ライフサイエンスコーパス: copy number gain

1 ith few changes, one with a tendency to show copy number gain).

2 r neutral regions, as well as two regions of copy number gain.

3 a morphological change attributable to a DNA copy number gain.

4 ixture of deletion, insertion, inversion and copy number gain.

5 plified alleles and haplotypes in regions of copy number gain.

6 L-Myc RNA in relative proportion to the DNA copy number gain.

7 l uncharacterized (12p13 and 16p13) regional copy number gains.

8 types: deletions, insertions, inversions and copy number gains.

9 positive regions flanking and throughout the copy-number gains.

10 omes, often in clusters, and associated with copy-number gains.

11 umors to spatially associate palindromes and copy-number gains.

12 e than one breakpoint) are more prevalent in copy-number gains (17.7%) than in copy-number losses (2.

13 Copy number gain (3 copies) was also observed for MUC2,

14 ddition, ABC-DLBCL frequently displays focal copy number gains affecting BCL2 Here, we generated a no

15 nt ALK-FISH patterns [ALK-rearrangement, ALK-copy number gain (ALK-CNG)] monitored on crizotinib coul

16 44 genes that exhibit high frequency somatic copy number gains/amplifications (>20 % cases) associate

17 allowed the identification of 70 regions of copy number gain and 55 regions of copy number loss.

18 ng assays for their ability to detect 2-fold copy number gain and loss (4n or 1n, respectively) as we

19 is study, we found seven frequent regions of copy number gain and loss in the mouse p53(+/-) osteosar

20 NA) and identified regions of peak and broad copy number gain and loss, including peak gains (3q21, 5

21 subsequent BRCA recovery upon progression by copy number gain and/or upregulation of the remaining fu

22 Cancer cells undergo a variety of DNA copy number gains and losses (CNV), raising two importan

23 DNA copy number gains and losses are commonly found in tumor

24 -EPN-B) tumours display frequent large-scale copy number gains and losses but have favourable clinica

25 HMM approach has greater power for detecting copy number gains and losses relative to existing method

26 The CGH map of chromosomal copy number gains and losses strikingly matched the SKY

27 e found that NCC-derived NBL tumors acquired copy number gains and losses that are syntenic to those

28 sent most of the major lineage-specific gene copy number gains and losses that have occurred in these

29 as identified chromosomal rearrangements and copy number gains and losses, including ETS gene family

30 enomes frequently contained many small-scale copy number gains and losses, termed micro-aberrations,

31 of DNA segments falsely identified as having copy number gains and losses.

32 iscuss the permanent and transient nature of copy number gains and relate these observations to a new

33 esis that multiple genetic events, including copy number gains and somatic mutations, are necessary f

34 subgroup, characterized genetically by c-MYC copy number gains and transcriptionally by enrichment of

35 nd to play an important role in USC, with 13 copy-number gains and 12 copy-number losses that occurre

36 alysis showed unique patterns of nonspecific copy-number gains and losses across multiple chromosomes

37 genomic hybridization (array CGH), measuring copy-number gains and losses among these species.

38 a distinct pattern of multiple recurrent DNA copy-number gains and losses that include alterations fr

39 that are up-regulated and show frequent DNA copy number gain, and 37 genes that are down-regulated a

40 ied at certain loci, and in some cases these copy-number gains are complex chromosome rearrangements

41 tion to address the chromosomal locations of copy number gains as well as losses.

42 Here we show (V600E)B-RAF copy-number gain as a mechanism of acquired B-RAF inhibi

43 To date, few efforts have focused on copy number gain at Xp22.31.

44 Vs and report the significant association of copy number gains at chromosome 7q36.3 with schizophreni

45 ed in 1.35% of cases the presence of de novo copy number gains at Xq28 encompassing the VAMP7 gene, w

46 Copy-number gain at 3q resulted in increased MAP3K13 mRN

47 tinib with that of placebo according to EGFR copy number gain (CNG) and EGFR, KRAS, BRAF, and PIK3CA

48 RKCI is targeted for frequent tumor-specific copy number gain (CNG) in both lung squamous cell carcin

49 KDR copy number gains (CNG), measured by quantitative PCR an

50 y loss and slightly improved in regions with copy number gain, comparing with the Bayesian Robust Lin

51 sitates the use of FISH to determine whether copy-number gains detected by array CGH represent tandem

52 2 first-degree relatives) carried a germline copy-number gain (duplication) of the genomic region on

53 On average, 26% of the copy number gain events occur by the mitotic recombinati

54 and other tumors due in part to the genomic copy number gain for 3-phosphoglycerate dehydrogenase, t

55 We found that the WWP1 gene had copy number gain in 15 of 34 (44%) xenografts and cell l

56 We demonstrated chromosomal copy number gain in 1q21-23 and loss in 17p13 by genomic

57 fusion gene expression locus, demonstrated a copy number gain in a majority of tumors of both genotyp

58 FISH analysis revealed copy number gain in a subset of cells within medulloblas

59 s located at 13q12.13, a region of recurrent copy number gain in a substantial fraction of colon canc

60 (PHGDH) is in a genomic region of recurrent copy number gain in breast cancer and PHGDH protein leve

61 es exhibiting frequent overexpression and/or copy number gain in cancer.

62 investigated 67 breakpoint junctions of gene copy number gains in 31 unrelated subjects.

63 ight into the direct and indirect effects of copy number gains in chromosome 15 and provides a framew

64 Copy number gains in chromosomes 3q, 5p, and 8q were obs

65 f human cancer revealed subtle but impactful copy number gains in E2F1 and E2F3 in hepatocellular car

66 F transcriptional output, we have shown that copy number gains in E2f1 or E2f3b resulted in dosage-de

67 e chromosome 3q region frequently subject to copy number gains in human tumours.

68 he 70-gene mRNA risk model, is driven by DNA copy number gains in MM.

69 For many CNVs, and copy number gains in particular, the responsible dosage-

70 cate previously uncharacterized regions with copy number gains in primary tumor samples.

71 ACSS2 exhibits copy-number gain in human breast tumors, and ACSS2 expre

72 nt tumor specimens from 10 patients revealed copy-number gains in PDL1 and PDL2 and increased express

73 Conversely, commonly reported genes with copy number gains, including MYC and GATA6, were frequen

74 Five PKC genes exhibited significant DNA copy number gains, including PKCiota (43.8%), PKCbeta1 (

75 ion of TRAF2 in cancer cells harboring TRAF2 copy number gain inhibits proliferation, NF-kappaB activ

76 cogenes that may be activated as a result of copy number gains involving 9p and 22q.

77 Copy number gains involving 9p23-p22.3 (NFIB) and 22q12-

78 currence of certain chromosomal aberrations (copy number gain, LOH, and somatic UPDs) during carcinog

79 NRAS mutations and KIT copy number gain may be mechanisms of therapeutic resist

80 ently amplified in a genomic region of focal copy number gain most commonly found in melanoma.

81 mber losses (NAFLD: 13.3%, controls: 12.9%), copy number gains (NAFLD: 32.9%, controls: 18.5%).

82 taining cells above the cutoff for polysomy (copy number gain of >/=2 probes) were classified as posi

83 this study was to analyze the association of copy number gain of 1q in favorable-histology Wilms tumo

84 ary medulloblastomas revealed frequent focal copy number gain of a region minimally containing OTX2 a

85 orf72 hexanucleotide repeat expansions and a copy number gain of APP, were found in 61 brains.

86 In addition to expected copy number gain of chromosome 12p and mutation of KIT,

87 gnificant correlations were observed between copy number gain of clones containing CCNE1 and gain of

88 s its overexpression is coupled with a focal copy number gain of its locus at 12q13.1, and its expres

89 r human colon cancer progression there was a copy number gain of the fak gene during conversion from

90 Recurrent copy number gain of the genes encoding the PD-1 ligands

91 rall, we define a novel cohesinopathy due to copy number gain of Xq25 and STAG2 in particular.

92 ng, we identified structural aberrations and copy number gains of 1q21 in the treated cells similar t

93 By contrast, large copy number gains of chromosomes 7, 12, 16 and 17 are us

94 Maternally derived copy number gains of human chromosome 15q11.2-q13.3 (Dup

95 Copy number gains of noncoding regions harboring super-e

96 omic microarray analysis identified oncogene copy number gains of PAK1 and JUNB in three of four case

97 NVs were found in <1.5% of brains, including copy number gains of PRPH that were overrepresented in A

98 alterations in the AKT/mTOR pathway included copy number gains of the AKT1 locus at 14q32.33 in 19% o

99 Solid tumors frequently have copy number gains of the PVRL4 locus and some have focal

100 Whether low copy-number gain of one or more of these genes drives ne

101 trol group revealed a radiation-specific DNA copy number gain on chromosomal band 7q11.23 and the rad

102 These third hits were mostly copy number gains or deletions, but could be protein-tru

103 cinoma have identified regions of consistent copy-number gain or loss, but in many cases the oncogene

104 chromosome arms show consistent large-scale copy-number gain or loss, of which only a handful have b

105 We show here that a copy-number gain or overexpression of the membrane-type

106 phism arrays and identified 1,747 genes with copy number gain organized into 30 amplicons.

107 Copy-number gains preferentially occur at late stages of

108 eterozygosity, as well as of genes that show copy-number gains, providing a potential mechanism for e

109 ough there may be little bias when there are copy number gains, small biases may result when one alle

110 rdant methylation changes (hypomethylated in copy number gains such as STC2 and CCND1 and hypermethyl

111 Early detection of copy number gains suggesting a predisposition toward can

112 ers (>60 pack-years) have significantly more copy number gains than non- or light smokers (</=60 pack

113 ALK gene copy number gain was detected in the vast majority of AR

114 OTX2 copy number gain was restricted to tumor subtypes that d

115 Copy-number gain was confirmed in an independent tumor s

116 polymorphism (SNP) risk alleles and somatic copy number gains were associated with increased LMO1 ex

117 Mutations in FOXA1 and ESR1 copy number gains were detected in 9% and 25% of the sam

118 PIK3CA copy number gains were more frequent in squamous cell ca

119 rcinoma patients is consistent with ALK gene copy number gain, whereas a stromal sarcoma patient carr

120 the tumor samples we could detect high-level copy number gains, which mapped to chromosome band 11E2,

121 The results demonstrate segmental copy number gains within chromosome 3p in cutaneous mali