ライフサイエンスコーパス: cooperative effect

1 er to dimer to trimer, signifying a positive cooperative effect.

2 binations of gif1 and grf mutations showed a cooperative effect.

3 creased the P(f) of T310I, consistent with a cooperative effect.

4 imer to trimer, signifying a strong positive cooperative effect.

5 he sites at -5.2, -5.5, and -6.1 kb elicit a cooperative effect.

6 e two subdomains independently, indicating a cooperative effect.

7 n, is both necessary and sufficient for this cooperative effect.

8 monium cation that suggests a supramolecular cooperative effect.

9 provided new insights on these distinct but cooperative effects.

10 ery of cargo in living cells may result from cooperative effects.

11 mutant cycles, to determine the presence of cooperative effects.

12 ETO degradation, but without any additive or cooperative effects.

13 e overall effect, indicating the presence of cooperative effects.

14 y a copy of sites III and IV abolishes these cooperative effects.

15 ding to the dehydratase domain, both through cooperative effects.

16 porphyrin core and with negligible negetive cooperative effects.

17 rd small molecules that exploit metal-borane cooperative effects.

18 of different sizes, changes under different cooperative effects.

19 l/mol to the overall resistance, most of the cooperative effect (0.8 +/- 0.7 kcal/mol) being mediated

20 est path structure of the connectome enables cooperative effects, accelerating the spread of cascades

21 pRB is mutually dependent, and without this cooperative effect, activation steps previously shown to

22 rved cell cycle arrest likely results from a cooperative effect among the modulations of these genes

23 were activated simultaneously, suggesting a cooperative effect among these kinases.

24 Cooperative effects among residues of the reactive-site

25 SK and JNK signaling pathways and subsequent cooperative effects among the transcriptional factors CH

26 has been established for the first time for cooperative effects and cross talk between the C/EBP fam

27 creasing concentrations of ATP or PknK exert cooperative effects and enhance the inhibitory function

28 hat the SPO ligand demonstrates ligand-metal cooperative effects and plays a seminal role in the hete

29 lity of phosphate to reduce the site to site cooperative effects and render each ligand binding site

30 linear relationship between the magnitude of cooperative effects and the number of mutant subunits.

31 sis on the stoichiometry of the interaction, cooperative effects, and their consequences for the inte

32 lication, Reynafarje and Pedersen claim that cooperative effects are an artifact caused by endogenous

33 interactions are additive, and no enthalpic cooperative effects are apparent.

34 The cooperative effects are most pronounced with medium chai

35 Modest cooperative effects are observed for the snugly fitting

36 We propose that these cooperative effects are propagated through a dynamic str

37 The role of cooperative effects arising from noncovalent attractive

38 has to exclude templating, allosteric and/or cooperative effects as the latter are specific for indiv

39 lications in understanding allostericity and cooperative effects, as well as protein engineering and

40 lower frequency by some 50-70 cm(-1) due to cooperative effects associated with the central amide ac

41 in low concentrations of Mn2+, and apparent cooperative effects at higher Mn2+ concentrations result

42 ge of BCR:ligand affinities and involved: 1) cooperative effects at promoting early cell cycle progre

43 However, a cooperative effect between adjacent Hg atoms is observed

44 K1 and a kinase-inactive mutant of S6K1, the cooperative effect between PDK1 and protein kinase Czeta

45 alone, showing an unexpected beneficial and cooperative effect between the vector and GDEPT.

46 A strong cooperative effect between these two transgenes induced

47 ciency were correlated with an unprecedented cooperative effect between two neighboring Nb centers on

48 It appears that a cooperative effect between two proximal functional group

49 To examine potential mechanisms for cooperative effects between bacterial and viral infectio

50 Addition of phalloidin did not alter cooperative effects between bound Ca2+ molecules in the

51 RNA virus assembly was created to model the cooperative effects between capsid proteins and genomic

52 olymerization results argue that substantial cooperative effects between catalytic sites are operativ

53 t of the receptor within the surface reveals cooperative effects between clustering and binding that

54 These experiments document cooperative effects between constitutively activated tyr

55 s change with peptide length and predict new cooperative effects between distant residues in HLA-B07:

56 have large dielectric response arising from cooperative effects between donor and acceptor units whe

57 Mutational analysis revealed cooperative effects between glycans and residues at thes

58 Our results show both negative and positive cooperative effects between hydrophobic pocket interacti

59 More simply, however, cooperative effects between Lewis acids and organocataly

60 In this work we study cooperative effects between neighboring cells of differe

61 of applied bias, suggesting the presence of cooperative effects between optical and electrical stimu

62 ) causes endothelial NO* release mediated by cooperative effects between PI 3-kinase/Akt-dependent eN

63 everal Raman and ROA bands also clearly show cooperative effects between the mismatch and pyrimidine-

64 This special cooperative effect can only be realized, if the ROS-prod

65 However, previous studies have suggested cooperative effects during the peptide binding process.

66 l to the protein concentration, suggesting a cooperative effect for DNA cleavage.

67 sociate with each other and exert a positive cooperative effect for gene regulation.

68 with enhanced an ionic liquid effect through cooperative effects for the substrate activation and fur

69 Dimers harboring two mutations with opposite cooperative effects had different allosteric properties

70 omplexes [3.12] and [4.12] showed a negative cooperative effect in both cases.

71 tert-butoxy)siloxide ligands induces a large cooperative effect in the reduction of CO2.

72 -component infusion evidently results from a cooperative effect in which charge is generated on g-C3N

73 concept is illustrated via investigation of cooperative effects in an extended system of compartment

74 of the mechanism and suggest the origins of cooperative effects in meta-substituted aryl oxazolines.

75 tgun scanning should be useful for assessing cooperative effects in other protein-protein interaction

76 , phosphate buffer significantly reduces the cooperative effects in serine binding without affecting

77 early half of these neuronal trios displayed cooperative effects in which the cortical discharge prob

78 n between clones is considered; there are no cooperative effects included.

79 DNA with similar affinity, but the negative cooperative effect is eliminated.

80 rminal deletion enzymes, suggesting that the cooperative effect is mediated via N-terminal intersubun

81 Obtaining insight into microscopic cooperative effects is a fascinating topic in condensed

82 lated electron transfers, and the associated cooperative effects lead to the formation of O(-) radica

83 Both AQP1 mutants exhibit a surprising cooperative effect leading to a reduction in the free-en

84 - than in the RasTg group suggests that this cooperative effect may be in part explained by increased

85 have suggested that strong, but short-range cooperative effects may occur in H-bond chains.

86 The strong cooperative effects observed between anti-Ig and TGF bet

87 The theory also predicts the cooperative effects observed in the calcium loading of T

88 This negative cooperative effect of 17b may provide insight into appro

89 its effect on cell size and number, and the cooperative effect of Akt on oncogene-driven proliferati

90 The cooperative effect of amine-templating and doping by Sn

91 eal carcinomatosis, was used to evaluate the cooperative effect of an antiangiogenic gene therapy com

92 h regulators were abundant (i.e., a negative cooperative effect of ATP x CTP).

93 ion of troponins that bound Ca2+, implying a cooperative effect of bound Ca2+ on cross-bridge cycling

94 linear clusters or chains, stabilized by the cooperative effect of chemical bonds with the substrate

95 but many behavioral studies find an apparent cooperative effect of D1 and D2 receptors in the nucleus

96 The adsorption is driven by the cooperative effect of divalent metal ion condensation al

97 hysiologic testing is critical in ensuring a cooperative effect of drug and implantable cardiovascula

98 S6K activation by EGF and contributes to the cooperative effect of GPCRs on p70S6K activity and cell

99 Hence, it is the cooperative effect of inactivation of both pRB and p53 t

100 ng affinities between the proteins, but to a cooperative effect of interactions in the TCR-SEA-MHC cl

101 In a nuclear factor-DNA binding assay, the cooperative effect of mmLDL and LPS costimulation on c-J

102 gratory front-back polarity emerges from the cooperative effect of myosin IIA (MIIA) and IIB (MIIB) o

103 Notably, a cooperative effect of ortho-substituents in the case of

104 Therefore, these results suggest a cooperative effect of p12 and CA during the early events

105 cognized and suggests an explanation for the cooperative effect of Raf-1 and Rho family proteins on c

106 finity interaction that is the result of the cooperative effect of single motifs simultaneously bindi

107 the transient transfection assay, a positive cooperative effect of SRF and TEF-1 was observed when DN

108 uperposition model for the evaluation of the cooperative effect of substituents in homo- and heterosu

109 ical reduction of Erk activity inhibited the cooperative effect of TGFbeta and ErbB2 on migration and

110 firing of a given place cell is primarily a cooperative effect of the activity of its neighbors on t

111 region of the IL-8 gene revealed a positive cooperative effect of the binding sites for AP-1 and NF-

112 A positive cooperative effect of the binding sites for the transcri

113 p of the reaction of the N-oxide is due to a cooperative effect of the C-H Bronsted acidity, the stre

114 tion between gp120 and its receptors and the cooperative effect of the CCR5 binding site on the CD4 b

115 superlattices is shown to be a result of the cooperative effect of the entropy-driven crystallization

116 ws an increased stability resulting from the cooperative effect of the multiple pi-stacking interacti

117 In the post-diauxic phase, the cooperative effect of the pheromone activated mitogen-ac

118 radient in the negative effect, suggesting a cooperative effect of the three CRX elements.

119 DFT studies support the presence of a cooperative effect of the two metal centers in the trans

120 s efficiently (Kd = 2 x 10(-8) M), showing a cooperative effect of the two motifs.

121 with respect to calix[6]-host 1a, due to the cooperative effect of their two subcavities.

122 The cooperative effect of these two classes of inhibitors on

123 Consistent with the cooperative effect of TSA and RA, coaddition of the two

124 served during EBOV infections results from a cooperative effect of two or more individual IRADs.

125 improvement in kcat is likely because of the cooperative effects of additional substitutions located

126 The cooperative effects of AKT, ERG, and androgen receptor i

127 hepatitis viral proteins could contribute to cooperative effects of alcohol consumption and viral hep

128 n the sensor and hydrogel host resembles the cooperative effects of an apoenzyme and cofactor: the ho

129 humoral immune responses that depends on the cooperative effects of B cells and T cells.

130 The results support a model in which cooperative effects of both Ag-DNA ligation and variatio

131 ervations provide evidence for near-neighbor cooperative effects of both rigor and cycling cross-brid

132 les larger property enhancement owing to the cooperative effects of both the increased cross-link den

133 ostatic interactions and it is proposed that cooperative effects of both water structure and surfacta

134 filament MgATPase rate and did not eliminate cooperative effects of Ca2+ binding.

135 efects of dE2F1-depleted cells depend on the cooperative effects of dE2F2 and DACAPO (DAP), an inhibi

136 hydrogels in physiological buffer driven by cooperative effects of electrostatic interaction, van de

137 important delta(H)-determinant, longer-range cooperative effects of extended hydrogen networks make s

138 However, the cooperative effects of fluid shear stress and matrix sti

139 Cooperative effects of genetic alterations are frequentl

140 tentiation of Treg responsiveness to IL-2 by cooperative effects of IL-6 and IL-1, both of which are

141 In this study, we explore the cooperative effects of ligand binding and Magnesium inte

142 The cooperative effects of ligand binding appear to be minim

143 ion within individual NCs; this supports the cooperative effects of mixed cation-anion doping in shif

144 Multibody potentials accounting for cooperative effects of molecular interactions have shown

145 nhibitors should take into account potential cooperative effects of multiple kinase mutations, and th

146 ortening is not the result of changes in any cooperative effects of myosin on Ca2+ binding to the thi

147 ls suggest that this patterning results from cooperative effects of Nf1 loss in glial cells and the a

148 ance in prostate cancer, we investigated the cooperative effects of Pim kinase inhibition with ABT-73

149 r is to modulate behaviors by inhibiting the cooperative effects of postsynaptic D1 and other D2 clas

150 The results suggest that the cooperative effects of PPARgamma- and RXR-specific ligan

151 ptor (alpha(1)-AR) pathway that requires the cooperative effects of protein kinase (PK)Cepsilon and P

152 regulation, for the redox reaction, and for cooperative effects of serine binding.

153 To characterize the allosteric, cooperative effects of serine, we identified W139G PGDH

154 elated activity between interneurons, by the cooperative effects of shared synaptic depolarization an

155 r microstructure is found to be based on the cooperative effects of the normal and thermal diffusion

156 gene transcription, which is mediated by the cooperative effects of the transcription factors, HIF-2

157 The cooperative effects of thrombin on Akt/p70S6K phosphoryl

158 ditive, and significant positive or negative cooperative effects often exist.

159 s shown to determine whether the substituent cooperative effect on a property is of an enhancing or d

160 type receptors in the shell of the ACB had a cooperative effect on DA-mediated reward processes.

161 We observed a striking cooperative effect on focus-forming ability when Galpha1

162 A significant cooperative effect on lifespan is observed between asm-3

163 ular pattern (PAMP) stimulation had a strong cooperative effect on macrophage activation and inflamma

164 The rate of decay of the cooperative effect on most properties, including the (hy

165 Bcl-2, caspase-3, P53, and survivin have a cooperative effect on progression of bladder cancer.

166 variations, we observed the influence of the cooperative effect on single base pair mismatches.

167 sfection of Smad2 and Runx2 constructs had a cooperative effect on TGF-beta 1-stimulated collagenase-

168 , and botrocetin had the expected positively cooperative effect on the binding of VWF A1 to GPIbalpha

169 from RET and regulate HIF-1, abrogated their cooperative effect on the CA9 promoter.

170 rough their electrostatic interaction have a cooperative effect on the proton-transfer rate.

171 We propose a model in which the Tax/Ets1 cooperative effect on the PTHrP P2 promoter is based on

172 the presence of both ligands can result in a cooperative effect on the transactivation of target gene

173 ecific CD8+ T cell numbers and resulted in a cooperative effect on tumor regression, with apparent cu

174 the receptor from which it exerts negatively cooperative effects on [3H]spiperone binding to the comp

175 polize the translational machinery to elicit cooperative effects on cell growth, cell cycle progressi

176 idence for an alternative mechanism based on cooperative effects on cell motility.

177 anced matrix stiffness, and together exerted cooperative effects on cellular modulation of matrix mec

178 interfere with hydrogen bond formation show cooperative effects on complex stability and affinity.

179 and protein kinase A pathways may occur via cooperative effects on GR-mediated gene transcription.

180 s showed that phenformin and PLX4720 exerted cooperative effects on inhibiting mTOR signaling and ind

181 results suggest that the effector exerts its cooperative effects on MDZ metabolism through simultaneo

182 tions and the N52I mutation, consistent with cooperative effects on protein folding and stability bei

183 alone, suggesting that Galphas and Hrs have cooperative effects on regulating EGF receptor degradati

184 nding to the competitive site and positively cooperative effects on the binding of the modulator to t

185 The cooperative effects on the rates of intrafilament motion

186 Cooperative effects on the reactivity of the complexes w

187 reover, these miRNAs produce overlapping and cooperative effects on tumor suppressor genes implicated

188 Cooperative effects on Zn(II) affinities stemming from t

189 Such cooperative effects provide a means of manipulating the

190 These cooperative effects rely on key aromatic residues, and a

191 To test whether there is a cooperative effect resulting from the two subunits being

192 The cooperative effect seen at low doses switches to antagon

193 which displaced each other and displayed no cooperative effects, several other combinations resulted

194 Such cooperative effects suggest a number of applications tha

195 hydrophobic contact also contributes to the cooperative effect, suggesting a role for all energetic

196 Ets1 interaction also inhibited the Tax/Ets1 cooperative effect, suggesting that the interaction betw

197 ns (V82A/I84V/M46I/I54V) only showed a small cooperative effect, suggesting that the mutations at the

198 The mechanism by which the present cooperative effects take place is investigated, as is th

199 or anionic species is attributed to a strong cooperative effect that arises from the properly positio

200 into the origins of the allosteric negative cooperative effects that are transmitted over long dista

201 Two cross-checking analyses show cooperative effects that cause individual hydrogen bond

202 aracteristic of the binding site accentuates cooperative effects that permit mutations in distal resi

203 In addition to exhibiting a strong cooperative effect, the Tgfbeta receptor inhibitor bypas

204 t to the aspect ratio of the dye, allowing a cooperative effect to increase their overall average ali

205 r influenza hemagglutinin FP, i.e., it has a cooperative effect versus the peptide/lipid ratio, suppo

206 the PTHrP promoter was mutated, the Tax/Ets1 cooperative effect was dramatically decreased.

207 k functional CD8+ T cells, suggesting that a cooperative effect was exerted by the combination of neu

208 In such complexes, a peripheral cooperative effect was found, alleviating the excess of

209 Also, a clear cooperative effect was observed for the taxoid-camptothe

210 No cooperative effect was observed with GFAP-hCDK4; Rb+/- m

211 To investigate these cooperative effects, we cultured bovine aortic ECs on hy

212 Cooperative effects were also evident in CheA binding an

213 Importantly, the mmLDL and LPS cooperative effects were evident at a threshold LPS conc

214 Cooperative effects were observed with local radiotherap

215 icity of [2]+ arises from both Coulombic and cooperative effects which lead to formation of a B-F-->P

216 l 30 amino acids of p53 does not affect this cooperative effect with DNA-damaging agents.

217 y, whereas the S domain is important for the cooperative effect with p54.

218 this study, we primarily investigated DMC's cooperative effect with tumor necrosis factor-related ap

219 t appears that the pKa of D96 is raised by a cooperative effect within the purple membrane.

220 d and, using hotspot descriptors which model cooperative effects within hotregions, we show how the c