ライフサイエンスコーパス: cooperative binding

1 ction between two consecutive PABPs promotes cooperative binding.

2 role in the mutually exclusive nature of the cooperative binding.

3 hancer activation that can be dissected from cooperative binding.

4 ding, suggesting that these segments mediate cooperative binding.

5 nd will also contribute significantly to the cooperative binding.

6 1 was enhanced by Nox1 and NOXO1, suggesting cooperative binding.

7 that dimerization is a major contributor to cooperative binding.

8 ssemble on TER with hierarchical rather than cooperative binding.

9 C with defective phosphorylation-independent cooperative binding.

10 a protein coat to the site of damage through cooperative binding.

11 in-protein interactions are not critical for cooperative binding.

12 e more globular conformations correlate with cooperative binding.

13 ted to exhibit signs of both competitive and cooperative binding.

14 d calcium, which was further enhanced by CD8 cooperative binding.

15 changes in the loop of the SL mediate their cooperative binding.

16 sigmoidal binding profile indicating highly cooperative binding.

17 , higher Ca(2)(+) affinity state, results in cooperative binding.

18 r CI dimer-dimer interactions and consequent cooperative binding.

19 Moderately cooperative binding (22.6 +/- 3.7 < or = omega < or = 14

20 tly increased intrinsic binding affinity and cooperative binding ability relative to PR-A.

21 However, we show here that highly cooperative binding also occurs in the (SSB)65/(SSB)56 b

22 We propose to use log-linear models to study cooperative binding among transcription factors and have

23 stedt and Brouhard report that DCX relies on cooperative binding and an affinity for growing microtub

24 This method takes advantage of the cooperative binding and catalytic properties of DNA-func

25 estriction endonuclease tetramers facilitate cooperative binding and cleavage of two short sites.

26 us and is likely to mediate nearest-neighbor cooperative binding and filament severing.

27 es the apo-WOC-PSII for the subsequent rapid cooperative binding and photo-oxidation of three additio

28 ce cofilin-binding site accessibility, favor cooperative binding and promote filament severing.

29 ing is nevertheless achieved, as a result of cooperative binding and reduced affinity of Arp2/3 compl

30 These structural changes are driven by the cooperative binding and subsequent hydrolysis of ATP, by

31 ere we evaluate the kinetic contributions to cooperative binding and the ability of this model to acc

32 binding free energy penalty, the absence of cooperative binding and the potential for ribosomal slid

33 exclusive switch, focusing on the effects of cooperative binding and the production of protein in bur

34 for the first time a functional link between cooperative binding and the repair reaction.

35 ause substantial changes in the magnitude of cooperative binding as expressed in the large difference

36 binding on both P'1,2 and P'2,3 substrates, cooperative binding at the arm-type sites P'2,3 was more

37 d the mutant L1014F channel is indicative of cooperative binding at two or more sites on these channe

38 nding of FoxO1 and FoxA1/A2 possibly entails cooperative binding because FoxO1 and FoxA1/A2 facilitat

39 The PNANs also exhibit cooperative binding behavior and nuclease resistance pro

40 We identified unique cooperative binding behavior of a number of 4,6-disubsti

41 cular contacts that explains how it achieves cooperative binding between adjacent sites.

42 Cooperative binding between dimers governs the concentra

43 Furthermore, NMR data showed cooperative binding between donor and acceptor substrate

44 n metal sites, appropriate pore geometry and cooperative binding between guest molecules is responsib

45 of the mutant Hoxb8 protein, implicating the cooperative binding between Hoxb8 hexapeptide motif and

46 NA and ATP substrates to DbpA, which reveals cooperative binding between larger RNAs and ATP with coo

47 oP-regulated promoters showed that there was cooperative binding between PhoP dimers at PhoP-activate

48 , DNase I footprinting assays indicated that cooperative binding between RhaR and CRP does not make a

49 of binuclear sites in EcMetAP formed through cooperative binding between the 5- and 6-coordinate Co(2

50 weaker TCR affinities for pMHC-II, a lack of cooperative binding between the TCR and CD4 coreceptor,

51 The affinities, spacing, and cooperative binding between the two sites is similar to

52 binding of 32 protein on forks too short for cooperative binding by 32 protein.

53 Many individual examples of cooperative binding by directly interacting TFs have bee

54 One mode involves cooperative binding by two GATA factors that interact wi

55 ectroscopy system is able to distinguish the cooperative binding conformation from the noncooperative

56 The approximately 50% cooperative binding conformation of wild-type PABPs indi

57 determine the binding site size and the non-cooperative binding constants to dsDNA for gp32 and I.

58 The analysis of cooperative binding data (either positive or negative) o

59 In addition to this hierarchical cooperative binding, discrimination requires a competiti

60 This corresponded to a positively cooperative binding effect with an entropic difference b

61 is of TREX2 and the heterodimers indicates a cooperative binding effect within the TREX2 protomer.

62 of attractive interactions results in clear cooperative binding effects that help overcome the entro

63 In the present study, we show cooperative binding energetics between distinct hot regi

64 hate must be achieved without benefit of the cooperative binding energetics of an associated primer.

65 This cooperative binding exhibited a Hill coefficient of 1.9

66 effectively displaced by distamycin, but the cooperative binding exhibited by distamycin was eliminat

67 proteins, but nucleic acids can also exhibit cooperative binding, for instance of transcription facto

68 The relative contributions of additive and cooperative binding forces and the influence of conforma

69 nificant difference between the additive and cooperative binding forces existing among the selected r

70 The non-contiguous and cooperative binding free energies are driven entirely by

71 n calorimetry to determine the intrinsic and cooperative binding free energies for a ligand-protein c

72 This cooperative binding has been interpreted with a model si

73 Cooperative binding has been shown to be the mechanism u

74 cently shown that porous solids that exhibit cooperative binding have substantial energetic benefits

75 ble system that preserves key ingredients of cooperative binding; i.e., at saturation, the lattice ca

76 rangements of the Ets and AP-1 sites support cooperative binding, (ii) the bZIP motifs of Fos and Jun

77 Nonetheless, the precise role of cooperative binding in defining cell-type identity is st

78 ions in the TLR4-Mal-MyD88 complex thus show cooperative binding in MAPPIT.

79 her with the acidic tip contribute to highly cooperative binding in the (SSB)35 binding mode.

80 fied His(10)-MrpC2 and FruA-His(6) indicated cooperative binding in vitro to three sites in the fmgE

81 del B accounts for the process of positively cooperative binding, in which noncovalent bonds are redu

82 as the chromogenic substrate all indicate a cooperative binding interaction in which the borate is e

83 el and general strategy for discovering such cooperative binding interactions in specific, flexible r

84 l division proteins are involved in multiple cooperative binding interactions, thus presenting a tech

85 Cooperative binding is commonly observed in proteins wit

86 Cooperative binding is eliminated by insertion of a half

87 This cooperative binding is essential for establishment and m

88 reased (GG-X-GG < X5 < X10), suggesting that cooperative binding is important for surface attachment

89 hat MepR dimers do not interact directly and cooperative binding is likely achieved by DNA-mediated a

90 for a second-order reaction, suggesting that cooperative binding is limited also by binding site acce

91 This cooperative binding is mediated by the conserved C-termi

92 Cooperative binding is most often observed in proteins,

93 Although cooperative binding is one mechanism for generating ultr

94 We have previously shown that cooperative binding is required for regulation of IgE pr

95 nked to the minimal tk promoter suggest that cooperative binding is required to activate transcriptio

96 of the D2 domain is required for adenovirus cooperative binding, it has a negative consequence upon

97 The rate of cooperative binding (ka) of both gp32 and of its proteol

98 High AGT densities resulting from cooperative binding may allow efficient search for lesio

99 how activators can operate through a simple cooperative binding mechanism but affect different steps

100 17 interaction is mediated by a specific and cooperative binding mechanism that includes two active b

101 complex with MLL, which suggests a positive cooperative binding mechanism, and the affinity for MLL

102 -bridged HBD2 dimers exhibited features of a cooperative binding mechanism.

103 recognition that involves a metal-dependent cooperative binding mechanism.

104 n lead to a noncompetitive, uncompetitive or cooperative binding mechanism.

105 BD6-FX interaction, exhibiting features of a cooperative binding mechanism.

106 concentrations is likely achieved through a cooperative binding mode.

107 These findings suggested a cooperative binding model for tallimustine in which one

108 The data support a cooperative binding model in which Nef functions as a cl

109 These data were interpreted using a cooperative binding model wherein multiple non-covalent

110 proved packing is associated with positively cooperative binding, occurring with a benefit in enthalp

111 Cooperative binding occurs if the number of binding site

112 Strong cooperative binding occurs only in the presence of two o

113 Cooperative binding occurs only with both operators pres

114 Cooperative binding of a bis(tridentate) ruthenium(II) c

115 Cooperative binding of a ligand to multiple subsites on

116 We also report the cooperative binding of a mixture of acetylene and ethyle

117 re of this network is the mutually exclusive cooperative binding of a repressor dimer (CI) to one of

118 ver, CD-BLM mediates ds-DNA cleavage through cooperative binding of a second CD-BLM molecule to effec

119 catalytic efficiency increased 8.4-fold upon cooperative binding of a second magnesium ion (Hill coef

120 rentiation of bacterial chromatin depends on cooperative binding of abundant nucleoid-associated prot

121 -actin helical structure can be modulated by cooperative binding of actin-binding proteins.

122 n structure of the ternary complex formed by cooperative binding of activation domains from the c-Myb

123 Cooperative binding of AdoMet and DTB may be an importan

124 We also provide evidence for cooperative binding of AerR and CrtJ to the puc promoter

125 Interestingly, this cooperative binding of ammonium sulfate salts was also e

126 is critically modulated by the specific and cooperative binding of anionic nonannular lipids close t

127 iation is reversible and is regulated by the cooperative binding of approximately two protons to the

128 e filament introduced by Arg can explain the cooperative binding of Arg to F-actin and might prevent

129 ed intrinsic protein fluorescence and highly cooperative binding of at least four Zn2+ ions (KD appro

130 that CD23 associates as an oligomer and that cooperative binding of at least two lectin domains is re

131 ctive state of a GroEL ring involves initial cooperative binding of ATP, recruiting GroES, followed b

132 ifications to the transmembrane subunits and cooperative binding of ATP.

133 ated for high affinity binding of InsP(6) by cooperative binding of both a new substrate and InsP(6).

134 ded nucleic acid binding motif that promotes cooperative binding of both aminoacylation and editing d

135 (ii) Selective and cooperative binding of both an acetato ligand and an ami

136 plot analysis of the data indicates positive cooperative binding of both recMoPrP(Q218K) and recMoPrP

137 nce follows a simple Hill plot demonstrating cooperative binding of Ca2+ to the binding sites in CaM.

138 erol concentration we observed high-affinity cooperative binding of cholesterol with sub-nM affinity

139 Our findings of cooperative binding of Cmr to these DNA regions and the

140 First, repression requires the cooperative binding of CodY to at least two adjacent mot

141 by a few copies of CP, RNA folding, and then cooperative binding of CP to the "labeled" nucleoprotein

142 nduced dissociation caused by the negatively cooperative binding of EGF to the second site on the EGF

143 n the stomach correlates with activation and cooperative binding of Elk-1 and the SRF to the proximal

144 The result of this cooperative binding of ER and p65 at adjacent response e

145 ther neurotransmitter receptors, rely on the cooperative binding of extracellular small-molecule and

146 is study demonstrates that the high-affinity cooperative binding of f-ImPyIm can be enhanced signific

147 Cooperative binding of FruA and MrpC2 appears to be a co

148 h appears to be regulated by three sites for cooperative binding of FruA and MrpC2.

149 at this condition can be fulfilled is by the cooperative binding of Gag molecules to nucleic acid.

150 studies of the dynamics of the isolated and cooperative binding of gp32 molecules within the replica

151 ith the use of a mathematical model based on cooperative binding of graded and uniform factors.

152 a "click-to-fit" mechanism that involves the cooperative binding of heparan sulfate and alpha5beta1 i

153 intercalated ethidium bromide and facilitate cooperative binding of Hoechst 33258 at the minor groove

154 The inhibition studies show that cooperative binding of inhibitors in the S1 and S2 subsi

155 Cooperative binding of ion pairs to receptors is crucial

156 l coefficient of 0.60, indicating negatively cooperative binding of L-arginine.

157 Therefore traditional models involving cooperative binding of ligand or robust allosteric regul

158 ively occurs upon positively, or negatively, cooperative binding of ligand.

159 sing the McGhee-von Hippel formalism for the cooperative binding of ligands to a monodimensional latt

160 pervades macromolecular function and drives cooperative binding of ligands to macromolecules.

161 Cooperative binding of ligands to proteins can serve to

162 In the presence of Zn(2+), cooperative binding of MAM to the DR1 dimer was also obs

163 The data support cooperative binding of MPO and HK on cells such that MPO

164 y site, which corresponded to a site of weak cooperative binding of MrpC2 and FruA and boosted dev ex

165 Allele-selective inhibition may involve cooperative binding of multiple protein-RNA complexes to

166 These findings suggest that cooperative binding of multiple transcription factors re

167 that acts through the functional synergy and cooperative binding of multiple transcription factors.

168 Using this approach, the cooperative binding of myosin along thin filaments has b

169 of thin filament activation by Ca2+ nor the cooperative binding of myosin S1-ADP to the thin filamen

170 inding locally, we successfully simulate the cooperative binding of myosin to actin observed experime

171 The cooperative binding of NAD(+) is also sensitive to pH; d

172 FERM domain of ezrin to NHERF regulates the cooperative binding of NHERF to bring two cytoplasmic ta

173 alter Lrp's non-specific binding affinity or cooperative binding of non-specific DNA.

174 main and provides a structural basis for the cooperative binding of one molecule of compound 3 to two

175 Non-cooperative binding of only one Ca(2+), and loss of ATPa

176 Together strong: Cooperative binding of organic (see picture, red) and in

177 of a single-myosin crossbridge, resulting in cooperative binding of other cycling crossbridges.

178 Cooperative binding of phenolic species to insulin hexam

179 Here, we examine cooperative binding of pi dimers and explore the role th

180 ed microscale thermophoresis to quantify the cooperative binding of PIP(2) and Ca(2+) to synaptotagmi

181 , the N-terminal POZ domain was required for cooperative binding of PLZF to a multimerized PLZF-RE.

182 inal motor neuron identity is established by cooperative binding of programming transcription factors

183 Cooperative binding of proximal sites for the same or di

184 Kinetics of cooperative binding of rat polymerase beta to a double-s

185 phaCTD) of RNA polymerase (RNAP) facilitates cooperative binding of ResD approximately P and RNAP, th

186 However, only the cooperative binding of RhoA to the central p120 domain a

187 Several laboratories have reported cooperative binding of S1 to actin in the presence of ca

188 nd revealed a strong correlation between the cooperative binding of S1 to the closed state and the mo

189 function through reduction in the nature of cooperative binding of S1.

190 and free energy measurements demonstrate the cooperative binding of S15 and the S6:S18 heterodimer, b

191 No evidence for highly cooperative binding of scRPA to ssDNA was found under an

192 NA decay is more complex and may involve the cooperative binding of several RNA-binding proteins at d

193 In contrast to the cooperative binding of SR proteins observed on the doubl

194 tation genes are supposedly regulated by the cooperative binding of Ste12 and Tec1 on a PRE adjacent

195 This work sheds light on cooperative binding of TF binding proteins in regulating

196 ciated that lac promoter repression involves cooperative binding of the bidentate lac repressor tetra

197 sing microtubule affinity as well as driving cooperative binding of the CHD.

198 en HMGB1 and target proteins, which leads to cooperative binding of the complex to DNA.

199 requirement of a 4-bp spacer and the highly cooperative binding of the dimer.

200 We conclude that cooperative binding of the hydrophobic cavity and basic

201 Our data further suggest that the cooperative binding of the RB69 DNA polymerase and SSB t

202 form the tetramer that is necessary for the cooperative binding of the repressor.

203 the fmgA gene by a novel mechanism involving cooperative binding of the response regulator FruA and t

204 transition associated with high affinity and cooperative binding of the second Ca(2+) and the engagem

205 duce a steady-state bimodal response without cooperative binding of the TF.

206 ter region, depends on FruA, consistent with cooperative binding of the two proteins in vivo.

207 We conclude that cooperative binding of the two proteins to this promoter

208 t a DNA U-turn is induced by progressive and cooperative binding of the two TFAM HMG-box domains and

209 Pol II (rpb1-1) mutant, indicating mutually cooperative binding of these components of the transcrip

210 In turn, the simultaneous and cooperative binding of these factors is required to regu

211 roximal to other footprints, consistent with cooperative binding of these footprints.

212 The results showed strongly positive cooperative binding of three equivalents of metal per mo

213 This relation is presumed to result from the cooperative binding of three to four Ca(2+) ions at the

214 Cooperative binding of transcription factors (TFs) to pr

215 Cooperative binding of transcription factors is known to

216 The TIN2-mediated cooperative binding of TRF1 and TRF2 to telomeres has im

217 DNA polymerase binds to DNA followed by the cooperative binding of two additional molecules of the p

218 rotein represses gene expression by a highly cooperative binding of two adjacent dimers to essentiall

219 The cooperative binding of two Ca(2+) ions to the C2 domain

220 High-affinity and cooperative binding of two Ca(2+) per ATPase (SERCA) occ

221 The cooperative binding of two calcium ions to the second an

222 is impaired, and full activity requires the cooperative binding of two forked DNA substrate molecule

223 We observe cooperative binding of two MsrA to each CaMox with an ap

224 tively and Na(+) binding appeared to involve cooperative binding of two Na(+).

225 tion of the papillomaviruses is specified by cooperative binding of two proteins to the ori site: the

226 ent genes have been shown to be regulated by cooperative binding of two transcription factors to the

227 ins three distinct activities, which are (i) cooperative binding of two U1A proteins to a 50-nucleoti

228 Thus, one site of interaction is cooperative binding of Val 12-ras-p21 to raf and JNK.

229 Dimerization allowed cooperative binding of wild-type (WT) PITX2a to DNA cont

230 subunits are independent, demonstrating that cooperative binding or concerted conformational changes

231 the combined effects of preorganization and cooperative binding permitted by the pyrrole NH donor gr

232 protein C (CENP-C) homologue Mif2 to form a cooperative binding platform for outer kinetochore assem

233 that the C-C domain interaction doubles the cooperative binding probability.

234 nd suggested to be the first occupied in the cooperative binding process activating phosphorylation f

235 lysis of the binding data reveals a possible cooperative binding process in solution.

236 This highly cooperative binding produces very sharp transitions betw

237 ssessing these activities, the CTD lacks the cooperative binding properties observed for full-length

238 We report here on the cooperative binding properties of a tetratopic ion-pair

239 emical recognition properties of DNA and the cooperative binding properties of DNA-functionalized gol

240 These observations imply that cooperative binding requires dimerization.

241 Highly cooperative binding requires the 56 amino acid intrinsic

242 This cooperative binding requires the POZ domain of BCL-6.

243 ntal units of Sir chromatin binding and that cooperative binding requiring two appropriately modified

244 A further substantial contribution to cooperative binding results from the proximity of the bo

245 ule ligands that induce positive or negative cooperative binding reveals that positive cooperativity

246 P450eryF cause an ample spin shift revealing cooperative binding ( S50 = 8.2 +/- 1.3 microM; n = 2.3

247 ch suggests that phosphorylation-independent cooperative binding sets the basal level for glutamine s

248 lirin SH3 domain is unique, containing novel cooperative binding site(s) for intramolecular PXXP liga

249 We localized cooperative binding sites for En, with the homeodomain-c

250 olecules bind interdependently to three anti-cooperative binding sites on the trimeric PII protein an

251 Predictions of known cooperative binding sites show a 0.85 area under an ROC

252 e IL-2 adaptive region contains at least two cooperative binding sites where the binding of a first l

253 ntial motif arrangements for TBX5 and NKX2-5 cooperative binding sites, supported at the atomic level

254 oth ATP and ADP at two equivalent but highly cooperative binding sites.

255 We have found that the cooperative binding strength increases as the square of

256 s and modeling, we propose possible modes of cooperative binding tandem poly(C) motifs by the KH doma

257 emblies is a result of significant levels of cooperative binding that is present in both solvents.

258 which serves as the nucleation step for the cooperative binding that occurs at transiently exposed s

259 action with DevR approximately P resulted in cooperative binding, thereby enabling co-regulation of t

260 ite NFAT/AP-1 sites, which typically support cooperative binding, thus further reinforcing the need f

261 ucture of the RNA reveals the origins of the cooperative binding to 5S rRNA that has been observed fo

262 However, 1-70 Int does show the same cooperative binding to adjacent arm sites as the full le

263 ormation that appears to facilitate pairwise cooperative binding to adjacent operator sites.

264 he CTD that is in pre-equilibrium to its non-cooperative binding to both dsDNA and ssDNA.

265 dependent cooperative binding, which relates cooperative binding to both the target concentration and

266 eved by interaction with protein partners or cooperative binding to closely separated Ets binding sit

267 Cooperative binding to DNA of tyrosine-phosphorylated ST

268 r, we show that self-association facilitates cooperative binding to DNA.

269 ediate Xis-Xis interactions required for its cooperative binding to DNA.

270 , intermolecular interactions as assessed by cooperative binding to DNA.

271 h BRFU and hB", which may then promote their cooperative binding to form TFIIIB-alpha.

272 ession by feedback modulation in response to cooperative binding to glycine.

273 on binding and is likely to be important in cooperative binding to KorB.

274 , one (Cdc20(M)) through well-characterized, cooperative binding to Mad2 and Mad3/BubR1 (forming the

275 e and cleave their cognate DNA sites through cooperative binding to opposite sides of the DNA substra

276 g to which Alx3 must act homodimerically via cooperative binding to P3-like sites is insufficient to

277 beta(1) concentration in a manner suggesting cooperative binding to PA.

278 involving direct hPAF1C-SII interactions and cooperative binding to RNA polymerase II.

279 th dsRNA translocation without unwinding and cooperative binding to RNA.

280 m occupancy of site I is required to trigger cooperative binding to site II and catalytic activation.

281 in a wild-type-like, salt-dependent shift in cooperative binding to ssDNA.

282 ties with the (SSB)35 mode displaying highly cooperative binding to ssDNA.

283 demonstrated two possibly distinct types of cooperative binding to substrates with Ets binding motif

284 element, multimeric forms are deficient for cooperative binding to tandemly duplicated elements, ind

285 o-terminal domain is largely dispensable for cooperative binding to the hb enhancer element, it is pr

286 r element, it is preferentially required for cooperative binding to the kni enhancer element.

287 By measuring CPBP cooperative binding to the msrA promoter, we have mapped

288 tion is the formation of tetramers, allowing cooperative binding to their DNA response elements.

289 ize similar binding sites and participate in cooperative binding via protein-protein interactions wit

290 Consistent with cooperative binding, we demonstrate that the Gal4-Tra1 i

291 Cooperative binding, whereby an initial binding event fa

292 stical mechanical model of density-dependent cooperative binding, which relates cooperative binding t

293 Cooperative binding with ELF4 increases the binding affi

294 carboxy-terminal auto-inhibitory domain, but cooperative binding with factors such as PU.1 or SPIB in

295 -terminal tail of Xis, which is required for cooperative binding with integrase, is unstructured in t

296 of KLF4 on SMC marker genes is dependent on cooperative binding with pELK-1 (downstream activator of

297 gion within SNAP190 that is (i) required for cooperative binding with TBP in the context of mini-SNAP

298 text of mini-SNAP(c) and (ii) sufficient for cooperative binding with TBP when fused to a heterologou

299 ding of MelR303 to sites 1' and 2' is due to cooperative binding with the adjacent site.

300 ently to outcompete the downstream MrpC2 for cooperative binding with the upstream MrpC2.

301 as well as assembly kinetics, and can treat cooperative binding within one of the interacting molecu