ライフサイエンスコーパス: corepressor

1 expression by functioning as a transcription corepressor.

2 sandwiched between the HDAC and its cognate corepressor.

3 cetylase 3 (HDAC3)-dependent transcriptional corepressor.

4 lling and deacetylase (NuRD) transcriptional corepressor.

5 structure of HDAC3 in complex with the SMRT corepressor.

6 pendently of the Groucho/Tle transcriptional corepressor.

7 (MGEs), LexA often does so in concert with a corepressor.

8 cluding Split Ends (SPEN), a transcriptional corepressor.

9 , less is known about how CSL interacts with corepressors.

10 emically stable and contain certain atypical corepressors.

11 a counteractive regulation by the Tup-family corepressors.

12 odulated by tissue-specific coactivators and corepressors.

13 stress-inducible genes via counteraction of corepressors.

14 he glucose sensors to promote binding of the corepressors.

15 sor element-1 silencing transcription factor corepressor 1 (LSD1/CoREST) histone demethylase complex

16 hormone receptor (SMRT) and nuclear receptor corepressor 1 (N-CoR) that accumulated in synchronized H

17 Nuclear corepressor 1 (NCoR) associates with nuclear receptors a

18 targeted inhibition of BCL6/nuclear receptor corepressor 1 (NCoR) complex by peptidomimetic inhibitor

19 lpha) with its cosuppressor nuclear receptor corepressor 1 (NCOR).

20 Conversely, mice expressing a mutant nuclear corepressor 1 (Ncor1) allele that cannot interact with T

21 that deletion of intestinal nuclear receptor corepressor 1 (NCoR1) completely diminishes hyperbilirub

22 ng to Rev-erbalpha recruits nuclear receptor corepressor 1 (NCoR1) into an active repressor complex.

23 Nuclear receptor corepressor 1 (NCoR1) is considered to be the major core

24 Expression of a mutated nuclear corepressor 1 (NCoR1) that lacks 2 NR interacting domain

25 The nuclear receptor corepressor 1 (NCOR1) was reported to mediate the domina

26 -binding protein-binding protein and nuclear corepressor 1 (NCoR1), fundamentals for the PPARgamma-me

27 in keratinocytes for either nuclear receptor corepressor 1 (NCoR1)/silencing mediator for retinoid or

28 ice ablated selectively for nuclear receptor corepressor 1 (NCoR1)/silencing mediator for retinoid or

29 llaboration with the corepressor CoREST/REST corepressor 1 (Rcor1) and regulates cell fates by epigen

30 Moreover, METH caused interactions of REST corepressor 1 and methylated CpG binding protein 2 with

31 ediator of transcription 13/nuclear receptor corepressor 1 axis, which in turn promotes Mef2 inhibiti

32 Knockdown of nuclear receptor corepressor 1 in primary male T cells abolished the effe

33 ment-1 silencing transcription factor (REST) corepressor 1, methylated CpG binding protein 2, and his

34 ceptor-interacting protein, nuclear receptor corepressor 1, to specific cis-regulatory elements in th

35 Rs, but not the presence of nuclear receptor corepressor 1, was required for repression of the NO syn

36 action between TR-alpha and nuclear receptor corepressor 2 (NCOR2) and suppressed Pln transcription.

37 ion Factor (CoREST) and the Nuclear Receptor Corepressor 2 (NCOR2).

38 NCOR2 (nuclear receptor corepressor 2) SNP rs150954431 was associated with P=1.1

39 on through interaction with nuclear receptor corepressor 2/histone deacetylase 3 for its repression.

40 of protein domains to create a diversity of corepressors, achieving similar properties with differen

41 ins (TLE1-4) are a family of transcriptional corepressors acting downstream of multiple signalling pa

42 at Src-1(-/-) mice have RTH due to unopposed corepressor action.

43 The corepressor activity of Tip60 at the ERE site is abolish

44 CSL interacts with both transcriptional corepressor and coactivator proteins, functioning as bot

45 lar basis for the anticancer actions of this corepressor and identify NCoR as a potential molecular t

46 in directly interacts with a transcriptional corepressor and ligand of the Slug promoter, ZBRK1.

47 ubcellular localization of CAR; 4) increases corepressor and reduces coactivator interaction with the

48 precipitation assays, we showed that nuclear corepressor and silencing mediator for retinoid and thyr

49 the SHH pathway, through recruitment of BCOR corepressor and SIRT1 deacetylase.

50 ndicate that TTP acts as a bona fide ERalpha corepressor and suggest that this protein may be a contr

51 LTM interacts with the TOPLESS corepressor and with several transcription factors that

52 has 10-fold greater potency than endogenous corepressors and binds an essential region of the BCL6 l

53 ination of the mRNA start site by Tup family corepressors and CBF/NF-Y proteins.

54 ent stem cells by recruiting transcriptional corepressors and coactivator complexes onto neuroectoder

55 We outline a general model by which corepressors and coactivators regulate histone acetylati

56 oic acid and thyroid hormone receptor (SMRT) corepressors and is largely unresponsive to ligand activ

57 rget genes via recruitment of its associated corepressors and subsequent induction of epigenetic modi

58 These transcriptional corepressors and tumor suppressors inhibit the expressio

59 NCoR1 (nuclear receptor corepressor) and SMRT (silencing mediator of retinoid an

60 teracting proteins, N-CoR, a transcriptional corepressor, and SON, a splicing/transcription factor re

61 omatin architecture created by the Cyc8-Tup1 corepressor, and that releasing the P nucleosome contrib

62 hroid transcription factors, transcriptional corepressors, and chromatin-modifying enzymes.

63 ooperatively recruit TOPLESS (Mt-TPL) family corepressors, and this recruitment is required for STF f

64 Notably, both NCoR and SMRT corepressors are subject to alternative mRNA splicing, y

65 Mutations in BCOR (Bcl6 corepressor) are found in patients with oculo-facio-card

66 eracted with histone H3-binding proteins and corepressor-associated proteins but not with H3 or the c

67 The transcriptional corepressor BASP1 interacts with WT1 and mediates WT1's

68 B cell lymphoma 6 (BCL6) corepressor (BCOR) was discovered as a BCL6-interacting

69 Despite both corepressors being present in the liver, deletion of SMR

70 analogues that induce the disruption of VDR-corepressor binding and promote VDR-coactivator interact

71 nd that this phosphorylation is required for corepressor binding and ultimately HXT expression.

72 of C20orf112, and does not require potential corepressor binding peptides elsewhere in the sequence.

73 type of mice engineered to express BCL6 with corepressor binding site mutations.

74 y X-ray crystallography, reveals a monomeric corepressor-bound protein.

75 ctor binding surfaces that are folded in the corepressor-bound wild-type protein are disordered.

76 y2 dephosphorylates Mth1, an Rgt1 associated corepressor, but does not dephosphorylate Rgt1 at sites

77 (BCOR) was discovered as a BCL6-interacting corepressor, but little is known about its other biologi

78 ones associated with aberrant recruitment of corepressors by TRalpha1 mutants underlies pathological

79 tivity of the NADH-sensitive transcriptional corepressor C-terminal binding protein 1 (CtBP1).

80 ding decreased levels of the transcriptional corepressor C-terminal binding protein 1.

81 w that the expression of the transcriptional corepressor C-terminal binding protein-2 (CtBP2) is elev

82 rough disruption of its interaction with the corepressor CABIN1 or by rendering it insensitive to inh

83 ations in human Atrophin1, a transcriptional corepressor, cause dentatorubral-pallidoluysian atrophy,

84 ion, which results in the prevention of SMRT corepressor clearance and induction of MMP-9 transrepres

85 d that MTA1 association with nucleosomes and corepressor/coactivator complexes is dynamic.

86 herefore, functional consequences of altered corepressor/coactivator exchange were examined at Mcsfr,

87 (PTMs) on histones and coregulators such as corepressors, coactivators, DNA-binding factors and PTM

88 However, both corepressors collaborate to control hepatic lipid conten

89 of JAZ10.4 links transcription factors to a corepressor complex and suggest how JA-induced transcrip

90 es involving the dysregulation of a specific corepressor complex as among the initiating events promo

91 ons correlated with reduced occupancy of the corepressor complex at inflammatory promoters, providing

92 trans-recruitment of the GR-N-CoR/SMRT-HDAC3 corepressor complex on these enhancers.

93 ve transcription factor Mth1 and the general corepressor complex Ssn6-Tup1 in the absence of glucose;

94 eport that expression of the transcriptional corepressor complex subunits GPS2 and SMRT was significa

95 of MLH1 and other CIMP genes, and recruits a corepressor complex that includes its heterodimeric part

96 Promoter-bound ZNF304 recruits a corepressor complex that includes the DNA methyltransfer

97 ntify NCoR1-GPS2-HDAC3 as a NELF-interacting corepressor complex that is associated with repressed HI

98 lass IIa deacetylase that interacts with the corepressor complex together with the highly active clas

99 in 1), identified as a component of the CtBP corepressor complex, binds to nearby DNA elements to ass

100 P is not only able to interact with the NCoR corepressor complex, but also with the H3K4 methyltransf

101 ion of GPS2 and TBL1, components of the SMRT corepressor complex, but not histone deacetylase 3 (HDAC

102 First identified as part of the NCoR-SMRT corepressor complex, GPS2 is known to play an important

103 nt of the mammalian Sin3-histone deacetylase corepressor complex, severely impairs the competitive re

104 chromatin binding module in the HDAC1:MIDEAS corepressor complex.

105 f retinoic acid and thyroid receptors (SMRT) corepressor complex.

106 control of the Mig1 repressor and Cyc8-Tup1 corepressor complex.

107 t has been thought that HDACs associate with corepressor complexes and repress gene transcription; ho

108 lation by histone deacetylase (HDAC)-bearing corepressor complexes is poorly understood.

109 s in association with components of the HDAC corepressor complexes Sin3, NuRD, and CoREST as homodime

110 tylase 1 (HDAC1) and HDAC2 are components of corepressor complexes that are involved in chromatin rem

111 AC3) is the catalytic component of NCoR/SMRT corepressor complexes that mediate the actions of transc

112 AC1/2) form the core catalytic components of corepressor complexes that modulate gene expression.

113 hly phosphorylated HDAC2 is recruited within corepressor complexes to regulatory regions, while the n

114 is associated with multiple transcriptional corepressor complexes, including CtBP/LSD1/HDAC complexe

115 These results suggest that corepressor complexes, including HDAC1 or HDAC2 homodime

116 ended on class I HDACs and involved multiple corepressor complexes, including HDAC1/2-containing Sin3

117 levels of proteins of the MeCP2-interacting corepressor complexes, including HDAC4 and TBL1X.

118 and transcriptional activity by inactivating corepressor complexes, which associate in a ligand-depen

119 cells is required for the formation of HDAC corepressor complexes.

120 and is mediated by multiple HDAC1-containing corepressor complexes.

121 n, BCL11A was found to interact with several corepressor complexes; however, the mechanisms underlyin

122 The Tup family corepressors contribute to critical cellular responses,

123 production in macrophages by recruiting the corepressor CoREST to the Th promoter.

124 4 (H3K4) residues in collaboration with the corepressor CoREST/REST corepressor 1 (Rcor1) and regula

125 eracting protein 5), and the transcriptional corepressor CtBP (C-terminal-binding protein).

126 s target genes depends on its recruitment of corepressors (CtBP, BRG1) or coactivators (p300) althoug

127 via a cascade involving the transcriptional corepressor Ctbp2 and the Notch suppressor Sirt1.

128 cides with the predicted binding site of the corepressor DAX-1 (dosage-sensitive sex reversal, adrena

129 factor that plays the role of coactivator or corepressor, depending on the cell and promoter contexts

130 is carried out by histone deacetylase (HDAC)/corepressor element-1 silencing transcription factor (Co

131 epresentative targets of the transcriptional corepressor ETO2.

132 with reduced protein level of hematopoietic corepressor ETO2.

133 licating SetD8 as a context-dependent GATA-1 corepressor expands the repertoire of coregulators media

134 Here, we show that the coupling of corepressor expression with HDAC3 degradation allows cel

135 The Sds3 transcriptional corepressor facilitates the assembly of the 1- to 2-MDa

136 h the Dnmt1, Sin3A, Nurd, CoRest, and B-Wich corepressor families.

137 Our findings show that the TPL/TPR corepressor family are components of the central circadi

138 eport that members of the plant Groucho/Tup1 corepressor family, topless/topless-related (TPL/TPR), i

139 ranscription factor Eos (Ikzf4), an obligate corepressor for Foxp3.

140 B-cell lymphoma-6 protein (Bcl-6) is a corepressor for inflammatory mediators such as vascular

141 onstrate that RSL1 recruits KAP1/TRIM28, the corepressor for KRAB action in vitro, to this enhancer.

142 DNA damage response, acting as an essential corepressor for KRAB family zinc finger proteins (KRAB-Z

143 storage and as a transcriptional coactivator/corepressor for metabolic nuclear receptors.

144 uN promoter as an antirepressor of Fur and a corepressor for NsrR.

145 ings, C-DIM12 also stabilized binding of the Corepressor for Repressor Element 1 Silencing Transcript

146 an development and has activity as a nuclear corepressor for the Notch transcription factor Suppresso

147 Thus, RUNX1 and PU.1 cooperate to exchange corepressors for coactivators, and the specific corepres

148 Here we report that CRY1/2 serve as corepressors for many NRs, indicating a new facet of cir

149 ngly, sites of GR repression utilize GRIP1's corepressor function and display reduced histone acetyla

150 ian BEN-solo factor that conserves the Notch corepressor function of Insv but not its capacity to bin

151 lar domain structure and performs a parallel corepressor function, revealed that the plant TPLs have

152 import, DNA binding, and recruitment of the corepressors G9a and HDAC1/2.

153 utations in the PRC1-like component and BCL6-corepressor gene Bcor.

154 miRNA101 subsequently repressesed the corepressor gene C-terminal binding protein-2 (CtBP2), a

155 In conjunction with its corepressor GR-interacting protein-1 (GRIP1), GR tethers

156 We show that the corepressor Grg3 is expressed in almost all beta-cells t

157 elements (nGREs), and GR recruitment of the corepressor GRIP1.

158 anscriptional coregulators (coactivators and corepressors) have emerged as the principal modulators o

159 ent of RNA polymerase II and transcriptional corepressor HDAC1 on endogenous ER target gene promoter

160 s in vitro, revealed that Prox1 recruits the corepressor HDAC3 to directly repress Nkx2.5 via a proxi

161 The nuclear localization of the MEF2 corepressor HDAC4 is impaired by Mrf4 knockdown, suggest

162 -alpha) and histone deacetylase 2 (HDAC2), a corepressor important for glucocorticoid action and whos

163 20 (H4K20me1), is a context-dependent GATA-1 corepressor in erythroid cells.

164 tes the effect of HIPK2 as a transcriptional corepressor in luciferase assays.

165 GR-interacting protein-1 (GRIP1) is a GR corepressor in macrophages, however, whether GRIP1 media

166 gene-related 1 (MTGR1) is a transcriptional corepressor in the myeloid translocation gene/Eight-Twen

167 dole-3-acetic acid (Aux/IAA) transcriptional corepressors in controlling response dynamics and highli

168 at p300/CBP and HDACs act as coactivators or corepressors in histone acetylation-induced PKCdelta up-

169 ts define a novel function of Groucho family corepressors in peripheral T cells and demonstrate that

170 retinoid or thyroid-hormone receptors (SMRT) corepressors in skin keratinocytes, Dex-induced direct r

171 binding of enhancer-associated coactivators/corepressors, including p300 and RIP140, permitting full

172 main 1 (AD1) of E2A has specifically reduced corepressor interaction due to E2A-specific amino acid c

173 On the other hand, the weak E2A-AD1-corepressor interaction imposes a critical importance on

174 LXR inverse agonist SR9243 that induces LXR-corepressor interaction.

175 ence for the differential involvement of E2A-corepressor interactions in distinct leukemogenic pathwa

176 Blocking SALL4-corepressor interactions released suppression of PTEN (t

177 cid and thyroid hormone receptor), a nuclear corepressor involved in transrepression.

178 The mechanisms and corepressors involved in PUF repression remain to be ful

179 The 2525 amino acid SMRT corepressor is an intrinsically disordered hub protein r

180 as Arabidopsis thaliana, the most prominent corepressor is TOPLESS (TPL), which plays a key role in

181 -CoREST (lysine-specific demethylase 1; REST corepressor) is an ideal model system to study the inter

182 our findings suggest that YY1, with HDACs as corepressors, is a critical negative transcriptional reg

183 HDAC3 acts canonically as a transcriptional corepressor, it functions as a coactivator of oestrogen-

184 g OR transcription, but as a transcriptional corepressor, it is incompatible with maintenance of OR e

185 ing the synergy between NF-kappaBeta and the corepressor JDP2.

186 TAT3 suppresses the cellular transcriptional corepressor Kruppel-associated box domain-associated pro

187 higher affinity for BCL6 than its endogenous corepressor ligands to evaluate their therapeutic effica

188 e we indicate a role for the transcriptional corepressor Lysine-Specific Demethylase 1 (LSD1) and its

189 wnstream ETO-interacting sequence (DES), for corepressor-mediated repression.

190 ED1 and its phosphorylated form, but not the corepressors N-CoR and SMRT, were recruited to the ERalp

191 Ralpha, but decreased the association of its corepressors (N-CoR and SMRT), with the miR-122 DR1 and

192 Molecular characterization of the nuclear corepressor NCoR and coactivator Src-1 revealed that rec

193 The corepressor NCoR interacts with inflammatory pathway gen

194 shing interactions with the nuclear receptor corepressor (NCOR or SMRT) render HDAC3 nonfunctional in

195 of the receptor along with nuclear receptor corepressor (NCoR) and silencing mediator of retinoic ac

196 f the MeCP2 with DNA or the nuclear receptor corepressor (NCoR)/silencing mediator of retinoic acid a

197 We show that the nuclear receptor corepressor NCoR1 is a key target of proteolysis and phy

198 on of the tumor-suppressive nuclear receptor corepressor NCOR1.

199 ct repression, but not bindings of GR and of corepressors NCoR1/SMRT, was abolished, indicating that

200 Recently, the nuclear corepressor, NCOR1, has been postulated to regulate TSH

201 e model harboring a mutated nuclear receptor corepressor (NCOR1DeltaID) (Thra1(PV/+)Ncor1(DeltaID/Del

202 the transcriptional repressor Bcl-6 and the corepressor Ncor2, miR-10a attenuated the phenotypic con

203 f a functional complex with nuclear receptor corepressors (NCORs) were critical in restricting differ

204 pha1 mutants to properly release the nuclear corepressors (NCORs), thereby inhibiting thyroid hormone

205 ption factors (MYC2, MYC3, and MYC4) and the corepressor NINJA as JAZ10.4-binding partners.

206 studies identify PIAS3 as a transcriptional corepressor of EKLF for at least a subset of its target

207 ual conundrum: mechanistically, as the FOXO1 corepressor of glucokinase is unknown, and clinically, a

208 rt that SIN3A is the insulin-sensitive FOXO1 corepressor of glucokinase.

209 h GR in protein complexes and functions as a corepressor of GR-mediated transcription.

210 tion of human small heterodimer partner, the corepressor of hCYP7A1 transcription, was also confirmed

211 oform of BET family member BRD4 (BRD4S) as a corepressor of HIV-1 transcription.

212 WASp from a transcriptional coactivator to a corepressor of nuclear factor (NF)-kappaB response genes

213 modeling and histone deacetylase (NuRD), and corepressor of RE1 silencing transcription factor (CoRES

214 Here we have discovered that MTA1 is a novel corepressor of serum and glucocorticoid-inducible kinase

215 We identified ZMYND8 as a transcriptional corepressor of the H3K4 demethylase JARID1D.

216 ein (SMILE) has been identified as a nuclear corepressor of the nuclear receptor (NRs) family.

217 Corepressors of the Polycomb family, which are frequentl

218 romatin-modifying proteins Sin3a and coREST (corepressors of the transcription factor REST) and subse

219 -modifying proteins (CMPs) Sin3a and coREST (corepressors of the transcription factor REST).

220 eacetylase (HDAC) classes I and II served as corepressors of YY1, and, accordingly, HDAC inhibitors i

221 Knockdown of nuclear corepressor or silencing mediator for retinoid and thyro

222 retinoid or thyroid-hormone receptors (SMRT) corepressors or histone deacetylase 3 (HDAC3), Dex-induc

223 coactivator peptide, and reduce binding of a corepressor peptide to RORgamma LBD.

224 BBX25 and BBX24 function as transcriptional corepressors, probably by forming inactive heterodimers

225 on, and what dictates its coactivator versus corepressor properties is unknown.

226 s GRIP1 coactivator but, remarkably, not its corepressor properties.

227 ins histone deacetylases 1 and 2, the MIDEAS corepressor protein and a protein called DNTTIP1 whose f

228 through the recruitment of nuclear receptor corepressor protein and silencing mediator of retinoid a

229 the candidates obtained, the transcriptional corepressor protein C-terminal binding protein-1 (CtBP1)

230 methylase-1 (LSD1/KDM1A) in complex with its corepressor protein CoREST is a promising target for epi

231 ng a MYC mutant unable to associate with the corepressor protein MIZ1 (ZBTB17).

232 H3K4 in peptide substrates, but requires the corepressor protein, CoREST, to demethylate nucleosome s

233 i, where it mono-ADP ribosylates the nuclear corepressor protein, KAP1, and facilitates KAP1 interact

234 , HDAC2, and HDAC3) are recruited by cognate corepressor proteins into specific transcriptional repre

235 unction of AF2 is to recruit coactivator and corepressor proteins that allow ERalpha to oscillate bet

236 th CSL is thought to both disrupt binding of corepressor proteins to CSL and anchor NICD to CSL, prom

237 ession in glial cells by stabilizing nuclear corepressor proteins, which reduces binding of p65 to in

238 The corepressor Rcor1 has been linked biochemically to hemat

239 epressors for coactivators, and the specific corepressors recruited to PU.1 as a consequence of RUNX1

240 We found that corepressor recruitment by RUNX1 contributes to a block

241 ts were shown to play a role in differential corepressor recruitment.

242 e retinoblastoma (RB) family transcriptional corepressors regulate diverse cellular events including

243 R1 can interact with GFI1, a transcriptional corepressor required for Paneth cell differentiation, an

244 MEK1 interacts with the nuclear receptor corepressor silencing mediator of retinoid and thyroid h

245 The corepressor SIN3 controls histone acetylation through as

246 but is unable to augment the actions of the corepressor SMRT.

247 Taken together, these data demonstrate that corepressor specificity exists in vivo and that NCoR1 is

248 adipogenesis is associated with a switch in corepressor splicing from NCoRomega to NCoRdelta, which

249 lso associated with extensive recruitment of corepressors such as NCoR and HDACs, indicating that thi

250 wild-type E2A is silenced by high levels of corepressors, such as the AML1-ETO fusion protein in t(8

251 Tup11/12 (the Tup-family corepressors) suppress direct binding of Rst2 to UAS2, b

252 Coactivators and corepressors tethered by proteins similar to ASEs and XS

253 SIN3 is a transcriptional corepressor that acts as a scaffold for a histone deacet

254 HDAC1 is a transcriptional corepressor that acts to silence expression of viral gen

255 has been characterized as a transcriptional corepressor that can associate with many different trans

256 D complex is a multi-protein transcriptional corepressor that couples histone deacetylase and ATP-dep

257 findings show that Mth1 is a transcriptional corepressor that facilitates the recruitment of Ssn6-Tup

258 HDAC4 is a transcriptional corepressor that has been linked to synaptic plasticity

259 1 (transducin-like enhancer of split 1) is a corepressor that interacts with a variety of DNA-binding

260 d CLOCK-BMAL1, thereby reconstituting a NuRD corepressor that is important for circadian transcriptio

261 ssor 1 (NCoR1) is considered to be the major corepressor that mediates ligand-independent actions of

262 ther contexts it serves as a transcriptional corepressor that potentiates transcriptional repression

263 signal from the sensors to the Mth1 and Std1 corepressors that are required for repression of HXT gen

264 PXR associates with multiple corepressors that attenuate and coactivators that enhanc

265 Promoter-bound MAFG recruits a set of corepressors that includes its heterodimeric partner BTB

266 pression involves a class of proteins called corepressors that link transcription factors to chromati

267 sors associate with ARF proteins and recruit corepressors that prevent auxin-induced gene expression.

268 te myelogenous leukemia, are transcriptional corepressors that regulate hematopoietic stem cell progr

269 inases, HIPK1 and HIPK2, are transcriptional corepressors that regulate TGF-beta-dependent angiogenes

270 verlap specific interaction sites for alpha2 corepressors: the Mcm1 interaction site in the central a

271 r-associated proteins but not with H3 or the corepressors themselves.

272 lis gastrulae and find that occupancy of the corepressor, TLE/Groucho, is a better indicator of tissu

273 and establish that NCOA5 functions as an LXR corepressor to attenuate Abca1 expression.

274 on (PIPTC), a mechanism to convert Cyc8-Tup1 corepressor to Cti6-Cyc8-Tup1 coactivator.

275 HDACs 1 and 2 are recruited by the MTA1 corepressor to form the catalytic core of the complex.

276 ur data suggest that, rather than recruiting corepressors to enhancers, Scl prevents ectopic cardioge

277 mechanism in which liganded TRbeta recruits corepressors to inhibit PLA2g2a expression.

278 mutated Bcl6 encoding Bcl-6 that cannot bind corepressors to its BTB domain resulted in disruption of

279 vation domain, and likely the recruitment of corepressors to the Foxo1 locus by c-Myb.

280 gether support a model in which STF recruits corepressors to transcriptionally repress its targets du

281 oregulators, including both coactivators and corepressors, to the estrogen response elements, modulat

282 uiting the Groucho/TUP1-like transcriptional corepressor TOPLESS (TPL).

283 This NINJA-like recruits the corepressor TOPLESS that contributes to the suppressive

284 KIX9, which act as adaptor proteins for the corepressor TOPLESS.

285 ession and for physical interaction with the corepressor TOPLESS.

286 Here we report that the transcriptional corepressor TRIM28 is the major binding partner for nucl

287 SETDB1 is required, but the widely utilized corepressor TRIM28/Kap1 is not.

288 Here we show that the corepressor Tup1 is sumoylated, at two specific lysines,

289 saccharomyces pombe fission yeast Tup family corepressors Tup11 and Tup12 (Tup11/12), which are ortho

290 ind to the Groucho-Tup1 type transcriptional corepressors Tup11 and Tup12, and locally antagonize the

291 mRNA splicing, yielding a series of distinct corepressor variants with highly divergent functions.

292 e data suggest that MTGR1, a transcriptional corepressor well characterized in hematopoiesis, plays a

293 trated that PER2 served as a transcriptional corepressor, which recruited polycomb proteins EZH2 and

294 n E2F-4/p107 complex that switches to a Smad corepressor, which represses TP53 transcription.

295 on repressor through recruitment of Atrophin corepressors, which bind to TLX via a conserved peptide

296 n of Tle4, a member of the Groucho family of corepressors, which is then recruited to a distal regula

297 sferase repressor (NIR) is a transcriptional corepressor with inhibitor of histone acetyltransferase

298 nding protein-1 (CtBP1) is a transcriptional corepressor with multiple in vitro targets, but its in v

299 with one of its targets, the transcriptional corepressor, XCtBP.

300 ions is demonstrated for the transcriptional corepressor ZMYM2/ZNF198 where its multi-SUMO-binding ac