ライフサイエンスコーパス: cord

1 anosensory feedback in the vertebrate spinal cord.

2 hundred micrometers of the zebrafish spinal cord.

3 mportantly, also in the injured human spinal cord.

4 rom the embryonic liver, heart and umbilical cord.

5 tectures within these lineages in the spinal cord.

6 tonomic regions of the brain stem and spinal cord.

7 s) that contribute to the regenerated spinal cord.

8 ike propagation of oligomeric SOD1 in spinal cord.

9 ors have distinct morphologies in the spinal cord.

10 rt of neural circuits for itch in the spinal cord.

11 unoreactivity pattern in the cervical spinal cord.

12 overns axonal wiring of the zebrafish spinal cord.

13 nd of tissue at the caudal end of the spinal cord.

14 n innervation of motor neurons in the spinal cord.

15 ndow for development of the brain and spinal cord.

16 xcitation of neurons in slices of rat spinal cord.

17 activation in the white matter of the spinal cord.

18 s and large diameter afferents in the spinal cord.

19 s at specific locations in the ventral nerve cord.

20 s to occur to a lesser extent than in spinal cord.

21 c afferents in the dorsal horn of the spinal cord.

22 his is controlled at the level of the spinal cord.

23 nd/or acute blood products within the spinal cord.

24 netrin from different regions of the spinal cord.

25 ive lumbosacral segments in the human spinal cord.

26 s project mostly to the hindbrain and spinal cord.

27 in skeletal muscle, heart, brain and spinal cord.

28 se sections from mechanically injured spinal cords.

29 d by stereotaxic injection into mouse spinal cords.

30 ns growing into a lesion epicenter in spinal cord after a concomitant dorsal column transection.

31 d tracking inflammatory damage in the spinal cord after TAR in a mouse model.

32 ivating muscles, motor neurons in the spinal cord also activate Renshaw cells, which provide recurren

33 ionic eminence (MGE) into adult mouse spinal cord ameliorates mechanical and thermal hypersensitivity

34 xample of non-monotonic coding in the spinal cord and better explains observations in human psychophy

35 stradiol, that are synthesized in the spinal cord and brainstem and act locally to influence pain pro

36 release is particularly common in the spinal cord and brainstem, but its presence in the midbrain is

37 hat AAVrh10 transduces neurons in the spinal cord and dorsal root ganglia of immunodeficient mice wit

38 lling, concomitant compression of the spinal cord and formation of post-traumatic cysts.

39 LC) projects throughout the brain and spinal cord and is the major source of central noradrenaline.

40 f embryos by contributing both to the spinal cord and mesoderm.

41 ants in which OPCs migrate out of the spinal cord and myelinate peripheral motor axons, we assayed pe

42 re is widespread demyelination of the spinal cord and optic nerves, we also show that thinly remyelin

43 l stem cells, derived from the murine spinal cord and organized as neurospheres, can be triggered to

44 gical effector systems, including the spinal cord and other peripheral organs.

45 ATP resulted in ROS production in the spinal cord and oxidative DNA damage in dorsal horn neurons.

46 rodent nervous system, including the spinal cord and primary sensory neurons.

47 H) neurons project to the lumbosacral spinal cord and ramify extensively in two regions: the dorsal g

48 extensively in the demyelinated mouse spinal cord and remyelinate axons.

49 ng fever, viremia, and viral loads in spinal cord and testes-and increased mortality.

50 ithin the various compartments of the spinal cord and their potential impact on the local vasculature

51 fuel embryo elongation by generating spinal cord and trunk mesoderm tissue.

52 , cord/total manganese ratio (total=maternal+cord), and by joint classification according to high or

53 analysis of the dorsal root ganglia, spinal cord, and cerebellum.

54 n essentially no PPT1 activity in the spinal cord, and vice versa.

55 is S-acylated in both human and mouse spinal cords, and in vitro in HEK293 cells.

56 ng protein TDP-43 in their brains and spinal cords, and rare mutations in the gene encoding TDP-43 ca

57 This foreshortened spinal cord appears to be related to anisotropic growth of the

58 its in the sensorimotor system (e.g., spinal cord) are thought to be assembled sequentially [10-14],

59 pport the concept of the state of the spinal cord as a negotiated equilibrium that reflects the concu

60 ness of the injured rat neocortex and spinal cord at 1.5 and three weeks post-injury using atomic for

61 s Myeloid cells infiltrated into the injured cord at 6 and 24 hours after TAR.

62 We aimed to investigate patterns of spinal cord atrophy and correlations with clinical markers.

63 Quantitative measurements of spinal cord atrophy are important in fully characterizing these

64 The blood-spinal cord barrier (BSCB) plays significance roles in recovery

65 o symptomatic G93A mice towards blood-spinal cord barrier (BSCB) repair.

66 ct on the local vasculature and blood-spinal cord barrier (BSCB).

67 Umbilical cord blood (UCB) is a promising source of stem cells to

68 We recently reported that umbilical cord blood (UCB) monocytes from babies born to obese mot

69 iferation, we compared the miRNA profiles of cord blood and peripheral blood ECFC-derived cells.

70 enotype and DNA methylation (DNAm) data from cord blood and peripheral blood to identify SNPs associa

71 In distributed lag models, both cord blood and placental telomere length were associated

72 In 641 newborns, cord blood and placental telomere length were significan

73 xposure during midgestation (weeks 12-25 for cord blood and weeks 15-27 for placenta).

74 y associated with maternal and GPx levels in cord blood as well as maternal TNF-alpha levels were inv

75 regnancy have been described in placenta and cord blood at delivery, in fetal lung, and in buccal epi

76 We collected maternal and cord blood at delivery, measured manganese using inducti

77 enatal lead exposure with DNA methylation in cord blood at epigenome-wide significance level [false d

78 A small subset of human cord blood CD34(+) cells express endothelial protein C r

79 e engineering of primary adult and umbilical cord blood CD34(+) human hematopoietic stem and progenit

80 Neonatal and human cord blood CD71(+) cells express arginase II, and this e

81 t human iTregs generated in vitro from naive cord blood cells preferentially recruit Disc large homol

82 3/ITD(neg) cells and spared normal umbilical cord blood cells.

83 e associations between maternal or umbilical cord blood concentrations of perfluorooctanoic acid and

84 llowed by independent validation of selected cord blood differentially methylated regions, using bisu

85 y levels were associated with lower regional cord blood DNA methylation at the Paraoxonase 1 gene (PO

86 sal effect of maternal vitamin B12 levels on cord blood DNA methylation using the maternal FUT2 genot

87 HMGB1 silencing in cord blood ECFC-derived cells confirmed its role in regu

88 m samples before and after immunisation, and cord blood from a subset of women and infants.

89 bolism) were hypermethylated in placenta and cord blood from SGA newborns, whereas GPR120 (related to

90 re-compatible marker of UM171-expanded human cord blood HSCs.

91 Moreover, resting cord blood KIR3DL1 NK cells exhibited a basal alloreacti

92 as early as the second trimester with fetal cord blood leptin and stronger association beginning as

93 with 8.8% (95% CI, -14.1% to -3.1%) shorter cord blood leukocyte telomeres and 13.2% (95% CI, -19.3%

94 With adjustment for potential confounders, cord blood log(FT3)pmol/L concentration was 0.11 lower i

95 ania, we evaluated the presence and level of cord blood MMc in offspring of women with and without PM

96 very Assay chip to survey DNA methylation in cord blood mononuclear cells from 36 children (18 nonast

97 epigenome-wide DNA methylation in umbilical cord blood nucleated cells in Project Viva, a prospectiv

98 explored sex-specific DNA methylation in the cord blood of 39 females and 32 males born at term and w

99 (LOI) of IGF2 and H19 genes in placentas and cord blood of 90 mother-child dyads in association with

100 s for detection of multiple viruses included cord blood or HLA-mismatched HCT, myeloablative conditio

101 source (n = 839; 84%); peripheral blood and cord blood progenitors were used in 73 (7%) and 88 (9%)

102 ecific gene expression of IGF2, but 32.4% of cord blood samples displayed LOI of IGF2 and 10.8% showe

103 Cord blood samples from neonates born to mothers supplem

104 ng was performed with a subset of placentas, cord blood samples, and buccal samples collected during

105 ith PON1 expression in an independent set of cord blood samples.

106 ntribute to inferior platelet recovery after cord blood stem cell transplantation and may underlie in

107 atching who received a single unit umbilical cord blood transplantation for non-malignant diseases re

108 ion for non-malignant diseases-for umbilical cord blood transplantation.

109 iving combination haploidentical single-unit cord blood transplants, we have added 4 Gy TBI to the wi

110 e standard for selecting unrelated umbilical cord blood units for transplantation for non-malignant d

111 Additionally, BPA and TNF-alpha levels in cord blood were inversely associated with maternal and G

112 red in blood cell samples obtained at birth (cord blood) and ages 1 and 3 years.

113 404 allogeneic HCT recipients, including 125 cord blood, 125 HLA-mismatched, and 154 HLA-matched HCTs

114 In cord blood, qPCR, TESA-blot, and micromethod sensitiviti

115 Comparison with expanded cord blood-derived CD4(+)CD25(hi) tTreg and expanded Tef

116 ator of adhesive properties in primary human cord blood-derived hematopoietic stem and progenitor cel

117 The LAD2 MC line or primary human cord blood-derived MCs (CBMCs) were infected with HRV or

118 nduces B cell lymphomas in a newly developed cord blood-humanized mouse model that allows EBV-infecte

119 encing (30 AGA, 21 SGA) and also analyzed in cord blood.

120 ethylated in placenta and hypermethylated in cord blood.

121 nd primary mast cells derived from umbilical cord blood.

122 in regulation of imprinting in placenta and cord blood; a lack of correlation of the methylome, tran

123 The CpG targets of ASD meQTLs across cord, blood, and brain tissues are enriched for immune-r

124 ding each gene primarily in brain and spinal cord, but also elsewhere.

125 tes from the blood into the brain and spinal cord by blocking the adhesion molecule alpha4-integrin.

126 treatment of the chronically contused spinal cord can provide a permissive substrate for the regenera

127 egions when comparing astrocytes from spinal cord, cerebellum, cerebral cortex, and hippocampus.

128 rdwired; but it is now clear that the spinal cord changes continually as new behaviors are acquired.

129 ic approaches in the mouse to map the spinal cord circuits that transmit and gate the cutaneous somat

130 and/or processes present in the radial nerve cords, circumoral nerve ring, digestive system (e.g., ca

131 bution, including expression in radial nerve cords, circumoral nerve ring, digestive system, tube fee

132 Delayed cord clamping also reduced the prevalence of anemia (hem

133 CI, 0.04-0.5) g/dL higher than in the early cord clamping group and a relative risk for anemia of 0.

134 Delayed umbilical cord clamping has been shown to improve iron stores in i

135 However, delayed cord clamping has not been shown to prevent iron deficie

136 Delayed cord clamping reduces anemia at 8 and 12 months of age i

137 At 12 months, delayed cord clamping still resulted in a hemoglobin level of 0.

138 The median time between delivery and cord clamping was 5 seconds and 60 seconds in the respec

139 obiotin retrograde transport from the spinal cord combined with immunofluorescence revealed spinal-pr

140 s (SREs) such as pathologic fracture, spinal cord compression, or the necessity for radiation or surg

141 codon-derived DPRs in chick embryonic spinal cord confirmed in vitro data, revealing that each of the

142 for epigenetic regulation within the spinal cord constitute the starting point for handedness, imply

143 We report that, after spinal cord contusion injury in adult female mice, the biosynth

144 cy (p = 0.04) correlate with T4 to T9 spinal cord cross-sectional area in HAM/TSP.

145 Spinal cord cross-sectional area was measured in individuals (2

146 p = 0.01) was associated with thinner spinal cord cross-sectional area.

147 Histopathological analysis of the spinal cord demonstrated a significant motoneurons loss, accomp

148 vity, (2) myelitis attack and (3) MRI spinal cord demonstrating ring-enhancement.

149 Using umbilical cord-derived mesenchymal stem cells (uMSC) from offsprin

150 fully characterizing these and other spinal cord diseases.

151 3, IL-4, IL-4R, STAT4 and TBET) in umbilical cord DNA at birth in a cohort of infants from the Southa

152 beta) and its upstream pathway in the spinal cord dorsal horn (SCDH).

153 any neurons in laminae I and V of the spinal cord dorsal horn and caudal spinal trigeminal nucleus an

154 c inhibitory neurotransmission in the spinal cord dorsal horn gates nociceptive signaling, is essenti

155 that were changed in astrocytes from spinal cord during chronic EAE involved decreases in expression

156 hesis that inducing plasticity in the spinal cord during chronic stroke could improve recovery from p

157 geal reflux, obstructive sleep apnoea, vocal cord dysfunction, obesity, dysfunctional breathing and a

158 eam has demonstrated that lumbosacral spinal cord epidural stimulation (scES) and activity-based trai

159 The mycolic acid-containing cord factor of mycobacteria, trehalose dimycolate, activ

160 acylated SOD1 fibrils to organotypic spinal cord failed to produce the SOD1 inclusion pathology that

161 dothelial cells were deficient in migration, cord formation and sprouting.

162 nsversal and longitudinal sections of spinal cord from control animals, but it strongly changed depen

163 Spinal cords from EAE-challenged Plg(-) mice demonstrated signi

164 rainstem regions and project onto the spinal cord, have long been recognised as key links in the mult

165 protein levels are suppressed in the spinal cord in a nerve injury-induced neuropathic pain mouse mo

166 ecific mRNA directly from the injured spinal cord in mice and performed RNA sequencing to investigate

167 in axon projection of DRG toward the spinal cord in vivo Furthermore, live-cell imaging of end-bindi

168 nd B cells were common infiltrates of spinal cords in diseased mice.

169 n the ependymal layer of the original spinal cord include populations of neural stem/progenitor cells

170 In lumbar spinal cord, inflammatory signaling is reduced in CX3CR1(-/-) m

171 ticipant was a 53-year-old man with a spinal cord injury (cervical level 4, American Spinal Injury As

172 384 patients with clinically complete spinal cord injury (SCI) and consequent anejaculation.

173 Spasms after spinal cord injury (SCI) are debilitating involuntary muscle co

174 ss of neuron-derived monoamines after spinal cord injury (SCI) in rats.

175 Spinal cord injury (SCI) induces a centralized fibrotic scar su

176 nificance roles in recovery following spinal cord injury (SCI), and diabetes mellitus (DM) impairs en

177 Following spinal cord injury (SCI), astrocytes demonstrate long-lasting r

178 asticity, a common complication after spinal cord injury (SCI), is frequently accompanied by chronic

179 Following spinal cord injury (SCI), newly formed endothelial cells, locat

180 Following spinal cord injury (SCI), the innate immune response of microgl

181 nce many pathological processes after spinal cord injury (SCI), the intrinsic molecular mechanisms th

182 Also, in rat T9-T10 hemisection spinal cord injury (SCI), we demonstrated that the tailored sca

183 on of inflammation is defective after spinal cord injury (SCI), which impairs tissue integrity and re

184 their therapeutic potential to treat spinal cord injury (SCI).

185 hat protect tissue and function after spinal cord injury (SCI).

186 very of hand motor function following spinal cord injury (SCI).

187 iated with persistent pain induced by spinal cord injury (SCI).

188 xterity increased in individuals with spinal cord injury after the I-wave protocol.

189 al early inflammation associated with spinal cord injury after thoracic aortic ischemia-reperfusion (

190 eling and involves netrin-1 signaling.Spinal cord injury can induce synaptic reorganization and remod

191 or, promotes recovery after traumatic spinal cord injury in mice, a benefit achieved in part by reduc

192 Therapeutic development for spinal cord injury is hindered by the difficulty in conducting

193 abilitation strategies in humans with spinal cord injury is to strengthen transmission in spared neur

194 cavities in a clinically relevant rat spinal cord injury model.

195 After paralyzing spinal cord injury the adult nervous system has little ability

196 nic tetraplegia, due to high-cervical spinal cord injury, can regain limb movements through coordinat

197 eurological disorders such as stroke, spinal cord injury, multiple sclerosis, amyotrophic lateral scl

198 m to restore motor function following spinal cord injury, the role of cortical targets remain poorly

199 n neuronal development, angiogenesis, spinal cord injury, viral invasion, and immune response.

200 on and reversed astroglial fate after spinal cord injury.

201 that improves breathing in models of spinal cord injury.

202 ent of spinal motor neurons following spinal cord injury.

203 nal wall defect at the base of the umbilical cord insertion containing the herniated abdominal organs

204 one to three LTMR classes, as well as spinal cord interneurons and corticospinal neurons.

205 linating Schwann cells in the injured spinal cord; invasion of peripheral myelinating (P0+) Schwann c

206 Two distinct MRI patterns of spinal cord involvement were described according to T2-weighted

207 velops following injuries to brain or spinal cord is a major obstacle for tissue repair in central ne

208 ABSTRACT: The dorsal horn (DH) of the spinal cord is an important site for modality-specific processi

209 of brain disease, but its role in the spinal cord is unclear.

210 ng current pain and craniocaudal location of cord lesion contemporary to pain onset.

211 brain and gray matter), and cervical spinal cord lesions (T2LV) and atrophy.

212 nal tract axons in the contralesional spinal cord makes a significant contribution to sensorimotor re

213 Cord manganese concentrations were not associated with n

214 or low (above or below median) maternal and cord manganese, was evaluated as a predictor of neurodev

215 Placental transfer, approximated by cord/maternal manganese ratio, cord/total manganese rati

216 Cord:maternal ratios were calculated.

217 Human umbilical cord mesenchymal stem cells (hUC-MSCs), originating in W

218 Umbilical cord-mesenchymal stem/stromal cell therapy decreased nic

219 awed cryopreserved xeno-free human umbilical cord-mesenchymal stem/stromal cells reduce the severity

220 hed to determine the potential for umbilical cord-mesenchymal stem/stromal cells to reduce E. coli-in

221 Associations between umbilical cord methylation of CpG loci within IL-4R with atopic ec

222 e that endogenous RGS10 is present in spinal cord microglia, and RGS10 protein levels are suppressed

223 cal examination, a baseline brain and spinal cord MRI scan obtained less than 3 months from clinical

224 In the developing dorsal spinal cord, multiple BMPs are required to specify sensory inte

225 targets of calpain in Xenopus laevis spinal cord neurons both in vivo and in vitro Inhibition of cal

226 approaches for recording signals from spinal cord neurons with a focus on motoneurons.

227 phB-NMDAR interaction in cortical and spinal cord neurons.

228 t closely resembles that of the adult spinal cord niche.

229 )Cu-rituximab uptake in the brain and spinal cord of huCD20tg EAE, and B220 immunostaining verified t

230 icularly of minor U12 introns, in the spinal cord of mice 30 d after SMA induction, which was then re

231 ty regulate locomotor networks in the spinal cord of neonatal mice.

232 In the spinal cord of patients with ALS, but not Con, AD or CJD cases,

233 nges also occur at every level of the spinal cord of PPT1-deficient (Ppt1(-/-) ) mice before the onse

234 -immunoreactive neurons in the ventral nerve cord of Zygentoma (Thermobia domestica, Lepisma sacchari

235 tured, and integrated into the rodent spinal cords over a time frame that aligned with the normal dev

236 These data show that spinal cord pathology significantly contributes to the clinical

237 Lumbar spinal cord PET signal was significantly higher in EAE mice tha

238 Our findings reveal that human cord plasma contains plasticity-enhancing proteins of hi

239 ly positively with asthma included umbilical cord plasma cotinine concentration (odds ratio per geome

240 e) were measured by LC-MS/MS in maternal and cord plasma from 259 Caucasian women at delivery (BMI 18

241 Here we show that human cord plasma treatment revitalizes the hippocampus and im

242 early developmental stage, namely umbilical cord plasma, provides a reservoir of such plasticity-pro

243 MP2), a blood-borne factor enriched in human cord plasma, young mouse plasma, and young mouse hippoca

244 sary for the cognitive benefits conferred by cord plasma.

245 Dopaminergic modulation of spinal cord plasticity has long been recognized, but circuits a

246 lex is associated with reduced dorsal spinal cord potassium chloride cotransporter expression and imp

247 Using a novel ex vivo spinal cord preparation, here we identify the functional organi

248 orn and RVM neurons to uncover an RVM-spinal cord-primary afferent circuit controlling pain threshold

249 introduces.SIGNIFICANCE STATEMENT The spinal cord provides a reliable final common pathway for motor

250 We propose that spinal cord regeneration in geckos represents a truncation of t

251 dorsal horn is a poorly characterized spinal cord region implicated in processing low-threshold mecha

252 ts to AMPAR-mediated signaling in the spinal cord remains unclear.

253 ts to AMPAR-mediated signaling in the spinal cord remains unclear.

254 ss properties that are well suited to spinal cord repair by supporting cell growth mechano-biology.

255 Spinal cord ring-enhancement accompanies one-third of NMOSD mye

256 mal stromal/stem cells (MSCs) from umbilical cord's Wharton's Jelly (WJ) on a molecular level, and po

257 Here, using cultured spinal cord (SC) neurons grown using a compartmented platform f

258 sum, when a new behavior changes the spinal cord, sensory feedback to the brain guides further chang

259 was used to identify metabolites in neonate cord serum associated with prenatal iAs exposure in part

260 Both maternal and cord serum samples were assayed for levels of IgG1 and I

261 The spinal cord showed architectural distortion, severe neuronal lo

262 We utilized ex vivo spinal cord slice cultures (SCSC) to demonstrate that anti-infl

263 Slack channels also occurs in intact spinal cord slices and that it is carried out by adaptor protei

264 ing targeted patch-clamp recording in spinal cord slices from adult transgenic mice that express enha

265 In spinal cord slices, clonidine reduced the frequency of capsaici

266 ent in mouse dorsal horn neurons from spinal cord slices.

267 large lamina I neurons in horizontal spinal cord slices.

268 tion of cortical evoked potentials by spinal cord stimulation was largest when the spinal electrodes

269 omponents for injured adult mammalian spinal cord that are different from those involved in normal ne

270 mechanisms of axonal guidance in the spinal cord that provide for a discussion of the current distin

271 nscriptome of both the cerebellum and spinal cord that was consistent with glial activation and incre

272 In the spinal cord, the expression of other proteins identifies additi

273 w variant is undetectable in brain or spinal cord, the only and most abundant known sources of KCC2.

274 Previous work measures spinal cord thinning in chronic progressive myelopathies, inclu

275 Spinal cord tissue from heterozygous (ARQ/VRQ or ARH/ARQ) scrap

276 ndent TDP-43 aggregates in cortex and spinal cord tissue.

277 iral vectors, serotype-9 (scAAV-9) in spinal cord tissues after intraspinal injection of mouse embryo

278 ral canal of the brain ventricles and spinal cord to circulate the cerebral spinal fluid (CSF).

279 fifty thousand axons emerge from the spinal cord to innervate the human upper limb, of which 10% are

280 strogen signaling within the cervical spinal cord to recover respiratory neuroplasticity in disorders

281 The median (range, n = 5) rilpivirine cord-to-maternal plasma concentration ratio was 0.50 (ra

282 proximated by cord/maternal manganese ratio, cord/total manganese ratio (total=maternal+cord), and by

283 at IDLVs may be efficient tools for in utero cord transduction in therapeutic strategies such as for

284 cells (RCs) is disrupted by thoracic spinal cord transection at postnatal day 5 (P5TX).

285 selectively ablating microglia in the spinal cord using a saporin-conjugated antibody to Mac1, we dem

286 ECFC proliferative potential is increased in cord versus peripheral blood and to define regulatory fa

287 Targeting the spinal cord via intrathecal administration of an adeno-associat

288 for motor impairment, mortality, and spinal cord viral load.

289 espread glial responses in the ventral nerve cord (VNC).

290 mpletely absent in both the brain and spinal cord when intracranial and intrathecal injections of the

291 SOD1 protein in the disease-affected spinal cord, where concomitant increases in copper and SOD1 act

292 cantly increased in the injured mouse spinal cord, where it is predominantly found in astrocytes.

293 ween prefrontal areas, brainstem, and spinal cord, which might represent a flexible mechanism through

294 ond derived feature is the very short spinal cord, which terminates midway along the thoracic vertebr

295 acked CCR7 were retained in brain and spinal cord while wild type DC migrated to cervical lymph nodes

296 placement tail includes a regenerated spinal cord with a simple morphology: an ependymal layer surrou

297 adducts was observed in samples from spinal cord with demyelination, while the intensity of the [M +

298 and trans-synaptic infection from the spinal cord with rabies viruses that carry glycoproteins in the

299 the circumvolutions of the brain and spinal cord without damaging neural tissues or triggering forei

300 implantation into the injured rodent spinal cord, yet they support delayed functional recovery, a fi