ライフサイエンスコーパス: core structure

1 ors exhibiting repetitive sequences in their core structure.

2 that share a 4-methoxypyrrolyldipyrromethene core structure.

3 onent reaction generating the peptidomimetic core structure.

4 l aza-[4+2] cyclization to form the cagelike core structure.

5 ds uniquely embedded in each natural product core structure.

6 nt is directly computed from the dislocation core structure.

7 as exchange share a common 'Farquhaur-model' core structure.

8 hydrate-based approach to build the bicyclic core structure.

9 -galactosidase) can be created from the same core structure.

10 a 4,5-diphenyl-1H-pyrrole-3-carboxylic acid core structure.

11 influence of disulfide bond formation on the core structure.

12 on, whereby (13)CO was incorporated into the core structure.

13 ain, generating a stacked alphabetabetaalpha core structure.

14 lective binding to a uniquely galactosylated core structure.

15 promote crystal packing without altering the core structure.

16 gonists based on a phenethylpiperazine amide core structure.

17 nsities that would correlate with a complete core structure.

18 mbered according to the size of the enediyne core structure.

19 onent reaction (4CR) for the assembly of the core structure.

20 a systematically H-bonded cross-beta amyloid core structure.

21 c Spt6 transcription factor adopts a similar core structure.

22 would correlate with the capsid region of a core structure.

23 methane oxidation) is supportive of an open-core structure.

24 peptide needs time to form and optimize the core structure.

25 hydroxyl moieties afforded upon a conserved core structure.

26 that connects the HlyIIC domain to the HlyII-core structure.

27 the reactivity of lactivicin and beta-lactam core structures.

28 he preparations of abiotic and sesquiterpene core structures.

29 ctivity, although they could possess varying core structures.

30 embered ring within their polyketide-derived core structures.

31 3 populates at least two discrete beta-sheet core structures.

32 release rates and efficiencies from isomeric core structures.

33 rick-shaped mature virions with well-defined core structures.

34 n lead to molecules with virtually identical core structures.

35 a new method for characterizing dislocation core structures.

36 They consist of four core structures; (1) A = mesitylene core, (2) B = benzen

37 eated with proton pump inhibitors having the core structure, 2-pyridyl-methylsulfinyl-benzimidazole.

38 on a 5-aminonaphthalen-1-yloxy nicotinamide core structure, 5-((3-amidobenzyl)oxy)nicotinamides offe

39 ffects from the image stress and dislocation core structure, a dislocation nucleated from the surface

40 uctasporine (2) contains an unprecedented TD core structure: a pyrrolinium indolocarbazole core that

41 Our IR data provide evidence that similar core structures also comprise wild-type PrP(res).

42 For the construction of the tricyclic core structure, an unusual intramolecular and diastereos

43 mbly such that 12 NPC proteins (Nups) form a core structure anchored across the nuclear envelope (NE)

44 TP, despite maintaining the canonical ATPase core structure and active site residues.

45 nsion of this chemical class, both modifying core structure and decorating benzamide moiety, was dire

46 The conservation of the core structure and diversification of the external featu

47 ts has distinct peptide segments forming the core structure and features different aggregate morpholo

48 idence that Q possesses a bis-mu-oxo diamond core structure and show that both bridging oxygens origi

49 e crystal structure shows the expected dimer core structure and significant conformational variations

50 omaterials of differing chemistries, and (3) core structure and surface chemistry both influence part

51 here is a notable lack of information on how core structure and surface chemistry may alter toxicity

52 Modifications in core structure and surface chemistry of manufactured nan

53 effects of twelve CNMs that differ in their core structure and surface chemistry to Daphnia magna ov

54 in, we report a strategy to probe the Au(25) core structure and surface thiolate ligand distribution

55 estigated how alterations in both the ligand core structure and the appended acrylic acid substituent

56 7 tricationic reagents were made from 1 of 4 core structures and 7 terminal charged groups.

57 However, the core structures and conformational dynamics of ribosomes

58 odies recognized epitopes consisting of both core structures and lacto-N-neotetraose (LNnT).

59 tivity toward N-linked and O-mannosyl glycan core structures and that its brain-specific gene express

60 are found to have such closely related metal core structures and the results may increase understandi

61 ngements of the NTDs that yield a functional core structure, and (iii) supports capsid function durin

62 Both Arps contain a shared actin core structure, and each Arp contains multiple insertion

63 129 residue is deeply buried in the amyloid core structure, and its mutation strongly impacts aggreg

64 The four glycoforms share a common core structure, and the differences are related to the n

65 In contrast, close contact between filament core structures ( approximately 50 A spacing) is observe

66 The salient features of this core structure are absolutely conserved between alphabet

67 emic synthesis, two asymmetric routes to the core structure are described: one exploiting a rhodium-c

68 alkaloids and its conversion to the atisine core structure are reported.

69 The native and recombinant core structures are all similar to the truncated bacteri

70 nvestigated imine/R-TRIP complexes, the four core structures are highly preserved.

71 Thus, these core structures are independent of electron density and

72 ions adjacent to helix F, showing that their core structures are similar.

73 exes is large and the variations of the four core structures are small.

74 d a class of compounds with a thiazolidinone core structure as inhibitors of hepatitis C virus (HCV)

75 The aim of TRFolder-W is to use the five core structures as fundamental units to predict potentia

76 to accept five naturally existing H-antigen core structures as good substrates, demonstrating its ve

77 ssary structural elements within the amyloid core structure, as well as producing idealised models to

78 The (mu-oxo)(mu-1,1-peroxo)diferric core structure associated with CmlI(P) is unprecedented

79 For that purpose, a UV-light-responsive core structure based on diaminopyrimidines with suitable

80 h lipopolysaccharide (R-LPS) with a complete core structure (beta-d-Glcp-(1-->4)-alpha-Kdop-(2-->4)[b

81 tivity through interactions with hydrophobic core structures (beta1, beta3, alpha5, and alpha6).

82 vacuolar pigments composed of a nitrogenous core structure, betalamic acid [4-(2-oxoethylidene)-1,2,

83 onovalent Smac mimetics with a diazabicyclic core structure bind to XIAP, cIAP1, and cIAP2 with low t

84 In the 'inactive' AP2 core structure both motif-binding sites are blocked by d

85 thout any stabilizing mutations had the same core structure, but revealed new insights and features.

86 bartoloside biosynthesis constrained the DAR core structure by defining key pathway intermediates, ul

87 Disruption of the incoming core structure by rhesus macaque TRIM5alpha did, however

88 All steps yielding to the linear core structures can be conveniently coupled without the

89 en compared to those with the peptidolactone core structure common to two ADEP natural products.

90 This N-glycan core structure, common to all chloroviruses, is a pentas

91 nto a thermodynamically highly stable fusion core structure composed of six antiparallel alpha-helice

92 nt of E. coli R-LPS structures with isomeric core structures confirmed the degree to which subtle str

93 NL63-CoV RBD has a novel beta-sandwich core structure consisting of 2 layers of beta-sheets, pr

94 mical steps of splicing revealed an averaged core structure consisting of three primary domains surro

95 The AAV9 viral protein (VP) has a conserved core structure, consisting of an eight-stranded, beta-ba

96 The core structure, consisting of residues 77-186, consists

97 Its core structure consists of eight multicomponent protein

98 the LPS from the waaL strain showed that the core structure consists of L-glycero-D-manno-heptose, D-

99 NMR analyses showed that the core structure contains a furan ring.

100 in the 6- and 7-positions of the quinazoline core structure decreased potency.

101 An alpha-amino acid-based core structure, derived from a hydantoin core, with uniq

102 early transcription is coupled to the viral core structure, detailing the structure of the nucleocap

103 first evidence that external O-glycans, with core structures distinct from N-glycans in type and numb

104 neO motif, though further modulations of the core structure due to the protein environment cannot be

105 7a that has a relatively rigid cyclopentene core structure exhibits the strongest inhibitory activit

106 ach to chiral bridged tricyclic benzopyrans, core structures featured in various natural products, is

107 dorsal anterior cingulate cortex (dACC) is a core structure for the governing of cognitive control, a

108 results presented show the importance of the core structure for the profile of the final compounds.

109 However, the lack of a core structure for vortex filaments appears to result in

110 magnesium oxide can exhibit polymorphism of core structures for a given dislocation species.

111 The fibrils have a common rod-like core structure, formed from an elongated stack of beta-s

112 ,2,3,4-tetrahydro-9a,4a-iminoethanocarbazole core structure found in the alkaloid minfiensine (2).

113 e racemic synthesis of the common propellane core structure found in various hasubanan alkaloids is r

114 e extensions serve to shield conserved inner core structures from recognition by host immune componen

115 d to be unable to close the six-helix bundle core structure fully.

116 ic natural product composed of a tetracyclic core structure further elaborated with a p-methoxyphenyl

117 ase (PRNTase) activities to produce a 5'-cap core structure, guanosine(5')triphospho(5')adenosine (Gp

118 An [Fe(IV)(2)(mu-O)(2)] diamond core structure has been postulated for intermediate Q of

119 This type of core structure has relevance to the oxygen-evolving comp

120 [3,2,1-hi]indole and pyrrolo[3,2,1-hi]indole core structures has been designed and was synthesized by

121 Access to elongated core structures has now been achieved by the reaction of

122 ule Smac mimetics containing a diazabicyclic core structure have been designed, synthesized, and eval

123 logues which contain the complete bryostatin core structure have been synthesized using a pyran annul

124 Proteinaceous materials based on the amyloid core structure have recently been discovered at the orig

125 Synthetic studies toward these challenging core structures have revealed a number of unanticipated

126 es that it contains a cyanine-based cationic core structure identical to thiazole orange.

127 d the shared beta-alpha-beta-beta-alpha-beta core structure identified SPI-1 as a member of the I9 in

128 virus particles possessing a complete capsid core structure.IMPORTANCE Studies of retroviral particle

129 imization by modifying the rings A-C and the core structure in further SAR studies.

130 ino[d]isothiazolone or benzo[d]isothiazolone core structure in lieu of the dimethylpyridine-fused iso

131 mingly flexible and projecting away from the core structure in RCL, but loops back and is positioned

132 D)LCu(I)-CO possess the same four-coordinate core structure in solution with the variable D moiety "d

133 Aminodibenzazepinone 1, the core structure in the gamma-secretase inhibitor LY411575

134 of 4R tau and 3R tau share a highly ordered core structure in the third repeat with parallel, in-reg

135 All clamp loaders share a core structure in which five subunits form a spiral cham

136 te reactivity, while the preservation of the core structures in conjunction with extensive pi-pi and

137 n electron microscopy can reveal dislocation core structures in high detail, particularly in annular

138 or antibiotics, assembly of their polyketide core structures in nature remains poorly understood.

139 ibodies are directed at both side chains and core structures in the LOS molecule.

140 howed that a leucinol moiety attached to the core-structure in the 7-position together with alpha-met

141 noparticles that are comprised of a membrane/core structure including a surface-grafted polyethylene

142 e recognition of the analytes' small generic core structure is a demanding task due to limited space

143 The arylmethylsulfonylpyrrole core structure is a new pharmacophore for hGSTA1-1, wher

144 The Ste24p core structure is a ring of seven transmembrane helices

145 n immunodeficiency virus type 1 (HIV-1) gp41 core structure is a stable six-helix bundle formed by it

146 peat regions of the fusion-active HIV-1 gp41 core structure is critical for viral entry and inhibitio

147 h to the synthesis of the (iso)cyclocitrinol core structure is described.

148 The RRSV core structure is equivalent to the core structure of Or

149 This unexpected core structure is explained by a strong coupling of the

150 The core structure is highly homologous to other members of

151 s have a unique nanostructure in that a soft core structure is rigidized with a silane reagent, while

152 eaturing a unique 5,6,5,12-fused tetracyclic core structure, is the major component of spinosad, an o

153 the bicyclic templates and the nature of the core structure itself have a significant impact on the c

154 e proteins to create a series of DNA/histone core structures known as nucleosomes; these are further

155 The core structure, like that from other phages, is cone sha

156 ore chromophores; however, alteration of the core structure may be the actual source of energy dissip

157 Unusual dislocation core structures may be present in other technologically

158 ted synthesis, wherein stereochemically rich core structures may be reorganized into chemotypes that

159 ies reveal that these fibrils possess a beta-core structure nearly indistinguishable from that of amy

160 n studies have predicted an almost invariant core structure of 12 amino acid residues flanked by basi

161 n microscopy model of C complex reflects the core structure of a catalytically competent particle.

162 mpounds tetrahydropyrans (THPs) constitute a core structure of a wide array of bioactive natural prod

163 rious non-natural nucleosides that mimic the core structure of adenosine to modulate drug resistance

164 me how a long saturated chain can fit in the core structure of an acyltransferase domain through a de

165 he effects of the benzylic leaving group and core structure of arylboronates on H2O2-induced formatio

166 In addition, the chiral core structure of Au(11)L(4)X(2)(+) is not sufficient to

167 ditions were applied to the synthesis of the core structure of BIIB042, a gamma-secretase modulator,

168 e and its elaboration to a model tetracyclic core structure of calyciphylline B-type alkaloids.

169 This report describes modifications to the core structure of cambinol, in particular by incorporati

170 The centriole is the core structure of centrosome and cilium.

171 re self-reproducing organelles that form the core structure of centrosomes or microtubule-organizing

172 being a member of the Tombusvirus genus, the core structure of CNV is highly similar to that of Tomat

173 ter variations, and nontrivial handle-shaped core structure of defects.

174 is shown by the expeditious synthesis of the core structure of diclofensine.

175 The core structure of dislocations in sapphire introduced by

176 teps at 3D twin boundaries and imaged the 3D core structure of edge and screw dislocations at atomic

177 monstrated through a concise approach to the core structure of glaciolide and formal syntheses of fra

178 d (S)-analogue compounds that maintained the core structure of HPP but added bulky terminal groups we

179 144) protofilament is similar to the amyloid core structure of HuPrP(112-141) predicted by Zweckstett

180 ices in an inward-facing conformation with a core structure of inverted repeats of 5 TM helices (TM2

181 The asymmetric synthesis of the core structure of leucosceptroids A-D has been achieved.

182 Biochemical assays revealed clues that the core structure of LF3 was essential for inhibition.

183 rongest to mutants lacking the O-antigen and core structure of LPS, but still exposing lipid A on the

184 Arylamines constitute the core structure of many therapeutic agents, agrochemicals

185 we characterize the six-helix bundle fusion core structure of MERS-CoV spike protein S2 subunit by X

186 The RRSV core structure is equivalent to the core structure of Orthoreovirus and the virion structure

187 The core structure of Ran, outside the COOH tail, is not alt

188 f two adjacent beta-propellers that form the core structure of Sro7.

189 domain of FIN219 alters ATP binding and the core structure of the active site.

190 The core structure of the arylomycins and lipoglycopeptides

191 was demonstrated in a short synthesis of the core structure of the Aspidosperma alkaloid jerantinine

192 ytic system has been developed modifying the core structure of the bipyridine.

193 The geometry of the core structure of the budding yeast kinetochore reported

194 ion to construct the third ring found in the core structure of the cladiellins.

195 from the human posteromedial cortex (PMC), a core structure of the default mode network, during vario

196 Deletions that disrupt core structure of the EF-hand domains abolish LMAN1 bind

197 lowing us to propose a possible model of the core structure of the fibrils.

198 Manalpha3)Manbeta4GlcNAcbeta4GlcNAc-R is the core structure of the major processed protein N-glycans

199 ilin inhibitors was synthesized based on the core structure of the natural product sanglifehrin A.

200 ope-Mannich rearrangement that assembled the core structure of the natural product's unique ring syst

201 hesis of the hydrobenzofuro[3,2-b]chromenone core structure of the natural products sanggenon A and s

202 n of the Delta(6,7)-double bond found in the core structure of the natural products.

203 Alternatively, the core structure of the polyQ fibrils might also be a zipp

204 was elaborated to form the hydroxypiperidine core structure of the pseudodistomin alkaloids.

205 on of a cross-conjugated pentadienone to the core structure of the rocaglate natural products has not

206 How the huge core structure of the SPB is anchored in the NE has not

207 nding domain have deleterious effects on the core structure of the Z-discs in skeletal muscle.

208 e topology in the appearance, stability, and core structure of these defects remains poorly understoo

209 The core structure of thiomuracin exhibits similar antimicro

210 been previously described as a DBP, and its core structure of tribromoethene has been demonstrated t

211 the Galbeta1-4GlcNAc motif, which forms the core structure of type II glycans and is the precursor o

212 of the Delta (6, 7)-double bond found in the core structure of vindoline and defined our use of a pro

213 iving force for heterodimer formation is the core structure of ZnTs and not the BiFC tags.

214 Scaffolds are mostly used to represent core structures of bioactive compounds.

215 Cyclic amines are ubiquitous core structures of bioactive natural products and pharma

216 e moieties which enabled rapid access to the core structures of curcumanolide A and curcumalactone.

217 The core structures of DRAs are formed in secondary (i.e. sp

218 stematically determine, analyze, and compare core structures of kinase inhibitors.

219 g while simulations corroborate these stable core structures of Luciferase, and indicate the relative

220 gen heterocycles would provide access to the core structures of many natural products and pharmaceuti

221 Here we report the core structures of Q and the following product complex,

222 The formation of Sm core structures of spliceosomal U-rich small nuclear rib

223 lder-W is a web server capable of predicting core structures of telomerase RNA (TR) in yeast genomes.

224 r the subgenual anterior cingulate and other core structures of the CSPTC.

225 nance of chromosome (SMC) proteins forms the core structures of three multisubunit complexes as follo

226 demonstrated in the concise syntheses of the core structures of vincorine, isocorymine, and aspidophy

227 namics simulations on the entire, as well as core, structure of bovine CcO in a lipid-solvent environ

228 s are compatible with a precisely positioned core structure, one in which each of the 16 yeast centro

229 e natural products that often constitute the core structures or complete chemical entities for many c

230 No prior knowledge of core structures or R-groups is required, which are autom

231 ve-membered ring fused bicyclic lactone, the core structure present in gracilioether F.

232 n of a reaction product to yield a tricyclic core structure, present in various natural products.

233 osyl, and methyl groups about their aromatic core structure produced distinguishable H/D exchange pat

234 LCK appears to be intrinsic to its catalytic core structure rather than an autoinhibitory segment.

235 accumulated about the morphology and fibril-core structure recently.

236 The core structures represent new structural motifs for FGFR

237 he target focusing on docking poses with the core structure resembling a known bioactive conformation

238 apparent lack of effect on the polyQ fibril core structure seem surprising.

239 ment of an enantioselective route toward the core structure shared by all members of the stolonoxide

240 The GCRV core structure shows that the inner proteins have strong

241 f a polyglutamic acid side chain linked to a core structure similar to the one present in archaeal me

242 from a continuum-mechanical description, via core-structure simulation, to their full experimental ch

243 ies of diverse natural products with complex core structures such as 9,10-deoxytridachione, photodeox

244 age to the basal ganglia have indicated that core structures, such as the cortico-thalamic-basal gang

245 y, can form a stable six-helix bundle fusion core structure, suggesting that MERS-CoV enters into the

246 tibodies was affected by modification of the core structure, suggesting that these functional antibod

247 uggest that stress granules contain a stable core structure surrounded by a dynamic shell with assemb

248 and contain a biphasic structure with stable core structures surrounded by a less concentrated shell.

249 Unexpectedly, MHV NTD contains a core structure that has the same beta-sandwich fold as h

250 e an extensive statistical evaluation of the core structure that is inherent to all gene- set analyse

251 human DGAT-1 led to the identification of a core structure that was subsequently optimized to afford

252 ctures reveals conformational changes in the core structure that will enable future deployment of thi

253 Cycloalkane[d]isoxazoles form new core structures that interact with the hydrophobic regio

254 cal synthesis, KIIIA analogues that had as a core structure the disulfide-depleted KIIIA[C1A,C2U,C9A,

255 seven amide bonds central to the vancomycin core structure, the approach relied on two aromatic nucl

256 strain-dependent, solvent-inaccessible beta-core structures throughout most of the C-terminal half o

257 developing an algorithm using SIMION as its core structure to compute ion trajectory at different ra

258 if hCA and sCA can coassemble into the same core structure to form a mixed core, rhTRIM5alpha would

259 This DNA frame is used as a core structure to organize other functional materials in

260 It has a very similar core structure to that of bacterial and algal cytochrome

261 This work sheds light on the amyloid core structures underlying prion strains and how I138M,

262 r both states and (2) a change to the diiron core structure upon reduction.

263 of CDK9, its cellular functions, and common core structures used to target CDK9, along with their se

264 kinetic resolution of the tetrahydroxanthone core structure using homobenzotetramisole catalysis and

265 wo flanking integrase dimers that engage the core structure via their integrase carboxy-terminal doma

266 The carbocyclic core structure was assembled using a tandem phenolic oxi

267 Each of these core structures was then extended to up to 11 HMOs by 4

268 oducing adaptive elements into the inhibitor core structure, we undertake the structure-based develop

269 the 7-amino-5-thio-thiazolo[4,5-d]pyrimidine core structure, we were able to achieve compounds with h

270 The final two bonds of the core structure were forged through a samarium diiodide-m

271 uct alangiobussinine and the marinacarboline core structure were functionalized using carboline-direc

272 smodium vivax (Pv) SHMT with a pyrazolopyran core structure were identified.

273 Forty-four substituted derivatives of this core structure were synthesized using a variety of benza

274 te (LCP) nanoparticles (NPs) with a membrane/core structure were used to encapsulate ACVP to facilita

275 the basis of 3 versatile building blocks, 3 core structures were chemically synthesized via consiste

276 sing automated glycan assembly, these common core structures were constructed and elaborated to acces

277 ses, angular capsids that contained internal core structures were readily observed by conventional el

278 allic acid substituted compounds, of diverse core structure, were characteristic of the phytochemical

279 (m/z = 449.174), which most likely represent core structures, were absent in all infected monkeys stu

280 Cu(I) series possess an identical tridentate core structure where the cuprous ion binds to the bispic

281 nds ThT, is ultrastable, and has a fibrillar core structure, whereas necrosis is partially inhibited

282 tetrameric form contained a D(2d)-symmetric core structure, whereas the dimers were determined exper

283 discovered a tobramycin-moxifloxacin hybrid core structure which enhances outer membrane permeabilit

284 ormed extensive modifications on its pyrrole core structure, which has culminated in the discovery of

285 erium and contain a bicyclic phosphotriester core structure, which is a rare motif among natural prod

286 y stable assembly of untranslated mRNPs into core structures, which could provide sufficient high loc

287 ch for active compounds containing different core structures, which is a topic of high interest in me

288 gram scale synthesis of a versatile bicyclic core structure with a high degree of stereoretention.

289 yclopeptides containing a 13-membered cyclic core structure with a synthetically challenging chiral t

290 MOHQ may be rationalized by invoking an open-core structure with a terminal Fe(IV) horizontal lineO m

291 e intermediate possesses a di-mu-oxo diamond core structure with a terminal hydroxide ligand to the M

292 el antiestrogens based on a simple adamantyl core structure with acrylate side chains optimized for c

293 extensive superfamily of PGTs that reveals a core structure with dual domain architecture featuring a

294 ituent amino acids within the peptidolactone core structure with more conformationally constrained co

295 rA3G-CD1 shares a conserved core structure with the previously determined catalytic

296 s spp. bearing the bicyclo[2.2.2]diazaoctane core structure with unusual structural diversity represe

297 f these metabolites arises by conjugation of core structures with diverse chemical moieties, such as

298 MCF, offering flexibility to fabricate dense core structures with same cladding diameter.

299 lso find samples with a truncated decahedral core structure, with some samples exhibiting a coexisten

300 d platform, a general shared decision-making core structure would accommodate simple, interchangeable