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1 ce of dual coregulator functions of a master coregulator.
2 ll type-specific functions of this important coregulator.
3 ide synthesis pathways and a transcriptional coregulator.
4 he nucleus and function as a transcriptional coregulator.
5 ogenic mutations in a global transcriptional coregulator.
6 quences may also contain binding sites for a coregulator.
7 base damage, is an important transcriptional coregulator.
8 s in directing in vivo functions of a master coregulator.
9 derstood about its role as a transcriptional coregulator.
10 ical complex with the LEUNIG transcriptional coregulator.
11 phosphorylation activates it into a powerful coregulator.
12 ne-rich protein-1 (PELP1/MNAR) is a novel NR coregulator.
13 gulatory transcription factor GATA-1 and its coregulators.
14 and are involved globally as transcriptional coregulators.
15 nerships with other DNA-binding proteins and coregulators.
16 extended to understand other transcriptional coregulators.
17 ssion by recruiting diverese transcriptional coregulators.
18 ceptor (GR) is mediated by interactions with coregulators.
19 y, respond to a wide range of amino acids as coregulators.
20 actions of transcription factor proteins and coregulators.
21 f AR is mediated largely by distinct nuclear coregulators.
22 eacetylases (HDACs) are important epigenetic coregulators.
23 eptor (TR) for regulating the recruitment of coregulators.
24 ll4, and LRH-1, as statistically significant coregulators.
25 uding THAP11 and ZNF143, and transcriptional coregulators.
26 d3 transcription complexes by competing with coregulators.
27 formations that interact differentially with coregulators.
28 rough competition for their microRNA (miRNA) coregulators.
29 were initially described as transcriptional coregulators.
31 rogram and suggest that this transcriptional coregulator acts as a bifunctional molecular switch for
32 o GCN5 or PCAF (GCN5/PCAF), other epigenetic coregulators (ADA2-A, ADA3, STAF36, and WDR5), cofactors
34 has been shown as a steroid hormone receptor coregulator and also as a crucial factor in DNA repair.
35 We have found that Pias3, a transcriptional coregulator and E3 SUMO ligase that is selectively expre
36 -1/steroid receptor coactivator-3, a nuclear coregulator and oncogene frequently amplified in human b
37 tiple mechanisms, including pioneer factors, coregulators and epigenetic modifications have been iden
39 tive, we retrace our steps into the field of coregulators and provide a summary of selected seminal w
40 ancer that affects ERalpha interactions with coregulators and shifts the DNA-binding signature of ERa
41 ittle is known about the identity of the key coregulators and the mechanisms by which they may potent
42 Second, coexpression of a set of 62 known NR coregulators and the six steroid receptors in 12 nonover
43 complexes containing transcription factors, coregulators, and additional non-DNA binding components.
44 disrupts the interaction between AR and its coregulators, and also increases cell survival by decrea
45 s of ERalpha expression, altered activity of coregulators, and cross-talk between the ERalpha and gro
47 e than 100 genes encoding nuclear receptors, coregulators, and their direct/indirect targets was stud
48 nscript HOTAIR is coordinated via ERs and ER coregulators, and this mechanism of HOTAIR overexpressio
49 iple coregulators at all loci, or if certain coregulators are dedicated to specific loci is unknown.
53 RNA polymerase II transcription factors and coregulators are recruited to promoters and other regula
54 omatin-associated factor and transcriptional coregulator, as a ligand-independent macrodomain-interac
55 e Trip-Br (SERTAD) family of transcriptional coregulators, as a molecule that is required for normal
57 urthermore, whether GATA-1 utilizes multiple coregulators at all loci, or if certain coregulators are
58 eractions with several transcription factors/coregulators at the promoter elements of various genes.
59 t binding of both, transcription factors and coregulators at the type 2 diabetes associated PPARG loc
63 the interaction of the VDR with a library of coregulator binding motifs in the presence of two ligand
65 receptor conformational changes that impact coregulator binding, transactivation and target gene exp
66 signals between dimer partners, ligands and coregulator-binding sites, thereby affecting signal tran
67 atory complexes that include both GR and the coregulator Brm, an ATPase subunit of the Swi/Snf chroma
72 ndings establish the principle that a single coregulator can function as a signal-dependent and coord
74 ification of both, transcription factors and coregulators, can profoundly improve understanding of me
75 rily conserved AAA ATPase ANCCA (AAA nuclear coregulator cancer-associated protein)/ATAD2 was identif
80 eam effector molecules, the nuclear receptor coregulators, compared with the full agonist dexamethaso
81 architectural factor HMGA1 and the Mediator coregulator complex cooperate to enhance basal transcrip
82 The Mediator is a conserved transcriptional coregulator complex required for eukaryotic gene express
83 hormone-induced assembly of transcriptional coregulator complexes at chromatin is a process facilita
85 is achieved by signal-dependent exchange of coregulator complexes that function to read, write, and
86 anisms involving the recruitment of specific coregulator complexes to the promoters of cell cycle gen
92 ver, a detailed picture of the complexity of coregulators (CoRs) bound to a defined enhancer along wi
94 th PPARgamma affected the recruitment of the coregulators cyclic-AMP response element-binding protein
96 establish Ldb1 as a critical transcriptional coregulator during islet alpha-, beta-, and delta-cell d
102 cally altered recruitment of transcriptional coregulator factors by SoxE proteins, displacing coactiv
104 DD4/5 is required for the recruitment of the coregulators FOG1 and the nucleosome remodeling and deac
106 as a positive and a negative transcriptional coregulator for discrete subsets of genes that are regul
108 cogene AIB1/ACTR/SRC-3 and a transcriptional coregulator for estrogen and androgen receptors and is s
117 e first authentic coregulator, more than 400 coregulators have been identified and characterized, and
118 evidence suggests that nuclear receptor (NR) coregulators have potential to act as master genes and t
119 ssociate physically with the transcriptional coregulator HCF-1 (host cell factor 1) and recruit HCF-1
121 of ES cells, binds with its transcriptional coregulator, Hcf-1, to a highly conserved enhancer eleme
122 issense mutation in a global transcriptional coregulator, HCFC1, was identified in the index case.
123 domain, but Lin11, Isl-1, Mec-3 (LIM) domain coregulator Hic-5 (TGFB1I1) binds to the relatively unch
124 we examined recruitment of nuclear receptor coregulators, histone modifications and RNA polymerase I
129 uclear receptor interacting factor 3 (NRIF3) coregulator in a wide variety of breast cancer cells sel
130 oma protein), functions as a transcriptional coregulator in many fundamental cellular processes.
131 abundance, primate-specific steroid receptor coregulator in normal tissues of the human reproductive
133 lysis suggested that addition of the nuclear coregulators in a multivariable analysis with ER and E2
134 ssion and activity of androgen receptor (AR) coregulators in prostate cancer is an important mechanis
136 role of specific nuclear receptors and their coregulators in the dynamic control of mitochondrial bio
137 ic combinations of transcription factors and coregulators in the fine tuning of organismal metabolism
138 s-associated protein 1 (MTA1), a dual master coregulator, in epithelial cells, and that MTA1 status i
140 R-mediated gene regulation is enhanced by AR coregulators, inactivation of those coregulators is emer
142 en stimulation, ERalpha recruits a number of coregulators, including both coactivators and corepresso
143 TR-FRET-based competitive ligand binding and coregulator interaction assays to screen 2693 compounds
146 ifies the measurement of ligand-modulated TR-coregulator interactions and should improve the overall
149 de evidence that targeting androgen receptor-coregulator interactions using peptidomimetics may be a
150 monstrate the unexpectedly dynamic nature of coregulator interactions within enhancer complexes, whic
151 on and activation as well as the dynamics of coregulator interactions within the enhancer complex.
153 far, the only example of a nuclear receptor coregulator involved in suppression of kidney cancer and
154 ed by AR coregulators, inactivation of those coregulators is emerging as a promising therapy for pros
157 e of combinational PTM codes on histones and coregulators is profoundly shaped by regulatory interpla
158 tivity by the androgen receptor (AR) and its coregulators is required for male reproductive developme
159 One such group of ubiquitously expressed coregulators is the metastasis-associated protein (MTA)
160 us, while Med1 is a context-dependent GATA-1 coregulator, it also exerts specialized functions in ery
161 -2 or SRC-3, we hypothesized that permissive coregulator levels comprise a necessary adipogenic equil
164 nt nuclear receptors at different domains by coregulator may lead to differential receptor transactiv
166 ncreasingly accepted that steroidal receptor coregulators may also function in the cytoplasmic compar
167 CoR and HDACs, indicating that this class of coregulators may play a previously unrecognized role dur
168 P-ribosyl)ation of transcription factors and coregulators, mediated by the poly(ADP-ribose) polymeras
169 (CITED2), a mechanosensitive transcriptional coregulator, mediates this chondroprotective effect of m
170 GATA-1 corepressor expands the repertoire of coregulators mediating establishment/maintenance of the
173 r coactivator-1 (SRC-1), the first authentic coregulator, more than 400 coregulators have been identi
174 the recently established role for the master coregulator MTA1 and MTA1-containing nuclear remodeling
175 ically interacts with bodies enriched in the coregulator NCoA-2, DNA-dependent foci and chromatin tar
176 identified component of the transcriptional coregulator network, was found to interact with the Nucl
183 These results demonstrate that FUS is a coregulator of MITF activity and provide new insights in
184 ng noncoding RNA, LincRNA-Tnfaip3, acts as a coregulator of NF-kappaB to modulate inflammatory gene t
187 , this work identifies CHD4 as an epigenetic coregulator of PAX3-FOXO1 activity, providing rational e
192 that TET2 protein is a cofactor of EBNA2 and coregulator of the EBV type III latency program and DNA
193 icate that HO-1 plays an important role as a coregulator of the erythroid differentiation process.
194 tor-gamma coactivator-1alpha (PGC-1alpha), a coregulator of the GCs receptor (GR), and that the overe
196 teracting protein (GRIP)1, a transcriptional coregulator of the p160 family, which is recruited to th
197 The histone acetyltransferase TIP60 is a coregulator of transcription factors and is implicated i
200 and -beta serve as inducible transcriptional coregulators of genes involved in mitochondrial biogenes
202 osphatases, Cdc25C and PP2Acalpha, which are coregulators of the G(2)-M checkpoint, are inhibited by
203 ry biomarker C-reactive protein as prominent coregulators of the observed annual pulse increases.
209 ciation of both PPARbeta/delta and PPARgamma coregulator peptides in response to ligand activation, c
210 complex that was devoid of ERRgamma and the coregulator peroxisome proliferator-activated receptor g
211 udies suggest that PRDM16 and its associated coregulators PPARgamma coactivator-1alpha (PGC-1alpha) a
212 rough the progesterone receptor (PR) and its coregulators prepares the human endometrium for receptiv
213 Here we report our study of endogenous human coregulator protein complex networks obtained from integ
214 Rgamma modulator characteristics by inducing coregulator protein interactions, PPARgamma-dependent ex
215 e "open" chromatin compartment together with coregulator proteins essential for regulation of gene ex
217 involving LXXLL motifs in androgen receptor-coregulator proteins such as PELP1 using a novel, small
218 tory elements of target genes and recruiting coregulator proteins to remodel chromatin and regulate t
222 pose energy homeostasis via these metabolism coregulators, provides a potential therapeutic strategy
223 ; the response regulator RcsB; the accessory coregulator RcsA; and an outer membrane bound lipoprotei
224 y impact SF-1 function, the conformation and coregulator recruitment of fully sumoylated SF-1 LBD pro
227 -L1 is mediated by differential RA-dependent coregulator recruitment to the receptor/Glucocorticoid R
229 -fold vs. E2) is enhanced at several levels (coregulator recruitment, chromatin binding); nevertheles
230 we show that MAGE-11 is an isoform-specific coregulator responsible for the greater transcriptional
232 ere, we demonstrate that the transcriptional coregulator RIP140 regulates intestinal homeostasis and
233 PXR and RXRalpha bind to the transcriptional coregulator SRC-1 with higher affinity when they are par
234 rogen receptors ERalpha and ERbeta, with key coregulators (SRC3 and RIP140) and chromatin binding sit
235 is recruited to ERalpha by steroid receptor coregulators (SRCs) for enhancer maturation and maintena
236 pregulation of the oncogenic transcriptional coregulator steroid receptor coactivator 2 (SRC-2), also
237 cal interactions of TBP with transcriptional coregulator subunits and with the general transcription
239 ational modifications (PTMs) on histones and coregulators such as corepressors, coactivators, DNA-bin
240 trogen receptors (ERs) along with various ER coregulators such as histone methylases MLL1 (mixed line
243 adipose tissue, nuclear receptors and their coregulators, such as peroxisome proliferator-activated
244 re complex than is generally recognized, and coregulators, such as Tax, likely play a critical role i
245 DC-specific transcript (DC-SCRIPT) as an NR coregulator, suppressing type I steroid NRs estrogen rec
247 essful transition between these two phases ("coregulator switching") is required for proper enhancer
249 g protein 140 (RIP140) is a nuclear receptor coregulator that affects a wide spectrum of biological p
250 s of melanoma antigen gene protein-11, an AR coregulator that binds the AR FXXLF motif and targets AF
251 vator-1alpha (PGC-1alpha), a transcriptional coregulator that binds to numerous transcription factors
252 c demethylase 1 (KDM1A) is a transcriptional coregulator that can function in both the activation and
253 yltransferase 1 (CARM1) is a dual functional coregulator that facilitates transcription initiation by
254 erosum SELF-PRUNING 6A), a FLOWERING LOCUS T coregulator that functions as a signal for tuberization.
255 ene protein-A11 (MAGE-11) is an AR selective coregulator that increases AR transcriptional activity.
256 Herein, we show that CoAA is a dual-function coregulator that inhibits G(1)-S transition in human kid
258 cells and acts as an ERalpha transcriptional coregulator that is recruited by 17beta-estradiol to the
259 eucine rich protein 1) is a nuclear receptor coregulator that is upregulated during breast cancer pro
260 eucine-rich protein 1) is a nuclear receptor coregulator that plays an important role in ER signaling
261 RERE is a widely-expressed nuclear receptor coregulator that positively regulates retinoic acid sign
262 y protein 4 (LMO4) is a transcription factor coregulator that promotes the assembly of multiprotein c
263 ivator activator (CoAA) is a dual-functional coregulator that regulates steroid receptor-mediated tra
264 a antigen gene protein 11 (MAGE-11) is an AR coregulator that specifically binds the AR NH(2)-termina
265 F3 is an estrogen-inducible nuclear receptor coregulator that stimulates estrogen receptor-alpha (ERa
266 CgrC proteins of Pseudomonas aeruginosa are coregulators that are required for the phase-variable ex
267 ases and a host of transcription factors and coregulators that control their activity during transcri
270 roid receptor RNA activator (SRA) binding NR coregulators that target steroid-responsive promoters an
271 on can alter the selective binding of TFs to coregulators, that prior binding events can lead to sele
273 el of metastasis-associated protein 1 (MTA1) coregulator, the physiological role of the MTA1 coactiva
274 proteomic technique, we identified a new AR coregulator, the transcription factor Grainyhead-like 2
275 e activity of transcriptional regulators and coregulators, there are few examples of core components
276 o the DAD limits HDAC3 interaction with this coregulator, thereby facilitating SMRT coactivation of p
277 fferent tissues expressing different sets of coregulators, thus facilitating the goal of developing t
279 tor of hematopoiesis GATA-1 recruits diverse coregulators to chromatin, which mediate transcriptional
284 his screen was directed against a variety of coregulators, transcription modifiers, signaling molecul
285 liver fluke Opisthorchis viverrini and this coregulator using both an Mta1(-/-) mouse model of infec
287 on of MTA1 (metastasis-associated protein 1) coregulator via NF-kappaB signaling in hepatic cells.
290 y in eukaryotic transcription is provided by coregulators, which are recruited by DNA-binding factors
291 summary, this study has identified a new AR coregulator with a multifaceted role in prostate cancer,
292 een the roles for BRCA1 as a transcriptional coregulator with control of its expression via an autore
293 d blocks the interaction between a subset of coregulators with both native and mutant forms of ER.
295 riptional activity of AR is modulated by the coregulators with which it interacts, and consequently d
296 ecific master regulators and transcriptional coregulators within developmental stage-specific enhance
298 esults indicate that YvrI and its associated coregulators YvrHa and YvrL are required for the regulat
299 cell factor 1 (Ebf1) and the transcriptional coregulator Zfp521 as components of the machinery that r
300 inc finger unit found in the transcriptional coregulator ZNF217 recognizes DNA but with an affinity a
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