ライフサイエンスコーパス: corneal endothelium

1 iferative mechanism in developing and mature corneal endothelium.

2 y across the apical membrane of the cultured corneal endothelium.

3 netics of p27kip1 expression in neonatal rat corneal endothelium.

4 nonviral method for delivering genes to the corneal endothelium.

5 mation that accompanies the formation of the corneal endothelium.

6 t to the lens epithelium differentiated into corneal endothelium.

7 he anterior chamber is promptly covered with corneal endothelium.

8 cultures, and whether VIP is produced by the corneal endothelium.

9 ameral injections have no adverse effects on corneal endothelium.

10 ed to stimulate concomitant proliferation of corneal endothelium.

11 creasing cAMP, decreases permeability of the corneal endothelium.

12 short and long-term effects of FLACS on the corneal endothelium.

13 technique that is the least traumatic to the corneal endothelium.

14 apoptosis in the Col8a2(Q455K/Q455K) mutant corneal endothelium.

15 croscopic images of the alizarin red-stained corneal endothelium.

16 r segment inflammation adversely affects the corneal endothelium.

17 response element-driven antioxidants in FECD corneal endothelium.

18 ylation of Akt and p38, respectively, in the corneal endothelium.

19 GF-2 and facilitated its nuclear location in corneal endothelium.

20 in the anterior chamber (AC) or attached to corneal endothelium.

21 ent deleterious effects on the health of the corneal endothelium.

22 Prx proteins were identified in human corneal endothelium.

23 id not detect OVOL2 expression in the normal corneal endothelium.

24 , p21WAF1/Cip1, and p27Kip1 are expressed in corneal endothelium.

25 olysis or by inducing apoptosis of the donor corneal endothelium.

26 the expression and function of JAM-A in the corneal endothelium.

27 proteins JAM-C, CAR, and AF-6 in the rabbit corneal endothelium.

28 expression was found to be restricted to the corneal endothelium.

29 , that have potentially toxic effects on the corneal endothelium.

30 binding of heparin binding growth factors to corneal endothelium.

31 ibute to the HCO(3)(-) transport in cultured corneal endothelium.

32 of fluid from the corneal stroma across the corneal endothelium.

33 sed to examine the expression of CLCA in the corneal endothelium.

34 asurements in all patients: (1) near central corneal endothelium; (2) in mid-AC; and (3) in AC angle.

35 ied in serial analysis of gene expression of corneal endothelium, a finding confirmed by immunohistoc

36 Human corneal endothelium, a neural crest-derived tissue, has

37 however, that growth factors released by the corneal endothelium also could modulate lens functions (

38 e mice resulted in efficient transduction of corneal endothelium and an increase in aqueous concentra

39 y) and cranial neural crest (corneal stroma, corneal endothelium and anterior iris).

40 , oxygen tension was 24 +/- 5 mm Hg near the corneal endothelium and decreased to 17 +/- 8 mm Hg near

41 The corneal endothelium and epithelium from 21 human corneas

42 section provides higher survival of both the corneal endothelium and graft, but lower visual acuity.

43 A expression in tight junctions of the human corneal endothelium and human RPE.

44 a wound closure model of the cultured rabbit corneal endothelium and in cultures treated with experim

45 By contrast, ocular tissues, such as the corneal endothelium and iris/ciliary body, are imperviou

46 rophy (FCD) is a progressive disorder of the corneal endothelium and is pathologically defined by the

47 rophy (FCD) is a hereditary dystrophy of the corneal endothelium and is responsible for majority of t

48 (FECD) is a common, familial disease of the corneal endothelium and is the leading indication for co

49 dystrophy (FCD) is a genetic disorder of the corneal endothelium and is the most common cause of corn

50 lliam Bourne, MD, summarizes his work on the corneal endothelium and its importance to corneal transp

51 ctopic expression of epithelial genes in the corneal endothelium and keratocytes, including the basem

52 e presence of a Na+-K+-2Cl- cotransporter in corneal endothelium and of its possible involvement in v

53 sular and zonular integrity, and protect the corneal endothelium and other anterior segment structure

54 Expression of Qa-2 in the corneal endothelium and other substructures lining the a

55 ey investigate JAM-A expression in the human corneal endothelium and retinal pigment epithelium (RPE)

56 structures lining the anterior chamber: the corneal endothelium and stroma, iris stroma, and trabecu

57 y reported that JAM-A is expressed in rabbit corneal endothelium and that antibody to JAM-A produces

58 AF-6 are expressed in tight junctions of the corneal endothelium and that JAM-A has a major role in m

59 However, 2 days after surgery, the corneal endothelium and the anterior chamber formed adja

60 misexpression disrupts the integrity of the corneal endothelium and the expression of extracellular

61 e adenovirus-mediated gene transfer to donor corneal endothelium and to delineate the kinetics of mar

62 ior surface of rejected grafts was devoid of corneal endothelium and was covered incompletely with bo

63 xpression of markers indicative of the human corneal endothelium, and can be tissue-engineered onto t

64 uveoscleral outflow pathway and in the iris, corneal endothelium, and ciliary nonpigmented epithelium

65 as observed in ciliary muscle, iris, sclera, corneal endothelium, and ciliary nonpigmented epithelium

66 ns epithelium, immature trabecular meshwork, corneal endothelium, and corneal epithelium, whereas NT-

67 nsferring a gene encoding soluble TNFR-Ig to corneal endothelium, and ex vivo production of a biologi

68 Expression of JAM-A was observed in human corneal endothelium, and its distribution correlated wit

69 is present in both fresh and cultured bovine corneal endothelium, and the expression is apparently hi

70 r fibrosis tissue did not originate from the corneal endothelium, and they maintained fibroblastic ph

71 PDGF-A is also present in the corneal endothelium anterior to the lens epithelium in e

72 cadherin expression and the formation of the corneal endothelium are regulated by signals from the le

73 stmortem studies showed no difference in the corneal endothelium between PPC and CCC eyes.

74 Corneal endothelium bound the antibody for all three TGF

75 denovirus receptor) was also observed in the corneal endothelium, but their distribution was diffuse

76 mmunolabeling was detected in normal control corneal endothelium, but was absent in corneal endotheli

77 TNF-alpha-induced barrier dysfunction in the corneal endothelium can be suppressed by inhibitors of p

78 der certain pathophysiologic conditions, the corneal endothelium can produce an abnormal posterior co

79 l cellular pattern during development of the corneal endothelium (CE), a monolayer of neural crest-de

80 Nevertheless, long-term corneal endothelium cell density and crystalline lens cl

81 changes in number, density, and shape of the corneal endothelium cells in 128 eyes of 64 patients div

82 F-alpha breaks down the barrier integrity of corneal endothelium, concomitant with the disruption of

83 The corneal endothelium, considered a nonrenewing population

84 owever, aqueous humor (AH), which bathes the corneal endothelium, contains a 12-kDa protein which inh

85 equired in neural crest for specification of corneal endothelium, corneal stroma and the sclera.

86 No recognizable corneal endothelium, corneal stroma, iris stroma, or ant

87 endothelial-mesenchymal transition in a rat corneal endothelium cryo-injury model and significantly

88 ser-assisted cataract surgery (FLACS) affect corneal endothelium during cataract surgery.

89 Our data suggest that formation of a corneal endothelium during early ocular morphogenesis is

90 y offer equal or increased protection of the corneal endothelium during surgery compared with viscoel

91 Our finding of a novel phenotype of corneal endothelium emphasizes the morphologic diversity

92 nists that increased intracellular Ca(2+) in corneal endothelium, enhanced HCO(3)(-) permeability by

93 It is unknown why human corneal endothelium exhibits limited capacity to divide

94 les, such as TGF-beta, which may protect the corneal endothelium from NK cell-mediated damage.

95 act inhibition and promoted proliferation in corneal endothelium from older donors.

96 The authors hypothesize that corneal endothelium from older individuals divide in sit

97 be an important modulator for protecting the corneal endothelium from unbridled NK cell-mediated inju

98 acterized by thin corneal stroma, absence of corneal endothelium, fusion of cornea to lens (a Peters'

99 The cells of the corneal endothelium had TRF lengths ranging from 11.0 to

100 The ultrastructure of tight junctions in the corneal endothelium has been studied extensively, yet li

101 Gene transfer to the corneal endothelium has potential for the prevention or

102 ct baseline CT, which is consistent with the corneal endothelium having a substantial functional rese

103 Expression of JAM-A in human corneal endothelium, human RPE tissue, and cultured ARPE

104 We also found a novel phenotype of corneal endothelium in 4 normal eyes of 2 subjects, whic

105 ine in aqueous humor could help maintain the corneal endothelium in a G1-phase-arrested state in vivo

106 As such, this cytokine may maintain the corneal endothelium in a G1-phase-arrested state in vivo

107 as observed in the tight junctions of rabbit corneal endothelium in a localization pattern identical

108 uman aqueous humor, promotes the survival of corneal endothelium in corneal organ cultures, and wheth

109 The presence of VIP in the corneal endothelium in fresh human donor and bovine eyes

110 Corneal endothelium in humans does not divide to any sig

111 ntrol corneal endothelium, but was absent in corneal endothelium in patients with endothelialization

112 ble deposits called guttae develop under the corneal endothelium in patients with FCD.

113 OL4A3, which is ectopically expressed by the corneal endothelium in PPCD.

114 The possible roles of corneal endothelium in promoting immune privilege of cor

115 iated state and suppressing apoptosis in the corneal endothelium in situ.

116 ession and localization of the three CKIs in corneal endothelium in situ.

117 tive proliferative capacity exhibited by the corneal endothelium in these two species may be caused b

118 gated whether PAF can affect the function of corneal endothelium in vitro.

119 Corneal endothelium in vivo is arrested in G1, the phase

120 Ki67, suggesting that, as in humans, rabbit corneal endothelium in vivo is arrested in G1-phase upst

121 and maintenance of mitotic inhibition of the corneal endothelium in vivo.

122 In vivo, gene transfer was evident in corneal endothelium, iris anterior surface, and trabecul

123 nded from 1 week to more than 5 weeks in the corneal endothelium, iris, and trabecular meshwork of nu

124 D), in which an epithelial transition of the corneal endothelium is associated with abnormal endothel

125 Fluid transport by the corneal endothelium is dependent on the presence of HCO(

126 Although the corneal endothelium is highly susceptible to Fas-induced

127 l, especially when the functional reserve of corneal endothelium is low.

128 The corneal endothelium is the most important single layer i

129 r chamber showed distributed localization in corneal endothelium, lens epithelium, and TM and did not

130 ons of rBV resulted in GFP expression in the corneal endothelium, lens, RPE, and retina.

131 PIOL's positional stability (distance to the corneal endothelium [M1] and the natural lens [M2]) as w

132 lation of AQP1 expression and/or function in corneal endothelium may reduce corneal swelling and opac

133 lated with fibroblast growth factor-2 and/or corneal endothelium modulation factor, they synthesize a

134 A confluent bovine corneal endothelium monolayer was used as the control.

135 The permeabilities of the RPE and bovine corneal endothelium monolayers to fluorescein (20 microg

136 Staining patterns of the corneal endothelium most closely corresponded to those o

137 Apoptosis was also not induced in human corneal endothelium, mouse corneal epithelium, or iris/c

138 tudy, the authors rephotographed the central corneal endothelium of 52 normal subjects with the same

139 roliferating subpopulation of cells from the corneal endothelium of adult normal and FECD donors that

140 scles, periocular mesenchymal-like cells and corneal endothelium of early zebrafish embryos.

141 The corneal endothelium of rabbits stained positively for cy

142 evidence of ectopic expression of COL4A3 in corneal endothelium of the proband of the original PPCD3

143 noclonal antibodies were localized in rabbit corneal endothelium only: cyclins D, E, A, and B1; prote

144 However, effects on corneal endothelium or ciliary epithelium are a potentia

145 pathway and did not show any activity in the corneal endothelium or other cells posterior to the scle

146 a lesser extent, the trabecular meshwork and corneal endothelium--revealed positive fluorescence stai

147 results following the repair are acceptable, corneal endothelium seems to be subjected to severe dama

148 The corneal endothelium showed polymegethism and cells conta

149 The corneal endothelium shows features consistent with HIV-r

150 In corneal endothelium, SLC4A11 displays robust Na(+)-coupl

151 lls of the corneal and limbal epithelium and corneal endothelium stained positively for protein kinas

152 corneal tissue in vivo demonstrated that the corneal endothelium stains with anti-type I collagen ant

153 We assessed features of the corneal endothelium that are known to be associated with

154 cross cell membranes, including those in the corneal endothelium that contribute to the fluid transpo

155 ssay revealed very few dead cells in ex vivo corneal endothelium that overexpressed E2F2.

156 D) is a degenerative genetic disorder of the corneal endothelium that represents one of the most comm

157 t rejection, and this is in contact with the corneal endothelium, this has the potential to restrict

158 cannot penetrate Descemet's membrane and the corneal endothelium to enter the anterior chamber (AC).

159 Rabbit corneal endothelium tolerated exposure to 6.8 M PROH, an

160 was measured by Goldmann tonometry, AHF and corneal endothelium transfer coefficient (ka) by fluorop

161 Therefore we ask whether SLC4A11 in corneal endothelium transports borate (B[OH](4)(-)), bic

162 ssion of N-cadherin and the formation of the corneal endothelium until E15.

163 aqueous humor stimulates FGF-2 synthesis in corneal endothelium via PI3-kinase and p38.

164 Using specular microscopy, the corneal endothelium was assessed for features of aging (

165 role of CKIs in inhibiting proliferation in corneal endothelium was examined by first determining th

166 rmeability across the apical membrane of the corneal endothelium was examined.

167 morphology, maturation, and function of the corneal endothelium was examined.

168 after cryotreatment, whereas FGF-2 in normal corneal endothelium was localized at the plasma membrane

169 f polymorphonuclear leukocytes (PMNs) to the corneal endothelium was observed after freezing, and IL-

170 When corneal endothelium was stained with anti-FGF-2 antibody

171 Changes in density of the corneal endothelium were quantified by specular microsco

172 The posterior stroma and corneal endothelium were unaffected.

173 embrane, a thick basement membrane under the corneal endothelium, where it forms a hexagonal lattice

174 A were localized in the cytoplasm of rabbit corneal endothelium, whereas cyclins B1 and p34cdc2 were

175 The absence of MHC class I Ags on the corneal endothelium, which lines the anterior chamber of

176 rated the colocalization of E2F2 and EGFP in corneal endothelium with a transfection efficiency of 10

177 FCD) is an autosomal dominant disease of the corneal endothelium with variable penetrance and express