP

292 rine balance, while polymerization may allow cooperative transitions between states.

293 class of switchable materials that can show cooperative transitions when long-range elastic interact

294 consisting of leadership from the four major cooperative trial groups (the International Childhood Li

295 We found cooperative two-state folding on a sub-millisecond time

296 how that the four-way junction increases the cooperative unfolding of its stems, although the reason

297 istribution are consistent with a two-state, cooperative unfolding transition having a melting temper

298 t show that proteins are assemblies of small cooperative units called foldons and that a number of pr

299 Cleavage was found cooperative with a cooperativity coefficient n = 2.3, su

300 ent in Pdf and slowing in the time course of cooperative XB recruitment (Trec), which collectively pr