ライフサイエンスコーパス: corneal

1 long-term (i.e., 28 days) protection against corneal aberration and retinal injury after pilocarpine

2 and remained stable thereafter and posterior corneal aberrations changed constantly over 12 months.

3 Environmental and corneal Acanthamoeba isolates from the American Type Cul

4 donor corneas can enhance graft survival in corneal allograft recipients with inflamed graft beds.

5 and CD4(+) cells, and significantly improved corneal allograft survival compared to saline-injected c

6 By stimulating corneal angiogenesis with an alkali burn in Tie2-GFP flu

7 cularization, as well as models with induced corneal angiogenesis, are widely used to investigate the

8 patient with scleral-buckle-induced regular corneal astigmatism and a patient with keratoconus follo

9 laser lens surgery on anterior and posterior corneal astigmatism and total corneal refractive power (

10 e and safe method for the correction of high corneal astigmatism in complicated cases with different

11 on can be an effective method for correcting corneal astigmatism in patients with vitreoretinal disea

12 Corneal astigmatism J0 was different (p = 0.01) for the

13 h EL are flatter and have a higher degree of corneal astigmatism.

14 Corneal avascularity is critical for achieving transpare

15 Dysthyroidism may directly influence corneal biomechanics and represents a clinically relevan

16 Hormonal changes affecting corneal biomechanics and topography during pregnancy cou

17 ry was used to analyze VEGF-R2 expression in corneal CD31 cells, and VEGF-A and IFNgamma expression i

18 cells, and VEGF-A and IFNgamma expression in corneal CD4 T cells.

19 from cornea organoids that include multiple corneal cell types and extracellular matrices.

20 ts with accelerated CXL, fewer morphological corneal changes were observed than after conventional CX

21 Outcome measures were the observed rate of corneal changes, differences between treatment groups an

22 and cytokines that persisted without loss of corneal clarity (subclinical inflammation).

23 epharospasm; increased intraocular pressure; corneal clouding at birth; and buphthalmos.

24 To evaluate the cost effectiveness of corneal collagen crosslinking (CXL) for progressive kera

25 To evaluate the safety and efficacy of corneal collagen crosslinking (CXL) for the treatment of

26 rment As opposed to corneal transplantation; corneal collagen crosslinking (CXL) is a relatively non-

27 Corneal collagen crosslinking affords the keratoconic pa

28 Corneal collagen crosslinking for progressive keratoconu

29 Corneal collagen crosslinking was effective in improving

30 lusion criteria were previous surgery, other corneal conditions or age above 50 years.

31 In vivo corneal confocal microscopy could be used in the assessm

32 These data suggest that corneal confocal microscopy demonstrates axonal loss and

33 te riboflavin dosing intervals with standard corneal cross-linking (epithelial removal and 30-minute

34 sing iontophoresis (T-ionto CL) and standard corneal cross-linking (standard CL) for the treatment of

35 compare clinical outcomes of transepithelial corneal cross-linking using iontophoresis (T-ionto CL) a

36 ed to evaluate the effect of misalignment on corneal curvature measurements.

37 the impact of the altered anterior/posterior corneal curvature relationship.

38 relevant change in the anterior to posterior corneal curvature relationship; this needs to be taken i

39 and CATCRP, but do not affect the posterior corneal curvature significantly, as measured by Scheimpf

40 ment and repeatability of axial length (AL), corneal curvature, and anterior chamber depth measuremen

41 ues for refractive error, axial length (AL), corneal curvature, anterior chamber depth, lens thicknes

42 The mean postoperative corneal cylinder was 1.2+/-1.0 and 1.2+/-0.8 diopters, r

43 l plugs with ocular lubricants in preventing corneal damage in mechanically ventilated and sedated cr

44 H2) is able to reduce oxidative stress after corneal damage induced by UVB irradiation.

45 The entire corneal data of pachymetry and elevation of both the ant

46 The Pentacam HR imaging system was used for corneal densitometry (12-mm corneal diameter) measuremen

47 Corneal densitometry decreased in all 4 layers over 2 ye

48 To investigate the 2-year course of corneal densitometry following Descemet membrane endothe

49 The corneal densitometry values were similar in all concentr

50 a powerful 3D model system for investigating corneal developmental processes and their disruptions in

51 Corneal diameter (CD) was measured in children undergoin

52 tem was used for corneal densitometry (12-mm corneal diameter) measurements.

53 (corneal epithelium to lens), and horizontal corneal diameter.

54 l state; on many genes, KLF7 antagonized the corneal differentiation-promoting KLF4.

55 t difference was that of more severe central corneal disease in DIF-negative patients.

56 Mild ocular surface and corneal disease may be treated effectively with aggressi

57 age-related macular degeneration, as well as corneal diseases with abnormal angiogenesis.

58 and explains how two SNPs may contribute to corneal diseases.

59 hod may also be applicable to other heredity corneal diseases.

60 corneal dystrophy (FECD), the most prevalent corneal disorder requiring transplantation, we conducted

61 Donor tissue parameters of 84 consecutive corneal donor grafts used for big-bubble DALK surgery be

62 The effect of diabetes on corneal donor tissue is unknown.

63 ether the 3-year rate of graft success using corneal donor tissue preserved 8 to 14 days is noninferi

64 Fresh and frozen corneal donors offer similar clinical outcomes when used

65 In addition, we used TGFBI corneal dystrophies as a model of autosomal dominant dis

66 K, performed primarily for Fuchs endothelial corneal dystrophy (96% of the cohort).

67 d the genetic aetiology of Fuchs endothelial corneal dystrophy (FECD), the most prevalent corneal dis

68 Granular corneal dystrophy (GCD) is an autosomal dominant heredit

69 Fuchs endothelial corneal dystrophy was the fourth most common indication

70 sty (1255 eyes [94.4%] for Fuchs endothelial corneal dystrophy).

71 luding myotonic dystrophy, Fuchs endothelial corneal dystrophy, and C9orf72-ALS/FTD.

72 maximum K value, CDVA, and UDVA in eyes with corneal ectasia 1 year after treatment, with an excellen

73 agen crosslinking (CXL) for the treatment of corneal ectasia after laser refractive surgery.

74 One hundred seventy-nine subjects with corneal ectasia after previous refractive surgery.

75 Keratoconus (KC) is usually a bilateral corneal ectatic disease.

76 corneal thickness due to delayed drainage of corneal edema and a trend towards prolonged corneal opac

77 ectedly beneficial role in the regulation of corneal edema and transparency.

78 ) algorithm, the repeatability of successive corneal elevation measurements taken post-LASIK.

79 e current study, we performed in vivo rabbit corneal endothelial cell (CEC) injury via CEC scraping,

80 es of SiNPs (50, 100, and 150 nm) in a human corneal endothelial cell (HCEC) line, B4G12.

81 ly received PIOL implantation and have a low corneal endothelial cell count.

82 Descemet's membrane supports corneal endothelial cell regeneration in rabbits after e

83 Here, isolated primary human corneal endothelial cells (CEnCs) propagated using a dua

84 Human corneal endothelial cells (HCEnCs) are terminally differ

85 not induce acute significant cytotoxicity in corneal endothelial cells at concentrations up to 100 mi

86 DM) helps maintain phenotype and function of corneal endothelial cells under physiological conditions

87 vision for individuals with blindness due to corneal endothelial dysfunction.

88 ional regulatory compliant tissue-engineered corneal endothelial graft substitute can alleviate this

89 We concluded that corneal endothelial wound healing in rabbits has differe

90 little is known about the function of DM in corneal endothelial wound healing process.

91 xpression of markers indicative of the human corneal endothelium, and can be tissue-engineered onto t

92 r fibrosis tissue did not originate from the corneal endothelium, and they maintained fibroblastic ph

93 understanding of the susceptibility of human corneal epithelial (HCE) cells to HSV-1 infection, we in

94 Previously we reported that corneal epithelial barrier function against Pseudomonas

95 t NaNO2 (0.1 muM to 100 muM) increased human corneal epithelial cell (HCEC) viability and migration.

96 fies a role for KLF7 as a KLF4 antagonist in corneal epithelial cell differentiation, and explains ho

97 effects of 1,25(OH)2D3 and 24R,25(OH)2D3 on corneal epithelial cell proliferation, migration, and on

98 ssay and immunohistochemistry study of human corneal epithelial cells (HCECs) and human keratocytes (

99 In VDR wildtype mouse corneal epithelial cells (WT), 1,25(OH)2D3 increased CYP

100 rived exosomes mediate communication between corneal epithelial cells and corneal keratocytes as well

101 te the effects of rapamycin on primary human corneal epithelial cells in vitro.

102 Exosomes secreted by mouse corneal epithelial cells were found to fuse to keratocyt

103 In human primary corneal epithelial cells, 24,25(OH)2D3 stimulated migrat

104 er, our work defines regulatory enhancers in corneal epithelial cells, highlights global gene-regulat

105 nd typical enhancers active in primary human corneal epithelial cells.

106 e a useful additive for ex vivo expansion of corneal epithelial cells.

107 d corneas and proliferation rate in cultured corneal epithelial cells.

108 mportant roles of KLF4 and KLF5 in promoting corneal epithelial differentiation.

109 re not effective in improving discomfort and corneal epithelial disease in all patients.

110 le to recover function in an animal model of corneal epithelial dysfunction after surgical transplant

111 el-like factor (KLF) motifs were enriched in corneal epithelial enhancers, consistent with the import

112 as tear clearance, goblet cells density and corneal epithelial integrity, suggesting that recruitmen

113 2 weeks, there was a significant increase in corneal epithelial nerve regeneration and substance P-po

114 ection and acheived long-term knockdown of a corneal epithelial reporter gene, demonstrating gene dis

115 Human Corneal epithelial stem cells (CESCs) have been identifi

116 In order to identify reliable markers of corneal epithelial stem cells, we employed an inducible

117 mycin treatment of HCEC prevents the loss of corneal epithelial stem/progenitor cells to replicative

118 ell types of the ectodermal lineage and that corneal epithelial super enhancers are already marked as

119 epresents a promising approach for xeno-free corneal epithelial tissue engineering for ocular surface

120 gulating collagen fibrillogenesis, promoting corneal epithelial wound healing, regulating gene expres

121 ike growth factor-1 are shown to promote the corneal epithelial wound healing.

122 etting and FACS sorting into a population of corneal epithelial-like progenitor cells.

123 d encoding S. pyogenes Cas9 and sgRNA to the corneal epithelium by intrastromal injection and acheive

124 inical relevance of promoting the healing of corneal epithelium debridement.

125 eneration of a functional and transplantable corneal epithelium derived from human induced pluripoten

126 ed by intracellular deposition of C3d in the corneal epithelium of vaccinated animals following chall

127 er (K), preoperative anterior chamber depth (corneal epithelium to lens), and horizontal corneal diam

128 Specific factors from the corneal epithelium underlying the stimulation of stromal

129 RNA-Seq data from corneal epithelium were compared to epidermal hair folli

130 he antioxidant and prooxidant enzymes in the corneal epithelium, followed by the imbalance between me

131 re localized in basal layer of entire murine corneal epithelium.

132 3-D in vitro CXL model, using primary Human corneal fibroblasts (HCFs) from healthy patients and Hum

133 ctive beta-catenin concentration in cultured corneal fibroblasts through p38 MAPK regulation of canon

134 tudy was to identify differences in clinical corneal findings after standard and accelerated epitheli

135 Seven patients presented with corneal findings ranging from superficial punctate epith

136 e clinical relevance of lymphangiogenesis in corneal fluid homeostasis.

137 s (P = .045) but not with tear breakup time, corneal fluorescein staining, or ocular medications used

138 o receive a B-KPro using a frozen or a fresh corneal graft carrier on the basis of tissue availabilit

139 erm clinical outcomes of fresh versus frozen corneal graft carriers for the Boston Keratoprosthesis t

140 ute can alleviate this reliance on cadaveric corneal graft material.

141 One hundred thirty-nine eyes (96 corneal grafts post penetrating keratoplasty or Descemet

142 In corneal grafts, in vivo relative thickening of the En/DM

143 Corneal haze was the most frequently reported CXL-relate

144 duction in both virus shedding and recurrent corneal herpetic disease.

145 and can cause potentially blinding recurrent corneal herpetic disease.

146 rus shedding in tears that trigger recurrent corneal herpetic disease.

147 , regulating gene expression and maintaining corneal homeostasis.

148 l for pump and barrier function required for corneal hydration and transparency.

149 To investigate the difference in corneal hysteresis (CH) and corneal resistance factor (C

150 All patients had undergone full-thickness corneal imaging by a LS-IVCM (Heidelberg Retina Tomograp

151 nderwent phacoemulsification with a temporal corneal incision and group B (superior group) including

152 nderwent phacoemulsification with a superior corneal incision.

153 y was to compare superior and temporal clear corneal incisions of uneventful phacoemulsification and

154 A very intriguing aspect of HSV-1 corneal infection is that the virus spread is normally r

155 hat influence immune responses to subsequent corneal infection or trauma.

156 anism that has the ability to cause blinding corneal infections following trauma and during contact l

157 the T-ionto CL group; 1 eye (8%) had sterile corneal infiltrates, which did not affect the final visu

158 Surprisingly, corneal injury and treatment with PEDF + DHA induced tra

159 in a mouse model of diabetes with or without corneal injury.

160 Following corneal inoculation of mice, the mutant was not signific

161 etion, conjunctival goblet cells, epithelial corneal integrity, and reduce the pro-inflammatory cytok

162 of the eye, which on histology demonstrated corneal keloid, fibrous infiltration of the angle, ectro

163 ication between corneal epithelial cells and corneal keratocytes as well as vascular endothelial cell

164 An R124H mutation in primary human corneal keratocytes derived from a GCD2 patient was corr

165 GFBI mutation in GCD patient-derived primary corneal keratocytes via homology-directed repair (HDR).

166 Corneal keratometry, expressed in the form of M, J0 and

167 No differences were identified in corneal Langerhans cell density (19.84 cells/mm2 for the

168 ome measures included densitometry data in 4 corneal layers (anterior layer [AL], central layer [CL],

169 Densitometry values (corneal light backscatter in grayscale units) measured b

170 Corneal light backscatter reduction was significantly hi

171 Regarding TL 0-2 mm, the reduction of corneal light backscatter was statistically significant

172 lowed for localization of these cells to the corneal limbus and their subsequent purification by FACS

173 fferential miRNA signatures of T1DM and T2DM corneal limbus harboring LESC and show that miR-10b coul

174 MS of elevation differences between anterior corneal measurements were statistically significant post

175 rficial punctate epitheliopathy to bilateral corneal melt with subsequent perforation.

176 However, outcomes remain poor secondary to corneal melting, scarring, and perforation.

177 al keratitis causes long-term changes in the corneal microenvironment that influence immune responses

178 anophthalmia, retinal dysplasia, keratitis, corneal neovascularization, cataracts, and calcification

179 mechanical drivers of angiogenesis in murine corneal neovessels.

180 Corneal nerve branch density and corneal nerve fiber len

181 hose with neuropathy and without neuropathy (corneal nerve branch density: 95.83/mm2 for the controls

182 Corneal nerve damage produced by aging, diabetes, refrac

183 questions regarding the relationship between corneal nerve density, morphology, and function.

184 Corneal nerve fiber density (mean [SE] difference, -6.78

185 Corneal nerve branch density and corneal nerve fiber length were reduced in patients with

186 53; 95.32% CI, -50.62 to -3.13; P = .01; and corneal nerve fiber length: 28.4 mm/mm2 for the controls

187 whether IVCCM can identify an abnormality in corneal nerve fibers and Langerhans cells in patients wi

188 ed at understanding the relationship between corneal nerve morphology and chronic disease may also ne

189 consider the effects of acute stimulation on corneal nerve morphology.

190 mbination with docosahexaenoic acid (DHA) on corneal nerve regeneration in a mouse model of diabetes

191 noic acid (DHA), has been shown to stimulate corneal nerve regeneration, but the mechanisms involved

192 Emerging technologies that allow imaging of corneal nerves in vivo are spawning questions regarding

193 Animals were sacrificed and corneal nerves were examined using immunocytochemistry a

194 ar surface pathologies were noted, including corneal opacification, ulceration, neovascularization, a

195 corneal edema and a trend towards prolonged corneal opacification.

196 conventional imaging techniques in eyes with corneal opacification.

197 ion about the posterior segment in eyes with corneal opacification.

198 Cataract corneal opacities, refractive error and amblyopia, globe

199 rment due to glaucoma (0.71 [0.57-0.86]) and corneal opacity (0.54 [0.43-0.66]) were more common amon

200 n 1 patient (2%), and there were no cases of corneal opacity.

201 compared to the normal subjects, whereas the corneal pachymetry and Ambrosio relational thickness max

202 However, neuropathic corneal pain (NCP) is currently an ill-defined disease.

203 ment (p = .975) did not significantly affect corneal parameters.

204 .28 times the odds of the patient developing corneal perforation and/or needing TPK (95% CI, 1.18-4.4

205 dentify those at highest risk for developing corneal perforation and/or needing TPK.

206 stics that predict a high risk of developing corneal perforation and/or the need to undergo therapeut

207 primary outcome of the trial was the rate of corneal perforation or the need for therapeutic penetrat

208 cuity (BSCVA), 3-month infiltrate/scar size, corneal perforation, and re-epithelialization rates stra

209 or chamber depth (ACD), lens thickness (LT), corneal power (CP), noncycloplegic subjective refraction

210 ative lens position, including axial length, corneal power (K), preoperative anterior chamber depth (

211 d 10 (16%) patients who directly underwent a corneal procedure and 24 (37.5%) patients who had endosc

212 nal procedures initially before undergoing a corneal procedure.

213 on in patients with poor prognosis for other corneal procedures.

214 9 to 15.5 years of age, with 6 being primary corneal procedures.

215 tion to decrease progression of this ectatic corneal process.

216 the Kruppel family member KLF7 promotes the corneal progenitor cell state; on many genes, KLF7 antag

217 Futhermore, correlations to biomechanical corneal properties and positional changes have not been

218 d in better prognostication and in reserving corneal reconstructive procedures for eyes with a favora

219 and posterior corneal astigmatism and total corneal refractive power (TCRP) astigmatism (CAant, CApo

220 toric intraocular lens (tIOL) or peripheral corneal relaxing incisions (PCRI) for keratometric astig

221 s when one utilizes mice as animal model for corneal research.

222 he difference in corneal hysteresis (CH) and corneal resistance factor (CRF) between Indian and Chine

223 Corneal resistance factor level was not associated indep

224 nanoparticles were "gulped" in conjunctival, corneal, retinal, and scleral cells, similar to the beha

225 conjunctival corkscrew vessels (P < 0.001), corneal scarring (P = 0.01) and pingueculae under the ag

226 causes of vision loss were cataract (19.7%), corneal scars (15.7%), refractive error and amblyopia (1

227 There also was elevated corneal sensitivity and tear production in the treated c

228 iabetic mice showed significant decreases of corneal sensitivity, tear production, and epithelial sub

229 asive procedure that leads to an increase in corneal stiffness.

230 h as androgen, luteotropin, and estrogen, on corneal stroma bioenergetics.

231 all time points tested, infiltration of the corneal stroma by P. aeruginosa revealed a high degree o

232 cellular and molecular effects on the human corneal stroma post CXL, and promises to establish optim

233 and vascularized, immature APCs in the donor corneal stroma quickly mature and migrate to lymphoid ti

234 es of 84 patients with disorders of anterior corneal stroma were correlated to clinical outcome param

235 aped granular opacities are deposited in the corneal stroma.

236 lium, and can be tissue-engineered onto thin corneal stromal carriers.

237 order to evaluate the effect of CXL on human corneal stromal cells in vitro, we developed a 3-D in vi

238 Decellularized human corneal stromal laminas transplantation seems safe and m

239 preservatives of antiglaucoma medications on corneal surface and tear function have been widely shown

240 active keratectomy in eyes with asymmetrical corneal surface and to compare such outcomes with a cont

241 Corneal surface glycosylation is modulated by IL-1R and

242 Here we explored their effect on corneal surface glycosylation using a metabolic label, t

243 ted to only a small fraction of cells on the corneal surface that connect with each other in a dendri

244 le (0.40 and 0.23 for anterior and posterior corneal surfaces, respectively) in different periods.

245 ), and topographic astigmatism (TA), central corneal thickness (CCT) and endothelial cell density 12

246 .0 mm diameter, lens thickness (LT), central corneal thickness (CCT) and white-to-white (WTW) distanc

247 Central corneal thickness (CCT) was also measured.

248 0-2 mm and peripheral zone 2-10 mm), central corneal thickness (CCT), best spectacle-corrected visual

249 cle corrected visual acuity (BSCVA), central corneal thickness (CCT), endothelial cell density (ECD)

250 cle-corrected visual acuity (BSCVA), central corneal thickness (CCT), endothelial cell density (ECD),

251 spherical equivalent refraction (D), central corneal thickness (CCT, micrometers) and endothelial cel

252 001) and a negative correlation with central corneal thickness (rs = -0.22; P = .02).

253 ical and demographic data (age, sex, central corneal thickness [CCT], intraocular pressure [IOP], ref

254 via VEGFR-3 inhibition results in increased corneal thickness due to delayed drainage of corneal ede

255 orrected distance visual acuity, and minimum corneal thickness were assessed.

256 ination to obtain axial length (AL), central corneal thickness, vitreous chamber depth (VCD), anterio

257 r chamber depth, lens thickness, and central corneal thickness.

258 Keratoconus (KC) is a corneal thinning disorder that leads to severe vision im

259 d after 2 years owing to vascularization and corneal thinning.

260 r 12 months, there were changes in posterior corneal tilt, coma, and hexafoil in the PCRI group.

261 Human corneal tissue culture with 100 microg/ml concentrations

262 re incubation regimens reflective of current corneal tissue handling protocols.

263 thamoeba-endosymbiont coinfection in a human corneal tissue model representing clinical amoebic kerat

264 fect EpiCorneal cells, a 3-dimensional human corneal tissue model.

265 The role of hormones in regulating corneal tissue structure in homeostatic and pathological

266 oplasty fungal infection using corresponding corneal tissue.

267 The study aimed to characterize the entire corneal topography and tomography for the detection of s

268 alignment components on the repeatability of corneal topography maps.

269 -ionto CL, though the average improvement in corneal topography readings was slightly lower than the

270 To report a series of patients who developed corneal toxicity after exposure to aquarium coral palyto

271 re are few prior reports of coral-associated corneal toxicity and that some species of coral secrete

272 In the cornea, lumican maintains corneal transparency by regulating collagen fibrillogene

273 ents were included who had undergone a first corneal transplant for keratoconus (KC), Fuchs endotheli

274 atibility, including H-Y incompatibility, on corneal transplant graft rejection and failure.

275 Allogeneic T cells from corneal transplant hosts promote VEC proliferation, prob

276 upports allograft survival in vivo, prevents corneal transplant rejection, and attenuates the progres

277 cal lymphangiogenesis mediates diseases like corneal transplant rejection, dry eye disease, and aller

278 stantial mismatch between need and supply of corneal transplant.

279 utine endothelial keratoplasty procedure for corneal transplantation in human patients.

280 Corneal transplantation is the only treatment available

281 In recent case series, corneal transplantation revealed unexpected damage to th

282 disease progression, and the probability of corneal transplantation, graft failure, or both were cal

283 In this study, using a mouse model of corneal transplantation, we investigated whether enrichm

284 In high-risk corneal transplantation, where the graft bed is inflamed

285 erve as an alternative to conventional donor corneal transplantation.

286 ds to severe vision impairment As opposed to corneal transplantation; corneal collagen crosslinking (

287 een accidentally transmitted by contaminated corneal transplants.

288 measures were follow-up inquiries from 6592 corneal transplants.

289 ed under topical anesthesia after creating a corneal tunnel with a femtosecond laser.

290 The most frequent pathogens that cause the corneal ulcers are P. aeruginosa and S. aureus.

291 ients with smear-positive filamentous fungal corneal ulcers who enrolled between May 2010 and August

292 ugh MUTT II could not find a benefit for all corneal ulcers, Fusarium keratitis may benefit from the

293 Current treatments of corneal vascularization are limited in efficacy and elic

294 To develop a safe and effective therapy for corneal vascularization, adeno-associated virus (AAV) ge

295 ithelial-derived exosomes may be involved in corneal wound healing and neovascularization, and thus,

296 omal fibrosis and myofibroblast formation in corneal wound healing have not been fully elucidated.

297 e known, the mechanism by which NO modulates corneal wound healing remains unclear.

298 In addition, PEDF+DHA accelerated corneal wound healing, selectively recruited type 2 macr

299 the effect of exogenous NO donor (NaNO2) on corneal wound healing.

300 or KA and steeper posterior KM and the total corneal Z2(-2) was low at 1 and 12 months.