ライフサイエンスコーパス: copper transporter

1 tly demonstrated that SLC25A3 functions as a copper transporter.

2 elta mutant, demonstrating its function as a copper transporter.

3 lasma membrane and is the primary Drosophila copper transporter.

4 ates with the intracellular location of this copper transporter.

5 atodes were found to have great diversity of copper transporters.

6 ecial structural and mechanistic features in copper transporters.

7 e action of the Ctr1 family of high affinity copper transporters.

8 Mammalian copper transporter 1 (CTR1) is a high-affinity copper in

9 Human copper transporter 1 (CTR1) is overexpressed in a variet

10 The mammalian copper transporter 1 (CTR1) is responsible for the uptak

11 We show here that the copper transporter 1 (Ctr1) protein is a critical router

12 Down-regulation of copper transporter 1 (CTR1) reduces uptake and sensitivi

13 The major copper influx transporter, copper transporter 1 (CTR1), has now been shown to contr

14 age of the copper-binding ecto-domain of the copper transporter 1 (Ctr1).

15 Human copper transporter 1 (hCTR1) is a homotrimer of a 190-am

16 Human copper transporter 1 (hCTR1) is the major high affinity

17 cellular uptake of (64)Cu mediated by human copper transporter 1 (hCtr1) or simply due to nonspecifi

18 It has been claimed that human copper transporter 1 (hCTR1), the human high-affinity co

19 The human copper transporter 1 (hCTR1), the major transporter resp

20 The human copper transporter 1 (hCtr1), when heterologously overex

21 ions and immunohistochemistry study of human copper transporter 1 expression in the tumor tissues.

22 r xenografts expressing high levels of human copper transporter 1 were well visualized on the PET ima

23 ulated not only by the copper importer CTR1 (copper transporter 1) but also by the copper exporter AT

24 chelation or genetic knockdown of the CTR1 (copper transporter 1) copper channel alters the spatiote

25 at CCS can interact with human high affinity copper transporter 1.

26 Copper transporter 2 (CTR2) is one of the four copper tr

27 e structurally related, previously enigmatic copper transporter 2 (Ctr2).

28 antly, this interaction is specific for this copper transporter, a finding consistent with the observ

29 rindled) mice, which lack a functional ATP7A copper transporter and serve as a model for Menkes disea

30 We explored the role of known copper transporters and chaperones in delivering copper

31 Because copper transporters and chaperones regulate platinum dru

32 thought to counter with an up-regulation of copper transporters and efflux pumps.

33 er, these results indicate that cell-surface copper transporters and SOD1 are required for completion

34 lls express high levels of CTR1, the primary copper transporter, and additional chaperones that are r

35 ially expressed genes such as lysyl oxidase, copper transporter ATP7A, EphB6, RUNX2 and a variant of

36 ntly, expression of Atox1 and its partner, a copper transporter ATP7A, is upregulated.

37 antioxidant enzymes that obtains copper via copper transporter ATP7A.

38 It was shown previously that an intestinal copper transporter (Atp7a) was co-regulated with iron tr

39 tion is disrupted due to inactivation of the copper transporter ATP7B resulting in hepatic copper ove

40 Excretion of copper into bile requires the copper transporter Atp7b, which is deficient in Wilson d

41 lson disease, a disorder due to mutations in copper transporter ATP7B.

42 ological disorder caused by mutations in the copper-transporter, ATP7B.

43 Both proteins are high affinity copper transporters but share distinct enzymatic propert

44 The Menkes and Wilson genes are homologous copper transporters, but differences in their expression

45 he iron transport ligand transferrin and the copper transporter caeruloplasmin in the control of iron

46 ed in this screen encoding homologues of the copper transporter Ccc2, the copper chaperone Atx1, the

47 copper transporter (CTR1), an intracellular copper transporter (CCC2), and a putative transcription

48 derstanding of the structure and function of copper transporters, chaperones and cupro-proteins, coup

49 se genes are annotated, respectively, as two copper transporter (CopA and CopB) genes and a zinc-cadm

50 rexpression of the Arabidopsis high-affinity copper transporter COPT1 slightly increases endogenous i

51 The copper transporter (Ctr) family of integral membrane pro

52 opper is transported by three members of the copper transporter (Ctr) family, namely Ctr4, Ctr5, and

53 accumulation is associated with the loss of copper transporter Ctr1 from the plasma membrane and the

54 We investigated the ability of the copper transporter CTR1 to control the accumulation of D

55 these were Cu/Zn-superoxide dismutase Sod1, copper transporter Ctr1, and copper chaperone Lys7, sugg

56 s associated with the down-regulation of the copper-transporter Ctr1 in the liver and appearance of a

57 Copper transporter (Ctr1) plays an important role in reg

58 s transport system include a plasma-membrane copper transporter (CTR1), an intracellular copper trans

59 The high-affinity copper transporter (Ctr1; SCLC31A1) plays an important r

60 study was to determine the role of an influx copper transporter, CTR1, in the ototoxicity induced by

61 Here we demonstrate that two Cryptococcus copper transporters, Ctr1 and Ctr4, differentially influ

62 ose that cisplatin uptake is mediated by the copper transporter Ctr1p in yeast and mammals.

63 l results, a model is presented in which the copper transporter Ctr1p serves as a molecular target of

64 the Saccharomyces cerevisiae plasma membrane copper transporter Ctr1p, in response to a change in ext

65 for strains lacking either the cell surface copper transporter, Ctr1p, or the putative copper transp

66 Under low-copper conditions, the copper transporters Ctr4 and Ctr5 are maximally expresse

67 We have cloned genes for a high affinity copper transporter (Ctr4) and copper-sensing transcripti

68 ructed using the cryptococcal CUF1-dependent copper transporter, CTR4.

69 tant Wilson cDNAs were expressed in a Menkes copper transporter-deficient mottled fibroblast cell lin

70 rotein expression and localization of Ctr1p (copper transporter), Fet3p (multicopper oxidase involved

71 dant but structurally distinct Ctr1 and Ctr3 copper transporters from Saccharomyces cerevisiae.

72 Thus, restoring copper transporter function is an essential therapeutic

73 ed binding region was upstream of a putative copper transporter gene (ctpB), and crp-deleted bacteria

74 ations Mac1 protein is rendered inactive for copper transporter gene transcription.

75 s characterized by analyzing the function of copper transporter genes in Arabidopsis thaliana.

76 udies using the sphingolipid hydroxylase and copper transporter genes, SCS7 and CCC2, respectively, s

77 Novel zinc and copper transporters have been identified as well, mostly

78 Therefore, these two copper transporters have opposite effects on DDP sensiti

79 Here, we report that human copper transporter (hCtr) 1 plays an important role in t

80 ation to CDDP through up-regulation of human copper transporter (hCtr) 1, which is also a transporter

81 The human copper transporter hCTR1 is a homotrimer composed of a p

82 he biochemical characterization of the human copper transporter hCtr1, which is important for underst

83 l transport is mediated by the high affinity copper transporter hCTR1.

84 The human high-affinity copper transporter (hCtr1) plays an important role in th

85 y that expression of the human high-affinity copper transporter (hCtr1) was transcriptionally up-regu

86 s, demonstrating abundant expression of this copper transporter in hippocampal neurons.

87 ggesting that this protein may function as a copper transporter in rat pinealocytes.

88 1p specifically delivers copper to the Ccc2p copper transporter in the Golgi.

89 e copper transporter, Ctr1p, or the putative copper transporter in the secretory pathway, Ccc2p.

90 d member of the conserved CTR/COPT family of copper transporters in Arabidopsis thaliana, COPT6.

91 R1, CTR2, CTR3, and COPT1, encoding CTR-type copper transporters in Chlamydomonas.

92 lta strain; these genes encode the two major copper transporters in laboratory yeast strains.

93 pper transporter 2 (CTR2) is one of the four copper transporters in mammalian cells that influence th

94 We have expressed hCTR1, the human copper transporter, in Sf9 cells using a baculovirus-med

95 entry route of platinum drugs, and that the copper transporter is not internalized in response to ex

96 et of meningoencephalitis, expression of the copper transporters is induced and is critical for Crypt

97 ansporter 1 (hCTR1), the human high-affinity copper transporter, is the major entry pathway for cDDP

98 ome, these results also show that defects in copper transporter localization contribute to hypopigmen

99 tinum-containing drugs and suggest that this copper transporter may also transport DDP.

100 Changes in the expression of copper "transporters" may be useful to monitor copper st

101 ngs reveal unique and opposing functions for copper transporters of the host and pathogen during infe

102 Cu-ATPases are membrane copper transporters present in all kingdoms of life.

103 ess AgNPs in association with membrane bound copper transporter proteins cause sequestration of coppe

104 distinct from that of RAN1, which encodes a copper transporter required for ethylene receptor functi

105 ast CTR1 gene, which encodes a high-affinity copper transporter, results in increased cisplatin resis

106 at overexpression of the human or mouse Ctr1 copper transporter stimulates copper uptake in mammalian

107 ATP7A is a faster copper transporter than Wilson disease protein as eviden

108 Human CTR1 is a high-affinity copper transporter that also mediates the uptake of the

109 ATP7B is a copper transporter that traffics between the intracellul

110 s subunit of a plasma membrane high affinity copper transporter, the presence of additional subunits

111 ls copper modulates phosphorylation of a key copper transporter, the Wilson's disease protein (WNDP).

112 carboxyl-terminal tail induce release of the copper transporter to the axons or axonal membranes.

113 module found in all eukaryotic high affinity copper transporters to date, which is sufficient for cop

114 The cue system employs an inner membrane copper transporter, whereas the cus system includes a tr

115 Perturbation of the human copper-transporter Wilson disease protein (ATP7B) causes