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1 sts, it is possibly not due to its role as a coreceptor.
2 gh viral adaptation to use a drug-bound CCR5 coreceptor.
3 acement of filamentous actin from the CD4(+) coreceptor.
4 i-inflammatory effect is binding to the CD14 coreceptor.
5 (CCR5) or C-X-C chemokine receptor 4 (CXCR4) coreceptor.
6 g via a plexin receptor without a neuropilin coreceptor.
7 interactions with the cellular receptor and coreceptor.
8 ss sensitive, even in the absence of the CD8 coreceptor.
9 protein (Env) and cellular CD4 receptors and coreceptors.
10 inhibitory receptors, as well as modulating coreceptors.
11 us interactions with both the CXCR4 and CCR5 coreceptors.
12 GPR15 and CXCR6 to serve as potential entry coreceptors.
13 p120 that allow high-affinity binding to its coreceptors.
14 ding of soluble Sema3A to Neuropilin/PlexinA coreceptors.
15 that lack expression of CD4 and CD8alphabeta coreceptors.
16 y superantigens does not require CD4 and CD8 coreceptors.
17 strong for cells with low surface density of coreceptors.
18 We cloned sabaeus CD4 and 10 candidate coreceptors.
20 ximately 100 times more efficiently and that coreceptor activation is reversible, enabling synchronou
21 erapeutic approach aimed at blocking the HIV coreceptor activity of CXCR4 without knocking down its c
22 ich is required to be phosphorylated for TCR coreceptor activity, and a dileucine endocytosis motif.
23 hough these DN thymocytes fail to re-express coreceptors after OP9-DL1 culture, they eventually matur
24 pt expression in testes, we show that the OR coreceptor, AgOrco, is localized to the flagella of A. g
25 e V3 loop, blocking its interaction with the coreceptor and altering the structure of the envelope sp
28 upled receptor (GPCR) that serves for an HIV coreceptor and was also recently found as a novel homing
29 The Arabidopsis genome encodes nine PP2C coreceptors and 14 different RCARs, which can be divided
30 , instead, processes in the thymus involving coreceptors and other molecules select MHC-specific TCRs
31 cooperative binding between the TCR and CD4 coreceptor, and a low frequency of Ag-specific CD4(+) T
33 hybrid pattern recognition receptors and TCR coreceptors, and they may function as antimicrobials.
40 CCR5, which indicates that alternative entry coreceptors are used by SIV in vivo in these animals.
41 o studied species, the expression of the SIV coreceptor as well as the expression of a number of host
44 aran sulfate proteoglycan were implicated as coreceptors because only the combination of anti-DC-SIGN
47 loop highly flexible, implying disruption of coreceptor binding and attachment to the target cell.
48 can coordinately suppress both receptor and coreceptor binding and conformationally entrap the prote
49 D4-induced conformational changes leading to coreceptor binding and fusion, and HIV-1 Env conformatio
52 e cell membrane can be inhibited by blocking coreceptor binding or by preventing fusion-inducing conf
53 essibility of bNAb epitopes in the CD4bs and coreceptor binding region, thus representing a potential
54 mponent of the Env trimer contributes to the coreceptor binding site and is a target for neutralizing
57 ycoproteins on these HIV-1 variants expose a coreceptor binding site that overlaps some CD4-induced (
58 xposure or the stability of the receptor and coreceptor binding site without affecting the integrity
59 (CD4) and an antibody (36D5) at part of the coreceptor binding site, we visualized multiple conforma
63 on that the antigenicity of the receptor and coreceptor binding sites can be modulated by a single gl
65 as insensitive to actin inhibitors, post-CD4/coreceptor binding steps during FFWO were abrogated.
68 i) antibodies, which recognize the conserved coreceptor-binding site of the HIV-1 envelope glycoprote
70 ides simultaneously target the receptor- and coreceptor-binding sites of the HIV-1 envelope glycoprot
73 ing between prefusion-closed, CD4-bound, and coreceptor-bound conformations by transitioning into a p
74 induced defense responses required the known coreceptor BRASSINOSTEROID INSENSITIVE 1-ASSOCIATED RECE
75 id differentiation protein 2 (MD2) is a TLR4 coreceptor, but its role in pollen- and cat dander-induc
80 p120 binds to CD4, the HIV-1 receptor, and a coreceptor, capturing an open conformational state in wh
81 y lipoprotein receptor-related protein 5 Wnt coreceptor causes constitutive activation of Wnt signali
86 IV) have been described that can utilize the coreceptor CCR5 or CXCR4 in the absence of CD4, these vi
87 ntry inhibitor drug maraviroc makes the cell coreceptor CCR5 unavailable for use by HIV-1 and is now
88 erse transcriptase, protease, integrase, and coreceptor CCR5 with EC50's ranging from 0.9 to 1.5 muM.
89 HIGH) CD4(+) T cells, do not express the HIV coreceptor CCR5 yet serve as a latent reservoir in GCs.
90 press very low levels of the canonical entry coreceptor CCR5, and recent studies have shown that CCR5
91 R3(+) cells preferentially expressed the HIV coreceptor CCR5, and vaccine-induced CXCR3(+)CXCR5(+) ce
92 memory CD4(+) T cells often express the HIV coreceptor CCR5, are significantly more proliferative, a
93 hosts have very low levels of the SIV entry coreceptor CCR5, suggesting that restricted entry may li
97 f T(SCM) cells were found to express the HIV coreceptors CCR5 and CXCR4 and were infected by HIV both
98 the viral entry receptor CD4 as well as the coreceptors CCR5 and CXCR4 from the surface of HIV-infec
105 double blockade of complement C5 and the TLR coreceptor CD14 could improve survival of experimental p
106 nally, antibodies against TLR2, TLR4, or the coreceptor CD14 reduced the profibrotic responses of ure
110 -particle tracking, we show how the negative coreceptor CD22 works with the cortical cytoskeleton in
113 on via the T cell antigen receptor (TCR) and coreceptor CD28 to accelerate and increase Mir210 expres
114 ulation with antigen or via the TCR plus the coreceptor CD28, with Lys325 and Lys506 being the main s
115 report the influence of signaling domains of coreceptors CD28 and 4-1BB on the metabolic characterist
116 substrate through the T-cell receptor (TCR) coreceptor CD3 and CD28, a costimulation signal essentia
120 ion of the gene encoding the T cell-specific coreceptor CD4 in helper and cytotoxic T cells exemplifi
122 T cells expressed memory markers and the HIV coreceptors CD4 and CCR5; they were not detected in subj
123 seconds) interaction between CD3zeta and the coreceptor CD8 that is independent of the binding of CD8
124 is triggered by interactions of the TCR and coreceptor (CD8 or CD4) with antigenic peptides embedded
125 ion, killing stimulatory receptor Ly49s6 and coreceptor CD8alphaalpha on this cell used rat nonclassi
126 -cadherin ligation and involves the cadherin coreceptor Cdo with its downstream effector, Cdc42.
127 eptor cluster of differentiation 4 (CD4) and coreceptors chemokine receptor type 5 and chemokine-rela
129 ates to the F-box protein COI1-JAZ jasmonate coreceptor complex and suggest that coincidence detectio
132 ory expression of an NB2 (Contactin5)/Caspr4 coreceptor complex, together with spinal interneuron exp
134 ppression and whether association with other coreceptor complexes is needed have remained unknown.
135 ort that formation of the pre-fusion Env-CD4-coreceptor complexes triggers non-apoptotic cell surface
137 ingly, we used HIV envelope gp140 and CD4 or coreceptor (CoR) binding site (bs) mutant probes to eval
139 udy, we demonstrate the efficient use of the coreceptor CXCR6 by SIVagmSab to infect sabaeus African
142 D8(+) T cells can, in the absence of the CD8 coreceptor, elicit CD4 T cell help and partially reverse
143 cells, are missing for the endothelial cell coreceptor endoglin and for the ALK1 type I receptor, wh
144 but also, critically, by promoting B7-2/CD28 coreceptor engagement, forcing the principal costimulato
150 e members of the Siglec family of inhibitory coreceptors expressed on B cells that participate in enf
152 st-selected double-positive cells lose CD4/8 coreceptor expression and masquerade as double-negative
153 ssion status, downregulates HIV receptor and coreceptor expression and may reduce susceptibility of i
155 ne their effects on cellular activation, HIV coreceptor expression, and innate restriction factor exp
162 t neuropilin 1 (Nrp1), an originally defined coreceptor for class 3 semaphorins and VEGF, plays impor
164 ng sites identified betaKlotho, an essential coreceptor for FGF21, as a direct target gene of Rev-erb
165 Membrane-bound Klotho acts as a permissive coreceptor for FGF23, and its expression was recently fo
166 ne-bound protein (mKL) and recognized as the coreceptor for fibroblast growth factor-23 (FGF23) and a
168 nt located in the CCR5 mRNA, which encodes a coreceptor for HIV-1 and is, to our knowledge, the first
171 results identify SorCS2 as an indispensable coreceptor for p75(NTR) and TrkB in hippocampal neurons
172 signal-dependent cooperation between TCR and coreceptor for pMHC binding previously observed for CD8
176 CCR5 has been described as the primary entry coreceptor for SIV in vivo, while human-derived CXCR6 an
178 tor-related protein 6 (LRP6) is an essential coreceptor for Wnt signaling, and its genetic variants h
179 ion is the use of CXCR6 or other alternative coreceptors for entry, which may direct SIV toward CD4(+
180 rt that acidic lipids function with Ypt7p as coreceptors for HOPS, supporting membrane tethering and
181 agmVer entry in vitro and may serve as entry coreceptors for SIVagm in vivo, since their mRNAs were d
184 ycan motifs of gangliosides serve as initial coreceptors for these protein complexes, whereby a membr
186 gnaling through promoting degradation of Wnt coreceptors Frizzled (FZD) and LRP6, and this activity i
187 ves to infect new cell types by changing the coreceptor from CCR5 to CXCR4 to infect naive T cells or
190 ch has been most notably applied to the CCR5 coreceptor gene, or the introduction of small mutations
192 ps, via the Ret receptor tyrosine kinase and coreceptor Gfralpha1; Ret signaling up-regulates transcr
196 ne morphogenetic protein 6 (BMP6) or the BMP coreceptor hemojuvelin (HJV) in mice leads to a similar
199 RT) drug to target a human protein, the CCR5 coreceptor; however, the mechanisms of maraviroc-associa
200 promoting or repressive activity of a single coreceptor in multiple simultaneously active pathways.
201 sociated receptor kinase1 (BAK1) is a common coreceptor in plants and regulates distinct cellular pro
205 ugh the use of the simian CD81 ortholog as a coreceptor, indicating that HCV entry is not restricted
206 rst extramembrane loop of CCR5 (the main HIV coreceptor), induce a long-lasting internalization (48 h
208 sults demonstrate that NF279 is a dual HIV-1 coreceptor inhibitor that interferes with the functional
209 sts could thus represent a new class of dual-coreceptor inhibitors with a structure and a mechanism o
210 er interfaces, areas remote from where these coreceptors interact, implying that inflammatory signali
212 depends on Ca(2+) signaling triggered by Env-coreceptor interactions and involves the lipid scramblas
214 er, the emergence of viruses using the CXCR4 coreceptor is a concern for therapies applying single-co
215 nist Eritoran, and provide evidence that the coreceptor is a molecular switch that undergoes ligand-i
216 nteraction of the Lck kinase with CD4 or CD8 coreceptors is critical for generation of MHC specificit
220 ent capacity for epigenetic reprogramming of coreceptor levels on effector CD8(+) T cells enables the
222 (-/-) mice to determine contributions of Wnt coreceptor low-density lipoprotein receptor-related prot
223 ncogenic Wnt signaling by binding to the Wnt coreceptor low-density lipoprotein receptor-related prot
224 ired Wnt signaling caused by loss of the Wnt coreceptor Lrp5 in models of lung fibrosis induced by bl
227 We show that folding of the Wnt signaling coreceptor LRP6 is promoted by ubiquitination of a speci
228 that miR-19a negatively regulates FZD4, its coreceptor LRP6, and WNT signaling, and that antagonism
229 gest that simultaneous disruption of the HIV coreceptors may provide a useful approach for the long-t
230 r 4 (TLR4) in complex with its lipid-binding coreceptor MD-2, but subtle structural variations in LPS
231 We identified two anti-HIV-1 antibodies, the coreceptor mimicking antibody 17b and the gp120-gp41 int
233 engaged T cell receptor (TCR) scans multiple coreceptor molecules to find one that is coupled to Lck;
235 anized mouse model of HIV-1 infection, these coreceptor negative cells engraft and traffic normally,
236 s for the extracellular matrix (ECM) and the coreceptor NRP1, which leads to distinct vascular phenot
237 eptor accessory protein (IL1RAP; IL1R3) is a coreceptor of interleukin-1 receptor type 1 and has been
238 tin (Siglec) family member, is an inhibitory coreceptor of the BCR with established roles in health a
239 CCR5 and CXCR4, the respective cell surface coreceptors of R5 and X4 HIV-1 strains, both form hetero
241 er defects associated with loss of receptor, coreceptor, or ligand, indicating that Norrin/Frizzled4
247 T cells with regard to the inhibitory T-cell coreceptors PD-1 and Tim-3 in patients with metastatic m
248 inactivates the phosphatase activity of the coreceptor, permitting phosphorelay of the ABA signal vi
249 expressing alphabeta TCR but lacking CD4/CD8 coreceptors play protective as well as pathogenic roles.
252 at synergy emerges when Env engages multiple coreceptors prior to inducing fusion and when high-affin
253 hereby the risk variant augments the BCR and coreceptor programs throughout B cell development, promo
254 B cell-activating factor receptor, and CD40 coreceptor programs, leading to broadly enhanced positiv
255 Evidence indicates that Abs binding to the coreceptors promotes T cell egress from these tissues.
256 oposed that differential kinetics of CD4/CD8 coreceptors regulate fate choice of selected thymocytes.
257 am of Lrp5, but not the closely related Lrp6 coreceptor, regulate the activation of beta-catenin and
258 nd its interaction with CD44 (a putative MET coreceptor regulated by Wnt signaling and highly express
259 a (TGF-beta) receptors and its modulation by coreceptors represent an important level of regulation f
260 substrate), a receptor tyrosine kinase (RTK) coreceptor required for cellular migration, and pro-NRG1
261 and transcriptional silencing of CD8 or CD4 coreceptors, respectively, in MHC class II or I (MHCII o
265 Monoclonal antibodies (mAbs) against the HCV coreceptor scavenger receptor class B type I (SR-BI) inh
266 -glycan branching of TCR and the CD4 and CD8 coreceptors separately altered the upper and lower affin
267 rmline encoded TCR bias for MHC, and for the coreceptor sequestration model in the context of allorea
268 early actin activity by hijacking chemokine coreceptor signaling, which activates a host dependency
270 nhibitors suppresses binding at both CD4 and coreceptor sites on Env and triggers gp120 shedding, lea
274 heir interactions with the type III TGF-beta coreceptor (TbetaRIII) in live cells and their effects o
276 receptor kinases (SERKs) are ligand-binding coreceptors that are able to combine with different liga
279 f their B-cell antigen receptor (BCR) and of coreceptors through which signals from helper T cells or
280 tion of the retinoid X receptor-alpha (RXRA) coreceptor to PML/RARA is required for transformation, w
281 -associated minor H antigen, HA-1; (2) a CD8 coreceptor to promote function of the class I-restricted
282 t a model in which TIM4 engages integrins as coreceptors to evoke the signal transduction needed to i
283 sion level is low, the use of CXCR6 or other coreceptors to mediate infection may target SIV toward d
284 nce in the env and pol genes, and determined coreceptor tropism and the frequency of drug resistance
286 neutralizing antibodies (bNab), determining coreceptor tropism of the virus, identifying compartment
289 at the modest but significant differences in coreceptor usage efficiency, IFN-alpha sensitivity and v
293 ogous and heterologous plasma, and chemokine coreceptor usages for cell entry, suggesting similar abi
294 presenting different clades, tissue origins, coreceptor usages, and neutralization sensitivities.
298 XCR6 and CCR5 were more efficient than other coreceptors when tested at limiting CD4/coreceptor level
299 due to preexisting virus that uses the CXCR4 coreceptor, while true resistance occurs through viral a
300 myeloid differentiation factor-2 (MD-2), the coreceptor within the TLR4/MD-2 receptor complex, as the
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