ライフサイエンスコーパス: copper-zinc superoxide dismutase

1 ncluding uncoupling protein 2, catalase, and copper zinc superoxide dismutase.

2 l killing was abrogated by 1,000 units/ml of copper-zinc superoxide dismutase.

3 oxidative damage in cells lacking cytosolic copper/zinc superoxide dismutase.

4 tivities of either glutathione peroxidase or copper/zinc superoxide dismutase.

5 having a point mutation in the gene encoding copper/zinc superoxide dismutase.

6 Similarly, two mutant copper zinc superoxide dismutase 1 (mSOD1) mouse models

7 otective role in mice harboring mutations of copper-zinc superoxide dismutase 1 (SOD1) in familial am

8 d in the reduced accumulation of chloroplast copper/zinc superoxide dismutase 1 (HvSOD1), whereas los

9 d in the reduced accumulation of chloroplast copper/zinc superoxide dismutase 1 (HvSOD1), whereas los

10 Mutations in the copper/zinc superoxide dismutase 1 (SOD-1) gene have pre

11 Mutations in copper/zinc superoxide dismutase 1 (SOD1) are found in a

12 rosis, FALS) associated with the most common copper/zinc superoxide dismutase 1 (SOD1) mutation, an a

13 ions confer one or more toxic function(s) on copper/zinc superoxide dismutase 1 (SOD1) that impair mo

14 Mutations in copper/zinc superoxide dismutase 1 (SOD1), a genetic cau

15 Mutations in copper/zinc superoxide dismutase 1 (SOD1), primary cause

16 The copper-zinc superoxide dismutase-1 (SOD1) is a highly st

17 Addition of copper-zinc superoxide dismutase (3,000 units/ml), which

18 constitutive ACHN proteins were identified: copper zinc superoxide dismutase, 60S acidic ribosomal p

19 t LSD1 and LOL1 have antagonistic effects on copper-zinc superoxide dismutase accumulation, consisten

20 Cytosolic copper zinc superoxide dismutase activity also increased

21 genic (Tg) rats with a five-fold increase in copper zinc superoxide dismutase activity.

22 l TH was not nitrated in mice overexpressing copper/zinc superoxide dismutase after MPTP administrati

23 tant for maintaining mitochondrial function (copper/zinc superoxide dismutase, aldehyde oxidase, and

24 Subpopulations of copper-zinc superoxide dismutase also localize to mitoch

25 Significant differences in copper zinc superoxide dismutase and catalase activities

26 rable with the level of protection seen with copper/zinc superoxide dismutase and the anti-apoptotic

27 regulation of one of its target genes, CSD2 (copper/zinc superoxide dismutase), and thereby helps pla

28 t abundant copper proteins, plastocyanin and copper/zinc superoxide dismutase, are found in chloropla

29 t is perhaps the most perplexing question in copper-zinc superoxide dismutase-associated familial ALS

30 metry at the active site of bovine and human copper,zinc-superoxide dismutases (bSOD1 and hSOD1) trea

31 sed (P<0.01) manganese superoxide-dismutase, copper-zinc superoxide-dismutase, catalase, and glutathi

32 d be found between cell growth and levels of copper/zinc superoxide dismutase, catalase, or glutathio

33 rophic lateral sclerosis-linked mutations in copper-zinc superoxide dismutase cause motor neuron deat

34 Mutations in copper-zinc superoxide dismutase cause the neurodegenera

35 for two genes encoding antioxidant enzymes, copper zinc superoxide dismutase (Cu/Zn SOD) and glutath

36 transgenic mice that under- or over-express copper, zinc superoxide dismutase (Cu,Zn-SOD; SOD-1).

37 space, which contains a recently identified copper, zinc superoxide dismutase (Cu,ZnSOD).

38 Copper,zinc superoxide dismutase (Cu,Zn-SOD) catalyzes t

39 Mutations of copper,zinc-superoxide dismutase (cu,zn SOD) are found i

40 H. ducreyi expresses a periplasmic copper-zinc superoxide dismutase (Cu, Zn SOD) that prote

41 Copper-zinc superoxide dismutase (Cu,ZnSOD) is the antio

42 Haemophilus ducreyi produces a periplasmic copper-zinc superoxide dismutase (Cu-Zn SOD), which is t

43 milies to mutations in the gene encoding for copper-zinc superoxide dismutase (Cu/Zn-SOD), a key enzy

44 riments showed a decrease in basal levels of copper/zinc superoxide dismutase (Cu/Zn SOD) and glutath

45 Copper/zinc superoxide dismutase (Cu/Zn SOD) is a first-

46 on basal activity of the antioxidant enzymes copper/zinc superoxide dismutase (Cu/Zn SOD), manganese

47 Inclusion of exogenous copper/zinc superoxide dismutase (Cu/ZnSOD, 100 microg/m

48 manganese superoxide dismutase (Mn-SOD) and copper-zinc superoxide dismutase (CuZn-SOD) and of L-fer

49 Mutations in copper-zinc superoxide dismutase (CuZn-SOD) have been im

50 Copper-zinc superoxide dismutase (CuZn-SOD) is believed

51 ) that delivers copper to the active site of copper-zinc superoxide dismutase (CuZn-SOD, a product of

52 whether transgenic (Tg) mice overexpressing copper/zinc-superoxide dismutase (CuZn-SOD) are protecte

53 Copper zinc superoxide dismutase (CuZnSOD) is an essenti

54 Copper-zinc superoxide dismutase (CuZnSOD) acquires its

55 Mutations in copper-zinc superoxide dismutase (CuZnSOD) cause 25% of

56 The three-dimensional structure of yeast copper-zinc superoxide dismutase (CuZnSOD) has been dete

57 Deletion of copper-zinc superoxide dismutase (CuZnSOD) in Sod1(-/-)

58 er ion at the active site of human wild type copper-zinc superoxide dismutase (CuZnSOD) is essential

59 ction cycle is proposed for the mechanism of copper-zinc superoxide dismutase (CuZnSOD) that involves

60 imed to determine if the expression of human copper-zinc superoxide dismutase (CuZnSOD) within the lu

61 Manganese superoxide-dismutase (MnSOD), copper-zinc superoxide dismutase (CuZnSOD), and heme oxy

62 Yeast lacking copper-zinc superoxide dismutase (CuZnSOD), manganese su

63 inherited mutations in the gene that encodes copper-zinc superoxide dismutase (CuZnSOD).

64 re due to lesions in SOD1, the gene encoding copper-zinc superoxide dismutase (CuZnSOD).

65 ieved to deliver copper ions specifically to copper-zinc superoxide dismutase (CuZnSOD).

66 Copper-zinc superoxide dismutase (CuZnSOD, SOD1 protein)

67 Mutations of the SOD1 gene encoding copper/zinc superoxide dismutase (CuZnSOD) cause an inhe

68 Copper/zinc superoxide dismutase (CuZnSOD; SOD1) is wide

69 Copper-zinc superoxide dismutases (CuZnSODs) are infrequ

70 lative amounts of copper-containing forms of copper-zinc superoxide dismutase (EC 1.15.1.1) from bovi

71 Mutations in the gene encoding copper/zinc superoxide dismutase enzyme produce an anima

72 The down-regulation of copper/zinc superoxide dismutase expression in response

73 copper in native polyacrylamide gels of the copper-zinc superoxide dismutase from purified preparati

74 A series of mutant human and yeast copper-zinc superoxide dismutases has been prepared, wit

75 sistent with these findings, the activity of copper-zinc superoxide dismutase in these tissues was eq

76 n is essential for photo-autotrophic growth, copper/zinc superoxide dismutase is dispensable and in p

77 of the main free radical scavenging enzymes copper/zinc superoxide dismutase, manganese superoxide d

78 Copper/zinc superoxide dismutase, manganese superoxide d

79 Mutations in the copper/zinc superoxide dismutase (mSOD1) gene are associ

80 motor neuron degeneration produced by mutant copper/zinc superoxide dismutase (mSOD1), the only prove

81 In addition, mice deficient in copper-zinc superoxide dismutase or cellular glutathione

82 ntified, of which five [i.e., alpha-amylase; copper zinc superoxide dismutase; protein disulfide isom

83 Over 130 mutations to copper, zinc superoxide dismutase (SOD) are implicated i

84 Mutations in copper, zinc superoxide dismutase (SOD) have been implic

85 Mutations in copper,zinc-superoxide dismutase (SOD) have been implica

86 ies reported that H(2)O(2) is metabolized by copper,zinc-superoxide dismutase (SOD) to form (.)OH tha

87 Copper-zinc superoxide dismutase (SOD) is of fundamental

88 zable substrates, the peroxidase reaction of copper-zinc superoxide dismutase (SOD) oxidizes SOD itse

89 ant SV expressing the O-2 scavenging enzyme, copper/zinc superoxide dismutase (SOD), potentiates SV-i

90 oavailability to support the activity of the copper/zinc superoxide dismutase Sod1 and that loss of S

91 re associated with mutations in the gene for copper/zinc superoxide dismutase ( SOD1 ), which catalys

92 ite (NO2(-)) and nitrate (NO3(-)) ions using copper, zinc superoxide dismutase (SOD1) and nitrate red

93 for copper loading of the antioxidant enzyme copper, zinc superoxide dismutase (SOD1) by its partner

94 ALS) cases are due to known mutations in the copper, zinc superoxide dismutase (SOD1) gene.

95 sts for the increased peroxidase activity of copper, zinc superoxide dismutase (SOD1) in oxidant-indu

96 Copper, zinc superoxide dismutase (SOD1) is activated in

97 on (HCO(3)(-)) on the peroxidase activity of copper, zinc superoxide dismutase (SOD1) was investigate

98 ied out using antibodies against the enzymes copper, zinc superoxide dismutase (SOD1), or manganese s

99 of identified linkages in the gene encoding copper, zinc-superoxide dismutase (SOD1).

100 elivers the essential copper ion cofactor to copper,zinc superoxide dismutase (SOD1), a key enzyme in

101 Copper,zinc-superoxide dismutase (SOD1) was shown to be

102 peroxide dismutase (Ccs1) activates immature copper-zinc superoxide dismutase (Sod1) by delivering co

103 Mutations in the gene encoding human copper-zinc superoxide dismutase (SOD1) cause a dominant

104 Mutations in human copper-zinc superoxide dismutase (SOD1) cause an inherit

105 ver 100 mutations in the gene encoding human copper-zinc superoxide dismutase (SOD1) cause an inherit

106 Mutations in the metalloenzyme copper-zinc superoxide dismutase (SOD1) cause one form o

107 e dissociation of apo- and metal-bound human copper-zinc superoxide dismutase (SOD1) dimers induced b

108 More than 90 mutations in the copper-zinc superoxide dismutase (SOD1) gene cause a sub

109 eral sclerosis (ALS)-linked mutations in the copper-zinc superoxide dismutase (SOD1) gene cause motor

110 Aggregation of copper-zinc superoxide dismutase (SOD1) is a defining fe

111 eral sclerosis (fALS) caused by mutations in copper-zinc superoxide dismutase (SOD1) is characterized

112 ously shown that several familial ALS-linked copper-zinc superoxide dismutase (SOD1) mutants (A4V, G8

113 We show that mutant copper-zinc superoxide dismutase (SOD1) overexpression i

114 eroxide can interact with the active site of copper-zinc superoxide dismutase (SOD1) to generate a po

115 Delivery of copper-zinc superoxide dismutase (SOD1), an efficient RO

116 o determine the misfolding pathway of mutant copper-zinc superoxide dismutase (SOD1), the protein kno

117 of bicarbonate on the peroxidase activity of copper-zinc superoxide dismutase (SOD1), using the nitri

118 In the course of studies on human copper-zinc superoxide dismutase (SOD1), we observed a m

119 binding to metal-free (apo) human and bovine copper-zinc superoxide dismutases (SOD1) were measured u

120 Mutations in copper/zinc superoxide dismutase (SOD1) are causative fo

121 Yeast strains lacking copper/zinc superoxide dismutase (SOD1) are sensitive to

122 type (WT) and 14 different variants of human copper/zinc superoxide dismutase (SOD1) associated with

123 d that 14 biologically metallated mutants of copper/zinc superoxide dismutase (SOD1) associated with

124 cell death as a consequence of mutations in copper/zinc superoxide dismutase (SOD1) associated with

125 "cage"-like nano-formulation (nanozyme) for copper/Zinc superoxide dismutase (SOD1) by polyion conde

126 orted that oxidative damage in yeast lacking copper/zinc superoxide dismutase (SOD1) can be alleviate

127 city in Saccharomyces cerevisiae lacking the copper/zinc superoxide dismutase (SOD1) can be suppresse

128 Mutations in copper/zinc superoxide dismutase (SOD1) cause a subset o

129 At least 119 mutations in the gene encoding copper/zinc superoxide dismutase (SOD1) cause amyotrophi

130 90 different mutations in the gene encoding copper/zinc superoxide dismutase (SOD1) cause approximat

131 Yeast deficient in the cytosolic copper/zinc superoxide dismutase (SOD1) exhibit metaboli

132 Mutations in the copper/zinc superoxide dismutase (SOD1) gene produce an

133 ts in the gene encoding the enzyme cytosolic copper/zinc superoxide dismutase (SOD1) have been report

134 mature animal, immature mice transgenic for copper/zinc superoxide dismutase (SOD1) have greater bra

135 Copper/zinc superoxide dismutase (SOD1) is an abundant i

136 onstrate here that the delivery of copper to copper/zinc superoxide dismutase (SOD1) is mediated thro

137 We have reported that overexpression of copper/zinc superoxide dismutase (SOD1) reduced superoxi

138 We have reported that overexpression of copper/zinc superoxide dismutase (SOD1) reduces apoptoti

139 tly inherited mutations in the gene encoding copper/zinc superoxide dismutase (SOD1) result in the fa

140 The cDNA encoding the equine copper/zinc superoxide dismutase (SOD1) was cloned from

141 (ALS) is mutation in ubiquitously expressed copper/zinc superoxide dismutase (SOD1), but the mechani

142 copper into the essential antioxidant enzyme copper/zinc superoxide dismutase (SOD1).

143 using transgenic (Tg) mice that overexpress copper/zinc superoxide dismutase (SOD1).

144 ve previously shown that a fraction of yeast copper/zinc-superoxide dismutase (SOD1) and its copper c

145 urthermore, transgenic mice that overexpress copper/zinc-superoxide dismutase (SOD1) show decreased l

146 in the absence of any Pb-induced changes in copper/zinc-superoxide dismutase (SOD1), manganese-SOD (

147 Whereas copper, zinc-superoxide dismutase, SOD1, efficiently dis

148 Yeast lacking copper-zinc superoxide dismutase (sod1Delta) show a prof

149 milial ALS (FALS) are caused by mutations of copper/zinc superoxide dismutase type 1.

150 Several of the ALS-associated mutant copper-zinc superoxide dismutases were also found to be

151 on of spheres, the association of the enzyme copper-zinc superoxide dismutase with superoxide anion,

152 structure, and intracellular localization of copper,zinc superoxide dismutase, with relevance to amyo