ライフサイエンスコーパス: core

1 molecular scaffold by introducing a bicyclic core.

2 f a protective fibrous cap that overlies the core.

3 ease/exonuclease/phosphatase (EEP) catalytic core.

4 pic signatures compared with its crystalline core.

5 roxy-5,6,7,7a-tetrahydro-3H-pyrrolizin-3-one core.

6 mbedded ester cross-linker in the particle's core.

7 ake can enzymatically digest the sugar based core.

8 with a approximately 150 nm shell and 300 nm core.

9 associated to potassium, the mantle and the core.

10 ative aromatization to generate the pyridine core.

11 also form an integral part of a small apolar core.

12 ion, opposite to the effect found in the NAc core.

13 provided a 4-oxa-1-azabicyclo[4.1.0]heptane core.

14 h nonfullerene acceptors owning unfused-ring cores.

15 n mercury records from ice and lake sediment cores.

16 to density and pressure excess within vortex cores.

17 e recovered from 10 of 11 stations using box cores.

18 ethyl 2,2-bis(aminomethyl)propionate (COOMe) cores.

19 well-defined planar and nonplanar molecular cores.

20 once daily), or both in combination, for the core 12-month treatment period.

21 al cortex and other brain regions beyond the core afferents identified previously.

22 Substituent modifications of the quinone core allow absorption from 400 to 600 nm.

23 ubbles (MagMBs), consisting of an oxygen gas core and a phospholipid coating functionalised with Rose

24 ability of the phenoxazine and phenothiazine core and also of the phenylpiperazine moiety for the dev

25 The nanoparticles comprising of iron core and carbon shell were decorated with ferrocene deri

26 ependent inhibition in the nucleus accumbens core and dorsal striatum, is also minimal in the shell i

27 t induction of thermal necrosis in the tumor core and efficient drug delivery to the tumor rim.

28 constituent XPB and XPD ATPases, and how the core and kinase subcomplexes of TFIIH are connected.

29 ) with poly (lactic-co-glycolic acid) (PLGA) core and lipid layer containing docetaxel and clinically

30 physicochemical properties of starches from core and outer pericarp were studied.

31 s how Chd1 senses DNA outside the nucleosome core and provides a basis for nucleosome spacing and dir

32 Microinjection of RO5166017 into the NAc core and shell inhibited cue- and drug-induced cocaine-s

33 Spiking patterns of single neurons in both core and shell subregions during singing correlated with

34 h the controlled properties of the inorganic core and the controlled properties of the coating molecu

35 inflammation resolution, notably a necrotic core and thinning of a protective fibrous cap that overl

36 Therefore, this core and variants thereof may be promising building bloc

37 ticles composed of quasi-stoichiometric PuO2 cores and hydrolyzed Pu(IV) moieties at the surface shel

38 f typical dry SSA particles composed of salt cores and organic-rich coatings.

39 regular secondary structures and hydrophobic cores, and can contain local structures not accessible w

40 as the redox probe in the development of HCV core antigen electrochemical immunosensor.

41 a similar modest change in hepatitis B virus core antigen polypeptide (HBcAg/p21) synthesis, it media

42 be HCV and antibody reacting to hepatitis B core antigen+, and less likely to have diabetes or hyper

43 In this context, a number of core areas of work for communications were established:

44 reas outside the MGN (30% in RTp vs. 1-5% in core areas).

45 this limited class of nanocrystals, CdSe/CdS core/arm tetrapods exhibit the unusual trait of two-colo

46 phenyl-linked rather than having the pyridyl core as in the peripheral cavities.

47 ions of meso-arylcorroles, both at the inner core, as well as the peripheral positions of the macrocy

48 inhibition of autophagy by knocking down the core autophagy protein Atg5 promotes cystogenesis, while

49 fects, we also found that several conserved (core) baculovirus proteins closely associate with NSF, a

50 tly across the toposequence, we identified a core beech rhizosphere microbiome.

51 R) mice, a model that reproduces most of the core behavioral phenotypes of ASD, to test the effects o

52 with three scales: the grief subscale of the Core Bereavement Items to assess normative grief; and th

53 en the core cohesive energy and the shell-to-core binding energy that appears to drive nanocluster st

54 for women whose ADH was diagnosed by needle core biopsy compared with excisional biopsy.

55 Magnetic resonance images and core biopsy findings.

56 y of mice to regulate brown fat and maintain core body temperature.

57 histology, qPCR, HPLC, LC/MS and measures of core body temperature.

58 sotope anomalies and marked decreases in ice core bromine consistent with increased surface UV radiat

59 Lipid burden was assessed as the lipid core burden index (LCBI), and large LRP were defined as

60 e enzymes that had a common Zn(2+) bimetallo core but little sequence similarity and different auxili

61 ites and containing proteins of the podosome core but not of the adhesive ring.

62 d AMPK and p70s6k phosphorylation in the NAc core but not shell.

63 low (CBF) leads to cell death in the infarct core, but tissue surrounding the core has the potential

64 nd controlling the expansion of the necrotic core by impairing efferocytosis.

65 ingle-particle cryo-EM reconstruction of the core CBF3 complex, incorporating the sequence-specific D

66 is by monomeric Cdc10 drives assembly of the core Cdc10 homodimer.

67 ndrial calcium uniporter (MCU), which is the core channel subunit of MCUC, has been shown to play a c

68 of surface nonlinearity polarization at the core-cladding interface of the PCF.

69 CRY1 and CRY2 bind independently of other core clock factors to many genomic sites, which are enri

70 , and its phase angle with the expression of core clock genes, Clock1 and Per1, are preserved in cons

71 Transverse arrays exhibit the same unimodal core coalignment but form local domains of microtubules

72 we reveal a fine energy balance between the core cohesive energy and the shell-to-core binding energ

73 graphy method with a C18 reverse-phase fused-core column has been developed for the determination and

74 technical and nontechnical skills for trauma core competencies before and after training and up to 18

75 compatible with discrete two-state models of core complex signaling states.

76 dentify proteins that associate with the THO core complex, and show that the TEX1 and MOS11 component

77 eals the molecular architecture of the TFIIH core complex, the detailed structures of its constituent

78 TIR spectra of both D1-N87A and D1-N87D PSII core complexes exhibited characteristics similar to thos

79 ritical residues for RNA interaction in PRC2 core complexes from Homo sapiens and Chaetomium thermoph

80 We studied PSII core complexes purified from D1-N87A and D1-N87D variant

81 ilar to those of wildtype Synechocystis PSII core complexes.

82 le in the management of their condition is a core component in the Chronic Care Model.

83 We conclude that Ambra1 is a core component of an intracellular trafficking network l

84 Mechanistically, the core component of Hippo pathway (YAP) is O-GlcNAcylated

85 CR8 as a direct interactor of Tcf7l1 mRNA, a core component of the pluripotency network.

86 that the expression of PTPRZ1 and Wnt8a, two core components of the beta-catenin pathway, is downregu

87 rtebrates, it has recently become clear that core components of the cGAS-STING pathway evolved more t

88 n Drosophila and suggests that miRNAs may be core components of the genetic programs underlying behav

89 nslational Mobilisation Theory, outlines its core components, and considers its application to nursin

90 that people consider mental life to have two core components-experience (e.g., hunger, joy) and agenc

91 This article outlines how a core concept from theories of homeostasis and cybernetic

92 Scaffolds are a core concept in medicinal chemistry, and they can be the

93 This review aimed to describe core constipation symptoms and their frequency patterns

94 med glacial lake, the degradation of the ice core could have implications for glacial lake outburst r

95 ster was commissioned in 2010, yet its eight-core CPUs with only 24GB RAM work well in 2017 for these

96 line shells and oxygen-permeable polystyrene cores crosslinked with metal-free purely organic phospho

97 We propose a core dataset including demographic and clinical informat

98 A recent hypothesis has suggested that core deficits in goal-directed behavior in obsessive-com

99 nsus Bureau's recent national projections of core demographic rates by race, we examine two definitio

100 ical racial differences and recent shifts in core demographic rates suggest that white and black olde

101 cold molecular gas to be delivered to their cores, despite strong feedback from stars or active gala

102 s and reactivity trends of the copper-oxygen cores discussed.

103 tegrase predominantly involves the catalytic core domain (CCD) and the C-terminal domain (CTD) of the

104 ding at the dimer interface of the catalytic core domain but at the same time markedly impair HIV-1 r

105 ted translation and show that the functional core domain of eIF4G plus an adjacent probable RNA-bindi

106 disease has revealed that inflammation is a core driver: the so-called "vicious circle" of inflammat

107 with non-structural HCV proteins, including core, E2, NS4B, and NS5A.

108 We argue that the vmPFC is a core element of a network that represents structured rel

109 The core elements of this multi-protein machine are the enve

110 he role of voyaging to understand better the core elements that produced the observed pattern of date

111 share a common architecture of an enzymatic core encapsulated in a selectively permeable protein she

112 gates membrane potential changes to the cell core, ensuring synchronous and uniform excitation-contra

113 The objective of this article is to explore core ethical issues related to physician-assisted suicid

114 e 17% lower SSM density compared to exonic cores, even after excluding canonical splice sites.

115 ght irritability and callous behavior as two core exemplars of early disruptive behavior.

116 xternal electric field shows a mobile vortex core exhibiting a reversible hysteretic transformation p

117 lin expression on the cell surface of an HCV core-expressing hepatocellular carcinoma (HepG2) cell li

118 copy revealed remodelling and degradation of core extracellular matrix components.

119 Thus, two temporal lobe areas extend the core face-processing network into a familiar face-recogn

120 Its dysregulation has been proposed as a core factor in the etiology of many neurological disease

121 steps in LDCV formation by controlling dense core formation at the TGN.

122 mic structural changes upon iron binding and core formation, as reflected by a quick alteration of it

123 In a coral core from Dongsha Atoll, a remote coral reef ecosystem,

124 are essential to correlate sediment and ice cores from the terrestrial, marine and glacial realms.

125 sults from a highly-resolved 'horizontal ice core' from the Weddell Sea Embayment, which records mill

126 Here, we identified core FtsH target proteins in S. aureus.

127 Removal of the core fucose of this glycan greatly increases the affinit

128 ntennary complex-type N-glycan also could be core-fucosylated by FUT8, albeit at much lower efficienc

129 MENT Despite a recent surge of interest, the core function of the pulvinar, the largest thalamic comp

130 ylamide-co-poly(ethylene glycol) diacrylate) cores functionalized with phenylboronic acid.

131 Protist predation influenced 14 metabolic core functions including membrane transport from which t

132 pithelial cells is mediated by the conserved core fusion machinery, composed of the fusogen gB and th

133 y spike and the global field produced by the core geodynamo.

134 Proper gp160 folding in the ER requires core glycosylation, disulfide-bond formation and proline

135 Correct processing of human renin in dense core granules was confirmed by immunogold labeling.

136 ow Tyr34 maintains solvent exclusion and the core H-bond network in the active site by relocating to

137 the infarct core, but tissue surrounding the core has the potential to recover if local reductions in

138 gous liver endothelial cells were grown from core hepatic specimens from swine.

139 a, based on a continuous high-resolution ice-core Hg record from the Belukha glacier in the Siberian

140 the nuclei of mast cells where it truncates core histones at their N-terminal ends.

141 nses in the anterior insular cortex (AIC), a core hub of the "salience network" that is critical for

142 we define the molecular architecture of the core human CPSF complex, identifying specific domains in

143 the internal spin structure of the skyrmion core, identifying a 25 nm central region of uniform magn

144 ssential omega-subunit of the RNA polymerase core in the DeltarpoZ strain of the model cyanobacterium

145 nificantly more deleterious in front than in core individuals, (ii) equally deleterious mutations are

146 The spheroid core is comprised mainly of astrocytes, while brain endo

147 diating MOB1's differential binding to Hippo core kinases, thereby establishing MOB1 variants with se

148 A core laboratory analyzed pre-discharge and 30-day abdomi

149 An independent echocardiographic core laboratory evaluated all echocardiograms.

150 roduce strong depressurization in the vortex core, leading to the formation of a cavitation ring.

151 relative abundances of these IPLs and their core lipid compositions differ systematically between th

152 ss promotes cellular fidelity, and while the core machinery of autophagy is known, the mechanisms tha

153 . under Indian Ocean) circulates down to the core-mantle boundary (CMB), but returns within >/=100 My

154 low the mantle transition zone, and atop the core-mantle boundary could efficiently sequester signifi

155 .Ultralow velocity zones are detected on the core-mantle boundary, but their origin is enigmatic.

156 Ox-LDL may reflect core mechanisms through which MS components develop and

157 glutamatergic synapses on nucleus accumbens core medium spiny neurons, but it is unknown how achievi

158 regulation in the endothelium and uncovered core metabolic pathways and mechanisms of regulation tha

159 n recent studies that have characterized the core molecular circuitry, circuit design and spatiotempo

160 Thus, the gas-giant cores must have formed before dissipation of the solar n

161 mizing nucleic acid yields in CT-guided lung core needle biopsies used for genomic analysis, there sh

162 indings were compared with histopathology of core needle biopsy samples or with ultrasound follow-up

163 d ratio (HR) of 3.0 (95% CI, 2-4.5) and, via core needle biopsy, with an adjusted HR of 2.2 (95% CI,

164 pping agent promotes oxidation of the silver core, occurring at 0.50 V (vs. Ag, compared with 1.15 V

165 Our findings indicate that the histone core of a nucleosome is more plastic than previously ima

166 ral lobe: spectral features are found in the core of A1, mixtures of spectral and articulatory in STG

167 avenger, was incorporated in the hydrophobic core of amphiphilic copolymer micelles, and was used to

168 his method provides access to the minimalist core of beta-mono- and beta,beta'-disubstituted porphyri

169 -heterocyclic products possess the tricyclic core of epimeloscine, deoxycalyciphylline B, daphlongami

170 nogen extravasation were demonstrated in the core of FCD-II lesions.

171 y with multipartite contacts with the native core of HspQ, is required for allosteric Lon activation.

172 ergent cyclopropanation-Cope approach to the core of ineleganolide, which was the first disclosed syn

173 d acyl-group of ACP occupies the hydrophobic core of ISD11, explaining the basis of ACP stabilization

174 Like rats and cats, mice have an ovoid core of medium-sized Bar neurons located medial to the l

175 d proteolysis demonstrates that a structural core of Nanog encompassing the homeodomain and the trypt

176 allele, carrying a mutation in the catalytic core of PRC2, strongly enhanced the clf phenotype; furth

177 metastasis but are infrequently found in the core of primary tumors.

178 ture focuses on the mesolimbic nuclei as the core of reward behavior regulation.

179 cts, we analyzed resting-state data from the core of the default-mode network.

180 s elegans, a specialized condensin forms the core of the dosage compensation complex (DCC), which spe

181 ation whose central engine is located in the core of the host galaxy.

182 ich was the first disclosed synthesis of the core of the norditerpene natural product ineleganolide.

183 7, and Y150 cluster at the predicted central core of the trimeric interface and are important for GP-

184 ricopeptide repeat (PPR) proteins are at the core of this posttranscriptional RNA modification.

185 Despite its very diverse applications, the core of tomography remains the same, that is, a mathemat

186 by fluorescence in-situ hybridisation of two cores of breast tumour tissue in a microarray, done in a

187 Here we explore the cores of disclinations in the so-called chromonic nemati

188 esis in both species, resulting in a shorter core oligosaccharide.

189 mes of patients with large baseline ischemic cores on CTP undergoing ET with the outcomes of matched

190 Four C libraries perform core operations in SeqLib: HTSlib for BAM access, BWA-ME

191 on and growth process instead of a shrinking-core or a particle-by-particle process.

192 The 26S holocomplex comprises the core particle (CP), where proteolysis takes place, and o

193 Packaging of DNA into the nucleosome core particle (NCP) is considered to exert constraints t

194 trates before they are translocated into the core particle to be degraded.

195 sophila sensory organ precursors (SOPs), the core PCP components initiate the planar polarization of

196 convert mitochondria to MTOCs independent of core pericentriolar proteins that regulate MT assembly a

197 al magnitude evaluation to a wide variety of core phenomena in decision making and challenge the idea

198 molecular photodetector was developed as the core photocurrent system through chemiluminescence for h

199 In its initial form, T-BAS v1.0 uses a core phylogeny of 979 taxa (including 23 outgroup taxa,

200 central region of Mpp6 bound to the exosome core, positioning its Mtr4 recruitment domain next to Rr

201 ty is embodied in the densely functionalized core, possessing a series of contiguous stereogenic cent

202 A core principle involves a comprehensive assessment and i

203 Specificity is a core principle of exercise training to promote the desir

204 A core principle of nervous system organization is the div

205 ults of cultural inheritance echo a suite of core principles that underlie organic Darwinian evolutio

206 A core problem is that there is no sufficiently fast diagn

207 t universally ready to independently perform Core procedures by the time they complete residency trai

208 of Opinion on Recommendations and Evidence (CORE) process.

209 s the interaction of Mpa with the proteasome core protease.

210 tifies other catalysts that contain a shared core protein fold but whose active sites are located in

211 sis from A36V mutant than from the wild-type core protein.

212 3.6 A resolution with atomic models for ten core proteins, nearly all essential domains of its RNA,

213 the hexon, penton, fiber, minor capsid, and core proteins.

214 ies are all mediated through nucleation of a core quaternary protein complex (SCL:E-protein:LMO1/2 [L

215 ibodies revealed regression for tumor tissue cores (R2 = 0.42-0.91) and cell line cores (R2 = 0.83-0.

216 tissue cores (R2 = 0.42-0.91) and cell line cores (R2 = 0.83-0.97) by quantitative immunofluorescenc

217 e most extreme non-polar biome on Earth, the core region of which is considered to represent the dry

218 effect from the A2UCOE is confined within a core region, we evaluated the anti-silencing effect of d

219 Our findings illuminate core regulatory mechanisms unique to the early Golgi Arf

220 pression data in CRC, whereby we generated a core regulatory network consisting of 58 significant FFL

221 ly unrecognised mar pathways reside within a core regulon, shared by most enteric bacteria.

222 coli Hfq CTD transiently binds the basic Sm core residues necessary for RNA annealing.

223 targeting multiple factors downstream of the core responder kinase ATM/ATR.

224 t with this, anoxic incubation of a sediment core resulted in an accumulation of these components in

225 3 and its tail with Domain III and with DIII(core) rRNA.

226 expanded from eight 20-mm, 18-gauge hepatic core samples to 50 x 10(6) autologous cells per pig.

227 between PCE concentrations in over 500 tree-core samples with PCE concentrations in over 50 groundwa

228 A multifunctional core-satellite nanoconstruct is designed by assembling c

229 -based nutrient limitation, underpinned by a core SDGVM hypothesis that plant nitrogen (N) status is

230 In this work, 112 Ponar grab and 28 core sediment samples were collected from Lakes Michigan

231 emerging property of interactions between a core 'self network' (e.g., medial prefrontal cortex; mPF

232 ns a clustered group of receptors that share core sequence similarities, together with a dispersed se

233 but insensitive at position 12 of the 15-bp core sequence.

234 By identifying shared motifs in core sequences, we were able to highlight key conserved

235 uilt from the widely used Lego Education EV3 core set alone, and this publication includes building a

236 We find that a core set of 51 constraints are essential but that additi

237 conserved among these nematodes, defining a core set of eliminated genes that are preferentially exp

238 estine from fish to mammals and identified a core set of genes comprising a vertebrate IEC signature.

239 eomics and RNA biochemistry, we identified a core set of mRNA m(6) A writer proteins in Arabidopsis t

240 Loss of THAP1 function disrupts a core set of OL maturation genes and reduces the DNA occu

241 We developed core shell lipid-polymer hybrid nanoparticles (CSLPHNPs)

242 ts that the thermodynamically less favorable core-shell Ag@Au nanostructure is kinetically stabilized

243 llow a diffusion-limited behavior leading to core-shell morphologies.

244 sonochemical Pu colloids can be described as core-shell nanoparticles composed of quasi-stoichiometri

245 ed oxygen detection platform by constructing core-shell nanoparticles with water-soluble polymethylox

246 The new PVP capped CoFe2O4@CdSe with core-shell nanostructure was synthesized by a facile syn

247 arises from the new synthesis method for the core-shell of CoFe2O4@CdSe.

248 e the rational engineering of multilayer and core-shell oxide nanomaterials.

249 A SnO2 bridged assembly on SnO2/TiO2 core/shell electrodes undergoes light-driven water oxida

250 nt migration toward the alloyed interface of core/shell QDs is a thermodynamically driven process to

251 In contrast, the N-terminal hydrophobic core showed extremely slow solvent exchange, suggesting

252 sive translational regulation of most of the core signalling circuitry including Shh, Wnt, Hippo, PI3

253 Although the tissue of residence defined the core signature of macrophages, phagocytosis imprinted a

254 We found that this "core" signature of asthma is shared by mild, moderate, a

255 onded networks with parallel indenofluorenyl cores, significant volume (64-70%) available for accommo

256 rage on nanocrystal surfaces and nanocrystal core size are responsible for the crystallization proces

257 f light, the recruitment of PIF3-EBFs to the core SKP1-CUL1-F box protein (SCF) scaffold is facilitat

258 Recurrent mutations in core splicing factors have been reported in several clon

259 The core SPOP(MT);MYC(High) transcriptomic response, defined

260 mpounds tetrahydropyrans (THPs) constitute a core structure of a wide array of bioactive natural prod

261 g while simulations corroborate these stable core structures of Luciferase, and indicate the relative

262 ous particles with sodium- and chloride-rich cores surrounded by organic enriched surface layers cont

263 ective evaluation of costs and benefits is a core survival capacity that in humans is considered as o

264 severe DG, relamorelin significantly reduced core symptoms of DG and overall composite score compared

265 ifying and extending the organization of the core system for face perception.

266 The core system is completed by additional functions that mi

267 CO2 (+0.7%), core temperature (Tcore, +0.5 degrees C) and HR (+54 bpm

268 Core temperature and vital signs were measured at baseli

269 In the prospectively cooled patients, core temperature reached target range less than or equal

270 Forty critically ill adults with fever (core temperature, >/= 38.3 degrees C).

271 Simultaneous core temperatures were recorded from 1 to 5 days.

272 the DWBC, characterized by a low temperature core, tends not to shift with the 90-day fluctuation.

273 ectron microscopy (cryo-EM) structure of the core tetrameric HIV-1 STC and a higher-order form that a

274 fications of histones forming the nucleosome core that are often regulated in cell-type-specific mann

275 ur search, we used a simple adamantyl ligand core that by avoiding stereochemical issues enabled rapi

276 N-methyl group at each end of the squaraine core that ensures fast macrocycle threading kinetics, an

277 rticles consist of a 60-nm gold nanoparticle core that is encapsulated in a 15-nm-thick silica shell

278 n pattern of the polyketide-derived aromatic core that seemingly contradicts the established reactivi

279 sychology's potential to serve as a unifying core theory.

280 he asymmetric [Ni(III) (mu-O)2 Co(III) ](2+) core through aromatic hydroxylation reactions represent

281 "arch-and-heel" region and connected to the core through the Prp42/Prp39 paralogs.

282 JA-biosynthesis genes in inoculated bark and core tissues further suggest that phloem and xylem might

283 Starches from the core tissues of kiwifruit tend to have higher amylose co

284 hyl-d-aspartate receptors (NMDAR) in the NAc core, TLR4.KO animals exhibit a deficit in low-frequency

285 Different combinations of TRMs add to a core TRM, broadly found across the whole landscape of CR

286 mmon underlying array architecture, having a core unimodal peak of coaligned microtubules in a split

287 The dense core vesicles (DCVs) of neuroendocrine cells are a rich

288 Synthesis of the phenylquinoxalinone core was generally accomplished by condensation of 1,2-p

289 a-floor geophysical data and marine sediment cores, we resolve the record of glaciation offshore of S

290 Observed cores were generally polygonal, and virus particles were

291 ys163) in domain 2 away from the active site core, whereas the two other active site lysines from the

292 f R696 is likely mediated by the hydrophilic core, which also showed fast water exchange.

293 segment of only 57 residues forms the fibril core, while other segments remain dynamically disordered

294 Mpp6 interacts with the nine-subunit exosome core, while Rrp47 stabilizes the exoribonuclease Rrp6 an

295 (a) a bis(4-amino-3-hydroxyphenyl)squaraine core with bright deep-red fluorescence and excellent pho

296 buds, the basal lamina, and a lamina propria core with matrix molecules, fibroblasts, nerves, and ves

297 fenethylline shares a common phenethylamine core with other amphetamine-type stimulants, it also inc

298 he nanoparticles, made by wrapping polymeric cores with cell membrane derived from macrophages, posse

299 ific deletion of CaMKII had smaller necrotic cores with concomitantly thicker collagen caps.

300 lk-shell nanostructures (YSNs) composed of a core within a hollow cavity surrounded by a porous outer