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1 licated by the fact that males only have one copy.
2 /- 0.44 mm Hg (pcom = 0.01) per risk variant copy.
3 gence and expression difference of duplicate copies.
4 equal expression of the two chromosomal gene copies.
5 units in addition to the native Hordeum rDNA copies.
6 inguish between CAM-related and non-CAM gene copies.
7 ELL gene with different number of functional copies.
8 rkably large and contain multiple chromosome copies.
9 ications, as well as for different number of copies and copy-neutral loss-of-heterozygosity (LOH).
10 ets of epigenetic regulation into (i) single copy and methylated exclusively at CpGs, readily forming
13 template is precisely defined, processively copied, and regenerated by release of single-stranded pr
14 mbination decreased the number of bound L7Ae copies, and either eliminated or changed the L7Ae footpr
16 er genetic variants determining amylase gene copies are associated with 2-year changes in adiposity a
20 etermined the number of CFHR3 and CFHR1 gene copies by quantitative PCR and collected clinical and bi
23 y purification of a sequence-specific single-copy endogenous chromosomal locus containing a DNA doubl
24 a 95% detection probability were 11.5 genome copy equivalents (GCE)/ml (95% fiducial limits, 7.9 to 2
25 n widely observed that sex-related genes are copied from sex chromosomes and inserted into autosomes,
28 ative PCRs and a telomere-sequence to single-copy-gene-sequence ratio method to determine telomere le
31 that production and packaging of the single-copy genome into gametes during the second meiotic divis
34 h 2 genital specimens each containing >/=105 copies herpes simplex virus DNA/ml collected a median of
36 he chromosome can be present at thousands of copies in a single cell (in contrast to two copies of nu
39 his aim, we coupled mobilization of a single-copy inactivating Sleeping Beauty transposon to Pten dis
41 pic changes in metabolism following a single copy knock-in of mutant PIK3CA (H1047R) in the MCF10A ce
42 of detection of 3.40 +/- 0.20 log10 genomic copies (LGC), which is comparable to most other reported
43 iated gene dependencies and identify partial copy-loss of wild-type SF3B1 as a novel, non-driver canc
45 ic coastal upwelling for OI (36 713 +/- 1485 copies ml(-1) ) and the Kuroshio Front for OII (50 189 +
46 d the Kuroshio Front for OII (50 189 +/- 561 copies ml(-1) ) and the two overlapped only in frontal r
47 -1 RNA increased from <20 copies/mL to >1500 copies/mL (range, 21-1571 copies/mL) during treatment.
49 apped substantially (range, 0.16-989.9 x 103 copies/mL and 0.01-551.9 x 103 copies/mL, respectively).
50 The probability of confirmed HIV RNA >1000 copies/mL by 48 months was 0.07 and 0.12 in the EFV and
52 ties determined by probit analysis were 19.3 copies/ml for the 1-ml assay and 126 copies/ml for the 0
56 oportion who died or had a viral load of 400 copies/mL or higher at 12 months post-ART initiation was
58 or 7.4 months, rebounding with HIV RNA of 36 copies/mL that rose to 59,805 copies/mL 6 days later.
59 cipants, plasma HIV-1 RNA increased from <20 copies/mL to >1500 copies/mL (range, 21-1571 copies/mL)
60 ing retained at 12 months with HIV-1 RNA <50 copies/ml was 1.21 (95% CI: 1.04, 1.38; p = 0.015) for t
61 Pneumococcal colonization density >6.9 log10 copies/mL was strongly associated with MCPP and could be
62 yses described the incidence of major (>1000 copies/mL) and minor (50-1000 copies/mL) viremic episode
63 lers (ie, persons with a viral load of </=40 copies/mL) and noncontrollers, antibody parameters were
65 56 cases with MCPP (MCPP cases; 17.28 x 106 copies/mL) exceeded that of cases without MCPP (non-MCPP
66 f major (>1000 copies/mL) and minor (50-1000 copies/mL) viremic episodes (VEs) and factors associated
68 (adjPRR) of detectable HIV shedding (VL > 40 copies/mL) were estimated by Poisson regression models w
69 an controls (median, 4.0 x 103 vs 0.19 x 103 copies/mL), but overlapped substantially (range, 0.16-98
78 first assessed the association between AMY1 copy number (genotyped by digital droplet polymerase cha
79 d volume were positively associated with CR1 copy number (mean number of CR1 molecules per erythrocyt
82 ed bees (7.45*10(12) +/- 1.62*10(12) average copy number +/- standard error) compared to other tested
85 tween immune metagene expression and somatic copy number alteration levels (rho = -0.484, P = 2 x 10-
86 ncordance of clonal somatic mutations (88%), copy number alterations (80%), mutational signatures, an
88 netic basis for immune evasion: near-uniform copy number alterations of chromosome 9p24.1 and the ass
89 ct primary tumors and did not harbor similar copy number alterations or demonstrate significant mutat
90 re frequently targeted by somatic mutations, copy number alterations, DE and AS, indicating their pro
91 aracterized by increased accumulation of DNA copy number alterations, greater genetic diversity and i
94 in the group of participants with a low AMY1 copy number and a high dietary intake of starch.Our find
95 and its target genes (IL8, CSF2), and TRIB1 copy number and expression were predictive of clinical o
97 ecDNA amplification would increase oncogene copy number and intratumoural heterogeneity more effecti
98 We investigated the association between AMY1 copy number and obesity traits, and the effect of the in
100 icant effect of the interaction between AMY1 copy number and starch intake on BMI (P-interaction = 0.
101 d the effect of the interaction between AMY1 copy number and starch intake on these obesity traits.We
104 pan of Tk2-deficient mice and restored mtDNA copy number as well as respiratory chain enzyme activiti
106 eneration sequencing analysis of chromosomal copy number changes and mutations is useful in distingui
109 trotransposons (RTs) can rapidly increase in copy number due to periodic bursts of transposition.
111 ovide evidence for the novel hypothesis that copy number elevations of these 22q11.2 genes alter the
112 Interestingly, we do not observe the extreme copy number expansion of the AMY2B gene characteristic o
113 tinib with that of placebo according to EGFR copy number gain (CNG) and EGFR, KRAS, BRAF, and PIK3CA
114 NVs were found in <1.5% of brains, including copy number gains of PRPH that were overrepresented in A
115 gree of aneuploidy and is partly due to gene copy number imbalances, suggesting that subtle changes i
119 Sal-1, one such fragment with the highest copy number in the infected cells, is derived from Salmo
120 (Rho = 0.3531; P = 0.0218) and the proviral copy number in the peripheral blood as an indirect measu
124 ity of NLRC5 caused by promoter methylation, copy number loss, or somatic mutations is associated wit
125 te that this approach can generate confident copy number measurements in independent transgenic lines
135 ailure and heart failure, we estimated GSTM1 copy number using exome sequencing reads in the Atherosc
144 rences in single-nucleotide polymorphisms or copy number variants, respectively, for differential dis
145 iant could be accelerated by the presence of copy number variation (CNV) at the K3L locus, which in m
149 sponding region in horse shows extraordinary copy number variation and different relative location an
151 on, DNA methylation, noncoding microRNA, and copy number variation data available from the Gene Expre
152 ceptibility to IAV segregates independent of copy number variation in multicopy ChrY gene families th
153 ic loci with extensive nucleotide diversity, copy number variation of paralogous genes, and long repe
155 3A/E6AP-dependent ASD.SIGNIFICANCE STATEMENT Copy number variation of the UBE3A gene and aberrant ove
156 orroborative pattern between the chromosomal copy number variation profiles of the AH cfDNA and tumor
157 latform, followed by genome-wide chromosomal copy number variation profiling to assess the presence o
159 athways, compounds, quantitative proteomics, copy number variation, and polysomal transcriptomics.
160 rovides an evolutionary alternative for gene copy number variation.Eukaryotic cells rely on the ubiqu
161 neity, total mutation load, neoantigen load, copy number variations (CNV), gene- or pathway-level som
162 hed array data from the 60 samples show that copy number variations (CNVs) and alterations in DNA met
164 microdeletion is among the most common gene copy number variations (CNVs) known to confer risk for i
165 ingle-nucleotide polymorphisms (SNPs) and 43 copy number variations (CNVs) with in-vitro piperaquine
166 ould be determined and 7.2% of these carried copy number variations and/or chromosomal abnormalities,
167 quences by Illumina paired-reads sequencing, copy number variations by qPCR, RNA concentrations by qR
168 K2 is one of the genes in the 16p11.2 locus, copy number variations of which are associated with auti
169 we report the first observation of abundant copy number variations on neuropeptides and receptors, w
172 les, 215 genes spanning rare and replication copy number variations, 99 genes overlapping with linkag
176 stimated that decreases in mitochondrial DNA copy number, a measure of mitochondrial genome abundance
177 and adenovirus receptor) expression and CVB3 copy number, and an improved left ventricular function i
179 and analyzed mRNA and miRNA expression, DNA copy number, and DNA methylation in 117 Wilms tumors, fo
180 es from 10 cases, the mutational signatures, copy number, and SNV mutational profiles reflect the exp
181 in respiratory activity: depletion of mtDNA copy number, decreases in mtRNA levels, and decreases in
182 ctivity or, through incrementally increasing copy number, may be sites of secondary selective pressur
186 nd loci, CD274/PD-L1 and PDCD1LG2/PD-L2, and copy number-dependent increased expression of these liga
191 amatically improved in GT mice with a vector copy number/genome higher than 1 in the BM and 2 in the
192 ve from chemorefractory disease, we examined copy-number aberrations (CNAs) in circulating tumor cell
193 Extensive prior research focused on somatic copy-number alterations (SCNAs) affecting cancer genes,
198 ssess the phenotypic consequences of genomic copy-number alterations that are repeatedly observed in
200 lted in parallel evolution of driver somatic copy-number alterations, including amplifications in CDK
202 sarcoma) are characterized predominantly by copy-number changes, with low mutational loads and only
210 y-matched controls for rare (< 1% frequency) copy-number variants (CNVs) using SNP microarray data.
211 Africa, we identify a diverse array of large copy-number variants affecting the host invasion recepto
212 analyses show six genes that have recurrent copy-number variants in three squamous-cell carcinomas (
214 (WGA) methods are limited by low accuracy of copy-number variation (CNV) detection and low amplificat
216 positively correlated with proviral HIV-DNA copy numbers in peripheral blood mononuclear cells (PBMC
217 ve evolutionary strategy to rapidly increase copy numbers of genomes per cell at the expense of the t
218 rison of genes and repeats unveiled that the copy numbers of NLRs were greatly increased by LTR-retro
222 e integrated mutations, gene expression, DNA copy numbers, DNA methylation and protein abundance, all
224 olyploid species to combine mutations in all copies of a gene (homoeologs), and to expose phenotypic
225 erance of the loss of one or both functional copies of a gene is related to the gene's causal role in
226 erated mice overexpressing either one or two copies of a kinase-dead mTOR mutant (KD-mTOR) transgene
229 s, the latter of which have given rise to 12 copies of alpha-gliadin genes clustered within a 550-kb
230 ngle dose of 5 x 10(12) or 2 x 10(13) genome copies of AMT-060/kilogram was administered to 5 partici
231 eptide epitopes (SunTag) recruiting multiple copies of antibody-fused de novo DNA methyltransferase 3
233 mpared with those whose tumors had wild-type copies of both genes, although only results for BRAFV600
234 n conditioning expression divergence between copies of duplicates generally holds for duplicates gene
236 TR lncRNAs transcribed from many of the 4000 copies of ERV-9 LTR retrotransposons acted by a similar
237 of small RNAs in live, single cells, tandem copies of FASTmiR122 were expressed in different cell li
238 ner, we used groES (7), a gene linking seven copies of groES, to incorporate I25 mutations in selecte
241 rences per 10,000 base pairs between the two copies of her genome, fewer than present-day humans, sug
242 kg or more, had virological suppression (<50 copies of HIV-1 RNA per mL) on a stable regimen for at l
243 copies in a single cell (in contrast to two copies of nuclear chromosomes), and mtDNA deletions may
244 , evidencing that as little as a few tens of copies of redox-labeled macromolecules immobilized on in
245 l to combined endpoint in SMA infants with 2 copies of SMN2 indicated a median age of 8 months at dea
246 this example is an inductive limit of unital copies of the Cuntz algebra [Formula: see text] or of th
248 L evolution, both models acquired additional copies of the mutant Flt3 or Nras alleles, but only Npm1
249 back process, methods to efficiently add new copies of the relevant gene to hematopoietic stem cells
252 tronic states emerge as a result of multiple copies of the TOTA(+) making pi-contact with cyanostar-a
253 mitosis, cells must segregate the replicated copies of their genome to their daughter cells with extr
254 etermined structures can interact with other copies of themselves and assemble into homomeric complex
255 electron microscopy, demonstrating that two copies of VirD4 dimers locate on both sides of the appar
258 also analyzed from mice that express only 1 copy of human REG3A transgene but were fed feces from co
259 nd used recombineering to reintegrate a full copy of the gene, generating the {for(BAC)} rescue allel
260 of ataxin 7 and replace it with an exogenous copy of the gene, highlighting the efficacy and transfer
261 th rs147210663 was particularly strong; each copy of the Thr allele conferred 42% lower triglycerides
264 ted RNA primer extension, allowing efficient copying of a variety of short RNA templates with mixed s
265 Despite recent progress, the nonenzymatic copying of templates containing mixed sequences remains
266 sma HIV-1 RNA concentrations of less than 50 copies per mL at week 24 according to the US Food and Dr
267 ipants with plasma HIV-1 RNA of less than 50 copies per mL at week 48 (assessed by the US Food and Dr
268 ipants with plasma HIV-1 RNA of less than 50 copies per mL at week 48 (US Food and Drug Administratio
269 ir group had HIV-1 RNA loads of less than 50 copies per mL compared with 31 (93.9%) of 33 in the dolu
270 NRTI group had viral loads of less than 400 copies per mL compared with 312 (81%) of 383 in the prot
271 proportion of participants with less than 50 copies per mL of plasma HIV-1 RNA at week 48 (by the US
272 ological rebound (confirmed viral load >/=50 copies per mL or premature discontinuations, with last v
274 discontinuations, with last viral load >/=50 copies per mL) cumulative through week 48; we tested non
275 ment of a single viral load of more than 200 copies per mL, and 1414 (31%) by a documented treatment
276 ntiretrovirals and had HIV RNA less than 200 copies per mL, or not receiving antiretrovirals and had
279 78%) of 375 had viral loads of less than 400 copies per mL; p=0.003 versus the protease inhibitor plu
280 s directly estimate the number of DNA target copies per reaction partition, lambda, where the partiti
283 cifically, the sheer abundance of genomic L1 copies prevents reliable quantification of new insertion
284 nerating site-specifically integrated single-copy promoter transgenes and measuring their expression
287 neous distribution of these new retroelement copies result from a combination of two mechanisms, of w
292 the nucleus are locations where viral DNA is copied to support virus persistence and amplification of
293 phase, whereas MIND and Ndc80 submodules add copies to form an "anaphase configuration" kinetochore.
295 correlate with learning ability - males that copied tutor songs more accurately had more bridge neuro
299 it of detection of 9.8pg of soybean DNA (8.6 copies), with adequate real-time PCR performance paramet
300 e relatively small-scale polymorphism of ITS copies within individuals has often been reported in lit
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