ライフサイエンスコーパス: cooperativity

1 tween different supercoiled states with high cooperativity.

2 f populations with and without intraspecific cooperativity.

3 irst CTQ- or TTQ-dependent enzyme to exhibit cooperativity.

4 ubstrate peptide coil-to-helix/helix-to-coil cooperativity.

5 and IVM, and improved the receptor subunits' cooperativity.

6 two-state solution is a hallmark of positive cooperativity.

7 mplex, indicated large variations in folding cooperativity.

8 n as a novel facility emerging from negative cooperativity.

9 eptors that demonstrate a mutually dependent cooperativity.

10 ling, and for negative and positive receptor cooperativity.

11 ts, suggesting a crucial role for high-order cooperativity.

12 modes that differ in occluded site size and cooperativity.

13 rpose of creating and controlling allosteric cooperativity.

14 (ADP and phosphopeptide) bind with positive cooperativity.

15 ies SPA as a major factor that controls this cooperativity.

16 ceptors can facilitate optimal electrostatic cooperativity.

17 receptor geometry individually contribute to cooperativity.

18 ibutes approximately 30% to overall positive cooperativity.

19 ion level has only minor effects on receptor cooperativity.

20 ence correlates with compactness and folding cooperativity.

21 o of myosin, but do not significantly affect cooperativity.

22 selectivity filter controls blocker binding cooperativity.

23 ctive GCK variant with substantially reduced cooperativity.

24 wer [Ca(2+)], but have only small effects on cooperativity.

25 supporting models that explain FtsZ polymer cooperativity.

26 ions within the enzyme's small domain govern cooperativity.

27 must communicate with each other, exhibiting cooperativity.

28 necessary for binding to actin with positive cooperativity.

29 rease in affinity while maintaining negative cooperativity.

30 ed that the active and allosteric sites show cooperativity.

31 the effect of flanking sequences or binding cooperativity.

32 n the substrate, apo-ACPP, and with negative cooperativity.

33 non-specific DNA binding and protein-protein cooperativity.

34 an identify the kinetic causes mediating the cooperativity.

35 constraining models of activation and system cooperativity.

36 he mtSSB does not show negative intersubunit cooperativity.

37 with the importance of (1) collaboration and cooperativity, (2) humanized relationships and mentorshi

38 antify, for the first time, the experimental cooperativity, alpha, for the equilibrium MC.Na(+) + MC.

39 This work reveals a previously unrecognized cooperativity among enhancer-associated chromatin modula

40 hA displays homotropic positive and negative cooperativity among its four protomers.

41 These findings reveal cooperativity among P-TEFb, PAF1C, and CDK12 in pausing

42 ligand binding and unbinding revealed modest cooperativity among the subunits in the conformational f

43 is has implications for facilitating genetic cooperativity among viral quasispecies as well as enhanc

44 iological activity into a potent one through cooperativity and avidity.

45 2 concentration, salt concentration, binding cooperativity and binding polarity at p/t junctions.

46 er effects, such as chromatin accessibility, cooperativity and cofactors, have been described, DNA sh

47 h has been discovered whereby reversible M-L cooperativity and coordination induced bond weakening li

48 kness; the binding isotherms showed negative cooperativity and could all be mapped onto a single mast

49 a Tyr in LodA, to Tyr or Ala eliminates the cooperativity and destabilizes the dimer.

50 replication and proviral latency lacks self-cooperativity and deterministic bistability.

51 lar (chelate) cooperativity and interannular cooperativity and discuss approaches to quantify them th

52 The relationship between folding cooperativity and downhill, or barrier-free, folding of

53 (at 45 mol % saturated phospholipid) had low cooperativity and hence most likely were of mixed compos

54 Here, we show that cooperativity and homodimer stabilization are strongly d

55 We further establish that folding cooperativity and hydrophobic collapse are balanced at t

56 ric) cooperativity, intramolecular (chelate) cooperativity and interannular cooperativity and discuss

57 ID function to inhibit CARD11 activity with cooperativity and redundancy.

58 mutation works without recovery of the lost cooperativity and selectivity of Na(+) binding and does

59 Here, we characterize the cooperativity and sequence specificity of MBD2-DNA bindi

60 f NICD-RBPjk-MAML-DNA complexes, integrating cooperativity and stability dependent on shared sequence

61 s extend our understanding of the origins of cooperativity and stability in protein folding, includin

62 nal beta-signal motif influences the folding cooperativity and stability of the folded beta-barrel an

63 mally designed, and particularly underscores cooperativity and synergy as a general design principle

64 gnificant, long-range interactions dominated cooperativity and this pattern held true whether the DNA

65 and D369A) do not significantly impair Na(+) cooperativity and transport.

66 ased on mobile VDCCs supports calcium domain cooperativity and tunes neurotransmitter release by equa

67 or two oxocarbon anions, resulting in strong cooperativity and very tight binding, with an apparent a

68 increased structural stability and assembly cooperativity, and can encapsulate small molecules.

69 ntify effects on allosteric ligand affinity, cooperativity, and efficacy.

70 urement of their stoichiometry, affinity and cooperativity, and frequently consideration of multiple

71 ves a custom peptide substrate with positive cooperativity, and its autoproteolysis can be stimulated

72 her local determinants of protein stability, cooperativity, and potentially also of function.

73 binding with high affinity and selectivity, cooperativity, and release triggered by external stimuli

74 However, the energetics of cooperativity are complicated by solvent effects and the

75 RF2 also assemble hierarchically, indicating cooperativity as a conserved driving force for shelterin

76 nhance its unfolding, resulting in unfolding cooperativity at an optimal force.

77 ent a useful tool for understanding positive cooperativity at the GLP-1R.

78 , all the tetrameric species present similar cooperativity behavior for proton sensing.

79 The cooperativity between a reovirus component and lipids re

80 CaM regulation of the channels, facilitating cooperativity between adjacent subunits and regulating f

81 na, thereby defining the incompatibility and cooperativity between all pairs of subsystems when integ

82 s into endosomal trafficking, illuminate the cooperativity between an ubiquitin ligase and a deubiqui

83 odermal developmental regulators, suggesting cooperativity between Brg1 and Polycomb complexes.

84 Mechanistic studies reveal redox cooperativity between Co(salophen) and H2Q.

85 l oxidation reactions, but the nature of the cooperativity between Cu and azodicarboxylates is not we

86 logical constraints also give rise to strong cooperativity between distal tertiary interactions, quan

87 elucidates that hierarchy and long-distance cooperativity between gene-regulatory elements target a

88 nd that these fuzzy interactions may promote cooperativity between nearby epigenetic marks.

89 isorder of the E domains mediates long-range cooperativity between nonneighboring G5 domains, allowin

90 vestibule may facilitate the transmission of cooperativity between orthosteric and allosteric sites.

91 re different in PD81723 and VCP171; positive cooperativity between PD81723 and NECA was reduced on al

92 g that involves a striking degree of evolved cooperativity between protein and RNA.

93 Other results show that (i) there is no cooperativity between sites; (ii) agonist association is

94 We also find cooperativity between structural mimicry and a crucial p

95 ent axons and postsynaptic neurons, boosting cooperativity between synaptic inputs.

96 ferent axon fibre polarization, which boosts cooperativity between synaptic inputs.

97 human plasma cell neoplasms, and implicates cooperativity between the Rad50(s) and Mef/Elf4 pathways

98 To understand the cooperativity between the substrates, we investigated th

99 ve rotation mode also explained the negative cooperativity between the two binding pockets.

100 s of the membrane shows substantial negative cooperativity between the two blocking sites.

101 It allows us to directly observe the cooperativity between the two nucleotide binding pockets

102 on, which is governed by reciprocal positive cooperativity between the UHRF1 histone- and DNA-binding

103 ic improvement in the activity signifies the cooperativity between Ti and W and indicates that the ke

104 Instead nucleosome sliding requires cooperativity between two INO80 complexes that monitor D

105 regulation, a quantitative understanding of cooperativity between various TF dimer partners and its

106 d the entire network or assess the degree of cooperativity between waters.

107 s with both factors reveal positive linkage (cooperativity) between RbpA and CarD with regard to thei

108 o the conventional patterns of sigma- and pi-cooperativity but a new type of polarization interaction

109 ifficulty in simultaneously measuring global cooperativity by determining population distributions of

110 We developed Coop-seq (cooperativity by sequencing) that is capable of efficien

111 We used the quantitative and scalable cooperativity-by-sequencing (Coop-seq) approach to inter

112 eractions between the binding partners, such cooperativity can be mediated through RNA secondary stru

113 Negative cooperativity can make a multimeric receptor's response

114 ea antifreeze protein (sfAFP), stability and cooperativity can occur without a hydrophobic core, and

115 ntal role that membrane-mediated ion-channel cooperativity can play in sensory physiology.

116 nding sites and does not necessarily require cooperativity, clustering, or binding site overlap.

117 Cleavage was found cooperative with a cooperativity coefficient n = 2.3, suggesting that the m

118 close to 0.5, the highest degree of negative cooperativity commonly observed (although smaller values

119 r binding mechanism that involves a positive-cooperativity component between adjacent monomers.

120 This cooperativity converts the BC into the first example of

121 e non-intuitive conclusion that the receptor cooperativity decreases with increasing levels of CheA,

122 posal in fragments, and the contributions of cooperativity demonstrates that it is now possible, with

123 The H-bond cooperativity does not belong to the conventional patter

124 release rate of IgG is governed by positive cooperativity due to pAG(MG).

125 variously modifies the change in allosteric cooperativity due to second site CAP mutations.

126 Radioligand-binding affinity cooperativity estimates were consistent with values deri

127 g constraints on the resultant "higher-order cooperativities." Even with such integration, there is a

128 and a plausible scheme by which such complex cooperativity evolved.

129 hes to quantify them thermodynamically using cooperativity factors.

130 Pax6 half-site were randomized yielding 1024 cooperativity factors.

131 electrostatic interactions explains the high cooperativity, fidelity, and stability of these SGQs.

132 ation yielded a Hill coefficient of 51 in pH cooperativity for a representative UPS block copolymer,

133 We find a moderate level of cooperativity for both the HD and NS RVD sequences (stab

134 Kinetic analysis of GoxA revealed allosteric cooperativity for its glycine substrate, but not O2 This

135 tely around the tetramer, displays "limited" cooperativity forming dimers of tetramers.

136 olecule, in good agreement with the negative cooperativity found in these systems.

137 de novel insights into homotropic Cu-binding cooperativity, gas-phase stabilities and conformational

138 salts, but a comprehensive understanding of cooperativity has been elusive.

139 The intensity of this cooperativity, however, was only moderate compared to ch

140 gh deterministic bistability, which requires cooperativity (i.e., nonlinear activation) and associate

141 nanoparticle conjugates occurs with negative cooperativity; i.e., each binding event destabilizes sub

142 ness of the titration data suggests positive cooperativity, implying the involvement of at least two

143 ters essential for deciphering mechanisms of cooperativity in a wide range of ligand-regulated homo-o

144 edly, for the human gene, NFkappaB exhibited cooperativity in activating the SLICK promoter.

145 we present direct measurements of energetic cooperativity in an experimental system in which the geo

146 urans founded on the idea that modulation of cooperativity in bimetallic catalysts can enable navigat

147 This bis-fullerene adduct exhibits different cooperativity in binding pairs of anions from the fuller

148 operative activation, as well as the role of cooperativity in dynamic tension generation across diffe

149 ich are also responsible for strong negative cooperativity in EcMazE-EcMazF binding.

150 Negative cooperativity in enzyme reactions, in which the first ev

151 ction of prostatic epithelial cells exhibits cooperativity in GEMMs, additional targeted Tp53 disrupt

152 elements that could play a role in negative cooperativity in GSTs.

153 Cooperativity in host-guest complexes as well as in self

154 Cooperativity in human glucokinase (GCK), the body's pri

155 larly puzzling has been the apparent lack of cooperativity in hydrolysis of the ATP in each protomer.

156 arises naturally as a consequence of protein cooperativity in large complexes and provides a useful m

157 activator systems, and we assess the role of cooperativity in maximizing gene expression.

158 r by protein-protein interactions leading to cooperativity in membrane binding or by the simultaneous

159 This may explain the observed cooperativity in miRNA-mediated gene silencing.

160 within the target site affect the extent of cooperativity in PPARgamma:RXRalpha-DNA binding.

161 ist-dependent deactivation because of strong cooperativity in proton binding.

162 In this study, we demonstrated PatZ-positive cooperativity in response to acetyl-CoA and the regulati

163 2 as a potential target reliant on Sox2/Pax6 cooperativity in several neural cell types.

164 orial review summarises different aspects of cooperativity in supramolecular complexes.

165 t the strength of homotypic contacts and the cooperativity in the action of D4D5 regions determines w

166 ing constants was used to establish positive cooperativity in the binding of the two guests.

167 s and the N2 ligand, they reveal a degree of cooperativity in the dinuclear Cu-N2 -Cu interaction.

168 providing an interpretation of the nature of cooperativity in the folding and unfolding processes.

169 present the first experimental evidence for cooperativity in the folding of a triple-stranded parall

170 The computer simulations reproduced positive cooperativity in the receptor aggregation model when the

171 , but not E402, was critical for high signal cooperativity in the receptor array.

172 s with other signaling molecules, leading to cooperativity in the system.

173 cohol oxidation and the underlying basis for cooperativity in this co-catalyst system.

174 ST analysis have pointed to positive binding cooperativity in TS-DHFR complex formation.

175 , we discovered that PRMT5 displays positive cooperativity in vitro, suggesting that this enzyme may

176 est that SSB likely binds to ssDNA with high cooperativity in vivo.

177 In addition, a paradigm of cooperativity in which combined loss of multiple negativ

178 Using this cooperativity-inclusive constant, we were able to build

179 However, as cooperativity increased, the expansions transitioned to

180 ted with the receptors, whereas the receptor cooperativity increases with increasing levels of CheW,

181 roquinoline compounds, which showed negative cooperativities instead.

182 We propose a systematic categorisation of cooperativity into cooperative aggregation, intermolecul

183 ive aggregation, intermolecular (allosteric) cooperativity, intramolecular (chelate) cooperativity an

184 These results suggest that high cooperativity involves interactions between IDL regions

185 Cooperativity is a feature many multimeric proteins use

186 gans mRNAs, and find that structure-mediated cooperativity is a generic feature.

187 Negative cooperativity is a phenomenon in which the binding of on

188 pMHC:TCR interaction it is evident that this cooperativity is accomplished by increasing the kinetic

189 Binding cooperativity is also observed in other proteins regulat

190 High "unlimited" cooperativity is associated with the 35 site size ((SSB)

191 Strikingly, this cooperativity is asymmetric in mGluR2/mGluR3 heterodimer

192 The cooperativity is attributed to the presence of dipole-di

193 cognition by the SF1-U2AF(65) complex (where cooperativity is defined as a nonadditive increase in RN

194 Furthermore, we find that this end-to-end cooperativity is determined by the UTR sequences while t

195 owth in nature, understanding the effects of cooperativity is essential to managing invading species

196 Furthermore, positive cooperativity is observed under conditions where the T c

197 fullerene-free parent: in one case, positive cooperativity is observed, while in another all binding

198 d 16 different GSTs, revealing that negative cooperativity is present only in more recently evolved G

199 elihood-based calibration, we uncovered that cooperativity is required for both anterior and posterio

200 s of GCK, we show that the origin of kinetic cooperativity is rooted in intramolecular protein dynami

201 TTR binding sites without the usual negative cooperativity, is therefore of interest.

202 Absent cooperativity, it is unclear how HIV can temporarily rem

203 are globally fit with a two-branch negative-cooperativity kinetic model in which ET in one-half of t

204 solute effects, structural flexibility, and cooperativity lead to nonlinear changes in enthalpy.

205 ssense mutations can disrupt transcriptional cooperativity, leading to aberrant chromatin states and

206 uding bistability and oscillations, negative cooperativity may be an important ingredient in many typ

207 indicate more unexpected differences in the cooperativity mechanism.

208 Finally, it is discussed that interligand cooperativity might constitute a more general principle

209 trong inhibitor of GSTs, we suggest negative cooperativity might have evolved to maintain a residual

210 imulating MT length distributions within the cooperativity model fits the data better.

211 In the "cooperativity" model, formation of a single GDMT promote

212 All mutants have similar cooperativity (n50), alkaline Bohr effect, and autoxidat

213 Interestingly, this cooperativity not only affects binding sites in close pr

214 Negative cooperativity occurs in human glutathione transferase (G

215 Triazolodiazepine PROTACs exhibited positive cooperativities of ternary complex formation and were mo

216 ubit using piezoelectric transduction with a cooperativity of 260.

217 Furthermore, we reveal the cooperativity of active sites in multifunctional catalys

218 classical surfactants in that they have low cooperativity of aggregation and work at molar concentra

219 e important to maintain the limited negative cooperativity of analogues of 1, and replacement of the

220 d structural rationalization for the folding cooperativity of AR proteins, and a challenging benchmar

221 he parameters related to the sensitivity and cooperativity of calcium binding to troponin C and the a

222 ATP increases the apparent cooperativity of DNA condensation, demonstrating that Bs

223 e (tachyzoite) stage of T. gondii depends on cooperativity of glucose and glutamine catabolism to mee

224 nt with the experimentally measured negative cooperativity of ketamine binding to GLIC.

225 ch accounts for experimentally observed weak cooperativity of kinesins motors.

226 We also show that cooperativity of NDC80 interactions is weak and is unaff

227 Owing to the cooperativity of protein structures, it is often almost

228 regulatory network data, to characterize the cooperativity of regulatory factors.

229 First, the high cooperativity of S3D cofilin generates fewer boundaries

230 eactants, it is concluded that the catalytic cooperativity of the acid-base pair can be affected by t

231 ologically relevant conformations and to the cooperativity of the coevolving pairs.

232 tension is mediated through obligate folding cooperativity of the intrinsically disordered E domains

233 Intricate cooperativity of the metal was observed with different p

234 hose interactions have a large effect on the cooperativity of the phase transition.

235 int temperature of trimerization and reduced cooperativity of the process thus widening the response

236 consequently, in an apparent increase in the cooperativity of the transition.

237 Cooperativity of the two intramolecular H-bonds on spect

238 inhibitor binding drastically decreases the cooperativity of unfolding by trapping the closed flap c

239 pecific structure-opening rates but also the cooperativity of unfolding of the different secondary st

240 The cooperativity of unfolding was measured in the absence o

241 equired for rapid synchronization and Ca(2+) cooperativity of vesicle release.

242 The gating characteristics (bursting, cooperativity) of the TRPV4 cluster enhance Ca(2+) sprea

243 ophobic micellization and resulting positive cooperativity offer a versatile strategy to convert resp

244 ge (lr) components from the ensemble-average cooperativity, omegaave.

245 f experimentally characterized hydrogen-bond cooperativity on fluorescence quenching with a modified

246 notion that NCNs require regions of negative cooperativity, or "frustrated" noncovalent interactions,

247 provides significant insight into the redox cooperativity, or lack thereof, between Cu and redox-act

248 ty, in terms of the maximum strength and the cooperativity parameter.

249 f efficiently and accurately determining the cooperativity parameters for hundreds of different DNA s

250 However, current methods to measure cooperativity parameters have been laborious and therefo

251 depleted by receptor binding, then negative cooperativity produces a qualitatively different type of

252 identified several genomic regions where the cooperativity promoting sequence pattern is co-bound by

253 ate modulation of binding affinity, and thus cooperativity, renders our new cuboctahedral receptor at

254 e of mathematical models, testing effects of cooperativity, repression, and factor potency.

255 molecules in topological defects, including cooperativity, reversibility and controlled growth.

256 Insight into this mode of catalyst cooperativity sheds light on the practical limitations t

257 y investigated phenomena (e.g. noise-induced cooperativity, stochastic bi-stability, quorum sensing).

258 e latter occurring with significantly higher cooperativity than previous steps; this results in the f

259 tractant stimuli in vivo, but with much less cooperativity than the wild type.

260 with lower affinity, but also with a higher cooperativity than wild-type cofilin, and severs actin w

261 lular phenotype, binds R179H actin with less cooperativity than WT actin.

262 id A and assisted by general depth-dependent cooperativities that exist between polar and ionizable r

263 tion angles, which depend only on the device cooperativity, this enables cancellation of light that d

264 e affinity of CAP for cAMP enhances negative cooperativity through an entropic penalty for ligand bin

265 rk2 loss and Pten loss also display striking cooperativity to promote tumorigenesis in vivo.

266 P and peptide substrates) bind with negative cooperativity to Src kinase while products (ADP and phos

267 r requires Zn(II), which binds with negative cooperativity to two regulatory sites per dimer to form,

268 We observe maximal binding affinity and cooperativity to unmodified di-nucleosomes and propose t

269 xine, both characterized by negative binding cooperativity, to distinct sites in TTR, consistent with

270 vour inclusion complexes with HAMS exhibited cooperativity-type binding behaviour; with a critical li

271 ar interactions, meaning that information on cooperativity typically is derived from theory or indire

272 iants, essentially due to the loss of global cooperativity under physiologically relevant conditions.

273 We then quantified cooperativity underlying heterodimer-DNA binding and der

274 The calculated trend of electrostatic cooperativity using pairs of spherical ions (NaCl > NaBr

275 of developmental enhancers: (1) potential TF cooperativity, using signatures of co-associations and c

276 It was previously thought that high cooperativity was associated only with the (SSB)35 bindi

277 n placed in different subunits, the observed cooperativity was dominated by the mutation with stronge

278 re placed in the same subunit, the resulting cooperativity was neutral.

279 Cooperativity was not observed for apo-ACPP which bound

280 Lack of structural cooperativity was observed between regions located close

281 plasmid topoisomers showed that the average cooperativity was sensitive to DNA twist, and was strong

282 endent trend, it overestimates electrostatic cooperativity; we suggest that binding of the individual

283 efore emphasizes the importance of assessing cooperativity when generating DNA binding specificity mo

284 interface, which appears to mediate positive cooperativity, whereas the folded segment of the cytosol

285 air melting by combined enzymes explains the cooperativity, wherein helicase stimulates the polymeras

286 e local functions, compartmentalization, and cooperativity, which makes them important tools for the

287 of glucose during glycolysis, is its kinetic cooperativity, whose understanding at atomic detail has

288 Org27569 also displayed negative binding cooperativity with [(3)H]SR141716A [5-(4-chlorophenyl)-1

289 d (BQCA) (1), but markedly improved positive cooperativity with acetylcholine, and retained exquisite

290 Cmpd-15 exhibits negative cooperativity with agonists and positive cooperativity w

291 These ligands exhibited cooperativity with benzodiazepine binding across the CCK

292 In contrast, ML375 displayed negative cooperativity with each of the agonists in a manner that

293 Moreover, glucocorticoid receptor cooperativity with factors, including nuclear factor-kap

294 ive cooperativity with agonists and positive cooperativity with inverse agonists.

295 on of W146ECL2 and W156ECL2 decreased VCP171 cooperativity with NECA.

296 1AR allosteric site and mechanisms governing cooperativity with orthosteric ligands.

297 Residues involved in cooperativity with the orthosteric agonist NECA were dif

298 f larvae, therefore increasing the degree of cooperativity within a cluster.

299 But due to negative cooperativity within the dimer, only one groove binds DN

300 ple that multimeric enzymes can exploit this cooperativity without conformational changes to maximize