ライフサイエンスコーパス: coordinate

1 tween subsets of amino acids based on atomic coordinates).

2 understanding of how synapse organization is coordinated.

3 t it remains unclear how these processes are coordinated.

4 generation of protein CD spectra from atomic coordinates.

5 n meta-analyses were conducted on peak voxel coordinates.

6 centered) or intrinsic (joint-configuration) coordinates?

7 ent (mean of 368mgkg(-1)), red colour (a( *) coordinate 15.6), and antioxidant capacity (e.g. ABTS me

8 structure is in good agreement with the NMR coordinates 1O8R.

9 Thus, HRI coordinates 2 key translation-regulation pathways, eIF2a

10 sts, and changes in beat frequency are often coordinated across extended or discontinuous surfaces.

11 This systemic response was coordinated across tissues and required for tumor eradic

12 The coordinated action of both pathways is required to ensur

13 ty correlates to their capacity to trigger a coordinated action of multiple specific molecules, mobil

14 wing transgenic mouse model of PDAC that the coordinated activation of both innate and adaptive immun

15 odel of resectable PDAC, we investigated the coordinated activation of T and natural killier (NK) cel

16 the activity of the CSTC pathway through the coordinated activation of two classes of medium spiny ne

17 nal growth rate differences generated by the coordinated activities of the apical notches.

18 al circuits in the visual cortex require the coordinated activity of excitatory and inhibitory neuron

19 ia, microvilli, and stereocilia requires the coordinated activity of many proteins.

20 ole cell responses most often arise from the coordinated activity of multiple SCPs, we developed a dy

21 icates that animal behavior results from the coordinated activity of neurons and astrocytes.

22 an alternative mechanosensing mechanism that coordinates actomyosin dynamics between epithelial cells

23 lipids, such as phosphoinositides, helps to coordinate all of these processes.

24 llecting vessels generate rapid contractions coordinated along lymphangions to propel lymph, but the

25 ion and synthesis of a terminal nitride from coordinated ammonia, a key step in NH3 oxidation.

26 In addition, BET proteins are required to coordinate an IL6-dependent AMPK nuclear signaling pathw

27 te response element-binding protein (ChREBP) coordinates an adaptive response to a high-fructose diet

28 crosstalk regulates mitochondrial fusion by coordinating an intricate balance between Fzo1 turnover

29 Principal coordinate analysis indicated a separation and clusterin

30 ly host species segregate based on principal coordinate analysis of their microbial communities, but

31 stering by GBS status was noted on principal coordinates analysis, and 18 individual taxa were found

32 vary with temperature and along the reaction coordinate and this makes the situation more complex.

33 We show that the experimentally measured coordinates and chemical species with 22 picometre preci

34 Coordinating angiogenesis with acquisition of tissue-spe

35 omplexes based on the vibrational modes of a coordinated anion and compare reactivities of various ir

36 e demonstrate that neither loss of spatially coordinated apical constriction nor its complete blockag

37 ely 1,000 presumptive mesoderm cells exhibit coordinated apical constrictions that mediate invaginati

38 c activation of cholinergic cells drives the coordinated arrests of all cilia.

39 s, corrole derivatives with a redox-inactive coordinated atom follow the Gouterman four-orbital model

40 ated that two of these, Lys-565 and Lys-663, coordinate ATP in the active site.

41 ing C(sp(3))-H activation directed by weakly coordinating auxiliaries, which provides great opportuni

42 Correlations between the color coordinate b( *), total and individual carotenoid conten

43 ties for identifying molecular signatures of coordinated behaviors of cancer cells as a population -

44 erer population, convey messages relevant to coordinating behaviour in a foraging ecology, such as co

45 How movements and growth are coordinated between the different posterior tissues (e.g

46 indicate that the electron transfer reaction coordinates between a triplet charge-transfer state and

47 ns in enhancer landscapes and associate with coordinated binding of CEBPD, IRF1, and NFkappaB.

48 , STAT3 does not efficiently bind 20% of its coordinated binding sites.

49 functionalization most likely involves Ru-O coordinate bond.

50 he immune system and on lymphoid organs that coordinate both the maintenance of lymphocytes and the i

51 iates opposing roles in DNA end resection by coordinating both the stabilization and exclusion of Rad

52 daptor molecule MAVS plays critical roles in coordinating both virus-induced type I interferon produc

53 morphogenesis of developing organs requires coordinated but poorly understood changes in epithelial

54 We show how brain regions tend to coordinate by forming a highly hierarchical chain-like s

55 lfur proteins in which the 2Fe-2S cluster is coordinated by a CDGSH domain that is followed by the "N

56 ametes during the second meiotic division is coordinated by a conserved casein kinase 1.

57 and integrative activities of the brain are coordinated by a series of midline-bridging neuronal com

58 imprinted gene expression in this region is coordinated by an imprinting center (PWS-IC).

59 HP-exonuclease has a trinuclear zinc center, coordinated by nine conserved residues.

60 rocessing and fate of nascent transcripts is coordinated by transcription elongation factors (TEFs) s

61 relationships among the different PDEs that coordinate cAMP-signaling cascades in these cells.

62 ic differentiation proceeds through a highly coordinated cascade of gene activation that necessitates

63 lyse sequencing data from 461 samples into a coordinated catalog of microRNA expression.

64 activity serve as a multi-step mechanism to coordinate cell motility during migration.

65 of the TORC1 and TORC2 signaling pathways to coordinate cellular stress responses with sterol homeost

66 tions, from serving as reaction catalysts to coordinating cellular propagation and development.

67 estigators, ILD experts at the National Data Coordinating Center (NDCC; Jaipur, India) with MDD, and

68 We examined the National Alzheimer Coordinating Center autopsy data to evaluate the effect

69 ly and source documents were reviewed at the coordinating center to confirm completeness and accuracy

70 vel information regarding signaling pathways coordinating central control of whole-body stress reacti

71 ugar-sensing pathways act via Pma1 to invoke coordinated changes in cellular pH and metabolism.

72 in which TDP-43 aggregation is targeted by a coordinated chaperone response.

73 COordiNated Chemical Shifts bEhavior (CONCISE) analysis

74 Coordinated clathrin assembly provides the earliest spat

75 ty-rather than specific codon identity-could coordinate co-translational folding of the encoded prote

76 ation process, resulting in the reduction of coordinated CO to a siloxymethyl (LnFe-CH2OSiMe3) group.

77 s been a national call in the USA to provide coordinated, comprehensive care for cancer survivors, wi

78 The coordinated control of Ca(2+) signaling is essential for

79 man brain develops, it increasingly supports coordinated control of neural activity.

80 et of structural brain networks that undergo coordinated cortical thinning during adolescence, which

81 Coordinated crosstalk of effector function suggests that

82 eal an important molecular mechanism whereby coordinated cytoskeletal dynamics contributes to cell ad

83 a and inducible nitric oxide synthase (iNOS) coordinates DC metabolism and function to limit DC-stimu

84 on and salt-bridge formation as key reaction coordinates describing the structural transition of the

85 esses because the neuroendocrine stress axis coordinates developmental remodelling, immune function a

86 nions reside in equidistant "clefts" between coordinating diglycolamide ligands in positions that sat

87 of protein ligandability and facilitates the coordinated discovery of bioactive small molecules and t

88 However, it is unclear how LC coordinates disparate behavioral functions.

89 Coordinated distributed experiments (CDEs) arrayed acros

90 eral neurochemicals converge and interact to coordinate divergent social behaviors.

91 A single coordinated drone network across all regions required 39

92 e activities of the two genomes involved are coordinated during chloroplast development.

93 s by which XPC influences gene regulation by coordinating efficient TDG-mediated DNA demethylation al

94 mitochondria and the nucleus communicate to coordinate energy production and utilization, providing

95 y inputs and control pain through temporally coordinated enkephalin- and GABA-mediated presynaptic in

96 crucial mitotic Cdk regulatory partner that coordinates entry into mitosis and is then destroyed in

97 e proteins identified originally in flies to coordinate epithelial planar cell polarity (PCP).

98 The mechanistic target of rapamycin (mTOR) coordinates eukaryotic cell growth and metabolism with e

99 These coordinated events can include toxins counteracting or a

100 the accessory gene regulator (agr) operon to coordinate expression of virulence factors required for

101 components, this element could concur to the coordinated expression of these proteins during erythrop

102 ethod termed "Genomic Regression Analysis of Coordinated Expression" (GRACE) to adjust for the effect

103 functional replacement is methionine, which coordinates F(-) through its partially positive gamma-me

104 inases and phosphatases, which interact in a coordinated fashion to regulate chemorepulsion exerted b

105 ts that residues are exposed to solvent in a coordinated fashion, but without necessarily being locat

106 s of the active Fe(III)-CN(-) and inactive 5-coordinate Fe(II) forms, revealing striking structural d

107 Thus, our results suggest that coordinated firing during sleep is essential for establi

108 formation of networks with Myo7a motors and coordinate force sensing in stereocilia.

109 to the question of how bacteria generate and coordinate forces during collective motion.

110 ficant interest as these cells may possess a coordinated functional and molecular phenotype which can

111 eactivity and selectivity that is enabled by coordinating functional groups.

112 promotes the formation of another domain of coordinated gene regulation: the dosage-compensated male

113 i appear to share an invariance principle to coordinate growth and chromosome replication.

114 maintain cell size within a narrow range by coordinating growth and division.

115 to be substantially lower than that of the 5-coordinate hemes present in myoglobin and hemoglobin.

116 Each Zn(2+) has two bis-coordinated histidine ligands, which bridge adjacent str

117 bstrate) was found to lead to the S = 2 five-coordinate HO-Fe(III)-Cl complex with the C(*) of the su

118 alled Sharing Experimental Animal Resources, Coordinating Holdings (SEARCH) with the aim of making re

119 We propose that physiological hypoxia coordinates homeostasis of CPCs, providing mechanistic e

120 sed in Nkx2.1(+ve) neurons are sufficient to coordinate hypothalamic response and expression of compu

121 dicating that two distinct pools of MinC are coordinated in S. elongatus.

122 ystallography, in which the triazolo N1 atom coordinates in a hitherto unreported monodentate interac

123 pecifying a molecular mechanism in which N2O coordinates in a mu-1,3 fashion to the fully reduced sta

124 ents with equivalent joint-angles (intrinsic coordinates) in motor cortices.

125 rm movements to identical targets (extrinsic coordinates) in visual cortices, and across movements wi

126 e-remodeling events, but the mechanisms that coordinate individual cell migratory behaviors for colle

127 veloped in tomato (Solanum lycopersicum) for coordinated induction of biosynthesis of anthocyanins, i

128 lar signaling pathways that are important to coordinating inflammatory responses within immune cells

129 s selective electrical coupling relates to a coordinated inhibitory chemical synapse formation betwee

130 its like limbs, brains, or eyes form through coordinated integration of diverse cell fates across dev

131 Appetitive drive is influenced by coordinated interactions between brain circuits that reg

132 Moreover, this region coordinates interactions with a distributed network to s

133 enerated by molecular clocks, which serve to coordinate internal time with the external world.

134 Branching morphogenesis requires the coordinated interplay of multiple types of cells with th

135 ple with alpha-diazoesters to generate metal-coordinated iodonium ylides, which undergo [2,3]-rearran

136 m mechanical tunneling along the heme doming coordinate is also included as an active channel for CO

137 ional cues for Z-ring formation and may help coordinate its assembly with chromosome replication and

138 y, implies a well-defined sequence of events coordinating K(+) uptake and the final stages of vesicle

139 Here, we describe the WHO-coordinated laboratory networks supporting VPD surveilla

140 d neutral substrate receptors; as ligands to coordinate large metal ions; as nonlinear optical materi

141 l three compounds undergo loss of the eta(2)-coordinated ligand followed by N-H bond activation, bis(

142 s are shared between the f-block element and coordinated ligands.

143 per oxidation state and succession of copper coordinating ligands within the biomass.

144 I-5 injection improves coordinated locomotion, and this functional recovery is

145 Autophagy coordinates lysosomal destruction of cytosolic constitue

146 Hence, our findings establish an exocytosis-coordinated mechanism underlying the cellular pathfindin

147 vere mental illness may need assistance with coordinating medical services.

148 itude coupling might serve as a mechanism to coordinate memory processes across distant brain areas.

149 for midbody assembly, but may accelerate or coordinate midbody maturation.

150 e perspective of how endothelial cells (ECs) coordinate migration and proliferation in response to gr

151 rol similar cellular processes, suggesting a coordinated mode of action but information about potenti

152 tifunctional proteins able to simultaneously coordinate/modulate several cellular pathways is unclear

153 nd extraembryonic tissues to orchestrate and coordinate morphogenesis with changes in developmental p

154 cked the ability to polarize their Golgi and coordinate motility systems for efficient movement.

155 The coordinated movement of the ciliated edge is represented

156 was linked with early twitching and eventual coordinated movement.

157 Active sampling of touch and smell involves coordinated movements first observed in the rat half a c

158 cal cues act upon individual cells to ensure coordinated multicellular behavior.

159 uired for normal sensory feedback to control coordinated muscle contractions and body posture.

160 regnancy, energy availability is mediated by coordinated muscle-placenta metabolic adjustments linked

161 ported room temperature stable, acyclic, two-coordinate N,O-silylene 7 exhibiting a fascinating silox

162 mission of this lethal disease.Significance: Coordinated neoadjuvant and adjuvant immunotherapies red

163 retrieval of contextual fear memory requires coordinated neural activity in the hippocampus, medial p

164 Our assay for functional autonomy of coordinated neural systems is broadly applicable, and ou

165 opressin (VP) neurons play a pivotal role in coordinating neuroendocrine and autonomic responses to m

166 dentify a potential paracrine mechanism that coordinates neuronal homeostasis and inflammation in the

167 Spt6 coordinates nucleosome dis- and re-assembly, transcripti

168 g a root-mean-square-distance-based reaction coordinate obtained in the presence and absence of the T

169 Here we determine the 3D coordinates of 6,569 iron and 16,627 platinum atoms in a

170 ions, there is a pressing need to use atomic coordinates of real systems beyond average crystallograp

171 and a fluorescent "on" state at well-defined coordinates on subdiffraction scales.

172 s included where available and reported peak coordinates otherwise.

173 or-none' fashion, HerA-NurA harbors a highly coordinated pairwise binding mechanism and enables the t

174 The process of wound repair requires the coordinated participation of multiple types of cells, wh

175 ticle rotation is lowest for the more highly coordinated particles and decreases during sintering.

176 idcell to form the cytokinetic Z-ring, which coordinates peptidoglycan (PG) remodeling and envelope c

177 Our results thus reveal a mechanism coordinating plant growth and drought tolerance.

178 th crucial roles in plant development and in coordinating plant stress tolerance.

179 by Celsr1-mediated homophilic adhesion, that coordinate polarity non-autonomously between cells [5, 6

180 he membrane in concentrated zones undergoing coordinated pole-to-pole oscillation to help ensure that

181 vision and social experience are required to coordinate precise movements between pairs of larvae, th

182 C-O bond cleavage occurs to generate a three-coordinate product of oxidative addition, a metallacycli

183 del in which sheath formation depends on the coordinated production of material in the endosperm and

184 Skin wound repair requires a coordinated program of epithelial cell proliferation and

185 Coordinated protocols and new analytical methods, partic

186 We found coordinated reactivations between the hippocampus and th

187 itatory and inhibitory synapse strength in a coordinated reciprocal manner have been identified.

188 aled that, in contrast to previous findings, coordinated recruitment of mRNAs at specialized structur

189 ) exert powerful effects on immunity through coordinate regulation of multiple target genes in a wide

190 evelopment of the taste system relies on the coordinated regulation of cues that direct the simultane

191 arasite, Plasmodium falciparum, depends on a coordinated regulation of gene expression for developmen

192 The molecular mechanisms supporting coordinated regulation of KCNQ and VGSCs and the cellula

193 The latter suggests a coordinated regulation of organellar multiple site editi

194 A common feature of sex chromosomes is coordinated regulation of X-linked genes in one sex.

195 eptor 4 (TLR4) in macrophages results in the coordinated release of proinflammatory cytokines, follow

196 How these cellular processes are coordinated remains elusive.

197 FA proteins regulate replication dynamics, coordinate replication-coupled repair of interstrand DNA

198 s rely heavily on acoustic communication for coordinating reproduction and typically have ears tuned

199 , yet well-defined roles for different Na(+)-coordinating residues.

200 Immunity to infectious agents involves a coordinated response of innate and adaptive immune cells

201 ystem is composed of diverse cell types that coordinate responses to infection and maintain tissue ho

202 se findings provide insights into how plants coordinate responses to nitrate availability, linking ni

203 the RNP1 and RNP2 consensus sequences, which coordinate RNA binding - suggesting a possible role for

204 These results implicate Ub signaling in coordinating RNA processing by TLR pathways during an im

205 this study, we report a probe of lanthanide-coordinated semiconducting polymer dots (Pdots), which p

206 As the primary cilium coordinates several signaling pathways essential for odo

207 MOR epigenetic regulation requires multiple coordinated signals converging at the MOR promoter, invo

208 examples of isolable acyclic, neutral, three-coordinate silanones 2 with indefinite stability as soli

209 l and hormonal signals, tune motivation, and coordinate social interactions.

210 t communicate to define group membership and coordinate social organization.

211 lithium species was enhanced by using a less coordinating solvent and short reaction times.

212 uster-randomized trial, compared NAVIGATE, a coordinated specialty care program, to usual community c

213 nd primarily affect residue 132, which helps coordinate substrate binding.

214 alkylammonium cations coupled to the loosely coordinating superweak TFPB(-) anion has been achieved.

215 sassembled a subset of enhancers by inducing coordinate suppression of binding by MAF, lineage-determ

216 wo active sites, both of which have an under-coordinated surface square site adjacent to a subsurface

217 ecognition complex (ORC) to DNA, but how ORC coordinates symmetrical MCM loading is unclear.

218 urons in different layers of the network can coordinate synaptic weight updates.

219 n this study, we 1) defined a 3D stereotaxic coordinate system for previously established in vivo pop

220 od-retina barrier is established through the coordinated terminal maturation of the retinal pigment e

221 osterior, dorsal-ventral, and medial-lateral coordinates that we interpret as cell types.

222 signal in the extracellular matrix (ECM) to coordinate the cross-talk between the LRP4-MuSK pathway

223 e lamellipodial actin network, and adhesions coordinate the dynamics of spreading fibroblasts.

224 dense clusters of elements that collectively coordinate the expression of shared target genes, and wh

225 s a mechanism for fatty acid biosynthesis to coordinate the expression, Fe-S cofactor maturation, and

226 ein that recruits Hsp70 to the ER surface to coordinate the function of ER-associated and cytosolic c

227 ges in the abundance of edited proteins that coordinate the function of multiple cellular pathways.

228 We propose that Spt4/5 may be important to coordinate the mechanical movement of RNAPII through the

229 d how the ULK1 and PI3KC3-C1 complexes might coordinate the nucleation and fusion of Atg9 and COPII v

230 The core planar cell polarity (PCP) proteins coordinate the orientations of hair cells across the epi

231 e complex cooperates with Mre11 and Rad50 to coordinate the repair of double-stranded DNA breaks.

232 ctant and radical scavenger, but it may also coordinate the soft Cu(I) cation and thereby yield pro-o

233 ling activity in the retinal endothelium and coordinate the timing of both vascular pruning and barri

234 naling, the key downstream coactivators that coordinate the transcriptional response have not been fu

235 on of SRC tyrosine kinase and simultaneously coordinates the attenuation of beta-catenin, both of whi

236 ocaSR to be a novel viral noncoding RNA that coordinates the expression of viral proteins and regulat

237 GLI family zinc finger 2 (GLI2) coordinates the Hh transcriptional program; however, the

238 s examined the physics and biochemistry that coordinates the motions of these groups of cells.

239 actomyosin polarity (WRAMP) structure, which coordinates the polarized localization of MCAM, actin, a

240 l-associated proteins play an active role in coordinating the adhesion and migration machinery in can

241 w that macrophages play an essential role in coordinating the epimorphic regenerative response in mam

242 ediated paraventricular hypothalamic circuit coordinating the global stress response.

243 of the roles of different viral proteins in coordinating the intercellular movement of viral replica

244 NA splicing and indicate a role for H2A.Z in coordinating the kinetics of transcription elongation an

245 lly, we identify mir-27 as a major regulator coordinating the temporal delay and spatial boundary of

246 ics simulations, the side chains of residues coordinating the zinc rearrange quickly to promote the n

247 ignals to communicate with each other and to coordinate their activities.

248 eria residing within biofilm communities can coordinate their behavior through cell-to-cell signaling

249 larvae are observed to align themselves and coordinate their movements in order to drag a common air

250 s share common regulatory mechanisms and can coordinate their responses to developmental challenges a

251 How the enzyme coordinates these phosphorylation events and new C-C bon

252 Coordinating these international initiatives and ensurin

253 but the specific extracellular signals that coordinate this regulation are poorly understood.

254 these different aspects of cell behavior are coordinated through a single receptor is not known.

255 ce cell expansion represents the key process coordinating tissue movements during doming.

256 ading to a model in which dorsoventral genes coordinate to regulate plant development by localizing a

257 een identified as a feasible ligand that can coordinate to the metal center of Cp*RhCl to accelerate

258 mple of one electron oxidized halide species coordinated to a metal ion of possible relevance to redu

259 -strand polymerases in the replisome must be coordinated to avoid the formation of significant gaps i

260 by which temporal and spatial regulators are coordinated to control Drosophila wing development durin

261 of microtubules, but how such regulation is coordinated to ensure proper circuit development is not

262 galacturonan-II side chains and backbone are coordinated to overcome steric constraints, and the degr

263 astatic tumors and mesenchymal cell lines is coordinated to that of collagen.

264 In the SFX structure, the CO is coordinated to the heme a3 iron atom, with a bent Fe-C-O

265 nalysis techniques demonstrate the NHC being coordinated to the palladium particles and affecting the

266 ealed that only the C2-symmetric ligand C2-L coordinated to the Rh, whereas CS-L underwent a Rh-catal

267 The two metal centres coordinated to this template have different roles: one r

268 organic reactions of aromatic ligands eta(2)-coordinated to tungsten or molybdenum and the use of the

269 e's smallest anion, is capable of covalently coordinating to eight silicon atoms.

270 hereby, as an upstream effector of TOR, ROP2 coordinates TOR function in translation reinitiation pat

271 These developing axonemes were positioned to coordinate trafficking into the furrow and mark the cent

272 This coordinated transcriptional-translational response to DN

273 cule-level graphitic carbon nitride (g-C3N4) coordinated transition metals (M-C3N4) as a new generati

274 , a functional proteasome was required for a coordinated transition that entails SC assembly between

275 with the accessory protein STRAP, needed for coordinated translation of collagen mRNAs.

276 tion of the plasma membrane and tonoplast in coordinating transport between the different cellular co

277 l control by leveraging both independent and coordinated variance to explore and consolidate neural p

278 he cell, the Arf GTPases are responsible for coordinating vesicle formation.

279 ot the nasal cavity, demonstrating that PlrS coordinates virulence specifically in the LRT.

280 on-path VTST (RP-VTST) and variable reaction coordinate VTST (VRC-VTST), system-specific quantum Rice

281 tional studies find that 2D CTGU-5 which has coordinates water and more open access to the cobalt sit

282 To understand how a tailored response is coordinated, we examined the inflammatory response elici

283 risingly little about how these pathways are coordinated when cells move in a complex environment in

284 e-dependent QCM data on (delta/a, -Deltaf/n) coordinates where delta is the viscous penetration depth

285 dynamic physiological processes are tightly coordinated while interacting with a dense and extremely

286 slice emittance as a function of intra-bunch coordinate with a resolution down to a few femtoseconds.

287 hiphilic copolymer micelles, and was used to coordinate with biocompatible Zn(2+) and encapsulate the

288 LDTFs coordinate with H3K4 mono-methyltransferases MLL3/MLL4 (

289 tics of enhanced synaptic efficacy that were coordinated with changes in perisynaptic astrocytic proc

290 cation and segregation being synchronous and coordinated with daughter cell assembly(2,3).

291 not known how its presence at repair loci is coordinated with downstream re-synthesis of resected DNA

292 a previously reported IEC expulsion that was coordinated with lipid mediator and cytokine production

293 in which combinatorial activation modes are coordinated with projection- and behavior-specific cell

294 ion profiles were assessed and statistically coordinated with reported allergies.

295 eral tolerance and whether their function is coordinated with T regulatory cells (Tregs).

296 ole metabolism toward bacteriochlorophyll is coordinated with the production of reaction centre and l

297 Here, we investigate anionic serine octamers coordinated with two chloride ions using a novel techniq

298 We propose that ORCA coordinates with the histone and DNA methylation machine

299 sts of high-frequency DA discharges that are coordinated within the minutes range.

300 structures, serves as a neural mechanism for coordinated working memory storage.