ライフサイエンスコーパス: core domain

1 the sequence and structure divergence of the core domain.

2 in accessorizes the ubiquitous Rossmann-fold core domain.

3 cket between loop L1 and sheet S3 of the p53 core domain.

4 ull-length construct lacking only the kinase core domain.

5 in dynamics at opposite ends of the troponin core domain.

6 are known to function through the catalytic core domain.

7 egulation of activity by TFIIF and the TFIIB core domain.

8 r on the N-terminal domain and W(113) in the core domain.

9 C-terminal domains that flank the catalytic core domain.

10 for a high-resolution model of the complete core domain.

11 flexible N terminus followed by a structured core domain.

12 the 600-bp fragment encoding the entire p53 core domain.

13 tudies of a soluble variant of the catalytic core domain.

14 re domain and a smaller domain that caps the core domain.

15 e-induced closure of the cap domain over the core domain.

16 teracts with a linker region adjacent to the core domain.

17 se of UbcH10 by the APC, specified by the E2 core domain.

18 IN C-terminal domain (CTD) and the catalytic core domain.

19 cturally and functionally independent of the core domain.

20 nical regulator of G protein signaling (RGS) core domain.

21 1 A resolution crystal structure of the GlpG core domain.

22 bed DNA- and protein-binding surfaces of the core domain.

23 ation with xanthine bound to residues in the core domain.

24 o the C-terminal segment of Rev1's catalytic core domain.

25 structs consisting of the predicted CASV GP2 core domain.

26 ed by a flexible linker and an alpha-helical core domain.

27 for its intrinsically disordered N-terminal core domain.

28 an form a four-helix bundle with other SNARE core domains.

29 ructural contacts between the suppressor and core domains.

30 the N-terminal tail domains, but also in the core domains.

31 er, due to relative movement of the gate and core domains.

32 g of the DNA duplex relative to the helicase core domains.

33 ome measurement instruments to measure these core domains.

34 ure of its supernumerary ensemble around the core domains.

35 erized by interactions between two catalytic core domains.

36 ls, suggesting interplay between the cap and core domains.

37 ther, these data highlight the plasticity of core domain 1 conformation and illustrate the relationsh

38 mis protein 4, also known as WAP 4-disulfide core domain-2 or Wfdc2) as the most upregulated gene in

39 The pentameric core domain, a doughnut-like structure with a central po

40 :DNA complex that includes an entire central core domain, a ssDNA GCAGT substrate, and two magnesium

41 ion and two amino acids within the enzymatic core domain account for cofactor specificity and proper

42 or through segregation within the allantoic core domain (ACD) through reduction of cell adhesion and

43 ntains a pool of cells, called the Allantoic Core Domain (ACD), critical for allantoic elongation to

44 The small nuclear ribonucleoprotein (snRNP) core domain, acting as an assembly nucleus for the matur

45 itioning of the general acid/base within the core domain active site is coordinated with substrate-in

46 glucose 6-phosphate (G6P) using Asp8 of the core domain active site to mediate phosphoryl transfer f

47 where the Asp10 side chain is located in the core domain active site.

48 ossess a classical alpha/beta-hydrolase fold core domain additionally equipped with a cap domain.

49 combinant enzymes, and showed that the first core domain affects overall catalytic activity.

50 on of appropriate dynamic flexibility to the core domain allowed the inclusion of multiple conformati

51 re a highly conserved NAD+-binding catalytic core domain although they exhibit distinct expression pa

52 The core domain amides of ECAK and TNAK in the open and clos

53 demonstrated that deletion of either the PL2 core domain (amino acids [aa] 47 to 180) or the immediat

54 s C2 and C3 are composed of a minimal ligase core domain, analogous to Mycobacterium LigC (another NH

55 FEN-1 consists of a nuclease core domain and a C-terminal extension.

56 ructure of dematin includes a loosely folded core domain and a compact headpiece domain that was orig

57 NhaA is made up of two distinct domains: a core domain and a dimerization domain.

58 UapA is formed from two domains, a core domain and a gate domain, similar to the previously

59 a distorted (betaalpha)(8) barrel catalytic core domain and a hydrophobic alpha-helical domain locat

60 red in an open active site cleft between the core domain and a lid subdomain.

61 cid phosphatase, consisting of an alpha/beta core domain and a smaller domain that caps the core doma

62 strates strong conservation of a beta-barrel core domain and an alpha-helix, from which emanate sever

63 Npm contains a pentameric N-terminal core domain and an intrinsically disordered C-terminal t

64 u153 and 154 on the first alpha-helix of the core domain and Arg19 on first alpha-helix of the N-term

65 These regions dock on the LOV2 core domain and bury several hydrophobic residues of the

66 ur model, the junction between the catalytic core domain and C-terminal domain adopts a helix-loop-he

67 explore its consequences, beginning with the core domain and extending to the full-length p53 mutant

68 derivative comprising the C-terminal protein core domain and for AnxA2 residing in a heterotetrameric

69 Here, we studied the histone H2B core domain and found that phosphorylation of H2B serine

70 he ability of MDM2 acidic domain to bind p53 core domain and induce p53 misfolding are also suppresse

71 ich connects an N-peptide motif to the SNARE core domain and is thought to participate in the binding

72 tations that impair p53 usually occur in the core domain and negate the p53 sequence-specific DNA bin

73 was covalently photo-crosslinked with the IN core domain and subjected to HPLC purification.

74 Its core domain and tetramerization domain are linked and fl

75 ulate Snf7 activation at both its N-terminal core domain and the C-terminus alpha6 helix through two

76 of IN via interactions between the catalytic core domain and the CTD and that understanding the inter

77 o the head, where it contacts both the motor core domain and the neck domain, forming an inhibited co

78 in has two F-actin binding sites, one in the core domain and the other in the headpiece domain.

79 ed by two negatively charged residues on the core domain and three positively charged ones on the N t

80 protein is unstructured but forms a compact core domain and two extended RNA-binding loops upon bind

81 a dimer the monomer of which consists of two core domains and a flexible protruding alphacap.

82 tivity always requires the conserved Type IA core domains and the same catalytic residue used in DNA

83 hat can interact with their respective SNARE core domains and thereby affect the kinetics of SNARE co

84 terminal region of Bud6 into a Bni1-binding "core" domain and a G-actin binding "flank" domain.

85 N-terminal extension in addition to its ABC "core" domain and transports substrates in the form of gl

86 ment in defining the overall topology of the core domain, and suggest that interhelical motions in P2

87 conformational changes on binding to the p53 core domain, and support the hypothesis that sequence-de

88 just 3' of the cleavage site and within the core domain, and which introduces a pseudoknot into the

89 e full-length Rev1 protein and its catalytic core domain are similar in their ability to support BER

90 nnecting the lid to the alpha/beta-hydrolase core domain, as a determinant in the oligomeric state an

91 The helix is stabilized by a core domain assembled from four beta strands donated by

92 main structural domains of the HAstV CP: the core domain at 2.60-A resolution and the spike domain at

93 present a crystal structure of the U4 snRNP core domain at 3.6 A resolution, detailing how the Sm si

94 vely regulated by phosphorylation in its ABC core domain at residues Ser-908 and Thr-911.

95 al arm residues, causing displacement of the core domain away from the monolayer.

96 Here we show that after oxidation, the core domain binds to part of the N terminus, thus restra

97 The p53 core domain binds to response elements (REs) that contai

98 we describe the crystal structure of the p53 core domain bound to a naturally occurring RE located at

99 of the Cronobacter sakazakii RecQ catalytic core domain bound to duplex DNA with a 3' single-strande

100 ding at the dimer interface of the catalytic core domain but at the same time markedly impair HIV-1 r

101 hereas oncogenic iASPP also binds to the p53 core domain but inhibits p53-dependent apoptosis.

102 Two alpha-helices C-terminal to the core domain, but unique to hPus1, extend along the back

103 uires both the suppressor and ligand-binding core domains, but has no effect on InsP3 binding to the

104 ed at similar rates and kinetics to isolated core domains, but there was some induced aggregation of

105 A moiety of Francisella LPS is linked to the core domain by a single 2-keto-3-deoxy-D-manno-octuloson

106 present high-resolution structures of their core domains (cABC, cHSP27), each in complex with a segm

107 ause of evolutionarily restrictive catalytic core domain-carboxy-terminal domain linker regions.

108 We show that each DNA-bound p53 core domain caused a local DNA conformational change wit

109 A weak interaction with the catalytic core domain (CCD) and a strong interaction with the C-te

110 tegrase predominantly involves the catalytic core domain (CCD) and the C-terminal domain (CTD) of the

111 971 fragments against the HIV-1 IN catalytic core domain (CCD) followed by a fragment expansion appro

112 ent IN inhibitor 11j within the IN catalytic core domain (CCD) is described as well as its binding mo

113 The x-ray crystal structure of the catalytic core domain (CCD) of IN in complex with the IN binding d

114 By dissecting the catalytic core domain (CCD) of IN into short structural fragments,

115 ains: the N-terminal domain (NTD), catalytic core domain (CCD), and C-terminal domain (CTD).

116 three-dimensional structure of its catalytic core domain (CCD).

117 a structural homology model of the catalytic core domain (CCD).

118 gical functions but share a common catalytic core domain composed of six membrane-spanning segments.

119 hree basic residues within Helix 1 of the E2 core domain, confirmed by transthiolation kinetics.

120 Monomers are organized into "head" and "core" domains connected by a flexible "linker".

121 tate with similar rate constants to those of core domain, consistent with a unimolecular initiation t

122 rom its RNA binding domain, wraps around the core domain consisting of the seven Sm proteins and fina

123 ucceeded in crystallising the human U4 snRNP core domain containing seven Sm proteins and a truncated

124 even when sound is consciously valued as the core domain content.

125 A) that can transfer Hg(2+) to the catalytic core domain (Core) for reduction to Hg(0).

126 ian NF, only constructs with intact head and core domains could form filaments with L-NFL.

127 olvent accessibility changes calculated from core domain crystal structures.

128 in the amino-terminal (Cys-2 and Cys-12) and core domains (Cys-95) of RGS4 is important for protein s

129 d studies on the recombinant MMP-2 catalytic core domain demonstrated that anacardic acid directly in

130 Mutations in the p53 DNA-binding core domain destabilize the structure and reduce DNA-bin

131 We have prepared a cross-linked trapped p53 core domain dimer bound to decamer DNA and have determin

132 shown that ALLINIs bind at the IN catalytic core domain dimer interface and bridge two interacting s

133 With these criteria we identify a core domain (domain A) of small subunit rRNA.

134 y the LPS composition, e.g., the lipid A and core domains, during proliferation within epithelial cel

135 rmational change at the region past the cSH2 core domain encompassing Tyr-771 and Tyr-783 to facilita

136 e orientation of troponin-T and the troponin core domain established troponin polarity.

137 of catalysis in which betaG1P binding to the core domain facilitates recruitment of the general acid/

138 The core domain features a five-stranded beta-sheet flanked

139 main organization, consisting of a catalytic core domain flanked by amino- and carboxy-terminal domai

140 cture comprising an anti-parallel beta-sheet core domain followed by a C-terminal helix that packs on

141 ains, alpha-14 giardin is composed of only a core domain, followed by a C-terminal extension that may

142 Core domain formation is a prerequisite for re-import in

143 While two core domains from both dimers of the p53 tetramer intera

144 While the core domain harbors the nuclease activity, the C-termina

145 yme mechanisms, but to date the IN catalytic core domain has proven resistant to such an analysis.

146 Structures of all helical elements of the core domain have been recently reported, providing the b

147 We find that the two core domains have a preferred relative orientation in th

148 x protein Mss116p indicate that the helicase core domains have modular functions that enable a novel

149 To identify the "core domains" (i.e., patient outcomes, health-related co

150 id and beta-car connection of peripheral and core domains, (iii) stabilization of the iron-sulfur pro

151 8, and 191 cluster on the surface of the Nef core domain in a region distinct from the dimerization a

152 Here we describe the structure of the E2 core domain in complex with an antigen-binding fragment

153 propose the fibrillar arrangement of the NSs core domain in crystals reveals the molecular basis of a

154 It contains a helicase core domain in its C terminus and a potential KH domain

155 th an intact, fully photoactive photosensory core domain in its dark-adapted Pfr state.

156 on of a pseudoknot (PK) in the conserved RNA core domain in the ribonucleoprotein human telomerase is

157 that CoA is bound to different parts of the core domain in these two enzymes and approaches the acti

158 ituted in vitro, and showed that the two RNA core domains in both systems can reconstitute activity i

159 Recombinant virus encoding the NSs core domain induced intranuclear filaments, suggesting i

160 monstrated that two isolated p53 DNA-binding core domains interact with one half-site of the p53 DNA

161 nance spectroscopy to study the longin-SNARE core domain interaction for VAMP7.

162 ng interactions that stabilize either a core-core domain interface or N-terminal domain intermolecula

163 by blocking the ion conduction pore, and the core domain is a functional enzyme that uses NADPH as a

164 ell-folded simian immunodeficiency virus Nef core domain is accompanied by a disorder-to-order transi

165 ns, revealing for the first time that the CP core domain is antigenic.

166 In particular, the stability of the core domain is linked to the conformation of its C-termi

167 een sequence and structure divergence of the core domain is shown to be monotonic and independent of

168 ing that hydration water dynamics around the core domain is significantly reduced after fiber formati

169 stal structures imply that a single helicase core domain is sufficient for DNA unwinding activity, bi

170 iron(III)] derivatives showed that the TFIIB core domain is surprisingly positioned away from Pol II,

171 is capable of rapid translocation, while the core domain is unable to slide and instead hops along DN

172 iate measurement instruments to assess these core domains is an important next step toward developing

173 al configuration, in which each of the SNARE core domains is individually rooted in the membrane bila

174 pon a conformational change in which the two core domains join to form a 'closed state' with an ATPas

175 Interestingly, the trypanosome template core domain lacks the ubiquitous pseudoknot found in all

176 ines are acetylated in histone tails and the core domain/lateral surface of histone octamers.

177 d the headpiece domain to associate with the core domain, leading us to the mechanism for cAMP-depend

178 headgroups during interaction, and that the core domain lies directly against the lipid headgroups,

179 the whey acidic protein (WAP) four-disulfide core domain locus (or WFDC locus), which contains 14 WFD

180 , based on their location in the nucleosome, core domain modifications may also function through dist

181 One patient with AML who had a p53 core domain mutation showed a reduction of blast percent

182 s unique in that it lies within the globular core domain near the entry-exit sites of the nucleosomal

183 between these domains and the transmembrane core domain nearly eliminated Ca(2+)-dependent desensiti

184 ions within Pezizomycotina TERs revealed two core domains nearly identical in secondary structure to

185 spite substantial sequence homology in their core domains, nTop1 and mitochondrial Top1B exhibit dram

186 eils the structural features of the homology core domain of all 10 human FHF isoforms.

187 t the crystal structure of the transmembrane core domain of an S2P metalloprotease from Methanocaldoc

188 by a topologically conserved alpha/beta-fold core domain of approximately 150 residues shared by all

189 he Golgi in association with vesicles, and a core domain of Bassoon is sufficient to facilitate forma

190 rminal sequences indicate that the Alba-type core domain of both Rpp20 and Rpp25 contains most of the

191 Both proteins bind to the core domain of CHMP4B, which has a strong propensity to

192 mutations in charged residues in the central core domain of each subunit delineated by the characteri

193 ted translation and show that the functional core domain of eIF4G plus an adjacent probable RNA-bindi

194 human single nucleotide polymorphism in the core domain of FGF12 (P149Q), we identified a surface pr

195 We identified a core domain of FSP27, amino acids 120-220, that interact

196 The non-core domain of Gpi8 following the caspase-like domain in

197 functions during S phase to deacetylate the core domain of histone H3 at lysine 56 (H3K56).

198 Acetylation within the globular core domain of histone H3 on lysine 56 (H3K56) has recen

199 We report three structures of the catalytic core domain of hPus1 from two crystal forms, at 1.8A res

200 In contrast to the core domain of hTDG (residues 110-308), hTDG(67-308) rem

201 ch is on the surface of the alpha crystallin core domain of human alphaB crystallin, was evaluated us

202 Designed sensor comprising the IP(3)-binding core domain of IP(3)-receptor fused between complementar

203 Here, structures of the catalytic-core domain of JMJD2A with and without alpha-ketoglutara

204 a higher abundance of Q in the alpha-helical core domain of keratins, neighboring residues and steric

205 f p53 by changing a single amino acid in the core domain of p53 (N268R), which abolishes binding of S

206 rigin on the mechanism of aggregation of the core domain of p53 (p53C) using light scattering, intrin

207 or suppressors, ASPP1 and ASPP2, bind to the core domain of p53 and stimulate transcription of apopto

208 ASPP2 primarily binds to the core domain of p53, whereas iASPP predominantly interact

209 (HPV-16) E6, the LxxLL motif of E6AP and the core domain of p53.

210 In mice lacking the non-core domain of RAG2 the ordered rearrangement is disturb

211 We present evidence that the non-core domain of recombination activating gene (RAG) prote

212 We identified a stable core domain of RVFV NSs (residues 83-248), and solved it

213 Here we show that the conserved catalytic core domain of SIRT1 has very low catalytic activity tow

214 A core domain of six helices harbours two sodium ions, and

215 First, the HD-PTP Bro1 domain binds the core domain of STAM2.

216 ATG14 binds to the SNARE core domain of STX17 through its coiled-coil domain, and

217 TMD0 connects to the core domain of SUR through a cytosolic linker (L0).

218 e cationic nanoparticles and the hydrophobic core domain of the anionic central cylindrical nanostruc

219 induces structural changes in the catalytic core domain of the enzyme.

220 model of a pseudoknot found in the conserved core domain of the human telomerase (hTR) by varying bot

221 We suggest that RPT is the amyloid core domain of the Pmel17 filaments so critical for mela

222 mediated by the conserved C-terminal annexin core domain of the protein and requires the presence of

223 The core domain of the protein consists of an extended singl

224 each small nuclear RNA (snRNA), to form the core domain of the respective snRNP particle.

225 mer with the C-terminal domain and catalytic core domain of the second monomer as well as direct inte

226 We have identified a core domain of the yeast SF3a complex required for compl

227 s localized to the DNA-binding codons in the core domain of TP53.

228 observations suggest that the transmembrane core domain of TRPV1, but not the intracellular domains,

229 erminal beta-barrel domain and the catalytic core domain of tTG.

230 of the AdMLP TATA sequence (TATAAAAG) by the core domain of yeast TBP allow quantitation of the roles

231 d 3 in an outward-open state reveal that the Core domains of Bor1 have rotated inwards to achieve an

232 tes were observed within the AMP binding and core domains of both AK homologs.

233 icipants completed three tasks that assessed core domains of cognitive functions: response inhibition

234 Here, we report the crystal structure of the core domains of NP (NPcore) encoded by Sin Nombre virus

235 The DNA sequences in the core domains of rice Cen4, Cen5 and Cen8 showed elevated

236 etiological double dissociation between two core domains of social perception (judgments of identity

237 igh-resolution crystal structures of the p53 core domains of the cancer-related proteins, the rescued

238 e hydroxyl group and residues of the cap and core domains of the protein, thereby providing exquisite

239 The core domains of vav2 bound to the intracellular domains

240 titative analysis on a unique dataset of 154 core-domain-only and cap-domain-only structures, basic p

241 not ATP or ADP) release P1 from the protein core (domains P3P4P5) and increase its mobility.

242 ed the level of recombinant folded human p53 core domain (p53C) and its mutants in Escherichia coli s

243 erial transcription factor suggests that the core domain performs nucleosome-independent activities,

244 riori consensus criteria to be designated as core domains: physical function, cognition, mental healt

245 in which interactions between the catalytic core domains play a prominent role.

246 it enhances the activity of the mouse PNGase core domain, presumably by increasing the affinity of mo

247 In this format, the IN catalytic core domain produced a K(i) of 15.2 nm while competing f

248 proteinase [SLPI], 0.6-fold; WAP 4-disulfide core domain protein [WFDC2], 0.5-fold; haptoglobin [HP],

249 ay structure of the drug-resistant catalytic core domain protein, which provides means for rational d

250 d on both the HIV-1 IN and RNase H catalytic core domains provided new structural insights for the fu

251 meric p53, and the proper folding of the p53 core domain, rather than the presence of the N- or C-ter

252 mily, show that the downward pivoting of the Core domains relative to the Gate domains may access an

253 on the orientations of the PH and catalytic core domains relative to the lipid membranes.

254 t with DNA within the complex, the other two core domains remain available for binding another DNA si

255 with amidation-based shell cross-linking the core domain remained accessible.

256 he N and C terminus of the catalytic otubain core domain, respectively.

257 The tetramerization helix is linked to a core domain responsible for RNA binding activity by a fl

258 2-A resolution crystal structure of the Bud6 core domain reveals an elongated dimeric rod with a uniq

259 main mediates fast sliding of p53, while the core domain samples DNA by frequent dissociation and rea

260 l an "open" conformation whereby the cap and core domains separate and visualize the striking conform

261 ous syndrome defined by impairments in three core domains: social interaction, language and range of

262 equires a surprisingly large rotation of the core domain, some 20 degrees against the dimerization in

263 idues to the N-terminal end of the DENV RdRp core domain stabilizes DENV1-4 proteins and improves the

264 e and tyrosine binding sites within the AP-1 core domain such that binding of a cargo signal to one s

265 alysis or to the structural integrity of the core domain, suggesting that it may play a role in media

266 Our functional study of trypanosome TR core domains suggests that the functional requirement of

267 The structures show that the core domain supplies the phosphoryl binding site, cataly

268 (TBP) and its isolated C-terminal conserved core domain (TBPc) were prepared with measured high spec

269 h IncA functions are encoded in a structured core domain that encompasses SLD1 and part of SLD2.

270 AP-1 induces a conformational change in its core domain that greatly enhances its interaction with A

271 er is contained in a conserved 33-amino acid core domain that has the same membrane topology as the f

272 erase RNAs contain a catalytically essential core domain that includes the template and a pseudoknot

273 CtBP contains a central NAD(H) binding core domain that is homologous to D2 hydroxy acid dehydr

274 The structure reveals a core domain that is homologous to methionine aminopeptid

275 we identified a conserved surface on the FHF core domain that mediates channel binding in vitro and i

276 tant for its activity: a sequence within the core domain that selects and positions the cleavage-site

277 ic residues of the central beta-sheet of the core domain that would otherwise be exposed to solvent.

278 try of TR comprising two distinct structural core domains that can assemble in trans with TERT and re

279 SNAREs generally consist of one or two core domains that can form a four-helix bundle with othe

280 m in which alternating access is provided by Core domains that carry substrates across a membrane.

281 is study generated a consensus-based list of core domains that should be assessed in all clinical res

282 mediating role of conserved residues in the core domain, the accompanying conformational changes (in

283 domains (LID and NMP) close over the larger CORE domain; the reverse (opening) motion limits the rat

284 to an extension of TnI linking the troponin core domain to actin at low (but not at high) Ca2+, ther

285 region stably associates with the catalytic core domain to form a SIRT1 holoenzyme.

286 the addition of TFIIF repositions the TFIIB core domain to the Pol II wall domain.

287 ly representing parts of TnT or the troponin core domain, to promote tropomyosin movement on actin to

288 re the stabilities of the human and worm p53 core domains using molecular dynamics simulations.

289 hed the basic kinetics of aggregation of its core domain, using the mutant Y220C that has a mutation-

290 this system to select mutations in catalytic core domain V (DV) that partially rescue retrohoming at

291 ior of the Ca(2+)-saturated cardiac troponin core domain was mapped in detail at 10 degrees C, using

292 The highly conserved Anx core domain was sufficient to mediate these effects, whe

293 While the ring-shaped core domain was surprisingly congruent between the two s

294 hide structural domain [whey four disulphide core domain (WFDC)], WAP proteins are increasingly being

295 lines carrying mutations in the first PNPase core domain, which does not harbor the catalytic site.

296 we found that ARF interacted with the topo I core domain, which encompasses most of the catalytic and

297 All Kvbeta subunits have a conserved core domain, which in one of them (Kvbeta2) is an aldoke

298 er, mutation of conserved amino acids in the core domain, which may be involved in a salt bridge, abo

299 However, core domains with the same cap type share greater simila

300 nd M. tuberculosis share a common structural core domain, with extensive, apparently disordered, N- a