ライフサイエンスコーパス: core region

1 regions at the flat surface that covers the core region.

2 ted with the distal portion of this extended core region.

3 ceptor-lipid interactions within the helical core region.

4 le Zn(2+) ions in its catalytically required core region.

5 limited by inverted repeats with a conserved core region.

6 nd fucose modifications on the Man2-3GlcNAc2 core region.

7 ure value in the boundary region than in the core region.

8 saccharide, consisting of an inner and outer core region.

9 s, or by influencing DNA conformation in the core region.

10 onkey auditory cortex were compared with the core region.

11 hether or not the mutation is in the amyloid core region.

12 but becomes increasingly cleaved in the lens core region.

13 the oligomerization states observed for the core region.

14 ctural features of tRNA, particularly in the core region.

15 3(10)-helix (residues 53-55) outside of the core region.

16 yA signal propagation through the C-terminal core region.

17 is of its interactions with the nucleic acid core region.

18 inetics for histidine side chains within the core region.

19 served despite a similar size of the PrP(Sc) core region.

20 is uneven, and is less dense in the central core region.

21 ible loop region (loop 2) within the central core region.

22 tory cortex, is made up of multiple distinct core regions.

23 that the domain contains limited hydrophobic core regions.

24 ith heuristics to preserve continuity within core regions.

25 in the expansion compared with the conserved core regions.

26 talytic core flanked by unique pre- and post-core regions.

27 d for using them to identify the small ictal core regions.

28 action and a C-terminal nonessential or "non-core" region.

29 The N-terminal core region (1-129) of P7 forms a novel homodimeric alph

30 n in-plane curling magnetization and a small core region (~10 nm) with out-of-plane magnetization.

31 e performed refined mapping to elucidate the core region (-317/-304) involved in mediating the PCBP-i

32 REX1 and YY1 share some similarity at their core regions (5'-CCAT-3').

33 The defect core regions (~50 A) mainly adopt the continuous U(1) sy

34 enic and immunogenic properties of LPS inner core region, a collection of well-defined L-glycero-D-ma

35 he secondary chemical shifts shows that this core region adopts predominantly beta-sheet secondary st

36 gulation, while mutations in the hydrophobic core region affect SecM secretion as well as translation

37 lume of this region, suggests that this is a core region affected by the disorder.

38 loss of viable brain tissue in the ischaemic core region after stroke is associated with damage to th

39 rated domains in CDD, which have pre-defined core regions, against COMPASS, HHalign and PSI-BLAST, us

40 region revealed there are three genes in the core region, all of which encode transcription factors w

41 icity are principally due to a stiff central core region and are instead indicative of an internal st

42 stigation of the hydrophobic networks in the core region and comparisons with similar studies on T. t

43 es present at different locations within the core region and correlated with observed differences in

44 the diversity of social entities within its core region and for the multiple agencies behind its wid

45 d to be enriched at the surface of the Fe(0) core region and had limited mobility into the interior o

46 ments identified both in the 20S proteolytic core region and in the 19S regulatory particle.

47 is specifically associated with the central core region and is required for the unusual chromatin st

48 teins contain a conserved central/C-terminal core region and possess variable N-terminal regions.

49 d LPS to inactivate Ba1, suggesting that the core region and possibly the O antigen were required for

50 l intramolecular interactions within the non-core region and suggests that the PHD finger adopts two

51 ion are required for GGR in both nucleosomal core regions and internucleosomal linker DNA, but play n

52 ng back-translocation, movements of the tRNA core regions and of mRNA are closely coupled to one anot

53 ter molecules can penetrate inside the inner core region, and hydration is critical to maintain the i

54 tilize Dod-P-GalA to attach GalAs on the LPS core region, and RgtD attaches GalA to the lipid A 4' po

55 Residues that flank this presumably exposed core region are not completely disordered, but adopt a p

56 the synthetic peptides corresponding to the core regions are biologically active and likely contribu

57 show by site-directed mutagenesis that these core regions are important for function.

58 as the N- and C-terminal regions outside the core region, are significantly less ordered.

59 peptides bind to the minor groove of an AATT core region as evidenced by an intermolecular nuclear Ov

60 -profile method CORAL that aligns individual core regions as gap-free units.

61 sulator activity has been mapped to a 250-bp core region, as well as to several proteins that bind th

62 epitopes to extend beyond a central nonamer core region at both the amino- and carboxy-terminus.

63 he exchange of a serine residue in the inner-core region at position 229, and a histidine residue at

64 ve transcription factor pCREB was reduced in core regions at all time points examined.

65 Core regions at the precuneus and inferior parietal lobe

66 map to a well-structured, stable hydrophobic core region away from the subdomain interfaces.

67 C-terminal core (alphaE), and the N-terminal core region (beta4-beta5, alphaL16, alphaC).

68 N terminus of zeta in an "inhibition-general core region," blocking further gamma rotation, while the

69 iption factors and PMA regulation within the core regions but contain significant differences in the

70 Conduction blocks crossing the core region, but not reaching any unexcitable boundary,

71 followed by the localized targeting of their core region by ablation.

72 ion promotes a remodeling of lipid A and the core region by addition of 4-aminoarabinose and/or phosp

73 sphorylation of the Hep(II) phosphate in the core region by the PmrG protein.

74 rted by the first eight residues of the post-core region (C-extension), not present in other PRMTs.

75 Ah receptor ligand inducibility when the XRE core region (CACGCA) was deleted or mutated.

76 We measured fractional anisotropy in a core region centered along the length of the aSLF.

77 arbon dates from residential features in the core region, combined with spatial analysis of agricultu

78 All three microcircles contain the core region common to minicircles, but are missing a cod

79 ated by a approximately 40-nm focal adhesion core region consisting of multiple protein-specific stra

80 ess organized than an ION, possesses a dense core region consisting of multipolar neurons.

81 apping of AsphyA shows that the photosensory core region consisting of PAS-GAF-PHY domains in the N-t

82 bait demonstrated that binding occurred in a core region containing 48% identity and 7 conserved cyst

83 A basal core region containing the TATA box, a negative region a

84 scenarios have been proposed for the spore's core region, containing the DNA and most enzymes.

85 The core region contains two "mirror-image" tonotopic maps o

86 This PHYA core region contains two protein-interactive motifs, PAS

87 two highly conserved motifs within the ECudA core region decrease its specific DNA binding in vitro.

88 We conclude that while the folding core region determines the thermophilic-like behavior of

89 Although the lengths of the respective core regions differ, fibrils from different amyloid prot

90 the transcription start site, consists of a core region directing basal transcription and an activat

91 rtain deletions and mutations in the central core region distant from the nucleotide binding sites.

92 everal months and these are clustered into a core region encompassing most of the beta-strands, at le

93 This parallel, in-register core region extends from residue 36 to residue 98 and is

94 e a subpopulation of molecules in which this core region extends N-terminally as far as to residue ap

95 syl residue was 3-linked and attached to the core-region external Kdo III residue of the LPS, the sam

96 ved, approximately 45-kDa N-terminal protein core region followed by a stalk region that is tethered

97 protease with thrombospondin type-1 modules) core region followed by eight and one-half tandem egg bi

98 ting a common trajectory with folding of the core region followed by the folding of the periphery.

99 ), 2 structures that have been identified as core regions for interoception.

100 ls are thread-like protein aggregates with a core region formed from repetitive arrays of beta-sheets

101 When inlet disturbance is located in the core region, helical vortex filaments evolve into large-

102 responding to heptoses I and II of the inner core region in many LPS.

103 hese results underline the importance of the core region in promoting the efficiency and accuracy of

104 ty and reveals a novel role for the RAG1 non-core region in RAG1 targeting.

105 approaches identify a relationship with the core regions in a crystal structure of Vibrio cholerae N

106 ed with the BrainMap database, we identified core regions in the DMN and examined their functional he

107 cted by site affinity (saf) mutations in the core region, in agreement with a model that the peptide

108 fied likely beta-strand segments within this core region, including beta-strand 130-139 containing cr

109 he way, while both the area and depth of the core region increase firstly, and then stay stable over

110 he same at all four locations throughout the core region, indicating the possibility of a single step

111 ar's modular organization: we propose that a core region integral to motor regulation is attached to

112 We show that this structured core region interacts with LRP5 and LRP6 via an NXI moti

113 tracentrifugation experiments show that this core region is composed almost entirely of alpha-helices

114 This core region is composed of aligned mineralized collagen

115 The CsgA amyloid core region is composed of five repeating units, defined

116 s of metrical parameters indicates that this core region is highly conserved, while the more peripher

117 The tRNA tertiary core region is important for both tRNA stability and act

118 region, providing further evidence that the core region is necessary for minicircle replication and

119 one H3 methylation activity, whereas the pre-core region is required for methylation of Arg26, but no

120 by spin state contributions, the valence to core region is shown to have greater sensitivity to chan

121 From recent crystal structures of this core region, it has been inferred that the chromophore s

122 Point mutations in either the core region (K41A) or the cysteine-rich region (C30G) of

123 lpha-helix formed at the central hydrophobic core region (L17-D23).

124 L-Rhap-(1,2)-alpha-L-Rhap-(1-]n, and the LPS core region lacks the acidic sugars commonly associated

125 core of amyloid fibrils is important because core regions likely control the process of fibril extens

126 st of a conserved ATP-dependent RNA helicase core region linked to N and C-terminal domains, the latt

127 The core region, marked by calbindin-D(28K) (CalB)-containin

128 nd high mCRP-levels spreading from infarcted core regions matched reduced expression of Abeta/Tau.

129 The C130S substitution within the core region may disrupt the protein recognition interfac

130 ring in superscript): I37(32)V in the active core region; N55(46)M, M56(47)I, and V59(50)I in the fla

131 x folding motif, such that each Abeta(15-36) core region occupies a single layer of a prismatic, H-bo

132 O(409-428) epitope has a minimum immunogenic core region of 11 amino acids, MPO(415-426), with severa

133 these disparate results, we have deleted the core region of 5'HS2 from the endogenous murine beta-LCR

134 p regions are usually more flexible than the core region of a protein structure, disagreement of a mo

135 g with the previously identified hydrophobic core region of alpha-synuclein (residues 61-95, particul

136 Interestingly, the central core region of alpha-synuclein exhibits several features

137 The core region of alpha-synuclein fibrils must therefore be

138 the majority of all sites located within the core region of alpha-synuclein fibrils.

139 There is a core region of approximately 70 amino acids, from residu

140 ghly ordered and specifically folded central core region of approximately 70 amino acids, whereas the

141 In its crystalline state, the core region of Ara h 1 forms trimeric assemblies, while

142 This core region of Asf1 adopts a compact immunoglobulin-fold

143 ry infiltrate in the adventitia and necrotic core region of atherosclerotic lesions, consisting prima

144 ue class of harmonic template neurons in the core region of auditory cortex of a highly vocal New Wor

145 port the crystal structures of the conserved core region of beta3, alone and in complex with AID, and

146 tually up to five fucose residues modify the core region of C. elegans N-glycans and that the alpha1,

147 ng and we found that it binds to the central core region of centromeres, in striking contrast to Chp1

148 the presence of PS in the membrane, and the core region of complexin-1, which binds to the SNARE com

149 cate that the cis-acting RNA elements in the core region of DENV2 RNA that include two DB structures

150 The core region of each subunit exhibits an intrinsic tenden

151 These findings suggest that the central core region of fatty acid and polyketide synthases plays

152 '-betaE loop interacts with the beta-trefoil core region of FGF1, in the FGF1-FGFR3c structure, this

153 eatures reminiscent of those observed in the core region of fibrillar Alzheimer's amyloid beta peptid

154 phology consisted of two distinct regions: a core region of layered fracture and a peripheral region

155 for Bvg-mediated modification of the lipid A core region of LPS that occurs on switching from the Bvg

156 genes, reducing phosphorylation of the inner core region of LPS.

157 binding between the CRD and heptoses in the core region of LPS.

158 he structurally conserved lipopolysaccharide core region of many Gram-negative bacteria is composed o

159 a model of the transmembrane domains of the core region of MRP1 that includes the amino acid side ch

160 A core region of only 19 residues adopts a stable structur

161 N-terminal segments, showing that it is the core region of PrP (residues 127-228) that is involved i

162 (PST) repeats of MDC1 and the N-terminal non-core region of RAG1 (R1Nt).

163 n(2+) ions bound to the catalytically active core region of RAG1 under various conditions.

164 I activation in the ventral striatum (VS)--a core region of reward processing--when successfully lear

165 ther the CTD communicates with the catalytic core region of Rpb1 and thus must be physically connecte

166 The essential core region of S protein required for 80R binding was id

167 ar modeling identified three residues in the core region of SF2 Nef (Ala83, His116, and Tyr120) which

168 a protease-labile state while maintaining a core region of stability in the C-terminal region, the e

169 ins of the receptor subunits and the central core region of Stat2 were partially purified and used in

170 e, we found that pBAF is associated with the core region of telophase chromosomes.

171 algorithm for RNA folding, we show that the core region of the 3'-untranslated region of the dengue

172 d SST record is representative for the wider core region of the AC.

173 and -2 also activated transcription from the core region of the catfish IgH enhancer (Emu3') in a man

174 oratory demonstrated that an extended 400-bp core region of the cHS4 element is necessary to achieve

175 d right medial prefrontal cortex (R.MPFC), a core region of the default network These results suggest

176 crystal structure of the N-terminal protein core region of the Drosophila glypican Dally-like (Dlp).

177 processed in this pathway, especially at the core region of the ectostriatum (Ec) in the telencephalo

178 nly backbone mutation within the hydrophobic core region of the fibril (residues 17-21) that signific

179 uded additional viral transcripts within the core region of the genome not detected in control RMs.

180 significant depletion of nucleosomes in the core region of the insulator as revealed by micrococcal

181 The core region of the insulator, which contains a cluster o

182 A mutagenic analysis showed that only a core region of the intracellular domain that exhibits at

183 -guided functional analyses of the conserved core region of the LD (cLD) leads us to a proposal for t

184 WaaL-mediated ligation of O-antigen onto the core region of the lipid A-core block is an important st

185 ate, both in the head group and in the inner core region of the lipid bilayer.

186 We have synthesized the inner core region of the lipopolysaccharide (LPS) of F. tulare

187 oli in part by interacting with the complete core region of the LPS molecule.

188 elix first partitions out of the hydrophobic core region of the membrane before it bends into the pro

189 We demonstrate that D1R expression in the core region of the NAc (NAc(Core)), but not the shell (N

190 Although the core region of the nucleus accumbens (NAcc) has been imp

191 a subpopulation of SCN cells located in the core region of the nucleus.

192 030) is located in the previously identified core region of the origin and is required for efficient

193 estricted to a subset of Kenyon cells in the core region of the peduncle.

194 ximity to the side chains of residues in the core region of the peptide ligand.

195 inding reveals that the residues forming the core region of the protein are sufficient for formation

196 the beta(O) allelic forms, showing that the core region of the protein including position 129 is act

197 ned to a small peptide domain located in the core region of the protein.

198 s of CentO satellite repeats harbored in the core region of the rice chromosome 4 centromere (CEN4).

199 ex (MTBC) DNA and mutations within the 81-bp core region of the rpoB gene that are associated with ri

200 , overall, genes corresponding to the 4.9 Mb core region of the S. coelicolor M145 chromosome were mo

201 s in precipitation in the hitherto unsampled core region of the SAMS.

202 ution speleothem delta(18)O records from the core region of the South American Monsoon System (SAMS),

203 ng to the Kbeta main line and the valence to core region of the spectra are experimentally assessed a

204 As the conserved core region of the Stachel sequence is highly similar be

205 Pseudoknot formation in the core region of the telomerase RNA has been demonstrated

206 t structural similarity with the IP3-binding core region of the type 1 IP3R.

207 ses in the right temporoparietal junction, a core region of the ventral attention network.

208 The right temporoparietal junction (TPJ), a core region of the ventral frontoparietal attention netw

209 ation of up to 86% within a 12 degrees -wide core region of their emission lobes in the far field.

210 ree of structural similarity within the beta-core region of these PrP aggregates.

211 Next, the core region of these rotors was specifically and precise

212 etwork surrounding the previously recognized core region of this area.

213 is absent due to a deletion that removes the core region of this enhancer.

214 The auditory cortex of primates contains a core region of three primary areas surrounded by a belt

215 east cancer, there was an association in the core region of tumors between MFN2 downregulation and th

216 cations occurred in the cytoplasm within the core region of Vp1 and depended on the coexpression of t

217 nsive to innocuous cooling terminated in the core region of VPL, significantly dorsal and medial rela

218 e most extreme non-polar biome on Earth, the core region of which is considered to represent the dry

219 xpressions in depression were evident in the core regions of affective facial processing, which were

220 structure and dynamics of the N-terminal and core regions of BtuB, an outer membrane vitamin B(12) tr

221 t both the terminal inverted repeats and the core regions of CREE are composed of distinct basic sequ

222 find that 4% of polar atoms in the non-polar core regions of membrane proteins have no hydrogen-bond

223 We provide the first evidence that the non-core regions of RAGs have critical functions in the prop

224 To investigate the role of the non-core regions of RAGs in the end-joining phase of antigen

225 The lipid A and inner core regions of Rhizobium leguminosarum lipopolysacchari

226 based on histologic evidence, and including core regions of the brain circuitry underpinning social

227 ior cingulate cortices, i.e., several of the core regions of the default mode network (DMN).

228 al eye field (FEF) and intraparietal sulcus, core regions of the dorsal frontoparietal attention netw

229 conserved conformational epitopes within the core regions of the GP1 subunit and a novel linear epito

230 ntial intrinsic functional connectivity with core regions of the language system.

231 erential RSFC with Wernicke's area and other core regions of the language system; and (3) the strengt

232 The lipid A and core regions of the lipopolysaccharide in Rhizobium legu

233 nes that mediate modifications of lipid A or core regions of the LPS.

234 ce of CXCR4 was found in the medial shell or core regions of the nucleus accumbens.

235 in sequences of these PerC homologues allows core regions of the PerC protein to be identified, and w

236 e transposition is not suppressed by the non-core regions of the RAG proteins.

237 tal cellular Nrf2 levels in peri-infarct and core regions of the stroke hemisphere after 24 h reperfu

238 The common structures of the core regions of the two fingers are superimposable.

239 transcriptional activity was observed in the core regions of tumors.

240 judgments, logic inference alone recruited "core" regions of deduction [Brodmann area (BA) 10p and 8

241 The truncated 'core' regions of RAGs are sufficient to catalyze the rec

242 lar interactions between MG antibodies and a core region on nAChR alpha1.

243 Use of dsRNA against the br core region, or against a pair of either the br-Z2 or br

244 CORAL improves alignment accuracy on core regions over general profile methods, returning a b

245 luted from HLA-DR3 and -DR4, encompassed two core regions overlapping the two most immunodominant and

246 e observed for diversity within HVR1 and the core region (P = .04).

247 sis suggested that the TATA box in the basal core region played a fundamental role in the exon 11 pro

248 nt evidence has emerged arguing that the non-core region plays a critical regulatory role in the reco

249 ffsets that confine charge carriers into the core region, potentially reducing scattering from charge

250 structurally and also functionally important core region primed for the final folding into the native

251 changes that restored homology in the common core region reduced the integration frequency.

252 rchitecture within the approximately 160-220 core region represents a distinct global minimum in the

253 th SECIS elements harbored a mutation of the core region required for Sec incorporation, context 5 re

254 ee sites, one within the immunoglobulin-type core region (residues 125, 126, and 151), one in the ups

255 n the N-terminal region (residues 1-17), the core region (residues 25-30), and double labels into the

256 howed MDH was substantially protected in two core regions (residues 95-156 and 228-252), which overla

257 replacement of most residues in the amyloid core region, residues 15-36, leads to destabilization of

258 y utilizing stabilizing mutations within the core region resulted in a mutant protein that is essenti

259 Lines of block away from the core region resulted merely in rotor destabilization (ie

260 structures of the approximately 900-residue core region reveal a series of putative nucleic acid and

261 contains conserved residues in the catalytic core regions shared by both class I and II mammalian HDA

262 he F. graminearum genome can be divided into core regions shared with closely related species and var

263 ctive antibody WN1 222-5 in complex with the core region shows that it recognizes LPS of all E. coli

264 ding between the flap hinge and the protease core regions shows significant structural rearrangements

265 t of LPS derivatives with truncations in the core region, some of which were pentaacylated and exhibi

266 Mutational analyses revealed a core region spanning -73 to -31 as being essential for h

267 Only a few sites within the core region, such as residues 62-67 located at the begin

268 structurally define a minimal liprin-alpha3 core region, sufficient to recapitulate the liprin-alpha

269 N5, and N7 site mutants, suggesting that the core region sugars are more important than the terminal

270 are correlational and do not tell us whether core regions support critical processes for simulation a

271 ed amyloidogenic fragment revealed a minimal core region that forms amyloid fibrils similar to the TD

272 ns of IntN1 cleavage within the 14 bp common core region that is identical in both NBU1 att sites.

273 domain of S. cerevisiae Asf1 (Asf1N) is the core region that mediates all tested functions of the fu

274 as a trimer, with each subunit containing a core region that mediates substrate translocation.

275 hout much of the sequence and identifies two core regions that are particularly critical for function

276 fields are markedly different, yet both are core regions that by definition receive most of their th

277 n elongated, alpha-helical fold for glypican core regions that does not appear homologous to any know

278 ters revealed size fluctuation around stable core regions that were surrounded by a rim the diameter

279 line of block is required reaching from the core region to at least 1 unexcitable boundary.

280 resulting in diffusion of Au atoms into the core region to form a non-random alloy.

281 mutagenesis attributed the activity of this core region to the presence of five SP1 sites within the

282 of growth-related transcripts encoded in the core region to those of less characterized genes, which

283 additional contacts with conserved catalytic core regions to stabilize the active RNA structure.

284 The core regions to which DC may draw attention from autorea

285 a conserved YXXL motif in the center of this core region was critical.

286 effect from the A2UCOE is confined within a core region, we evaluated the anti-silencing effect of d

287 human transgenes in which only individual HS core regions were deleted showed drastic loss of express

288 e O-antigen subunits attached to the lipid A-core region when separated on a SDS/PAGE gel, suggesting

289 izes 2 nm < d(p) < 50 nm, there is a central core region where the influence of interactions of the m

290 ngle base changes near one end of the common core region, which introduced heterology, actually incre

291 homologs in Pseudomonas revealed a conserved core region, which is strictly required for RgsA target

292 I intron binding than do neighboring protein core regions, which also function in intron binding but

293 They are part of a stable "core" region whose assembly dynamics are distinct from o

294 thin the MSD core, we initially replaced the core region with 12 leucine residues and then constructe

295 le receptor simultaneously binds through its core region with G protein and through its phosphorylate

296 alpha22 protein contains a conserved central core region with structurally variable regions at the am

297 ely, BSA was encapsulated selectively in the core region within DWMS with higher loading and encapsul

298 1, from valine to methionine (V631M), in the core region within the C-terminal half of PHYA.

299 We identify a core region within the HU-DNA interface that can be targ

300 e unliganded SIV and the complexed HIV gp120 core regions within our resultant shape constraints reve