ライフサイエンスコーパス: cornea

1 almic practitioners to protect the patient's cornea.

2 ible for maintaining the transparency of the cornea.

3 s from central and limbal explants of murine cornea.

4 and the unique cellular architecture of the cornea.

5 HA increased nerve regeneration in the mouse cornea.

6 itis followed by re-establishment of a clear cornea.

7 ed by local CD4(+) T cell depletion from the cornea.

8 n of the nervous system and can occur in the cornea.

9 e would position a strain well to infect the cornea.

10 s and gammadelta T-cells) recruitment to the cornea.

11 did not result in added toxic effects to the cornea.

12 restoring normal rhythmicity in the diabetic cornea.

13 of ciliary neurotrophic factor (CNTF) in the cornea.

14 pression was also observed in the human MECD cornea.

15 ensity of nerve endings at the center of the cornea.

16 andidate genes using the human and zebrafish cornea.

17 ored the altered rhythmicity in the diabetic cornea.

18 the intracranial dura but not facial skin or cornea.

19 Furthermore, WNT7B is expressed in the human cornea.

20 approach is demonstrated in ex-vivo porcine cornea.

21 eaker wound electric signals than the normal cornea.

22 may reflect biomechanical differences of the cornea.

23 5% of iTregs converting into ex-Tregs in the cornea.

24 tivation, that fosters axon outgrowth in the cornea.

25 o the slow IgG diffusion rate in the healthy cornea.

26 king sites in skin, bone, tendon, aorta, and cornea.

27 c T cell-mediated inflammatory lesion in the cornea.

28 the relative En/DM thickening to the entire cornea.

29 , and characterize slow cycling cells in the cornea.

30 ection did not influence chemokine levels in cornea.

31 limbal regions of normal and diabetic human corneas.

32 h adherent bacteria in superficially-injured corneas.

33 al keratoplasty (DSAEK) using imported donor corneas.

34 ded to differentiate subclinical from normal corneas.

35 unwounded eyes compared with vehicle-treated corneas.

36 vity was seen in ex vivo cultures of porcine corneas.

37 nd Sri Lanka exported large numbers of donor corneas.

38 neration was also delayed in the DC-depleted corneas.

39 ients with keratoconus compared with healthy corneas.

40 neration and retarded regeneration in normal corneas.

41 differentiating forme fruste KC from normal corneas.

42 ber of intraepithelial DCs in unwounded (UW) corneas.

43 yes with diseased, scarred, and postsurgical corneas.

44 d faster egress of macrophages from inflamed corneas.

45 helial toxic effects were measured in stored corneas.

46 vices in differentiating normal from ectatic corneas.

47 performing keratoplasty with imported donor corneas.

48 and proliferation was studied on forty-eight corneas.

49 tively differentiate keratoconus from normal corneas.

50 pacities occurring secondarily in post-DSAEK corneas.

51 neutrophil infiltration in diabetic wounded corneas.

52 an-induced endothelial damage occurred in 59 corneas (0.2%) but was not associated with the presence

53 related families had typical signs of GCD on corneas; 5 patients from 5 unrelated families had atypic

54 Due to the global shortage of donor corneas, a wide interest in the development of cultured

55 e (DTL Plus Electrode) was placed across the cornea, above the lower eyelid.

56 Hypoxic conditions in the cornea affect epithelial function by activating Polo-lik

57 ations, suggesting ongoing remodeling of the cornea after restoration of endothelial function.

58 s posterior fibrosis tissue formation in the corneas after DM stripping on day 14.

59 r the cultivation of HCEnCs from older donor corneas (age > 60 years).

60 IL-1R (-/-) corneas also showed down-regulation of IL-6 and CXCL1 ge

61 ime, conjunctival hyperemia, staining of the cornea and conjunctiva, and amount of mucus.

62 educed myeloid and T-cell populations in the cornea and did not affect viral contents at 4 and 8 days

63 a fellowship (25% vitreoretinal surgery, 22% cornea and external disease, and 20% glaucoma).

64 b that was upregulated in limbus vs. central cornea and in diabetic vs. normal limbus also showed sig

65 Pax and Six genes incorporate into the lens, cornea and iris, and the eye placode is the sole source

66 hough the more chronic forms can involve the cornea and lead to sight-threatening conditions.

67 vision by providing nutritive support to the cornea and lens, and by maintaining intraocular pressure

68 ll as higher TIMP2 expression in the central cornea and nasal sclera (Mann-Whitney tests, both p </=

69 atics transiently and selectively invade the cornea and regulate the resolution of corneal edema.

70 matrix organization, at five regions of the cornea and sclera in chickens developing high myopia and

71 In stratified epithelia such as the cornea and skin, healing occurs in three steps that incl

72 ten leads to neurotrophic ulcerations in the cornea and skin; however, the underlying cellular mechan

73 istatin, blocked all of these changes in the cornea and TG.

74 ion reduction changes were restricted to the cornea and the anterior chamber, where they caused profo

75 rious adverse event was adhesion between the cornea and the iris (synechia; n = 24).

76 e avian retina unidirectionally, through the cornea and the lens, and is often partially polarized.

77 ition alters the circadian rhythm in a mouse cornea and whether insulin can synchronise the corneal c

78 try, and Scheimpflug topography in 47 normal corneas and 23 keratoconic corneas from November 2014 to

79 e significantly discordant in eyes with thin corneas and advanced glaucoma.

80 ined from the anterior stroma of human donor corneas and decellularized with a sodium dodecyl sulfate

81 Consecutive donor corneas and keratoplasty recipients at a single tertiary

82 eased Ki-67 staining in human organ-cultured corneas and proliferation rate in cultured corneal epith

83 n ultrastructural alterations of DM in donor corneas and the graft failure rate after DMEK.

84 abetes altered the normal rhythmicity of the cornea, and insulin administration had a beneficial effe

85 evealed CPAMD8 expression in the lens, iris, cornea, and retina early in development, including stron

86 cells, the recruitment of leukocytes to the cornea, and the expression of main core clock genes (Clo

87 nly 70% of eyes with post-refractive surgery corneas, and (2) astigmatism accuracy within 0.5 D is ac

88 edly upregulated in inflamed human and mouse corneas, and galectin-8 inhibitors reduce inflammatory l

89 the outer coats of these abnormal eyeballs, cornea anteriorly and sclera posteriorly, are regulated

90 Sclera, pericardium, dura mater and cornea are available as a patch graft.

91 Multiple diseases of the cornea arise from genetic defects where the ultimate phe

92 density remained reduced relative to healthy corneas at final follow-up (mean reduction, 8.5 mm/mm2 [

93 Children with established MFS have flat corneas at least to the same degree as adults.

94 hortage of corneal graft tissue, with only 1 cornea available for 70 needed.

95 Of the 11 corneas available for analysis, 9 showed normal anatomic

96 Both groups had flat corneas (average keratometry [Kmed] of 41.59 +/- 0.35 di

97 When differentiating subclinical from normal corneas, BAD-D was similar to the surface regularity ind

98 Donor corneas were precut by a single cornea bank.

99 Cornea barrier disruption develops by protease-mediated

100 showed that the epithelium of healthy mouse corneas becomes vulnerable to Pseudomonas aeruginosa adh

101 vent and potentially reverse MPS1-associated cornea blindness.

102 tating toll of excessive inflammation at the cornea - blindness.

103 t membrane (DM) was still in situ across the cornea (both of these eyes had required rebubbling); and

104 IL-10 was not expressed in healthy corneas but was up-regulated in inflamed corneas by infi

105 the eyes and spread a film of tears over the cornea, but also on several socio-emotional factors.

106 eally suited for controlled drug delivery to cornea, but incorporation of any drug loaded particulate

107 splayed similar GalNAz labeling to wild-type corneas, but labeling was reduced and patchy on IL-1 rec

108 Uninjured IL-1R (-/-) or TLR4 (-/-) corneas, but not TLR2 (-/-), TLR5 (-/-), TLR7 (-/-), or

109 ed the mutation rate of subjects with normal corneas, but positive family history.

110 was recurrence of pterygium >/=1 mm onto the cornea by 3 and 6 months post surgery.

111 nds-exert potent antifibrotic effects in the cornea by blocking phosphorylation of p38 mitogen-activa

112 transplant technology promise to repair the cornea by implanting healthy LSCs to encourage regenerat

113 thy corneas but was up-regulated in inflamed corneas by infiltrating macrophages.

114 HCEnCs from old donor corneas can be cultured using this method which may furt

115 hment of tolerogenic APCs (tolAPCs) in donor corneas can enhance graft survival in corneal allograft

116 previously found that UVB irradiation of the cornea caused the imbalance between the antioxidant and

117 nal study in comprehensive ophthalmology and cornea clinics at an academic institution among a conven

118 is type 1 (MPS1) patients, over 95% manifest cornea clouding with about 50% progressing to blindness.

119 nsitivity and tear production in the treated corneas compared with vehicle.

120 poptosis was increased 17-fold in the mutant cornea, compared with the wild-type (P < 0.001).

121 Cornea confocal microscopy (CCM) is a novel non-invasive

122 crimal functional unit (LFU), comprising the cornea, conjunctiva, lacrimal gland and interconnecting

123 KC corneas consistently show higher misalignments between s

124 The surface of the cornea contains the highest density of nociceptive nerve

125 Transplantation of these tolAPC-enriched corneas decreased frequencies of interferon gamma (IFNga

126 usceptible to infection whereas the cultured corneas demonstrate a higher ability to restrict the inf

127 In wounded corneas, diabetes markedly delayed sensory nerve regener

128 Efforts to encourage cornea donation must continue in all countries, but it i

129 Total of 39 679 cornea donor eyes from SightLife Eye Bank between 2012 a

130 technician-induced endothelial damage during cornea donor tissue processing.

131 technician-induced endothelial damage during cornea donor tissue processing.

132 fer a practical solution to screen brains of cornea donors for evidence of CJD.

133 These data suggest that cornea donors have a high frequency of diabetes.

134 A high proportion of cornea donors have respiratory disease prior to donation

135 nsity and suitability for transplantation in cornea donors with type 1 or 2 diabetes and determine th

136 nsity and suitability for transplantation in cornea donors with type 1 or 2 diabetes and determine th

137 long-term transplant outcomes of diabetes in cornea donors.

138 The rate of clear corneas dropped from 52.2% pre-operation (OP) to a minim

139 as in the induction of IFN-alpha/beta in the cornea during HSV-1 infection.

140 biomechanical and topographic changes of the cornea during pregnancy and the postpartum period and it

141 centration 0.5 ppm wt/vol, applied on rabbit corneas during UVB irradiation and healing (UVB doses 1.

142 supplementation and the control condition; 4 corneas each received the different amphotericin B conce

143 ath to refrigeration and preservation of the cornea, endothelial cell count, lens status, medical and

144 of 6 porcine eyes, 4 regions were obtained: cornea, equatorial and posterior sclera, and posterior p

145 tralization retarded reinnervation in normal corneas, exogenous CNTF accelerated nerve regeneration i

146 tal Fc receptor (FcRn) is upregulated in the cornea following infection or injury concomitant with in

147 eliminates the need for reaching the central cornea for successful pneumatic dissection and substanti

148 findings demonstrate that PS protects human cornea from hyperosmolarity-induced inflammation and oxi

149 od vessel growth extended 2 to 5 mm into the cornea from the limbus.

150 Surprisingly, corneas from MyD88(-/-) mice displayed similar GalNAz la

151 lbar conjunctiva and near the limbal area of corneas from NK1R(-/-) mice.

152 aphy in 47 normal corneas and 23 keratoconic corneas from November 2014 to July 2015.

153 s (C, n = 264), were compared to keratoconic corneas, further categorized as forme fruste (FFKc, n =

154 though placement of gamma-irradiated sterile cornea (GISC) as a patch graft over the tube is commonly

155 ratively visual outcomes following cataract, cornea, glaucoma, strabismus and oculoplastics procedure

156 e IOL calculation errors in eyes with normal corneas, greater difficulties in measuring corneal power

157 The tonometer tip cracks can irritate the cornea, harbor microbes, or allow disinfectants to enter

158 e organoids share features of the developing cornea, harboring three distinct cell types with express

159 is in a primarily avascular site such as the cornea has not been described.

160 of cultured graft substitutes and artificial corneas has increased.

161 The corneas healed with scar formation and neovascularizatio

162 The corneas healed with the restoration of transparency.

163 In the normally avascular cornea, however, pathological lymphangiogenesis mediates

164 vectors persisted only in the trauma-induced corneas; however, a neutralizing antibody response to th

165 fering RNA-mediated knockdown of FcRn in the cornea impeded protection against ocular HSV-1 challenge

166 (13%) and pseudopterygium extending onto the cornea in 5 (63%) patients.

167 ially expressed miRNAs in limbus vs. central cornea in normal and diabetic (DM) corneas including bot

168 ), a corneal disease that slowly deforms the cornea in young people; and sequellae of infectious kera

169 gatus hyphal growth in vitro and in infected corneas in a murine model of fungal keratitis; however,

170 We found rabbit corneas in the CEC scraping group healed with transparen

171 g confocal microscopy of immunostained whole corneas in which cells and their interrelationships rema

172 se achieved in Western series using domestic corneas in which fresher tissues were available for tran

173 . central cornea in normal and diabetic (DM) corneas including both type 1 (T1DM/IDDM) and type 2 (T2

174 Donor corneas, independent of excision techniques or preservat

175 We showed that C57BL/6 mouse corneas infected with HSV-1 KOS, which induces transient

176 However, in the corneas injured via DM stripping, most of the cells in t

177 The cornea is densely innervated to sustain the integrity of

178 r blisters are more common, occasionally the cornea is infected resulting in vision loss.

179 The cornea is the transparent outermost surface of the eye,

180 precise regulation of these processes in the cornea is unclear.

181 The structure of the cornea is vital to its transparency, and dystrophies tha

182 Availability of the old donor corneas is higher especially for research.

183 eruginosa adhesion to MyD88(-/-) and blotted corneas is not due to reduction in total surface glycosy

184 eatment labeled the surface of healthy mouse corneas, leaving most cells viable, and bacteria prefere

185 In the cornea, lumican maintains corneal transparency by regula

186 owever, it is important to know that central cornea may provide an alternative source of stem cells w

187 (Heidelberg Retina Tomograph 3 with Rostock Cornea Module; Heidelberg Engineering, Heidelberg, Germa

188 ral sensitization, and a group with abnormal cornea morphology parameters without and with signs of c

189 n a subgroup analysis: one group with normal cornea morphology without and with signs of central sens

190 tably, lymphatics are also detectable in the cornea of a patient with acute edema due to spontaneous

191 lls, are detected in both limbal and central cornea of mouse eye.

192 ratin expression profile was observed in the cornea of mutant mice, confirmed by western blot, RNA-se

193 the morphology of small nerve fibers of the cornea of patients with fibromyalgia in terms of density

194 Both proteins are expressed in the cornea of zebrafish embryos and adults.

195 y the third week of transplantation, whereas corneas of control rabbits remained significantly thicke

196 ccelerated nerve regeneration in the wounded corneas of diabetic mice and healthy animals, in which D

197 increased and remained elevated in inflamed corneas of IL-10(-/-) mice, indicating that IL-10 defici

198 Bacteria adherent to the corneas of IL-1R (-/-) or TLR5 (-/-) mice penetrated bey

199 pes often need modification to optimally fit corneas of individual test subjects.

200 phages are the predominant infiltrate in the corneas of mice that have been ocularly infected with he

201 ted with an increased viral load in infected corneas of NK1R(-/-) mice.

202 otected C57BL/6 (B6) mice, but not in TG and corneas of nonprotected CXCL10(-/-) or CXCR3(-/-) defici

203 greater crossing angles were observed in the corneas of patients with keratoconus compared with healt

204 The corneas of patients with MFS with ectopia lentis (EL) we

205 Corneas of patients with MFS with EL are flatter and hav

206 al nerve density of 10.3 (5.6) mm/mm2 in the corneas of patients with stage 1 or 2 keratoconus was re

207 CR3(+) CD8(+) T cells was detected in TG and corneas of protected C57BL/6 (B6) mice, but not in TG an

208 epithelial apoptosis, was also found in the corneas of wild-type and Plk3(-/-)-deficient mice.

209 The cornea offers an ideal site for lymphatic research due t

210 Neutrophils were found in the peripheral cornea on day 1 after infection and then declined, follo

211 Healthy corneas, or controls (C, n = 264), were compared to kera

212 ultures of multiple epithelia, including the cornea, oral and lingual epithelia, salivary gland, esop

213 s in a blinding inflammatory reaction in the cornea, orchestrated mainly by proinflammatory CD4 T cel

214 Cornea organoid cultures provide a powerful 3D model sys

215 ulture modeling of diseases can benefit from cornea organoids that include multiple corneal cell type

216 In contrast, in H2 treated irradiated corneas oxidative stress was suppressed and malondiladeh

217 tchy on IL-1 receptor (IL-1R)-knockout mouse corneas (P < 0.05, ANOVA).

218 cutive DSAEK procedures using imported donor corneas performed at a single university-based hospital

219 ard protocol group compared with 50.7% clear corneas pre-OP and a minimum of 40.8% in the accelerated

220 keratoplasty (DSAEK) is independent of donor cornea preservation time (PT) could increase the pool of

221 -90 years], 60.8% women, 93.0% white) in the Cornea Preservation Time Study that had not experienced

222 yes of 769 participants were included in the Cornea Preservation Time Study that had not experienced

223 thelial keratoplasty is similar across donor cornea preservation times (PTs) could increase the donor

224 reserved 8 to 14 days was similar to that of corneas preserved 7 days or less with respect to the pre

225 to conclude that the success rate with donor corneas preserved 8 to 14 days was similar to that of co

226 For these corneas, problematic issues are quantifying anterior cor

227 vibrating probe to demonstrate that diabetic corneas produced significantly weaker wound electric sig

228 es (P = 0.03 and P = 0.04, respectively) and cornea (protein; P = 0.04) of HR compared with low-risk

229 0 surgeons) in the United States, with donor corneas provided by 23 US eye banks.

230 0 surgeons) in the United States, with donor corneas provided by 23 US eye banks.

231 DSAEK with imported donor corneas provides rapid and good visual rehabilitation.

232 HSV-1 infections of the cornea range in severity from minor transient discomfort

233 After the cornea reaches adult size, the ECD decreases at a rate s

234 Some irradiated corneas remained untreated or buffer treated.

235 However, severe shortage of available donor corneas remains a global challenge.

236 how the CXCL10/CXCR3 pathway affects TG- and cornea-resident CD8(+) T cell responses to recurrent ocu

237 tes reduces DC populations in UW and wounded corneas, resulting in decreased CNTF and impaired sensor

238 ticles entered the cells of the conjunctiva, cornea, retina, and sclera after subconjunctival deliver

239 dissected eye tissues from the conjunctiva, cornea, retina, and sclera were performed to determine t

240 netrating keratoplasty at Wills Eye Hospital Cornea Service between 2007 and 2015 were reviewed.

241 A steeper cornea, shallower anterior chamber, and greater lens thi

242 s of the ROP children also exhibited steeper corneas, shallower anterior chamber depths, thicker lens

243 MiR-10b transfected human organ-cultured corneas showed downregulation of PAX6 and DKK1 and upreg

244 in various cell lines, and animal tissues of cornea, skin, small intestine and bladder.

245 in TGFbeta-stimulated in vitro primary human cornea stromal fibroblasts (pHCSFs) and in vivo in a pho

246 confused with infections of the superficial cornea, such as herpes simplex virus keratitis or Acanth

247 n, but not their activation from the skin or cornea, suggesting a potential explanation for selectivi

248 The greatest concern about the use of donor corneas supplied by foreign eye banks is the effect of t

249 esquamation; an irregular, poorly lubricated cornea surface; and exposure and sensitization of epithe

250 In conclusion, we uncovered here an active cornea-TG axis, driven by PEDF-R activation, that foster

251 to initiate an inflammatory reaction in the cornea that leads to tissue damage and loss of vision.

252 ailure, and immunohistochemistry analysis of corneas that underwent SLET also were described.

253 In these corneas the oxidative stress appeared, followed by the e

254 the inner stromal structure of a live mouse cornea, the fine structures inside the mouse pinna, and

255 erve density of 21.0 (4.2) mm/mm2 in healthy corneas, the mean (SD) preoperative subbasal nerve densi

256 en the virus was actively replicating in the cornea, they increased around 2-fold during the time whe

257 Cornea thickness of rabbits receiving TE-EK graft gradua

258 spacing of collagen lamellae in the central cornea to facilitate spread throughout the stroma.

259 ion, especially pertaining to eyes with thin corneas, to not place reliance on GAT readings, and aban

260 r PK (405) for FED and BK from the Singapore Cornea Transplant Registry performed from 1991 to 2011.

261 Eleven corneas transplanted with a DMEK graft were procured aft

262 Asymmetrical-topography corneas treated with myopic surface ablation presented a

263 , cells that had migrated toward the central cornea underwent a transient fibrotic endothelial-mesenc

264 change of a disc of full-thickness recipient cornea (up to the DSAEK stromal surface),7.0 mm in diame

265 e and thickness measurements over the entire cornea using the Zernike method based on the Pentacam HR

266 ring infection of ex vivo and in vivo rabbit corneas using multiphoton fluorescence and second harmon

267 Over 1.5 million individuals suffer from cornea vascularization due to genetic and/or environment

268 5/101 (54.5%) girls and 62/131 (47.3%) boys: cornea verticillata in 53/101 (52.5%) girls and 55/131 (

269 manifestations, except for angiokeratoma and cornea verticillata.

270 AAV8G9-opt-IDUA administered to human corneas via intrastromal injection demonstrated widespre

271 mmune response throughout the eye, including cornea, vitreous humor, and retina, suggesting a coordin

272 ed beyond the epithelial surface only if the cornea was superficially-injured.

273 Cs and neutrophils infiltrating the infected corneas was significantly higher in NK1R(-/-) than C57BL

274 s acute and severe fluid accumulation in the cornea, we show that lymphatics transiently and selectiv

275 For KC, M-->M matched corneas were 30% less likely to fail (p = 0.05) and 20%

276 Corneas were assessed for viral content by plaque assay,

277 H-Y mismatched (male [M]-->female [F]) corneas were at greater risk of graft failure or rejecti

278 In a separate safety study, 12 pairs of corneas were divided between amphotericin B supplementat

279 65, control CRF 11.03 +/- 1.72, P = .01) and corneas were flatter in Marfan syndrome (Marfan syndrome

280 he Tema Eye Survey who had clinically normal corneas were included in this study.

281 f West African descent and clinically normal corneas were included.

282 Donor corneas were precut by a single cornea bank.

283 Corneas were procured in only 82 countries.

284 th accelerated CXL, significantly more clear corneas were seen at three (p = 0.015) and six (p = 0.00

285 Ex vivo, rabbit corneas were subject to three partial thickness wounds p

286 s responded to bacterial challenge even when corneas were uninjured.

287 ution of mouse CESCs is different from human cornea, where limbal stem cell concept has been well est

288 ties and increased magnetization transfer in cornea, whereas glyceraldehyde also increased magnetizat

289 -1) sets off an inflammatory reaction in the cornea which leads to both virus clearance and chronic l

290 te safe and efficient IDUA delivery to human corneas, which may prevent and potentially reverse MPS1-

291 ive and nitrosative stress in UVB irradiated corneas, which may represent a novel prophylactic approa

292 lution with enhancers and by irradiating the cornea with a 10 mW/cm(2) ultraviolet A device for 9 min

293 s can detect a single-photon incident on the cornea with a probability significantly above chance.

294 ratoplasty with random assignment of a donor cornea with a PT of 7 days or less (0-7d PT) or 8 to 14

295 DSAEK with random assignment of a donor cornea with PT of 0 to 7 days (0-7d PT) or 8 to 14 days

296 e first postoperative year, suggesting donor corneas with donor age down to 17 years as safe donor ti

297 Treatment of donor corneas with interleukin-10 (IL-10) and transforming gro

298 Corneas with subclinical inflammation developed signific

299 atial measurements illustrated that diabetic cornea wound currents at the wound edge but not wound ce

300 but did not affect the electric currents at cornea wounds.